DK1015445T3 - Antimikrobielle quinoloner, deres sammensætninger og anvendelser - Google Patents

Antimikrobielle quinoloner, deres sammensætninger og anvendelser

Info

Publication number
DK1015445T3
DK1015445T3 DK98948208T DK98948208T DK1015445T3 DK 1015445 T3 DK1015445 T3 DK 1015445T3 DK 98948208 T DK98948208 T DK 98948208T DK 98948208 T DK98948208 T DK 98948208T DK 1015445 T3 DK1015445 T3 DK 1015445T3
Authority
DK
Denmark
Prior art keywords
compositions
antimicrobial quinolones
quinolones
antimicrobial
Prior art date
Application number
DK98948208T
Other languages
English (en)
Inventor
Benoit Ledoussal
Ji-In Kim Almstead
Jeffrey Lyle Gray
Xiufeng Eric Hu
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Application granted granted Critical
Publication of DK1015445T3 publication Critical patent/DK1015445T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
DK98948208T 1997-09-15 1998-09-15 Antimikrobielle quinoloner, deres sammensætninger og anvendelser DK1015445T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5889197P 1997-09-15 1997-09-15
US13985998A 1998-08-25 1998-08-25
PCT/US1998/019138 WO1999014214A1 (en) 1997-09-15 1998-09-15 Antimicrobial quinolones, their compositions and uses

Publications (1)

Publication Number Publication Date
DK1015445T3 true DK1015445T3 (da) 2009-05-11

Family

ID=26738133

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98948208T DK1015445T3 (da) 1997-09-15 1998-09-15 Antimikrobielle quinoloner, deres sammensætninger og anvendelser

Country Status (30)

