EE04308B1 - Bensimidasooli ühendid, neid ühendeid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine - Google Patents

Bensimidasooli ühendid, neid ühendeid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine

Info

Publication number: EE04308B1
Authority: EE; Estonia
Prior art keywords: compounds; pct; phenyl; disorders; sec
Prior art date: 1995-04-21

Application number

EE9700282A

Other languages

English (en)

Estonian (et)

Other versions

EE9700282A (et

Inventor

Teuber Lene

W�tjen Frank

Fukuda Yoshimasa

Ushiroda Osamu

Sasaki Toshiro

Original Assignee

Neurosearch A/S

Meiji Seika Kaisha, Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-21

Filing date

1996-04-19

Publication date

2004-06-15

1996-04-19 Application filed by Neurosearch A/S, Meiji Seika Kaisha, Ltd. filed Critical Neurosearch A/S

1998-06-15 Publication of EE9700282A publication Critical patent/EE9700282A/xx

2004-06-15 Publication of EE04308B1 publication Critical patent/EE04308B1/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 3
125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010010904 Convulsion Diseases 0.000 abstract 1
208000026139 Memory disease Diseases 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
206010015037 epilepsy Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000019116 sleep disease Diseases 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

EE9700282A 1995-04-21 1996-04-19 Bensimidasooli ühendid, neid ühendeid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine EE04308B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK46095		1995-04-21
DK74195		1995-06-27
PCT/EP1996/001649 WO1996033191A1 (en)	1995-04-21	1996-04-19	Benzimidazole compounds and their use as modulators of the gabaa receptor complex

Publications (2)

Publication Number	Publication Date
EE9700282A EE9700282A (et)	1998-06-15
EE04308B1 true EE04308B1 (et)	2004-06-15

Family

ID=26064049

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9700282A EE04308B1 (et)	1995-04-21	1996-04-19	Bensimidasooli ühendid, neid ühendeid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine

Country Status (27)

Country	Link
US (1)	US5922725A (pl)
EP (1)	EP0821682B1 (pl)
JP (1)	JP3171852B2 (pl)
KR (1)	KR100283363B1 (pl)
CN (1)	CN1089762C (pl)
AT (1)	ATE194836T1 (pl)
AU (1)	AU699623B2 (pl)
BR (1)	BR9608056A (pl)
CA (1)	CA2218552C (pl)
CZ (1)	CZ287538B6 (pl)
DE (1)	DE69609413T2 (pl)
DK (1)	DK0821682T3 (pl)
EE (1)	EE04308B1 (pl)
ES (1)	ES2150671T3 (pl)
GR (1)	GR3034558T3 (pl)
HU (1)	HU224031B1 (pl)
IS (1)	IS2020B (pl)
MX (1)	MX9708147A (pl)
NO (1)	NO314502B1 (pl)
NZ (1)	NZ307532A (pl)
PL (1)	PL184020B1 (pl)
PT (1)	PT821682E (pl)
RU (1)	RU2136676C1 (pl)
SK (1)	SK282105B6 (pl)
TR (1)	TR199701219T1 (pl)
UA (1)	UA54394C2 (pl)
