HK5796A - Polymer, production and use thereof - Google Patents

Polymer, production and use thereof Download PDF

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Publication number
HK5796A
HK5796A HK5796A HK5796A HK5796A HK 5796 A HK5796 A HK 5796A HK 5796 A HK5796 A HK 5796A HK 5796 A HK5796 A HK 5796A HK 5796 A HK5796 A HK 5796A
Authority
HK
Hong Kong
Prior art keywords
water
polymer
lactic acid
high molecular
acid
Prior art date
Application number
HK5796A
Other languages
German (de)
English (en)
Inventor
Yamamoto Masaki
Okada Hiroaki
Ogawa Yasuaki
Miyagawa Tsutomu
Original Assignee
Takeda Pharmaceutical Company Limited
Wako Pure Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=14197161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK5796(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical Company Limited, Wako Pure Chemical Industries, Ltd. filed Critical Takeda Pharmaceutical Company Limited
Publication of HK5796A publication Critical patent/HK5796A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
  • Processing Of Solid Wastes (AREA)

Claims (8)

  1. Polymère biodégradable de poids moléculaire élevé, dont le poids moléculaire moyen est de 5 000 à 35 000, caractérisé en ce que ledit polymère consiste à raison de 50 à 100 moles pourcent en radicaux d'acide lactique et à raison de 50 à 0 moles pourcent en radicaux d'acide glycolique et qu'il a une teneur en acide lactique ou acide lactique et acide glycolique inférieure à 0,01 mole par 100 grammes dudit polymère.
  2. Polymère biodégradable de poids moléculaire élevé selon la revendication 1, dans lequel ladite teneur en acide lactique ou acide lactique et acide glycolique est de 0,0055 mole ou moins par 100 grammes dudit polymère.
  3. Procédé de préparation du polymère selon la revendication 1, lequel procédé consiste à préparer le polymère à partir d'acide lactique ou d'acide lactique et d'acide glycolique en des conditions réactionnelles aqueuses, puis à réduire la teneur en acide lactique ou acide lactique et acide glycolique dans ledit polymère jusqu'à un niveau inférieur à 0,01 mole par 100 grammes dudit polymère par extraction à l'eau ou au moyen d'un mélange d'eau et d'un solvant organique soluble dans l'eau, caractérisé en ce que, pour ladite étape d'extraction, on dissout ledit polymère qui ne contient pas moins de 0,01 mole pourcent d'acide lactique ou d'acide lactique et d'acide glycolique dans une quantité (poids/volume) de 3 à 20 fois plus grande d'un solvant organique et on verse la solution obtenue dans l'eau, en agitant, à une température de 20°C à 70°C.
  4. Procédé selon la revendication 3, dans lequel ledit solvant organique soluble dans l'eau est l'éthanol.
  5. Microcapsule pour libération prolongée par injection, contenant une quantité efficace d'une substance active et, comme excipient, un polymère biodégradable de poids moléculaire élevé selon la revendication 1 ou la revendication 2.
  6. Microcapsule selon la revendication 5, dans laquelle ladite substance active est un peptide soluble dans l'eau.
  7. Procédé de préparation d'une microcapsule selon la revendication 5 ou 6, selon lequel on prépare une émulsion d'eau dans l'huile (eau/huile) à partir d'une solution contenant ladite substance active, servant de phase aqueuse interne, et d'une solution contenant ledit polymère biodégradable, servant de phase huileuse, on disperse ladite émulsion dans une phase aqueuse (eau) pour obtenir une émulsion (eau/huile)/eau, et on met en contact l'émulsion obtenue avec une troisième phase aqueuse, pour obtenir une émulsion en phase ternaire (eau/huile)/eau avec désorption du solvant dans la phase aqueuse.
  8. Utilisation d'un polymère biodégradable de poids moléculaire élevé selon la revendication 1 comme matrice dans une microcapsule pour la libération prolongée d'une substance active à partir de ladite microcapsule.
HK5796A 1985-05-07 1996-01-11 Polymer, production and use thereof HK5796A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9761785 1985-05-07

Publications (1)

Publication Number Publication Date
HK5796A true HK5796A (en) 1996-01-19

Family

ID=14197161

Family Applications (1)

Application Number Title Priority Date Filing Date
HK5796A HK5796A (en) 1985-05-07 1996-01-11 Polymer, production and use thereof

Country Status (8)

Country Link
US (2) US4728721A (fr)
EP (1) EP0202065B1 (fr)
JP (2) JP2551756B2 (fr)
AT (1) ATE87946T1 (fr)
CA (1) CA1262005A (fr)
DE (1) DE3688213T2 (fr)
HK (1) HK5796A (fr)
HU (1) HU196703B (fr)

Families Citing this family (177)

* Cited by examiner, † Cited by third party
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US4849228A (en) 1989-07-18
EP0202065A2 (fr) 1986-11-20
CA1262005A (fr) 1989-09-26
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ATE87946T1 (de) 1993-04-15
HU196703B (en) 1989-01-30
EP0202065B1 (fr) 1993-04-07
HUT43488A (en) 1987-11-30
JPH08169818A (ja) 1996-07-02
US4728721A (en) 1988-03-01
EP0202065A3 (en) 1987-10-21
JPS6254760A (ja) 1987-03-10

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