ES2158223T3 - Utilizacion de derivados de hidantoina para la preparacion de un medicamento para el tratamiento de las enfermedades asociadas con la presencia de oxigeno activo y de radicales libres. - Google Patents
Utilizacion de derivados de hidantoina para la preparacion de un medicamento para el tratamiento de las enfermedades asociadas con la presencia de oxigeno activo y de radicales libres.Info
- Publication number
- ES2158223T3 ES2158223T3 ES96120597T ES96120597T ES2158223T3 ES 2158223 T3 ES2158223 T3 ES 2158223T3 ES 96120597 T ES96120597 T ES 96120597T ES 96120597 T ES96120597 T ES 96120597T ES 2158223 T3 ES2158223 T3 ES 2158223T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- diseases
- hidantoine
- free radicals
- active oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 6
- 201000010099 disease Diseases 0.000 title abstract 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 3
- 239000001301 oxygen Substances 0.000 title abstract 3
- 229910052760 oxygen Inorganic materials 0.000 title abstract 3
- 229940126601 medicinal product Drugs 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 208000036487 Arthropathies Diseases 0.000 abstract 1
- 208000002177 Cataract Diseases 0.000 abstract 1
- -1 HYDROXYL GROUP Chemical group 0.000 abstract 1
- 208000012659 Joint disease Diseases 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 230000010410 reperfusion Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
LA PRESENTE INVENCION SE DIRIGE A UNA COMPOSICION FARMACEUTICA QUE INCLUYE UN DERIVADO DE HIDANTOINA REPRESENTADO POR LA SIGUIENTE FORMULA (I) O UNA SAL ACEPTABLE FARMACEUTICAMENTE DEL MISMO. DONDE R{SUB,1} Y R{SUB,2}, QUE PUEDEN SER LOS MISMOS O DIFERENTES, REPRESENTAN HIDROGENO, UN GRUPO ALQUIL, O UN GRUPO CICLOALQUIL; Y CUALQUIERA DE X E Y, QUE PUEDEN SER IGUALES O DIFERENTES, REPRESENTA HIDROGENO, UN GRUPO HIDROXIL, UN GRUPO ALQUIL O UN GRUPO ALCOXI, O X E Y DE FORMA CONJUNTA REPRESENTAN UN GRUPO OXO, Y UN VEHICULO O DILUYENTE ACEPTABLE FARMACEUTICAMENTE. EL DERIVADO DE HIDANTOINA MENCIONADO ANTERIORMENTE TIENE LA ACCION DE ELIMINAR EL OXIGENO ACTIVO Y LOS RADICALES LIBRES. CONFORME CON ESTO, ES UTIL PARA PREPARAR UN AGENTE FARMACEUTICO PARA TRATAR UNA VARIEDAD DE ENFERMEDADES EN LAS QUE EL OXIGENO ACTIVO Y LOS RADICALES LIBRES SE VEN IMPLICADOS COMO EL INFARTO DE MIOCARDIO, LOS TRASTORNOS POR REPERFUSION, ENFERMEDADES AUTOINMUNES, LA FIBROSIS, ENFERMEDADES PULMONARES, ENFERMEDADES DERMATOLOGICAS, ARTROPATIA, EFECTOS COLATERALES DE AGENTES ANTICANCERIGENOS, ENFERMEDADES POR RADIACION, SHOCK SEPTICO, ENFERMEDADES INFLAMATORIAS Y CATARATAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34983195 | 1995-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2158223T3 true ES2158223T3 (es) | 2001-09-01 |
Family
ID=18406411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96120597T Expired - Lifetime ES2158223T3 (es) | 1995-12-20 | 1996-12-20 | Utilizacion de derivados de hidantoina para la preparacion de un medicamento para el tratamiento de las enfermedades asociadas con la presencia de oxigeno activo y de radicales libres. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6197806B1 (es) |
| EP (1) | EP0780125B1 (es) |
| KR (1) | KR100468109B1 (es) |
| CN (1) | CN1093401C (es) |
| AT (1) | ATE200622T1 (es) |
| AU (1) | AU705447B2 (es) |
| CA (1) | CA2193551C (es) |
| DE (1) | DE69612540T2 (es) |
| DK (1) | DK0780125T3 (es) |
| ES (1) | ES2158223T3 (es) |