Country Link
US (3) US6329391B1 (da)
EP (1) EP1015445B1 (da)
JP (1) JP4669607B2 (da)
KR (1) KR100423778B1 (da)
CN (1) CN1264837C (da)
AR (1) AR013493A1 (da)
AT (1) ATE423776T1 (da)
AU (1) AU735186B2 (da)
BR (1) BR9812644B1 (da)
CA (1) CA2303389C (da)
CO (1) CO4970702A1 (da)
CY (1) CY1110255T1 (da)
CZ (1) CZ299554B6 (da)
DE (1) DE69840599D1 (da)
DK (1) DK1015445T3 (da)
ES (1) ES2321042T3 (da)
HU (1) HUP0100051A3 (da)
ID (1) ID24703A (da)
IL (2) IL135036A0 (da)
MY (1) MY138335A (da)
NO (1) NO323563B1 (da)
NZ (1) NZ503740A (da)
PE (1) PE128799A1 (da)
PL (1) PL339408A1 (da)
PT (1) PT1015445E (da)
RU (1) RU2193558C2 (da)
SA (1) SA99191136B1 (da)
SK (1) SK286420B6 (da)
TR (2) TR200001435T2 (da)
WO (1) WO1999014214A1 (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2321042T3 (es) 1997-09-15 2009-06-01 THE PROCTER & GAMBLE COMPANY Quinolonas antimicrobianas, composiciones y usos de las mismas.
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
BR9915599A (pt) * 1998-11-24 2001-11-20 Daiichi Seiyaku Co Derivados de aminometilpirrolidina substituìdacom cicloalquila
US6750224B1 (en) 1999-05-07 2004-06-15 Wockhardt Limited Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment
WO2000068229A2 (en) * 1999-05-07 2000-11-16 Wockhardt Limited (s)-benzoquinolizine carboxylic acids and their use as antibacterial agents
US6514986B2 (en) 2000-11-22 2003-02-04 Wockhardt Limited Chiral fluoroquinolone arginine salt forms
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
EP1336611B1 (en) * 2000-11-20 2007-09-05 Daiichi Pharmaceutical Co., Ltd. Dehalogeno compounds
RU2298006C2 (ru) * 2000-11-20 2007-04-27 Дайити Фармасьютикал Ко., Лтд. Дегалогенированные соединения, антибактериальное средство и терапевтическое средство на их основе, способ получения антибактериального или лекарственного средства, применение дегалогенированных соединений для получения антибактериального или лекарственного средства
NZ525571A (en) * 2000-12-14 2004-09-24 Procter & Gamble Antimicrobial quinolones
DE10114364A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Verfahren zur Herstellung von antibiotischen Kompositen
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6664267B1 (en) 2002-05-28 2003-12-16 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
CN101353321A (zh) 2002-11-21 2009-01-28 辉瑞产品公司 3-氨基-哌啶衍生物及其制备方法
BR0215954A (pt) * 2002-11-26 2005-09-13 Uc Tech Métodos de redução da possibilidade de mortalidade em um animal, de expressão virulenta em um patógeno intestinal, e da expressão de adesina / lectina pa-i em uma célula bacteriana, de inibição de expressão de adesina / lectina pa-i em um patógeno intestinal, de ativação induzida por intestino de adesina / lectina pa-i, de mudança morfológica induzida por c4-hsl de um patógeno intestinal, e de aderência de célula bacteriana em um intestino de mamìfero, de melhoria de patogênese intestinal, de prevenção de uma doença ou condição anormal, de infecção de pele e respiratória, de uma doença sexualmente transmitida, de um distúrbio de trato digestivo, de perda de capacidade lactante em um animal, e de desenvolvimento de um distúrbio epitelial mediado por micróbio em uma animal de idade de amamentação, de irrigação de pelo menos uma porção do trato urinário, e para monitoração da administração de poli (etileno-glicol) (peg) a um animal, composição farmacêutica, kits para a prevenção ou tratamento terapêutico de sepsia derivada de intestino, e para a monitoração da administração de poli (etileno-glicol), e, preservativo
