ES2170734B2 - Metodo para la preparacion de citalopram. - Google Patents

Metodo para la preparacion de citalopram.

Info

Publication number
ES2170734B2
ES2170734B2 ES200101919A ES200101919A ES2170734B2 ES 2170734 B2 ES2170734 B2 ES 2170734B2 ES 200101919 A ES200101919 A ES 200101919A ES 200101919 A ES200101919 A ES 200101919A ES 2170734 B2 ES2170734 B2 ES 2170734B2
Authority
ES
Spain
Prior art keywords
citalopram
formula
compound
preparation
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200101919A
Other languages
English (en)
Other versions
ES2170734A1 (es
Inventor
Hans Petersen
Haleh Ahmadian
Robert Dancer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of ES2170734A1 publication Critical patent/ES2170734A1/es
Application granted granted Critical
Publication of ES2170734B2 publication Critical patent/ES2170734B2/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)

Abstract

Método para la preparación de citalopram, que comprende hacer reaccionar 5-carboxiftalida sucesivamente con un reactivo de Grignard de 4-halo-fluorofenilo y un reactivo de Grignard de 3- halo-N,N-dimetil-propilamina y efectuar después el cierre de anillo del compuesto resultante de Fórmula XI **FIGURA 01** para formar un compuesto de Fórmula IV **FIGURA 02** seguido por la conversión del compuesto de Fórmula IV en citalopram. También se describen métodos para la producción y conversión del compuesto de fórmula IV.
ES200101919A 2000-08-18 2001-08-17 Metodo para la preparacion de citalopram. Expired - Fee Related ES2170734B2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001231 2000-08-18

Publications (2)

Publication Number Publication Date
ES2170734A1 ES2170734A1 (es) 2002-08-01
ES2170734B2 true ES2170734B2 (es) 2003-09-16

Family

ID=8159660

Family Applications (4)

Application Number Title Priority Date Filing Date
ES01957786T Expired - Lifetime ES2228920T3 (es) 2000-08-18 2001-08-14 Metodo para la preparacion de citalopram.
ES01957785T Expired - Lifetime ES2230347T3 (es) 2000-08-18 2001-08-14 Metodo para la preparacion de citalopram.
ES200101920A Expired - Fee Related ES2170735B2 (es) 2000-08-18 2001-08-17 Metodo para la preparacion de citalopram.
ES200101919A Expired - Fee Related ES2170734B2 (es) 2000-08-18 2001-08-17 Metodo para la preparacion de citalopram.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES01957786T Expired - Lifetime ES2228920T3 (es) 2000-08-18 2001-08-14 Metodo para la preparacion de citalopram.
ES01957785T Expired - Lifetime ES2230347T3 (es) 2000-08-18 2001-08-14 Metodo para la preparacion de citalopram.
ES200101920A Expired - Fee Related ES2170735B2 (es) 2000-08-18 2001-08-17 Metodo para la preparacion de citalopram.

Country Status (41)

