DK2325207T3 - Fc-varianter med ændret binding til FcRn - Google Patents
Fc-varianter med ændret binding til FcRn Download PDFInfo
- Publication number
- DK2325207T3 DK2325207T3 DK10178237.3T DK10178237T DK2325207T3 DK 2325207 T3 DK2325207 T3 DK 2325207T3 DK 10178237 T DK10178237 T DK 10178237T DK 2325207 T3 DK2325207 T3 DK 2325207T3
- Authority
- DK
- Denmark
- Prior art keywords
- antibody
- binding
- polypeptide
- variant
- igg
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2893—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (8)
1. Polypeptid omfattende en Fc-variant af et humant IgG-Fc-polypeptid, hvor Fc-varianten har fra én til fem aminosyremodifikationer sammenlignet med et humant lgG1-, lgG2-, lgG3- eller lgG4-moder-Fc-polypeptid som defineret i figur 2, hvor Fc-varianten omfatter en tryptophan i position 308, hvor Fc-varianten udviser øget binding til FcRn sammenlignet med det humane lgG1-, lgG2-, lgG3- eller lgG4-moder-Fc-polypeptid, og hvor nummereringen er i overensstemmelse med EU-indekset i Kabat et al.
2. Polypeptid ifølge krav 1, hvor polypeptidet er et antistof.
3. Polypeptid ifølge et hvilket som helst af kravene 1 til 2, hvor polypeptidet er en Fc-fusion.
4. Polypeptid ifølge et hvilket som helst af kravene 2 til 3, hvor polypeptidet har specificitet for et målmolekyle, der er udvalgt fra gruppen bestående af et cytokin, en opløselig proteinfaktor og et protein, der er udtrykt på cancerceller.
5. Fremgangsmåde til fremstilling af et polypeptid ifølge krav 1 til 4, hvilken fremgangsmåde omfatter at tilvejebringe en celle omfattende en nukleinsyre, som koder for polypeptidet, hvor cellen dyrkes under betingelser, som er egnede til ekspression af polypeptidet.
6. Fremgangsmåde ifølge krav 5, hvor nukleinsyren er indeholdt i en ekspressionsvektor.
7. Værtscelle omfattende en nukleinsyre, som koder for et polypeptid ifølge krav 1 til 4.
8. Ekspressionsvektor, hvor ekspressionsvektoren koder for et polypeptid ifølge krav 1 til 4.
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62776304P | 2004-11-12 | 2004-11-12 | |
| US64288605P | 2005-01-11 | 2005-01-11 | |
| US64950805P | 2005-02-02 | 2005-02-02 | |
| US66246805P | 2005-03-15 | 2005-03-15 | |
| US66931105P | 2005-04-06 | 2005-04-06 | |
| US68160705P | 2005-05-16 | 2005-05-16 | |
| US69020005P | 2005-06-13 | 2005-06-13 | |
| US69660905P | 2005-07-05 | 2005-07-05 | |
| US70301805P | 2005-07-27 | 2005-07-27 | |
| US72645305P | 2005-10-12 | 2005-10-12 | |
| EP05851619A EP1817340B1 (en) | 2004-11-12 | 2005-11-14 | Fc variants with altered binding to fcrn |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2325207T3 true DK2325207T3 (da) | 2017-06-06 |
Family
ID=36337300
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10178237.3T DK2325207T3 (da) | 2004-11-12 | 2005-11-14 | Fc-varianter med ændret binding til FcRn |
| DK05851619.6T DK1817340T3 (da) | 2004-11-12 | 2005-11-14 | Fc-varianter med ændret binding til fcrn |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05851619.6T DK1817340T3 (da) | 2004-11-12 | 2005-11-14 | Fc-varianter med ændret binding til fcrn |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US9200079B2 (da) |
| EP (6) | EP2845865A1 (da) |
| JP (1) | JP4652414B2 (da) |
| KR (2) | KR101019525B1 (da) |
| CN (1) | CN102746404B (da) |
| AU (2) | AU2005304624B2 (da) |
| BR (1) | BRPI0517837A (da) |
| CA (1) | CA2587617C (da) |
| DK (2) | DK2325207T3 (da) |
| IL (2) | IL183158A (da) |
| WO (1) | WO2006053301A2 (da) |
Families Citing this family (294)
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