LV5483A3 - Izohinolinija atvasinajumu iegusanas panemiens - Google Patents

Izohinolinija atvasinajumu iegusanas panemiens

Info

Publication number
LV5483A3
LV5483A3 LV930178A LV930178A LV5483A3 LV 5483 A3 LV5483 A3 LV 5483A3 LV 930178 A LV930178 A LV 930178A LV 930178 A LV930178 A LV 930178A LV 5483 A3 LV5483 A3 LV 5483A3
Authority
LV
Latvia
Prior art keywords
isohinolinium
derivatives
acquisition
yield
image
Prior art date
Application number
LV930178A
Other languages
English (en)
Latvian (lv)
Inventor
Roy Archibald Swaringen Jr
Hassan A El-Sayad
David Arthur Yeowell
John Joseph Savarese
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of LV5483A3 publication Critical patent/LV5483A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Jib Cranes (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Fats And Perfumes (AREA)
  • Cephalosporin Compounds (AREA)
LV930178A 1984-07-18 1993-03-10 Izohinolinija atvasinajumu iegusanas panemiens LV5483A3 (lv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848418303A GB8418303D0 (en) 1984-07-18 1984-07-18 Compounds
SU853926201A SU1468414A3 (ru) 1984-07-18 1985-07-17 Способ получени производных изохинолини

Publications (1)

Publication Number Publication Date
LV5483A3 true LV5483A3 (lv) 1994-03-10

Family

ID=10564058

Family Applications (1)

Application Number Title Priority Date Filing Date
LV930178A LV5483A3 (lv) 1984-07-18 1993-03-10 Izohinolinija atvasinajumu iegusanas panemiens

Country Status (30)

Country Link
US (1) US4761418A (da)
EP (1) EP0181055B1 (da)
JP (1) JPH0662568B2 (da)
AT (1) ATE60759T1 (da)
AU (1) AU574481B2 (da)
BG (1) BG60411B2 (da)
CA (1) CA1273341A (da)
CY (1) CY1687A (da)
DD (1) DD235638A5 (da)
DE (2) DE19675039I2 (da)
DK (1) DK168093B1 (da)
ES (1) ES8609260A1 (da)
FI (1) FI85019C (da)
GB (1) GB8418303D0 (da)
GE (1) GEP19960468B (da)
HK (1) HK47593A (da)
HU (1) HU193996B (da)
IE (1) IE58138B1 (da)
IL (1) IL75833A (da)
LT (1) LT2078B (da)
LU (1) LU88801I2 (da)
LV (1) LV5483A3 (da)
MC (1) MC1690A1 (da)
MX (1) MX9203667A (da)
NL (1) NL940023I2 (da)
NZ (1) NZ212766A (da)
PL (1) PL146066B1 (da)
SG (1) SG3493G (da)
SU (1) SU1468414A3 (da)
ZA (1) ZA855407B (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
CN1203061C (zh) * 1997-03-25 2005-05-25 艾弗拉药品公司 取代异喹啉类，其制备方法，药物组合物及其制药用途
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
WO2005041960A2 (en) * 2003-10-28 2005-05-12 Cornell Research Foundation, Inc. Neuromuscular blocking agents and antagonists thereof
US7872137B2 (en) * 2006-06-20 2011-01-18 Farmabios S.P.A. Process for the preparation of mivacurium chloride
AU2007328210B2 (en) * 2006-12-06 2012-11-22 Cornell Research Foundation, Inc. Intermediate duration neuromuscular blocking agents and antagonists thereof
AU2008222298A1 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
EP2125743A1 (en) * 2007-03-26 2009-12-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
US8293912B2 (en) * 2007-05-01 2012-10-23 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
CA2685488A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
CA2687157A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
BRPI0812625A2 (pt) * 2007-07-09 2019-02-19 Chemagis Ltd processo para preparar um sal de cis-atracúrio
CA2702535A1 (en) * 2007-10-29 2009-05-07 Chemagis Ltd. Novel r,r'-atracurium salts
ITMI20080319A1 (it) 2008-02-28 2009-08-29 Recordati Chem Pharm Processo per la risoluzione di derivati isochinolinici
CA2722651A1 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
US9220700B2 (en) 2009-08-19 2015-12-29 Cornell University Cysteine for physiological injection
WO2013021398A2 (en) * 2011-08-05 2013-02-14 Sequent Scientific Limited A process for preparation of mivacurium chloride
JP6236077B2 (ja) * 2012-06-29 2017-11-22 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ 持続時間が超短期、短期、または中期の非対称性逆転可能神経筋遮断物質
CN103373959A (zh) * 2013-06-14 2013-10-30 安徽省先锋制药有限公司 顺式苄基异喹啉类化合物的制备方法及其用途
CN107782821B (zh) * 2016-08-26 2021-11-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂的分析方法
CN107778237A (zh) * 2016-08-26 2018-03-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN108938573B (zh) * 2017-05-26 2021-08-10 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) * 2017-09-30 2018-09-07 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) * 2019-07-29 2022-04-29 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) * 2019-11-11 2021-03-09 武汉大安制药有限公司 一种5’-甲氧基劳丹素的拆分方法
CN116410078B (zh) * 2021-12-29 2026-04-03 苏州特瑞药业股份有限公司 一种制备(e)-辛-4-烯-1,8-二酸的方法
WO2025140288A1 (zh) * 2023-12-25 2025-07-03 上海森辉医药有限公司 一种四氢异喹啉及其药物用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
GB863717A (en) * 1958-07-03 1961-03-22 Allen & Hanburys Ltd Tetrahydropapaverine derivatives and their preparation
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
NL7808067A (nl) 1977-08-01 1979-02-05 Massachusetts Gen Hospital Werkwijze voor het bereiden van een middel dat zenuw- spieren blokkeert.
US4192877A (en) * 1977-08-01 1980-03-11 Massachusetts General Hospital Neuromuscular blocking agents
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
US4235906A (en) * 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
CA1153380A (en) 1979-10-19 1983-09-06 Hassan A. El-Sayad Neuromuscular blocking tetrahydroisoquinolinium salts
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
EP0054309B1 (en) * 1980-12-17 1984-08-22 The Wellcome Foundation Limited Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
JPS5899465A (ja) * 1981-11-23 1983-06-13 ザ・ウエルカム・フアウンデ−シヨン・リミテツド イソキノリン誘導体