WO (1)	WO1996033191A1 (pl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ334868A (en) *	1996-10-21	2001-02-23	Neurosearch As	1-Phenyl-benzimidazole compounds and their use as BAGA-a receptor modulators
ATE223576T1 (de) *	1996-10-25	2002-09-15	Neurosearch As	Methode zur identifizierung von verbindungen mit anxiolytischem potential
GB9702524D0 (en) *	1997-02-07	1997-03-26	Merck Sharp & Dohme	Therapeutic agents
WO1999019323A1 (en) *	1997-10-10	1999-04-22	Neurosearch A/S	Benzimidazole compounds, pharmaceutical compositions containing the compounds and their use
AU1224499A (en) *	1997-12-09	1999-06-28	Neurosearch A/S	Chemical compounds for use as anxiolytic agents and a method for the identification of anxiolytic compounds
AU4652699A (en) *	1998-07-15	2000-02-07	Meiji Seika Kaisha Ltd.	Process for producing 4-substituted-2-nitro-fluorobenzenes
JP2002528499A (ja) *	1998-10-29	2002-09-03	ブリストル−マイヤーズスクイブカンパニー	Ｉｍｐｄｈ酵素のインヒビターであるアミノ核誘導化合物
US6380210B1 (en)	1999-04-02	2002-04-30	Neurogen Corporation	Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
US6281237B1 (en)	1999-04-02	2001-08-28	Neurogen Corporation	N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives
US6627624B1 (en)	1999-04-02	2003-09-30	Neurogen Corporation	Aryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
US6271241B1 (en)	1999-04-02	2001-08-07	Neurogen Corporation	Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors
NZ515543A (en) *	1999-06-22	2003-11-28	Neurosearch As	Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds
EP1294723A1 (en) *	2000-05-24	2003-03-26	MERCK SHARP & DOHME LTD.	3-phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors
TWI248936B (en) *	2001-03-21	2006-02-11	Merck Sharp & Dohme	Imidazo-pyrimidine derivatives as ligands for GABA receptors
JP2004531499A (ja) *	2001-03-23	2004-10-14	メルクシャープエンドドームリミテッド	Ｇａｂａ受容体用リガンドとしてのイミダゾ−ピリミジン誘導体
US7329678B2 (en) *	2003-01-28	2008-02-12	Smithkline Beecham Corporation	Chemical compounds
AU2004226179A1 (en)	2003-04-03	2004-10-14	Neurosearch A/S	Benzimidazole derivatives and their use for modulating the GABA-a receptor complex
ATE386519T1 (de)	2003-04-03	2008-03-15	Neurosearch As	Benzimidazole derivate und ihre anwendung als gaba a rezeptor komplex modulatoren
TWI391381B (zh)	2006-03-24	2013-04-01	Neurosearch As	新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途
US8974526B2 (en)	2007-08-27	2015-03-10	Amo Groningen B.V.	Multizonal lens with extended depth of focus
WO2010055126A1 (en) *	2008-11-14	2010-05-20	Neurosearch A/S	Benzimidazole derivatives and their use for modulating the gabaa receptor complex
WO2011047315A1 (en)	2009-10-15	2011-04-21	Concert Pharmaceuticals, Inc.	Subsitituted benzimidazoles
AU2018341781B2 (en)	2017-09-28	2023-03-30	Cstone Pharmaceuticals	Fused ring derivative as A2A receptor inhibitor
US11886046B2 (en)	2019-12-30	2024-01-30	Amo Groningen B.V.	Multi-region refractive lenses for vision treatment

