ECSP099802A - SALES DEL INHIBIDOR DE JANUS CINASA (R)-3-(4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3- CICLOPENTILPROPANITRILO - Google Patents

SALES DEL INHIBIDOR DE JANUS CINASA (R)-3-(4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3- CICLOPENTILPROPANITRILO

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Publication number
ECSP099802A
ECSP099802A EC2009009802A ECSP099802A ECSP099802A EC SP099802 A ECSP099802 A EC SP099802A EC 2009009802 A EC2009009802 A EC 2009009802A EC SP099802 A ECSP099802 A EC SP099802A EC SP099802 A ECSP099802 A EC SP099802A
Authority
EC
Ecuador
Prior art keywords
janus
cyclopentilpropanitrile
cinasa
pirimidin
pirrolo
Prior art date
Application number
EC2009009802A
Other languages
English (en)
Inventor
Hui Yin Li
James D Rodgers
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40029273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP099802(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of ECSP099802A publication Critical patent/ECSP099802A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

La presente invención proporciona formas de sal de (R)-3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanitrilo que son útiles en la modulación de la actividad de la cinasa Janus que incluye, por ejemplo, enfermedades relacionadas con el sistema inmunitario, trastornos de la piel, trastornos proliferativos mieloides, cáncer, y otras enfermedades.
EC2009009802A 2007-06-13 2009-12-14 SALES DEL INHIBIDOR DE JANUS CINASA (R)-3-(4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3- CICLOPENTILPROPANITRILO ECSP099802A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94370507P 2007-06-13 2007-06-13
PCT/US2008/066662 WO2008157208A2 (en) 2007-06-13 2008-06-12 Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Publications (1)

Publication Number Publication Date
ECSP099802A true ECSP099802A (es) 2010-01-29

Family

ID=40029273

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009802A ECSP099802A (es) 2007-06-13 2009-12-14 SALES DEL INHIBIDOR DE JANUS CINASA (R)-3-(4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3- CICLOPENTILPROPANITRILO

Country Status (41)

Country Link
US (10) US20080312259A1 (es)
EP (6) EP2740731B1 (es)
JP (1) JP5475653B2 (es)
KR (2) KR20150036210A (es)
CN (2) CN101932582B (es)
AU (1) AU2008266183B2 (es)
BR (1) BRPI0814254B8 (es)
CA (1) CA2689663C (es)
CO (1) CO6251256A2 (es)
CR (1) CR11151A (es)
CU (2) CU24179B1 (es)
CY (3) CY1115145T1 (es)
DK (3) DK3070090T3 (es)
DO (1) DOP2009000280A (es)
EA (1) EA019784B1 (es)
EC (1) ECSP099802A (es)
ES (4) ES2714092T3 (es)
GE (1) GEP20125533B (es)
GT (1) GT200900314A (es)
HR (3) HRP20140541T4 (es)
HU (2) HUE043732T2 (es)
IL (5) IL202524A (es)
LT (1) LT3070090T (es)
MA (1) MA31517B1 (es)
ME (1) ME00960B (es)
MX (2) MX342814B (es)
MY (1) MY154969A (es)
NI (1) NI200900216A (es)
NO (1) NO2019025I1 (es)
NZ (1) NZ581803A (es)
PL (3) PL2740731T3 (es)
PT (2) PT3070090T (es)
RS (3) RS54878B1 (es)
SG (3) SG182198A1 (es)
SI (3) SI2740731T1 (es)
SM (1) SMP201000002B (es)
TN (1) TN2009000514A1 (es)
TR (1) TR201903488T4 (es)
UA (1) UA99467C2 (es)
WO (1) WO2008157208A2 (es)
ZA (1) ZA200908826B (es)

Families Citing this family (137)

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JP5191391B2 (ja) 2005-11-01 2013-05-08 ターゲジェン インコーポレーティッド キナーゼのビ−アリールメタ−ピリミジン阻害剤
US8133900B2 (en) 2005-11-01 2012-03-13 Targegen, Inc. Use of bi-aryl meta-pyrimidine inhibitors of kinases
US8604042B2 (en) 2005-11-01 2013-12-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
SG10202003901UA (en) 2005-12-13 2020-05-28 Incyte Holdings Corp Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
CA2673038C (en) * 2006-12-22 2015-12-15 Incyte Corporation Substituted tricyclic heteroaryl compounds as janus kinase inhibitors
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
KR20150036210A (ko) 2007-06-13 2015-04-07 인사이트 코포레이션 야누스 키나제 억제제（Ｒ）―３―（４―（７Ｈ―피롤로［２，３－ｄ］피리미딘―4―일）―1Ｈ―피라졸―1―일）―３―사이클로펜틸프로판니트릴의 염
UA104849C2 (uk) * 2007-11-16 2014-03-25 Інсайт Корпорейшн 4-піразоліл-n-арилпіримідин-2-аміни і 4-піразоліл-n-гетероарилпіримідин-2-аміни як інгібітори кіназ janus
HUE029767T2 (en) * 2008-03-11 2017-04-28 Incyte Holdings Corp JAK inhibitor azetidine and cyclobutane derivatives
TWI720517B (zh) 2009-01-15 2021-03-01 美商英塞特公司 製造ｊａｋ抑制劑之方法及相關中間化合物
MY159327A (en) 2009-02-27 2016-12-25 Ambit Biosciences Corp Jak kinase modulating quinazoline derivatives and methods of use thereof
AR076794A1 (es) 2009-05-22 2011-07-06 Incyte Corp Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen
SI2432472T1 (sl) 2009-05-22 2019-11-29 Incyte Holdings Corp 3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK
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EA021478B1 (ru) * 2009-10-09 2015-06-30 Инсайт Корпорейшн ГИДРОКСИЛЬНЫЕ, КЕТО И ГЛЮКУРОНИДНЫЕ ПРОИЗВОДНЫЕ 3-(4-(7Н-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1Н-ПИРАЗОЛ-1-ИЛ)-3-ЦИКЛОПЕНТИЛПРОПАННИТРИЛА
SA111320200B1 (ar) 2010-02-17 2014-02-16 ديبيوفارم اس ايه مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة
JP5858434B2 (ja) * 2010-02-18 2016-02-10 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｊａｎｕｓキナーゼ阻害薬としてのシクロブタンおよびメチルシクロブタン誘導体
EP3354652B1 (en) 2010-03-10 2020-05-06 Incyte Holdings Corporation Piperidin-4-yl azetidine derivatives as jak1 inhibitors
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