| TW (1) | TW461814B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU775606B2 (en) * | 1998-08-31 | 2004-08-05 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Methimazole derivatives and tautomeric cyclic thiones to treat autoimmune diseases |
| AU754989B2 (en) * | 1998-11-16 | 2002-11-28 | Nippon Zoki Pharmaceutical Co., Ltd. | A therapeutic agent for intractable vasculitis |
| JP4711523B2 (ja) | 2001-02-13 | 2011-06-29 | 日本臓器製薬株式会社 | 低アルブミン血症改善剤 |
| US6919365B2 (en) | 2001-04-11 | 2005-07-19 | Senju Pharmaceutical Co., Ltd. | Imidazolidinedione derivatives and use thereof as drugs |
| BRPI0214256B8 (pt) * | 2001-11-19 | 2021-05-25 | Medigene Ag | medicamento |
| TWI353979B (en) * | 2002-04-10 | 2011-12-11 | Nippon Zoki Pharmaceutical Co | Novel crystal form of 5-hydroxy-1-methylhydantoin |
| US20060241162A1 (en) * | 2005-04-20 | 2006-10-26 | Kaoru Okamoto | Optically active (R)-hydantoin derivative |
| US20060241163A1 (en) * | 2005-04-20 | 2006-10-26 | Kaoru Okamoto | Optically active (S)-hydantoin derivative |
| CN101732348B (zh) | 2008-11-11 | 2015-01-14 | 威世药业（如皋）有限公司 | 牛痘疫苗致炎兔皮提取物在制备急性脑血管疾病治疗药物中的用途 |
| BRPI1107312B1 (pt) * | 2011-11-25 | 2021-09-08 | Universidade Federal De Santa Catarina | Composto de acil-hidrazona |
| EP2801573A1 (en) * | 2013-05-09 | 2014-11-12 | Sanofi | Hydantoine derivatives as CD38 inhibitors |
| CN103360320B (zh) * | 2013-07-30 | 2015-12-02 | 邱智东 | 1-甲基海因的制备方法 |
| EP3639821B1 (en) | 2017-06-13 | 2024-08-28 | National Cancer Center | Carcinogenesis inhibitor |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4099007A (en) | 1969-04-02 | 1978-07-04 | Hoechst Aktiengesellschaft | N,n-substituted 2,4,5-triketoimidazolidines and a process for their preparation |
| IL39042A (en) | 1971-03-26 | 1976-04-30 | Ciba Geigy Ag | 2,4,5-trioxoimidazolidine-1-carboxylic acid derivatives,their preparation and their use for the control of plant metabolism |
| CH563711A5 (en) | 1972-03-03 | 1975-07-15 | Ciba Geigy Ag | Agents for regulating plant metabolism - contg. imidazolidine-2,4,5-trione-3-carboxylic acid derivs. |
| US3818031A (en) | 1971-03-26 | 1974-06-18 | Ciba Geigy Corp | Imidazolidinetrionecarboxylic acid derivatives |
| DE2612926A1 (de) | 1976-03-26 | 1977-10-06 | Boehringer Mannheim Gmbh | Neue acyl-derivate der 6-(alpha- amino-phenylacetamido)-penicillansaeure |
| AU578068B2 (en) | 1984-03-08 | 1988-10-13 | Nippon Zoki Pharmaceutical Co., Ltd. | Hydantoin derivatives and pharmaceutical compositions containing them |
| JPH0686436B2 (ja) | 1984-11-15 | 1994-11-02 | 日本臓器製薬株式会社 | 新規ヒダントイン誘導体及び該化合物を含有する医薬組成物 |
| US4656034A (en) | 1985-05-20 | 1987-04-07 | Survival Technology, Inc. | Absorption enhancing agents |
| US5078680A (en) | 1984-08-08 | 1992-01-07 | Survival Technology, Inc. | Automatic injector for emergency treatment |
| DE3586845T2 (de) | 1984-08-08 | 1993-04-01 | Survival Technology | Absorptionsverbesserer. |
| US4658830A (en) | 1984-08-08 | 1987-04-21 | Survival Technology, Inc. | Method and apparatus for initiating reperfusion treatment by an unattended individual undergoing heart attack symptoms |
| US4661469A (en) | 1984-08-08 | 1987-04-28 | Survival Technology, Inc. | t-PA composition capable of being absorbed into the blood stream and method of administration |
| US4832682A (en) | 1984-08-08 | 1989-05-23 | Survival Technology, Inc. | Injection method and apparatus with electrical blood absorbing stimulation |
| US5340829A (en) * | 1984-11-20 | 1994-08-23 | Washington Research Foundation | Immunoregulatory agents |