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS55500349A (pl) *	1978-04-17	1980-06-19
DE2853765A1 (de) *	1978-12-13	1980-06-26	Bayer Ag	Verfahren zur herstellung von benzimidazolylbenzofuranen
US4329348A (en) *	1979-02-26	1982-05-11	Ciba-Geigy Corporation	N-Oxacyclic-alkylpiperidines as psychostimulants
PH30434A (en) *	1989-04-07	1997-05-09	Janssen Pharmaceutica Nv	Hydroxyalkylfuranyl derivatives
EP0520200B1 (en) *	1991-06-24	1998-02-18	Neurosearch A/S	Imidazole compounds, their preparation and use
US5158969A (en) *	1991-08-21	1992-10-27	Neurosearch A/S	Indole derivatives as potassium channel blockers
DK40192D0 (da) *	1992-03-26	1992-03-26	Neurosearch As	Imidazolforbindelser, deres fremstilling og anvendelse
AU675484B2 (en) *	1993-03-24	1997-02-06	Neurosearch A/S	Benzimidazole compounds, their use and preparation
IT1261432B (it) *	1993-03-26	1996-05-23	Sigma Tau Ind Farmaceuti	Uso di acil l- carnitina gammaidrossibutirrato per il trattamento dell'alcolismo.

1996
- 1996-04-19 CN CN96193421A patent/CN1089762C/zh not_active Expired - Fee Related
- 1996-04-19 SK SK1406-97A patent/SK282105B6/sk unknown
- 1996-04-19 MX MX9708147A patent/MX9708147A/es not_active IP Right Cessation
- 1996-04-19 HU HU9802272A patent/HU224031B1/hu not_active IP Right Cessation
- 1996-04-19 AT AT96914957T patent/ATE194836T1/de not_active IP Right Cessation
- 1996-04-19 PL PL96322944A patent/PL184020B1/pl not_active IP Right Cessation
- 1996-04-19 WO PCT/EP1996/001649 patent/WO1996033191A1/en not_active Ceased
- 1996-04-19 NZ NZ307532A patent/NZ307532A/xx unknown
- 1996-04-19 KR KR1019970707463A patent/KR100283363B1/ko not_active Expired - Fee Related
- 1996-04-19 DE DE69609413T patent/DE69609413T2/de not_active Expired - Lifetime
- 1996-04-19 CZ CZ19973291A patent/CZ287538B6/cs not_active IP Right Cessation
- 1996-04-19 EP EP96914957A patent/EP0821682B1/en not_active Expired - Lifetime
- 1996-04-19 RU RU97119174A patent/RU2136676C1/ru not_active IP Right Cessation
- 1996-04-19 PT PT96914957T patent/PT821682E/pt unknown
- 1996-04-19 ES ES96914957T patent/ES2150671T3/es not_active Expired - Lifetime
- 1996-04-19 CA CA002218552A patent/CA2218552C/en not_active Expired - Fee Related
- 1996-04-19 US US08/945,123 patent/US5922725A/en not_active Expired - Lifetime
- 1996-04-19 DK DK96914957T patent/DK0821682T3/da active
- 1996-04-19 UA UA97115592A patent/UA54394C2/uk unknown
- 1996-04-19 JP JP53148496A patent/JP3171852B2/ja not_active Expired - Fee Related
- 1996-04-19 AU AU56906/96A patent/AU699623B2/en not_active Ceased
- 1996-04-19 TR TR97/01219T patent/TR199701219T1/xx unknown
- 1996-04-19 BR BR9608056-6A patent/BR9608056A/pt not_active IP Right Cessation
- 1996-04-19 EE EE9700282A patent/EE04308B1/xx not_active IP Right Cessation
1997
- 1997-10-17 IS IS4593A patent/IS2020B/is unknown
- 1997-10-20 NO NO19974843A patent/NO314502B1/no unknown
2000
- 2000-10-04 GR GR20000402248T patent/GR3034558T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
RU2136676C1 (ru)	1999-09-10
AU699623B2 (en)	1998-12-10
NO974843D0 (no)	1997-10-20
CZ329197A3 (cs)	1998-03-18
GR3034558T3 (en)	2001-01-31
NO314502B1 (no)	2003-03-31
US5922725A (en)	1999-07-13
EP0821682A1 (en)	1998-02-04
NZ307532A (en)	1999-03-29
ES2150671T3 (es)	2000-12-01
CN1182425A (zh)	1998-05-20
WO1996033191A1 (en)	1996-10-24
HK1018048A1 (en)	1999-12-10
PL322944A1 (en)	1998-03-02
CA2218552C (en)	2002-04-16
SK140697A3 (en)	1998-05-06
CZ287538B6 (en)	2000-12-13
CN1089762C (zh)	2002-08-28
HU224031B1 (hu)	2005-05-30
DE69609413T2 (de)	2000-11-23
ATE194836T1 (de)	2000-08-15
DE69609413D1 (de)	2000-08-24
PL184020B1 (pl)	2002-08-30
KR19990007940A (ko)	1999-01-25
TR199701219T1 (xx)	1998-03-21
UA54394C2 (uk)	2003-03-17
MX9708147A (es)	1997-12-31
JP3171852B2 (ja)	2001-06-04
DK0821682T3 (da)	2000-12-04
BR9608056A (pt)	1999-11-30
EE9700282A (et)	1998-06-15
HUP9802272A2 (hu)	1999-09-28
SK282105B6 (sk)	2001-11-06
KR100283363B1 (ko)	2001-03-02
AU5690696A (en)	1996-11-07
EP0821682B1 (en)	2000-07-19
IS2020B (is)	2005-06-15
PT821682E (pt)	2000-11-30
IS4593A (is)	1997-10-17
CA2218552A1 (en)	1996-10-24
NO974843L (no)	1997-12-15
HUP9802272A3 (en)	2002-02-28
JPH11511734A (ja)	1999-10-12

Legal Events

Date	Code	Title	Description
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2007-12-17	MM4A	Lapsed by not paying the annual fees	Effective date: 20070419

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ATE136029T1 (de)	1996-04-15	Carbostyrylderivate
TH18598A (th)	1996-05-21	อนุพันธ์ 1,5-เบนโซไดอะเซฟีน