RU2260002C2 (ru) * 2003-08-08 2005-09-10 ООО "Исследовательский институт химического разнообразия" Замещенные 6-сульфо-2-оксо-1,2-дигидрохинолин 4-карбоновые кислоты и их производные (варианты) и фокусированная библиотека
WO2004108680A1 (ja) * 2003-06-06 2004-12-16 Daiichi Pharmaceutical Co., Ltd. 光学活性なキノロンカルボン酸誘導体の製造中間体およびその製造法
WO2005023805A1 (en) * 2003-09-04 2005-03-17 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
DE10341534A1 (de) * 2003-09-09 2005-03-31 Bayer Chemicals Ag Difluoralkylaromaten
SG144936A1 (en) * 2003-09-10 2008-08-28 Kyorin Seiyaku Kk 7-(4-substituted-3-cyclopropylaminomethyl-1- pyrrolidinyl)quinolonecarboxylic acid derivative
CN1997642B (zh) * 2003-09-22 2012-06-13 詹森药业有限公司 7-氨基亚烷基-杂环喹诺酮类和萘啶酮类
SE0400235D0 (sv) * 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
US20090117205A1 (en) * 2004-07-02 2009-05-07 Daiichi Pharmaceutical Co., Ltd Quinolone-containing medicinal composition
US7732612B2 (en) * 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
DE102006005861A1 (de) * 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
DE102006010643A1 (de) * 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
TWI391378B (zh) * 2006-03-16 2013-04-01 Astellas Pharma Inc 喹啉酮衍生物或其製藥學上可被容許之鹽
CN101045725B (zh) * 2006-03-28 2012-12-05 太景生物科技股份有限公司 某些喹诺酮化合物的苹果酸盐和多晶型物
EP1999106B1 (en) * 2006-03-28 2012-06-27 TaiGen Biotechnology Co., Ltd. A hydride reduction process for preparing quinolone intermediates
PL2001862T3 (pl) * 2006-03-28 2011-09-30 Warner Chilcott Co Llc Jabłczany oraz odmiany polimorficzne kwasu (3S,5S)-7-[3-amino-5-metylo-piperydynylo]-1-cyklopropylo-1,4-dihydro-8-metoksy-4-okso-3-chinolinokarboksylowego
WO2007110835A2 (en) * 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
TW200811153A (en) 2006-06-23 2008-03-01 Japan Tobacco Inc 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor
CA2688008A1 (en) * 2007-05-24 2008-11-27 Kyorin Pharmaceutical Co., Ltd. Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
US8658183B2 (en) * 2007-08-09 2014-02-25 Taigen Biotechnology Company, Ltd. Antimicrobial parenteral formulation
CN101361739B (zh) * 2007-08-09 2012-03-14 太景生物科技股份有限公司 抗菌剂的肠胃外制剂
NZ588898A (en) * 2008-07-01 2012-09-28 Taigen Biotechnology Co Ltd Use of nemonoxacin for treating antibiotic-resistant staphylococcus aureus infection
CN101618039B (zh) * 2008-07-02 2012-04-11 太景生物科技股份有限公司 肺炎的治疗药物
US20120157492A1 (en) * 2008-07-15 2012-06-21 Taigen Biotechnology Co., Ltd. Antibiotic drug
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2936951B1 (fr) * 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
EP2376477A4 (en) * 2008-12-15 2012-08-08 Taigen Biotechnology Co Ltd STEREOSELECTIVE SYNTHESIS OF PIPERIDINE DERIVATIVES
JP5789611B2 (ja) * 2009-10-23 2015-10-07 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 嚢胞性線維症膜コンダクタンス制御因子のモジュレーターを調製するためのプロセス
EP2569303A1 (en) * 2010-05-11 2013-03-20 Sanofi Substituted n-alkyl and n-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
CN102746223B (zh) * 2012-07-30 2013-10-23 浙江新东港药业股份有限公司 一种氟哌酸与氯哌酸的分离方法
CN103819401B (zh) * 2012-11-19 2016-04-13 浙江中欣氟材股份有限公司 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法
US20160326165A1 (en) 2013-12-26 2016-11-10 Kinki University Alkoxycarbonyl hemiacetal-type ester prodrug of pyridone carboxylic acid antibacterial drug
RU2636751C1 (ru) 2016-11-02 2017-12-01 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Антибактериальные средства на основе производных ципрофлоксацина
MX2022004742A (es) * 2019-10-23 2022-05-16 Taigen Biotechnology Co Ltd Derivados del acido carboxilico de quinolona.
JP2023517539A (ja) * 2020-03-03 2023-04-26 レドナ・セラピューティクス，インコーポレーテッド Ｒｎａ結合タンパク質またはｒｎａ修飾タンパク質を標的とする化合物