Country Link
US (2) US6426422B1 (es)
EP (2) EP1309582B1 (es)
JP (2) JP2004506730A (es)
KR (2) KR100887206B1 (es)
CN (3) CN1239490C (es)
AR (3) AR029598A1 (es)
AT (4) ATE281447T1 (es)
AU (6) AU2001279609B2 (es)
BE (2) BE1013443A6 (es)
BG (2) BG65964B1 (es)
CA (2) CA2354880C (es)
CH (2) CH691969A5 (es)
CL (2) CL2008002412A1 (es)
CZ (2) CZ295863B6 (es)
DE (4) DE60106932T2 (es)
DK (4) DK1309582T3 (es)
EA (2) EA005946B1 (es)
ES (4) ES2228920T3 (es)
FI (2) FI20011621A7 (es)
FR (2) FR2813077B1 (es)
GB (2) GB2365865B (es)
GR (1) GR1004074B (es)
HK (2) HK1044538B (es)
HR (2) HRP20030065A2 (es)
HU (2) HUP0103291A3 (es)
IE (2) IES20010760A2 (es)
IL (2) IL144816A (es)
IS (2) IS2121B (es)
ME (2) MEP2208A (es)
MX (2) MXPA03001329A (es)
NL (2) NL1018776C1 (es)
NO (2) NO326570B1 (es)
NZ (2) NZ523853A (es)
PL (2) PL359969A1 (es)
PT (2) PT1309582E (es)
RS (2) RS50287B (es)
SI (2) SI1309581T1 (es)
SK (2) SK287236B6 (es)
UA (2) UA72340C2 (es)
WO (2) WO2002016342A1 (es)
ZA (1) ZA200106683B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
IL145615A0 (en) * 1999-04-14 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
HK1043129B (zh) 1999-10-25 2004-10-21 H‧隆德贝克有限公司 西酞普蘭的製備方法
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
NZ519739A (en) 1999-12-28 2004-03-26 H Method for the preparation of citalopram
PT1246813E (pt) 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
WO2001051477A1 (en) * 2000-01-14 2001-07-19 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
BR0109364A (pt) * 2000-03-13 2002-12-24 Lundbeck & Co As H Métodos para fabricação de citalopram através de alquilação escalonada de 5-substituìda 1- (4-fluorofenil) - 1,3- diidroisobenzofuranos e citalopram
SK14602002A3 (sk) * 2000-03-13 2003-02-04 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IL151488A0 (en) 2000-03-14 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
TR200202168T2 (tr) * 2000-03-16 2002-12-23 H. Lundbeck A/S 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144816A (en) 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
TR200201166T1 (tr) 2000-12-22 2002-10-21 H.Lundbecks A/S Saf sitalopram hazırlanması için yöntem
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
AR040970A1 (es) * 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
WO2009111031A2 (en) * 2008-03-04 2009-09-11 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
JP6222973B2 (ja) * 2013-04-19 2017-11-01 日本テルペン化学株式会社 ジベンジルトリチオカーボネート誘導体
CN103936702A (zh) * 2014-05-07 2014-07-23 成都诺维尔生物医药有限公司 艾司西酞普兰杂质j的合成方法
US9809524B1 (en) * 2014-10-14 2017-11-07 Syngenta Participations Process for the preparation of 1-(3,5-dichloro-4-fluoro-phenyl)-2,2,2-trifluoro-ethanone
CN118724848A (zh) * 2023-03-29 2024-10-01 中国石油化工股份有限公司 一种制备2,5-呋喃二甲腈的方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (es) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
JP3526581B2 (ja) 1997-07-08 2004-05-17 ハー・ルンドベック・アクティーゼルスカブ シタロプラムの製造方法
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CN1286687A (zh) 1997-11-11 2001-03-07 H·隆德贝克有限公司 制备西酞普兰的方法
WO2000023431A1 (en) * 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
HK1043130B (zh) 1998-12-23 2005-03-04 H‧隆德贝克有限公司 制备5-氰基2-苯并[c]呋喃酮的方法
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
IL145615A0 (en) 1999-04-14 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) * 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL144816A (en) 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
TR200201166T1 (tr) 2000-12-22 2002-10-21 H.Lundbecks A/S Saf sitalopram hazırlanması için yöntem
JP2003519121A (ja) 2000-12-28 2003-06-17 ハー・ルンドベック・アクチエゼルスカベット 純粋なシタロプラムの製造方法

