DK0900233T3 - Steroid-nitrit- og -nitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler - Google Patents

Steroid-nitrit- og -nitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler

Info

Publication number: DK0900233T3
Authority: DK; Denmark
Prior art keywords: inflammatory drugs; ester derivatives; nitrate ester; nitrite; steroid
Prior art date: 1996-05-02

Application number

DK97923417T

Other languages

Danish (da)

English (en)

Inventor

Foe S Tjoeng

Mark G Currie

Mark E Zupec

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-02

Filing date

1997-04-28

Publication date

2001-01-22

1997-04-28 Application filed by Searle & Co filed Critical Searle & Co

2001-01-22 Application granted granted Critical

2001-01-22 Publication of DK0900233T3 publication Critical patent/DK0900233T3/da

Links

229910002651 NO3 Inorganic materials 0.000 title abstract 2
-1 Steroid nitrite Chemical class 0.000 title 2
229940124599 anti-inflammatory drug Drugs 0.000 title 1
MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 2
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000005556 hormone Substances 0.000 abstract 1
229940088597 hormone Drugs 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
230000003637 steroidlike Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK97923417T 1996-05-02 1997-04-28 Steroid-nitrit- og -nitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler DK0900233T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/643,018 US5837698A (en)	1996-05-02	1996-05-02	Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
PCT/US1997/006373 WO1997041144A1 (en)	1996-05-02	1997-04-28	Novel steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs

Publications (1)

Publication Number	Publication Date
DK0900233T3 true DK0900233T3 (da)	2001-01-22

Family

ID=24579022

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97923417T DK0900233T3 (da)	1996-05-02	1997-04-28	Steroid-nitrit- og -nitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler

Country Status (12)

Country	Link
US (1)	US5837698A (de)
EP (1)	EP0900233B1 (de)
JP (1)	JP2000509072A (de)
AT (1)	ATE197799T1 (de)
AU (1)	AU2922797A (de)
CA (1)	CA2253346A1 (de)
DE (1)	DE69703619T2 (de)
DK (1)	DK0900233T3 (de)
ES (1)	ES2152670T3 (de)
GR (1)	GR3035088T3 (de)
PT (1)	PT900233E (de)
WO (1)	WO1997041144A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5824669A (en) *	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it)	1996-10-04	1998-06-18	Nicox Sa	Composti corticoidei
ATE473759T1 (de)	1998-05-22	2010-07-15	Univ Leland Stanford Junior	Bifunktionelle moleküle sowie darauf basierende therapien.
WO2000049993A2 (en) *	1999-02-24	2000-08-31	Nitromed, Inc.	Nitrosated and nitrosylated steroids for the treatment of cardiovascular diseases and disorders
IT1311922B1 (it) *	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
IT1320176B1 (it) *	2000-12-22	2003-11-26	Nicox Sa	Dispersioni solide di principi attivi nitrati.
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
ITMI20020148A1 (it) *	2002-01-29	2003-07-29	Nicox Sa	Nuovi corticosteroidi
ITMI20021025A1 (it) *	2002-05-14	2003-11-14	Nicox Sa	Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale
JP4274784B2 (ja) *	2002-05-28	2009-06-10	新光電気工業株式会社	配線形成システムおよびその方法
US6968669B2 (en) *	2002-11-06	2005-11-29	Lancer Partnership Ltd.	Flexible packaging
SE0300971D0 (sv) *	2003-04-03	2003-04-03	Aga Ab	Nitric oxide in treatment of inflammation
CN102379684B (zh)	2005-04-28	2014-11-19	普罗透斯数字保健公司	药物信息系统
CN101300265A (zh) *	2005-09-02	2008-11-05	尼科克斯公司	糖皮质激素硝酰氧基衍生物
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
NZ590454A (en) *	2008-07-31	2012-09-28	Nicox Sa	Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
EP2398500B1 (de)	2009-02-20	2019-03-13	2-BBB Medicines B.V.	Arzneiabgabesystem auf glutathion-basis
ES2942923T3 (es)	2009-05-06	2023-06-07	Laboratory Skin Care Inc	Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
CN102302501B (zh)	2010-06-07	2012-10-03	刘超	糖皮质激素硝基衍生物在制备利尿药物制剂中的应用
WO2018071736A1 (en) *	2016-10-14	2018-04-19	Van Andel Research Institute	Structures and mechanism for the design of highly potent glucocorticoids
KR20250114431A (ko)	2016-11-08	2025-07-29	리제너론 파마슈티칼스 인코포레이티드	스테로이드 및 이의 단백질-접합체
KR20200007905A (ko)	2017-05-18	2020-01-22	리제너론 파마슈티칼스 인코포레이티드	사이클로덱스트린 단백질 약물 접합체
IL313068A (en)	2017-11-07	2024-07-01	Regeneron Pharma	Hydrophilic linkers for antibody drug conjugates
IL275757B2 (en) *	2018-01-08	2025-08-01	Regeneron Pharma	Steroids and antibody-conjugates thereof
MX2020011546A (es)	2018-05-09	2021-01-29	Regeneron Pharma	Anticuerpos anti-msr1 y metodos de uso de los mismos.