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017622A (en) 1972-12-18 1977-04-12 Dainippon Pharmaceutical Co., Ltd. Piperazine derivatives
JPS5186476A (en) 1975-01-17 1976-07-29 Yoshitomi Pharmaceutical Shinkina kinoronkarubonsanjudotaino seiho
JPS5845426B2 (ja) 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
JPS604820B2 (ja) 1979-02-26 1985-02-06 大塚製薬株式会社 キノリンカルボン酸誘導体
JPS5649382A (en) 1979-09-28 1981-05-02 Dainippon Pharmaceut Co Ltd 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt
IE55898B1 (en) 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
US5281612A (en) 1982-09-09 1994-01-25 Warner-Lambert Company Naphthyridine antibacterial agents
US4665079A (en) 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
DE3248506A1 (de) 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
FR2548664B1 (fr) * 1983-07-06 1986-03-21 Provesan Sa Derives 7-(pyrrol-l-yl) des acides l-ethyl-1,4-dihydro-4-oxoquinoleine-3-carboxyliques et l-ethyl-1,4-dihydro-4-oxo-(1,8-naphtyridine)-3-carboxyliques substitues, leur preparation et leur application en tant que medicaments
US4994599A (en) 1987-11-20 1991-02-19 Abbott Laboratories Intermediates for producing quinolone-3-carboxylic acids
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
JPS60221484A (ja) * 1984-04-17 1985-11-06 Fuji Photo Film Co Ltd 放射線像変換方法およびその方法に用いられる放射線像変換パネル
US4822801A (en) 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
US4771054A (en) 1985-01-23 1988-09-13 Warner-Lambert Company Antibacterial agents
JPS61225181A (ja) * 1986-02-04 1986-10-06 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
HUT40639A (en) 1985-03-08 1987-01-28 Kyorin Seiyaku Kk Process for producing quinolon-carboxylic acid derivative and pharmaceutical composition containing them
EP0207420B1 (en) 1985-06-26 1992-05-06 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives
JPS6236377A (ja) * 1985-07-03 1987-02-17 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
DE3524411A1 (de) * 1985-07-09 1987-01-15 Kernforschungsz Karlsruhe Verfahren zum herstellen von spinnduesenplatten
JPS6256673A (ja) 1985-09-03 1987-03-12 Kayaba Ind Co Ltd カウンタ−バランス弁の制御装置
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
DE3705621C2 (de) 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
JPS62215572A (ja) 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPS63198664A (ja) 1986-03-31 1988-08-17 Sankyo Co Ltd キノロンカルボン酸誘導体
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
JPH0717608B2 (ja) 1986-04-25 1995-03-01 杏林製薬株式会社 ６−アルコキシキノロンカルボン酸誘導体
DE3704907A1 (de) 1987-02-17 1988-08-25 Bayer Ag Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden
JPS6416767A (en) 1987-07-09 1989-01-20 Dainippon Pharmaceutical Co 8-halogenoquinoline derivative, its ester and salt
JPS6416767U (da) 1987-07-20 1989-01-27
JP2608413B2 (ja) 1987-07-26 1997-05-07 本多電子株式会社 超音波駆動装置
US4780468A (en) 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
US4921857A (en) 1987-09-18 1990-05-01 Merck & Co., Inc. 4-Oxo-4h-quinolizine-3-carboxylic acids and derivatives thereof
FR2625200A1 (en) * 1987-12-29 1989-06-30 Esteve Labor Dr 7-(1-Azetidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their application as medicaments
US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
DE3816119A1 (de) * 1988-05-11 1989-11-23 Bayer Ag 7-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
JPH0395177A (ja) 1988-05-19 1991-04-19 Chugai Pharmaceut Co Ltd 新規キノロンカルボン酸誘導体
JP2844079B2 (ja) 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
DE3906365A1 (de) 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
FI95130C (fi) 1988-07-20 1995-12-27 Sankyo Co Menetelmä lääkeaineena käyttökelpoisten 4-oksokinoliini-3-karboksyylihapon johdannaisten valmistamiseksi
US5286723A (en) 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
US5328908A (en) 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
CA2001203C (en) 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
EP0997466A1 (en) 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Novel antimicrobial lactam-quinolones
US5164402A (en) 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
RU2049777C1 (ru) 1989-08-16 1995-12-10 Пфайзер Инк. Азабицикло-хинолон-карбоновые кислоты или их фармацевтически приемлемые кислотно-аддитивные соли и промежуточные продукты для их получения
JPH03115277A (ja) 1989-09-28 1991-05-16 Banyu Pharmaceut Co Ltd ピリドンカルボン酸誘導体
EP0443498A1 (en) * 1990-02-19 1991-08-28 Kyorin Pharmaceutical Co., Ltd. Isoindoline derivatives
JPH03244733A (ja) 1990-02-21 1991-10-31 Shimizu Corp 外壁の接続構造
US5116834A (en) 1990-04-12 1992-05-26 Warner-Lambert Company Quinolinecarboxylic acid antibacterial agents