Also Published As

Publication number Publication date
RS50258B (sr) 2009-07-15
FI20011622L (fi) 2002-02-19
IL144816A0 (en) 2002-06-30
NO20013943D0 (no) 2001-08-14
UA72340C2 (uk) 2005-02-15
SI1309581T1 (en) 2005-04-30
GB2365865A (en) 2002-02-27
EP1309581B1 (en) 2004-11-03
US20020026062A1 (en) 2002-02-28
GB2362647A (en) 2001-11-28
ZA200106683B (en) 2002-08-05
EA200300279A1 (ru) 2003-08-28
BG107583A (bg) 2004-01-30
DK200101216A (da) 2002-02-19
CZ294746B6 (cs) 2005-03-16
PT1309581E (pt) 2005-03-31
UA71676C2 (en) 2004-12-15
MEP2208A (xx) 2010-02-10
AU2001279608B2 (en) 2006-10-05
PL359969A1 (en) 2004-09-06
IES20010761A2 (en) 2002-02-20
HK1047086A1 (en) 2003-02-07
AU7960801A (en) 2002-03-04
NZ523877A (en) 2004-08-27
SK3202003A3 (en) 2003-08-05
CZ20012958A3 (cs) 2002-04-17
NL1018775C1 (nl) 2001-10-24
CZ295863B6 (cs) 2005-11-16
ES2228920T3 (es) 2005-04-16
PL359825A1 (pl) 2004-09-06
IS2120B (is) 2006-06-15
HK1068069A1 (en) 2005-04-22
IS6048A (is) 2001-10-19
FR2813077B1 (fr) 2004-08-20
CA2354880A1 (en) 2002-01-22
HRP20030065A2 (en) 2005-02-28
FR2813078A1 (fr) 2002-02-22
HUP0103295A2 (hu) 2002-05-29
CH691969A5 (de) 2001-12-14
KR20030022385A (ko) 2003-03-15
EA005811B1 (ru) 2005-06-30
EP1309581A1 (en) 2003-05-14
JP2004506730A (ja) 2004-03-04
KR100887207B1 (ko) 2009-03-06
NO20013942D0 (no) 2001-08-14
HUP0103291A3 (en) 2003-02-28
DE60106933D1 (de) 2004-12-09
IL144816A (en) 2005-09-25
HK1044538A1 (en) 2002-10-25
MXPA03001329A (es) 2003-06-06
AU2001279609B2 (en) 2007-09-06
IES20010760A2 (en) 2002-02-20
IL144817A0 (en) 2002-06-30
MEP2308A (xx) 2010-02-10
CA2354880C (en) 2003-06-03
DK200101219A (da) 2002-02-19
CL2008002412A1 (es) 2009-01-02
NO20013942L (no) 2002-02-19
NO20013943L (no) 2002-02-19
IS6047A (is) 2001-10-20
ATE281447T1 (de) 2004-11-15
AU2001100271A4 (en) 2001-09-13
HK1047086B (zh) 2005-04-22
FI20011622A0 (fi) 2001-08-09
FR2813078B1 (fr) 2004-04-02
CZ20012959A3 (cs) 2002-04-17
CH691968A5 (de) 2001-12-14
DE60106932T2 (de) 2005-11-03
NO326570B1 (no) 2009-01-12
FI20011621L (fi) 2002-02-19
KR20030022378A (ko) 2003-03-15
DE10140028A1 (de) 2002-04-18
BG65964B1 (bg) 2010-07-30
WO2002016341A1 (en) 2002-02-28
CN1159307C (zh) 2004-07-28
US6426422B1 (en) 2002-07-30
BG65965B1 (bg) 2010-07-30
CA2354877A1 (en) 2002-02-18
IS2121B (is) 2006-06-15
DK1309582T3 (da) 2005-03-14
HUP0103291A2 (hu) 2002-05-29
CN1515564A (zh) 2004-07-28
PT1309582E (pt) 2005-03-31
GB2365865B (en) 2002-07-17
AR029597A1 (es) 2003-07-10
CN1239490C (zh) 2006-02-01
CN1339435A (zh) 2002-03-13
EA200300277A1 (ru) 2003-08-28
JP2004506729A (ja) 2004-03-04
AU2001100271B4 (en) 2001-11-29
AT4946U1 (de) 2002-01-25
SK3222003A3 (en) 2003-08-05
BE1013443A6 (fr) 2002-01-15
MXPA03000913A (es) 2003-06-24
AU2001100278A4 (en) 2001-09-13
HK1044538B (zh) 2006-07-07
FI20011622A7 (fi) 2002-02-19
BE1013444A6 (fr) 2002-01-15
GR1004074B (el) 2002-11-26
US20020025982A1 (en) 2002-02-28
EP1309582B1 (en) 2004-11-03
SI1309582T1 (en) 2005-06-30
KR100887206B1 (ko) 2009-03-06
CN1222517C (zh) 2005-10-12
AT5026U1 (de) 2002-02-25
AR066694A2 (es) 2009-09-09
SK287236B6 (sk) 2010-04-07
ES2170735A1 (es) 2002-08-01
EP1309582A1 (en) 2003-05-14
RS50287B (sr) 2009-09-08
YU6903A (sh) 2006-05-25
AU2001100278B4 (en) 2001-11-29
BG107584A (bg) 2004-01-30
WO2002016342A1 (en) 2002-02-28
DE10140029A1 (de) 2002-05-02
AR029598A1 (es) 2003-07-10
HUP0103295A3 (en) 2005-01-28
ES2170735B2 (es) 2003-09-16
FI20011621A0 (fi) 2001-08-09
CA2354877C (en) 2006-05-02
HU0103291D0 (en) 2001-10-28
SK287008B6 (sk) 2009-09-07
DK1309581T3 (da) 2005-03-14
NO326772B1 (no) 2009-02-16
EA005946B1 (ru) 2005-08-25
DE60106933T2 (de) 2005-12-01
ES2170734A1 (es) 2002-08-01
HRP20030064A2 (en) 2005-02-28
GB0119733D0 (en) 2001-10-03
NL1018776C1 (nl) 2001-10-24
GB0119734D0 (en) 2001-10-03
ATE281448T1 (de) 2004-11-15
US6509483B2 (en) 2003-01-21
CL2008002673A1 (es) 2009-01-02
DE60106932D1 (de) 2004-12-09
FI20011621A7 (fi) 2002-02-19
FR2813077A1 (fr) 2002-02-22
ES2230347T3 (es) 2005-05-01
AU7960901A (en) 2002-03-04
CN1339436A (zh) 2002-03-13
GB2362647B (en) 2002-09-18
GR20010100398A (el) 2002-05-24
YU11503A (sh) 2006-05-25
NZ523853A (en) 2004-07-30

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