ES2071033T3 - Nuevos derivados de n-aril y n-heteroarilamida y urea como inhibidores de la acil coenzima a: colesterol acil transferasa. - Google Patents

Nuevos derivados de n-aril y n-heteroarilamida y urea como inhibidores de la acil coenzima a: colesterol acil transferasa.

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Publication number
ES2071033T3
ES2071033T3 ES90310009T ES90310009T ES2071033T3 ES 2071033 T3 ES2071033 T3 ES 2071033T3 ES 90310009 T ES90310009 T ES 90310009T ES 90310009 T ES90310009 T ES 90310009T ES 2071033 T3 ES2071033 T3 ES 2071033T3
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Spain
Prior art keywords
acil
cholesterol
inhibitors
heteroarylamide
coenzyme
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Expired - Lifetime
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ES90310009T
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English (en)
Inventor
Peter A Mccarthy
Frederick J Walker
Thien Truong
Ernest S Hamanaka
George Chang
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Pfizer Inc
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Pfizer Inc
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

COMPUESTOS DE LA FORMULA SALES FARMACEUTICAMENTE ACEPTABLES, EN DONDE Q Y R1 SE DEFINEN MAS ABAJO, Y NUEVOS PRODUCTOS INTERMEDIOS DE ACIDO CARBOXILICO Y DE HALURO ACIDO UTILIZADOS EN LA SINTESIS DE DICHOS COMPUESTOS. LOS COMPUESTOS DE LA FORMULA I SON INHIBIDORES DE LA ACILCOENZIMA A: COLESTEROL ACILTRANSFERASA (ACAT), Y RESULTAN DE GRAN UTILIDAD COMO AGENTES HIPOLIPIDEMICO Y DE ANTIATEROESCLEROSIS.
ES90310009T 1989-09-15 1990-09-13 Nuevos derivados de n-aril y n-heteroarilamida y urea como inhibidores de la acil coenzima a: colesterol acil transferasa. Expired - Lifetime ES2071033T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/004033 WO1991004027A1 (en) 1989-09-15 1989-09-15 New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)

Publications (1)

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ES2071033T3 true ES2071033T3 (es) 1995-06-16

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ES90310009T Expired - Lifetime ES2071033T3 (es) 1989-09-15 1990-09-13 Nuevos derivados de n-aril y n-heteroarilamida y urea como inhibidores de la acil coenzima a: colesterol acil transferasa.
ES94200437T Expired - Lifetime ES2127878T3 (es) 1989-09-15 1990-09-13 Nuevos derivados de n-heteroarilamida como inhibidores de la acil coenzima a: la colesterol acetiltransferasa.

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ES94200437T Expired - Lifetime ES2127878T3 (es) 1989-09-15 1990-09-13 Nuevos derivados de n-heteroarilamida como inhibidores de la acil coenzima a: la colesterol acetiltransferasa.

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JP (1) JPH0825974B2 (es)
KR (1) KR930011303B1 (es)
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AT (2) ATE177082T1 (es)
AU (1) AU652345B2 (es)
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DD (1) DD298092A5 (es)
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DK (2) DK0418071T3 (es)
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FI (1) FI111362B (es)
GR (1) GR3029826T3 (es)
HU (1) HUT70027A (es)
IE (1) IE66324B1 (es)
IL (3) IL95610A (es)
MX (1) MX22406A (es)
NO (1) NO904022L (es)
NZ (1) NZ235323A (es)
PL (4) PL165357B1 (es)
PT (1) PT95310B (es)
WO (1) WO1991004027A1 (es)
ZA (1) ZA907346B (es)

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ZA907346B (en) 1992-05-27
DE69018908T2 (de) 1995-08-24
PL291470A1 (en) 1992-07-13
CA2025301C (en) 2001-10-16
KR910006233A (ko) 1991-04-27
DE69032981D1 (de) 1999-04-08
JPH03120243A (ja) 1991-05-22
PL165370B1 (pl) 1994-12-30
EP0609960A1 (en) 1994-08-10
AU652345B2 (en) 1994-08-25
CN1050183A (zh) 1991-03-27
AU6255390A (en) 1991-04-18
ATE177082T1 (de) 1999-03-15
KR930011303B1 (ko) 1993-11-29
GR3029826T3 (en) 1999-06-30
JPH0825974B2 (ja) 1996-03-13
IE903336A1 (en) 1991-04-10
PL291472A1 (en) 1992-07-13
IE66324B1 (en) 1995-12-27
DD298092A5 (de) 1992-02-06
IL110321A0 (en) 1994-10-21
IL95610A (en) 1994-12-29
DE69032981T2 (de) 1999-07-08
EP0609960B1 (en) 1999-03-03
PL291471A1 (en) 1992-06-26
NZ235323A (en) 1993-02-25
NO904022L (no) 1991-03-18
PL165357B1 (pl) 1994-12-30
FI111362B (fi) 2003-07-15
WO1991004027A1 (en) 1991-04-04
HUT70027A (en) 1995-09-28
DE69018908D1 (de) 1995-06-01
EP0418071A3 (en) 1992-03-25
IL110324A0 (en) 1994-10-21
EP0418071B1 (en) 1995-04-26
NO904022D0 (no) 1990-09-14
ES2127878T3 (es) 1999-05-01
PT95310A (pt) 1991-05-22
HU9302945D0 (en) 1993-12-28
ATE121730T1 (de) 1995-05-15
FI904537A0 (fi) 1990-09-14
MX22406A (es) 1994-01-31
IL95610A0 (en) 1991-06-30
DK0609960T3 (da) 1999-09-27
EG19358A (en) 1994-12-30
PT95310B (pt) 1997-06-30
DK0418071T3 (da) 1995-09-04
EP0418071A2 (en) 1991-03-20
CA2025301A1 (en) 1991-03-16

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