Also Published As

Publication number Publication date
FI852807A0 (fi) 1985-07-17
IE851791L (en) 1986-01-18
FI85019B (fi) 1991-11-15
IE58138B1 (en) 1993-07-14
AU4510885A (en) 1986-01-23
GEP19960468B (en) 1996-08-29
EP0181055A1 (en) 1986-05-14
DK168093B1 (da) 1994-02-07
MC1690A1 (fr) 1986-07-18
HUT40626A (en) 1987-01-28
PL146066B1 (en) 1988-12-31
JPH0662568B2 (ja) 1994-08-17
MX9203667A (es) 1992-07-31
HK47593A (en) 1993-05-21
US4761418A (en) 1988-08-02
DK324985D0 (da) 1985-07-17
LT2078B (lt) 1993-06-15
CY1687A (en) 1993-10-10
DD235638A5 (de) 1986-05-14
NZ212766A (en) 1988-03-30
EP0181055B1 (en) 1991-02-06
CA1273341A (en) 1990-08-28
PL254571A1 (en) 1986-07-15
GB8418303D0 (en) 1984-08-22
NL940023I1 (nl) 1995-01-02
DE19675039I2 (de) 2003-01-09
IL75833A0 (en) 1985-11-29
DK324985A (da) 1986-01-19
AU574481B2 (en) 1988-07-07
ZA855407B (en) 1986-04-30
ATE60759T1 (de) 1991-02-15
DE3581699D1 (de) 1991-03-14
SU1468414A3 (ru) 1989-03-23
SG3493G (en) 1993-03-12
FI852807L (fi) 1986-01-19
ES545319A0 (es) 1986-09-01
IL75833A (en) 1988-11-30
ES8609260A1 (es) 1986-09-01
HU193996B (en) 1987-12-28
BG60411B2 (bg) 1995-02-28
JPS6187666A (ja) 1986-05-06
FI85019C (fi) 1992-02-25
LU88801I2 (fr) 1996-11-05
NL940023I2 (nl) 1998-06-02

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