| EP0194226B1 (en) | 1985-02-06 | 1990-02-07 | Nippon Zoki Pharmaceutical Co. Ltd. | A pharmaceutical composition containing an imidazolidinetrione derivative or pharmaceutically acceptable salt thereof |
| JPH0764729B2 (ja) | 1985-02-06 | 1995-07-12 | 日本臓器製薬株式会社 | イミダゾリジントリオン誘導体を含有する医薬組成物 |
| JP2567593B2 (ja) | 1986-12-29 | 1996-12-25 | 日本臓器製薬株式会社 | イミダゾリジントリオン誘導体及び該化合物を有効成分として含有するアレルギ−性疾患治療剤 |
| JPS6456614A (en) | 1987-08-27 | 1989-03-03 | Ono Pharmaceutical Co | Maillard reaction inhibitor |
| JPH01156965A (ja) | 1987-09-29 | 1989-06-20 | Taiho Yakuhin Kogyo Kk | チオヒダントイン化合物 |
| JP2544183B2 (ja) | 1988-07-29 | 1996-10-16 | 日本臓器製薬株式会社 | 新規パラバン酸誘導体及び該化合物を有効成分として含有する医薬組成物 |
| JP2817219B2 (ja) | 1988-09-08 | 1998-10-30 | 武田薬品工業株式会社 | カルバジン酸誘導体、その製造法及び製剤 |
| JPH02225485A (ja) | 1989-02-27 | 1990-09-07 | Taiho Yakuhin Kogyo Kk | チエノピリミジン―３―酢酸誘導体 |
| CA2011899A1 (en) | 1989-03-13 | 1990-09-13 | Masaaki Toda | Benzopyran derivatives |
| JP2678499B2 (ja) | 1989-08-09 | 1997-11-17 | 日本臓器製薬 株式会社 | 尿毒症毒素低下剤 |
| JPH0667827A (ja) | 1992-08-18 | 1994-03-11 | Nec Software Ltd | データ表示制御装置 |
| JP3267698B2 (ja) | 1992-10-27 | 2002-03-18 | 株式会社三和化学研究所 | ヒダントイン誘導体及びその塩並びにこれらを有効成分とするメイラード反応阻害剤 |
| AU669427B2 (en) | 1993-02-26 | 1996-06-06 | Otsuka Pharmaceutical Co., Ltd. | Thiazole or imidazole derivatives as maillard reaction inhibbitors |
| JPH06305964A (ja) | 1993-02-26 | 1994-11-01 | Otsuka Pharmaceut Co Ltd | メイラード反応阻害剤 |
| WO1996004248A1 (en) | 1994-07-29 | 1996-02-15 | Suntory Limited | Imidazolidine derivative and use thereof |
| JPH08157473A (ja) | 1994-10-06 | 1996-06-18 | Nissan Chem Ind Ltd | ピラゾール系チアゾリジン類 |
| US5681843A (en) | 1994-12-20 | 1997-10-28 | Nippon Zoki Pharmaceutical Co., Ltd. | Parabanic acid derivatives |
| US5912261A (en) | 1994-12-20 | 1999-06-15 | Nippon Zoki Pharmaceutical Co., Ltd. | Carboxyalkyl heterocyclic derivatives |
-
1996
- 1996-12-18 US US08/769,008 patent/US6197806B1/en not_active Expired - Fee Related
- 1996-12-19 CN CN96123286A patent/CN1093401C/zh not_active Expired - Fee Related
- 1996-12-20 DE DE69612540T patent/DE69612540T2/de not_active Expired - Lifetime
- 1996-12-20 ES ES96120597T patent/ES2158223T3/es not_active Expired - Lifetime
- 1996-12-20 EP EP96120597A patent/EP0780125B1/en not_active Expired - Lifetime
- 1996-12-20 KR KR1019960069207A patent/KR100468109B1/ko not_active Expired - Lifetime
- 1996-12-20 AT AT96120597T patent/ATE200622T1/de not_active IP Right Cessation
- 1996-12-20 AU AU76414/96A patent/AU705447B2/en not_active Ceased
- 1996-12-20 CA CA002193551A patent/CA2193551C/en not_active Expired - Fee Related
- 1996-12-20 DK DK96120597T patent/DK0780125T3/da active
-
1997
- 1997-01-04 TW TW086100051A patent/TW461814B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW461814B (en) | 2001-11-01 |
| ATE200622T1 (de) | 2001-05-15 |
| EP0780125A2 (en) | 1997-06-25 |
| CA2193551A1 (en) | 1997-06-21 |
| EP0780125A3 (en) | 1997-11-05 |
| DE69612540T2 (de) | 2001-08-30 |
| DE69612540D1 (de) | 2001-05-23 |
| KR100468109B1 (ko) | 2005-04-13 |
| AU7641496A (en) | 1997-06-26 |
| DK0780125T3 (da) | 2001-05-07 |
| CN1093401C (zh) | 2002-10-30 |
| CN1159324A (zh) | 1997-09-17 |
| CA2193551C (en) | 2006-03-21 |
| KR970032863A (ko) | 1997-07-22 |
| EP0780125B1 (en) | 2001-04-18 |
| AU705447B2 (en) | 1999-05-20 |
| US6197806B1 (en) | 2001-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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