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2990401A (en) *	1958-06-18	1961-06-27	American Cyanamid Co	11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
US3002010A (en) *	1958-06-18	1961-09-26	American Cyanamid Co	Acylated steroids and method of preparing the same
US3215713A (en) *	1960-04-04	1965-11-02	Schering Corp	Steroid nitrite esters
US3298941A (en) *	1961-05-29	1967-01-17	Schering Corp	Photochemical process for rearranging organic hypohalite and nitrite compounds
US3183252A (en) *	1963-09-05	1965-05-11	Syntex Corp	16-nitratoalkyl-pregnanes
GB1082573A (en) *	1965-02-12	1967-09-06	Boots Pure Drug Co Ltd	Improvements in the preparation of steroid esters
US3639434A (en) *	1967-02-02	1972-02-01	Boots Pure Drug Co Ltd	17-acyloxysteroids and their manufacture
DE1643036B2 (de) *	1967-08-16	1976-04-15	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue 11 beta-halogensteroide, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung
HU164115B (de) *	1971-05-07	1973-12-28
HU163145B (de) *	1971-09-23	1973-06-28
DD113355A1 (de) *	1972-06-15	1975-06-05
DE2236115A1 (de) *	1972-07-20	1974-02-07	Schering Ag	Verfahren zur herstellung von delta hoch 4.9(11).16 -3.20diketosteroiden
GB1446126A (en) *	1974-05-16	1976-08-18	Res Inst For Medicine Chemistr	Photolytic preparation of diol mononitrates
US5264422A (en) *	1986-06-30	1993-11-23	Fidia S.P.A.	Esters of alginic acid with steroidal alcohols
SU1510131A1 (ru) *	1986-11-21	1991-02-15	1-Й Московский Медицинский Институт Им.И.М.Сеченова	Состав дл пломбировани корневых каналов зубов
DE4223800A1 (de) *	1992-07-20	1994-01-27	Cassella Farbwerke Mainkur Ag	Verwendung von 1.2.5-Oxadiazol-2-oxiden zur Behandlung erektiler Dysfunktionen
ATE172183T1 (de) *	1992-07-30	1998-10-15	Cal Int Ltd	Ester und kombinationen von einem organischen nitrat und einem salicyclat
ES2059264B1 (es) *	1992-11-05	1995-06-16	Berrazueta Fernandez Jose Ramo	Utilizacion de los nitrovasodilatadores en la preparacion de medicamentos antiinflamatorios y analgesicos de uso topico.

1996
- 1996-05-02 US US08/643,018 patent/US5837698A/en not_active Expired - Fee Related
1997
- 1997-04-28 ES ES97923417T patent/ES2152670T3/es not_active Expired - Lifetime
- 1997-04-28 JP JP9538946A patent/JP2000509072A/ja not_active Abandoned
- 1997-04-28 DE DE69703619T patent/DE69703619T2/de not_active Expired - Fee Related
- 1997-04-28 AU AU29227/97A patent/AU2922797A/en not_active Abandoned
- 1997-04-28 AT AT97923417T patent/ATE197799T1/de not_active IP Right Cessation
- 1997-04-28 EP EP97923417A patent/EP0900233B1/de not_active Expired - Lifetime
- 1997-04-28 DK DK97923417T patent/DK0900233T3/da active
- 1997-04-28 CA CA002253346A patent/CA2253346A1/en not_active Abandoned
- 1997-04-28 PT PT97923417T patent/PT900233E/pt unknown
- 1997-04-28 WO PCT/US1997/006373 patent/WO1997041144A1/en not_active Ceased
2000
- 2000-12-15 GR GR20000402776T patent/GR3035088T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT900233E (pt)	2001-03-30
DE69703619T2 (de)	2001-05-03
JP2000509072A (ja)	2000-07-18
US5837698A (en)	1998-11-17
AU2922797A (en)	1997-11-19
ATE197799T1 (de)	2000-12-15
EP0900233B1 (de)	2000-11-29
EP0900233A1 (de)	1999-03-10
WO1997041144A1 (en)	1997-11-06
CA2253346A1 (en)	1997-11-06
GR3035088T3 (en)	2001-03-30
ES2152670T3 (es)	2001-02-01
DE69703619D1 (de)	2001-01-04

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