DE69132348T2 (de) 1990-05-02 2001-03-15 Abbott Laboratories, Abbott Park Verbindungen vom chinolizinon-typ
US5580872A (en) 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
US5726182A (en) 1990-05-02 1998-03-10 Abbott Laboratories Quinolizinone type compounds
CS567590A3 (en) * 1990-11-16 1992-06-17 Vyzk Ustav Farm Biochem Sp Fluoroquinolone derivatives having in the position 7 4-piperidone radical or modifications thereof
US5364861A (en) 1990-11-30 1994-11-15 Warner-Lambert Company Optical isomers of 7-[3-(1,1-dialkylmethyl-1-amino-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents
US5072001A (en) 1990-11-30 1991-12-10 Warner-Lambert Company Certain optically active substituted 3-pyrraidine acetic acid derivatives useful as intermediates
US5258528A (en) 1990-11-30 1993-11-02 Warner-Lambert Company Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group
JPH04265511A (ja) 1991-02-19 1992-09-21 Sony Corp 磁気記録媒体
DE4120646A1 (de) 1991-06-22 1992-12-24 Bayer Ag 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
DE4123918A1 (de) 1991-07-19 1993-01-21 Bayer Ag 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren
KR930703292A (ko) 1991-12-27 1993-11-29 쿠사이 요시히로 신규 퀴놀론 유도체 또는 그의 염 및 이 화합물을 함유하는 항균제
EP0550016A1 (en) * 1991-12-31 1993-07-07 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and processes for preparing same
JPH05112554A (ja) 1992-02-19 1993-05-07 Chugai Pharmaceut Co Ltd 新規なキノロンカルボン酸誘導体
JPH05345777A (ja) 1992-04-16 1993-12-27 Hokuriku Seiyaku Co Ltd ７−（４，４−ジアルキル−３−アミノ置換ピロリジニル）キノロン−３−カルボン酸誘導体
NO304832B1 (no) 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
DE4230804A1 (de) 1992-09-15 1994-03-17 Bayer Ag 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate
DE4234078A1 (de) 1992-10-09 1994-04-14 Bayer Ag Chinoloncarbonsäuren
KR0148277B1 (ko) 1993-01-18 1998-11-02 채영복 신규한 플루오르퀴놀론계 유도체 및 그의 제조방법
DE4301246A1 (de) * 1993-01-19 1994-07-21 Bayer Ag Chinolon- und Naphthyridoncarbonsäurederivate
DE4301245A1 (de) 1993-01-19 1994-07-21 Bayer Ag Fluor-trifluormethylbenzoesäure-Derivate
CA2152828A1 (en) 1993-03-16 1994-07-07 Shin-Ichi Uesato 8-methoxy-quinolonecarboxylic acid derivatives
TW252107B (da) * 1993-08-27 1995-07-21 Hokuriku Pharmacetical Co Ltd
JPH09503783A (ja) 1993-10-14 1997-04-15 アボツト・ラボラトリーズ キノリジノン型化合物
JPH0780847B2 (ja) 1994-03-24 1995-08-30 大日本製薬株式会社 ビシクロアミン誘導体
ATE245638T1 (de) 1994-08-12 2003-08-15 Toyama Chemical Co Ltd Neue chinolon- oder naphthyridoncarbonsäurederivate oder deren salze
CA2212226A1 (en) 1995-02-02 1995-08-10 Katsumi Chiba Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof
DK0807630T3 (da) 1995-02-02 2003-09-01 Daiichi Seiyaku Co Heterocykliske forbindelser
JP3745433B2 (ja) 1995-02-02 2006-02-15 第一製薬株式会社 複素環式化合物
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
EP0871628A1 (en) 1995-06-06 1998-10-21 Abbott Laboratories Quinolizinone type compounds
JPH092953A (ja) 1995-06-16 1997-01-07 Chugai Pharmaceut Co Ltd バルフロキサシン製剤
IT1279532B1 (it) 1995-07-24 1997-12-16 Mediolanum Farmaceutici Spa Derivati chinolonici non fluorurati e loro impiego come agenti antibatterici
JPH0952893A (ja) 1995-08-10 1997-02-25 Yoshitomi Pharmaceut Ind Ltd キノロンカルボン酸誘導体の工業的な製造法およびその合成中間体
JP3833738B2 (ja) 1995-11-15 2006-10-18 第一製薬株式会社 置換アミノメチルピロリジン誘導体
DE69635812T2 (de) 1995-11-22 2006-10-19 Daiichi Pharmaceutical Co., Ltd. Substituierte aminocycloalkylpyrrolidinderivate
JP2697720B2 (ja) 1995-12-27 1998-01-14 日本電気株式会社 ポラリメトリ合成開口レーダ装置
WO1997029102A1 (en) 1996-02-09 1997-08-14 Toyama Chemical Co., Ltd. Quinolonecarboxylic acid derivatives or salts thereof
JPH09240318A (ja) 1996-03-07 1997-09-16 Mitsubishi Motors Corp インストルメントパネル取付け構造
JPH09287669A (ja) 1996-04-23 1997-11-04 Toshiba Corp 弁装置
US6384050B1 (en) 1996-10-25 2002-05-07 Daiichi Pharmaceutical Co., Ltd. Tricyclic amine derivatives
US6274592B1 (en) 1997-02-04 2001-08-14 Senju Pharmaceutical Co., Ltd. Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
KR20010012740A (ko) 1997-05-21 2001-02-26 스즈키 다다시 시스-이치환된 아미노사이클로알킬 피롤리딘 유도체
ZA984527B (en) 1997-05-30 1998-12-03 Daiichi Seiyaku Co Substituted cyclobutylamine derivative
KR100241673B1 (ko) 1997-08-09 2000-03-02 김충섭 퀴놀리진 카르복실산 유도체
US6387928B1 (en) * 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
ES2321042T3 (es) * 1997-09-15 2009-06-01 THE PROCTER & GAMBLE COMPANY Quinolonas antimicrobianas, composiciones y usos de las mismas.
GB9822440D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9914486D0 (en) 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
YU55902A (sh) 2000-01-24 2006-01-16 Warner-Lambert Company 3-aminohinazolin-2,4-dioni kao antibakterijska sredstva
NZ525571A (en) * 2000-12-14 2004-09-24 Procter & Gamble Antimicrobial quinolones
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses

Also Published As

Publication number Publication date
NO323563B1 (no) 2007-06-11
IL135036A (en) 2007-12-03
US20090111851A1 (en) 2009-04-30
EP1015445A1 (en) 2000-07-05
HK1030415A1 (en) 2001-05-04
JP4669607B2 (ja) 2011-04-13
AU735186B2 (en) 2001-07-05
WO1999014214A1 (en) 1999-03-25
CO4970702A1 (es) 2000-11-07
CA2303389C (en) 2007-07-17
US6329391B1 (en) 2001-12-11
CY1110255T1 (el) 2015-01-14
SK3812000A3 (en) 2000-09-12
SA99191136B1 (ar) 2006-07-30
US7482454B2 (en) 2009-01-27
US20060100436A1 (en) 2006-05-11
TR200505120T2 (tr) 2006-08-21
RU2193558C2 (ru) 2002-11-27
CZ299554B6 (cs) 2008-09-03
HUP0100051A2 (hu) 2001-10-28
AU9482998A (en) 1999-04-05
PL339408A1 (en) 2000-12-18
TR200001435T2 (tr) 2000-08-21
NZ503740A (en) 2002-09-27
SK286420B6 (sk) 2008-09-05
ATE423776T1 (de) 2009-03-15
PE128799A1 (es) 2000-02-17
CZ2000931A3 (cs) 2000-08-16
CA2303389A1 (en) 1999-03-25
BR9812644A (pt) 2001-12-18
DE69840599D1 (de) 2009-04-09
JP2001516756A (ja) 2001-10-02
IL135036A0 (en) 2001-05-20
MY138335A (en) 2009-05-29
PT1015445E (pt) 2009-05-14
AR013493A1 (es) 2000-12-27
ID24703A (id) 2000-08-03
US7868021B2 (en) 2011-01-11
HUP0100051A3 (en) 2002-08-28
ES2321042T3 (es) 2009-06-01
EP1015445B1 (en) 2009-02-25
NO20001340L (no) 2000-05-15
KR100423778B1 (ko) 2004-03-24
CN1278813A (zh) 2001-01-03
CN1264837C (zh) 2006-07-19
NO20001340D0 (no) 2000-03-15
KR20010024007A (ko) 2001-03-26
BR9812644B1 (pt) 2010-07-13

Similar Documents

Publication Publication Date Title
NO20001340L (no) Antimicrobielle quinoloner, deres sammensetninger og anvendelser
NO20021449L (no) Substituerte 2-tio-3,5-dicyano-4-aryl-6-aminopyridiner og deres anvendelse
FR12C0010I2 (fr) Composition herbicide
DK1128729T3 (da) Herbicid sammensætning
DE60020342D1 (de) Tiefeindringende antimikrobielle zusammensetzungen
NO20011956L (no) Substituerte fenylderivater, deres fremstilling og anvendelse
NO20015156L (no) 5-pyridyl-1,3-azolforbindelser, deres fremstilling og anvendelse
DE60014105D1 (de) Verbesserte herbizidzusammensetzunen
IT1292088B1 (it) Composizioni erbicide
DE69904699D1 (de) Pestizide Zusammensetzungen
NO20014603D0 (no) Tienopyrimidinforbindelser, deres fremstilling og anvendelse
DK1073672T3 (da) Antipicornavirale forbindelser, deres fremstilling og anvendelse
DK1019358T3 (da) 3,3-diarylpropylaminer, deres anvendelse og fremstilling
PT1139761E (pt) Composicoes herbicidas e concentrados tensioactivos
DE69837482D1 (de) Entschäumende zusammensetzungen
ID25463A (id) Komposisi-komposisi pestisida
ID23096A (id) Komposisi-komposisi pestisida
NO20013085D0 (no) Fosfororganiske forbindelser og deres anvendelse
NO20032666D0 (no) Antimikrobielle 2-pyridoner, deres sammensetninger og anvendelser
NO20006479D0 (no) Tienopyridinforbindelser, deres fremstilling og anvendelse
NO20014988L (no) Pseudomycin antifungale sammensetninger og fremgangsmåter for deres anvendelser
TR199801835A3 (tr) Antimikrobiyal kompozisyonlar.
NO996156L (no) Substituerte cykloheptener, deres fremstilling og anvendelse
ID30224A (id) Komposi-komposisi fungisida
NO20011859D0 (no) Imidazoisokinolinforbindelser, deres sammensetninger og anvendelse