HK5796A - Polymer, production and use thereof - Google Patents

Polymer, production and use thereof Download PDF

Info

Publication number
HK5796A
HK5796A HK5796A HK5796A HK5796A HK 5796 A HK5796 A HK 5796A HK 5796 A HK5796 A HK 5796A HK 5796 A HK5796 A HK 5796A HK 5796 A HK5796 A HK 5796A
Authority
HK
Hong Kong
Prior art keywords
water
polymer
lactic acid
high molecular
acid
Prior art date
Application number
HK5796A
Other languages
German (de)
English (en)
Inventor
Yamamoto Masaki
Okada Hiroaki
Ogawa Yasuaki
Miyagawa Tsutomu
Original Assignee
Takeda Pharmaceutical Company Limited
Wako Pure Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=14197161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK5796(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical Company Limited, Wako Pure Chemical Industries, Ltd. filed Critical Takeda Pharmaceutical Company Limited
Publication of HK5796A publication Critical patent/HK5796A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
  • Processing Of Solid Wastes (AREA)

Claims (8)

  1. Polymère biodégradable de poids moléculaire élevé, dont le poids moléculaire moyen est de 5 000 à 35 000, caractérisé en ce que ledit polymère consiste à raison de 50 à 100 moles pourcent en radicaux d'acide lactique et à raison de 50 à 0 moles pourcent en radicaux d'acide glycolique et qu'il a une teneur en acide lactique ou acide lactique et acide glycolique inférieure à 0,01 mole par 100 grammes dudit polymère.
  2. Polymère biodégradable de poids moléculaire élevé selon la revendication 1, dans lequel ladite teneur en acide lactique ou acide lactique et acide glycolique est de 0,0055 mole ou moins par 100 grammes dudit polymère.
  3. Procédé de préparation du polymère selon la revendication 1, lequel procédé consiste à préparer le polymère à partir d'acide lactique ou d'acide lactique et d'acide glycolique en des conditions réactionnelles aqueuses, puis à réduire la teneur en acide lactique ou acide lactique et acide glycolique dans ledit polymère jusqu'à un niveau inférieur à 0,01 mole par 100 grammes dudit polymère par extraction à l'eau ou au moyen d'un mélange d'eau et d'un solvant organique soluble dans l'eau, caractérisé en ce que, pour ladite étape d'extraction, on dissout ledit polymère qui ne contient pas moins de 0,01 mole pourcent d'acide lactique ou d'acide lactique et d'acide glycolique dans une quantité (poids/volume) de 3 à 20 fois plus grande d'un solvant organique et on verse la solution obtenue dans l'eau, en agitant, à une température de 20°C à 70°C.
  4. Procédé selon la revendication 3, dans lequel ledit solvant organique soluble dans l'eau est l'éthanol.
  5. Microcapsule pour libération prolongée par injection, contenant une quantité efficace d'une substance active et, comme excipient, un polymère biodégradable de poids moléculaire élevé selon la revendication 1 ou la revendication 2.
  6. Microcapsule selon la revendication 5, dans laquelle ladite substance active est un peptide soluble dans l'eau.
  7. Procédé de préparation d'une microcapsule selon la revendication 5 ou 6, selon lequel on prépare une émulsion d'eau dans l'huile (eau/huile) à partir d'une solution contenant ladite substance active, servant de phase aqueuse interne, et d'une solution contenant ledit polymère biodégradable, servant de phase huileuse, on disperse ladite émulsion dans une phase aqueuse (eau) pour obtenir une émulsion (eau/huile)/eau, et on met en contact l'émulsion obtenue avec une troisième phase aqueuse, pour obtenir une émulsion en phase ternaire (eau/huile)/eau avec désorption du solvant dans la phase aqueuse.
  8. Utilisation d'un polymère biodégradable de poids moléculaire élevé selon la revendication 1 comme matrice dans une microcapsule pour la libération prolongée d'une substance active à partir de ladite microcapsule.
HK5796A 1985-05-07 1996-01-11 Polymer, production and use thereof HK5796A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9761785 1985-05-07

Publications (1)

Publication Number Publication Date
HK5796A true HK5796A (en) 1996-01-19

Family

ID=14197161

Family Applications (1)

Application Number Title Priority Date Filing Date
HK5796A HK5796A (en) 1985-05-07 1996-01-11 Polymer, production and use thereof

Country Status (8)

Country Link
US (2) US4728721A (fr)
EP (1) EP0202065B1 (fr)
JP (2) JP2551756B2 (fr)
AT (1) ATE87946T1 (fr)
CA (1) CA1262005A (fr)
DE (1) DE3688213T2 (fr)
HK (1) HK5796A (fr)
HU (1) HU196703B (fr)

Families Citing this family (176)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
US4897268A (en) * 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
JP2670680B2 (ja) * 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
AU634723B2 (en) * 1988-08-08 1993-03-04 Biopak Technology, Ltd. Degradable thermoplastic from lactides
US6323307B1 (en) 1988-08-08 2001-11-27 Cargill Dow Polymers, Llc Degradation control of environmentally degradable disposable materials
KR900701934A (ko) * 1988-08-08 1990-12-05 원본미기재 락티드로부터 분해성 열가소성 수지
US5424346A (en) * 1988-08-08 1995-06-13 Ecopol, Llc Biodegradable replacement of crystal polystyrene
US5180765A (en) * 1988-08-08 1993-01-19 Biopak Technology, Ltd. Biodegradable packaging thermoplastics from lactides
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
DE3936191C2 (de) * 1989-10-31 1996-10-17 Boehringer Ingelheim Kg Neue Copolymere aus Milchsäure und Weinsäure, ihre Herstellung sowie ihre Verwendung
JP2653255B2 (ja) * 1990-02-13 1997-09-17 武田薬品工業株式会社 長期徐放型マイクロカプセル
MY107937A (en) * 1990-02-13 1996-06-29 Takeda Chemical Industries Ltd Prolonged release microcapsules.
US5075115A (en) * 1990-04-02 1991-12-24 Fmc Corporation Process for polymerizing poly(lactic acid)
CA2040141C (fr) * 1990-04-13 2002-05-14 Minoru Yamada Polymeres biodegradables a haute densite moleculaire production et utilisation desdits polymeres
MY108621A (en) * 1990-08-01 1996-10-31 Novartis Ag Polylactide preparation and purification
AU8660191A (en) * 1990-09-06 1992-03-30 Biopak Technology, Ltd. Packaging thermoplastics from lactic acid
PH31064A (en) * 1990-09-07 1998-02-05 Nycomed As Of Nycoveten Polymers containing diester units.
NZ240214A (en) 1990-10-16 1993-02-25 Takeda Chemical Industries Ltd Polymer compositions comprising a polylactic acid and a copolymer of glycolic acid and a hydroxycarboxylic acid; use as carrier for prolonged release pharmaceutical compositions of water soluble drugs
IT1249045B (it) * 1991-02-21 1995-02-11 Himont Inc Processo per la sintesi allo stato solido di polimeri dell'acido lattico e prodotti cosi ottenuti
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US6005067A (en) * 1992-01-24 1999-12-21 Cargill Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247059A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for the manufacture of a purified lactide from esters of lactic acid
US5247058A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5142023A (en) * 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5258488A (en) * 1992-01-24 1993-11-02 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6326458B1 (en) 1992-01-24 2001-12-04 Cargill, Inc. Continuous process for the manufacture of lactide and lactide polymers
FR2692147B1 (fr) * 1992-06-15 1995-02-24 Centre Nat Rech Scient Microsphères en polymère biorésorbable exemptes de tensioactif, leur préparation et leur application comme médicament.
BR9305661A (pt) * 1992-10-02 1996-11-26 Cargill Inc Pano de polímero de lactideo estável em fusao e processo para a sua fabricaçao
US5338822A (en) * 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
US6005068A (en) * 1992-10-02 1999-12-21 Cargill Incorporated Melt-stable amorphous lactide polymer film and process for manufacture thereof
NZ256978A (en) * 1992-10-02 1996-05-28 Cargill Inc Paper product coated with a poly(lactide) composition comprising no more than 5 wt % lactide monomer, the poly(lactide) having a number average mw of 10,000 to 200,000
TW333456B (en) 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6913767B1 (en) 1993-10-25 2005-07-05 Genentech, Inc. Compositions for microencapsulation of antigens for use as vaccines
US5643605A (en) * 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
US6080429A (en) * 1993-10-25 2000-06-27 Genentech, Inc. Method for drying microspheres
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
TW448055B (en) * 1995-09-04 2001-08-01 Takeda Chemical Industries Ltd Method of production of sustained-release preparation
US5942253A (en) * 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
SE505146C2 (sv) * 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
US6303134B1 (en) 1996-08-29 2001-10-16 Advanced Research And Technology Institute, Inc. Pharmacotherapeutic process and composition for central nervous system disorders
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US20070185032A1 (en) * 1996-12-11 2007-08-09 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US6126919A (en) * 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US5989463A (en) * 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
US6217844B1 (en) 1998-04-27 2001-04-17 Praecis Pharmaceuticals, Inc. Methods for detecting lesions in dense breast tissue using LHRH antagonists
US6565874B1 (en) * 1998-10-28 2003-05-20 Atrix Laboratories Polymeric delivery formulations of leuprolide with improved efficacy
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
ES2169980B1 (es) 1999-12-17 2003-11-01 Lipotec Sa Microcapsulas para la liberacion prolongada de farmacos.
TWI284048B (en) 2000-01-27 2007-07-21 Zentaris Ag Compressed microparticles for dry injection
AU2001257129A1 (en) * 2000-04-21 2001-11-07 Advanced Research And Technology Institute, Inc. Novel pharmacotherapeutic process and composition for central nervous system disorders
EP1310517B2 (fr) * 2000-08-07 2010-11-17 Wako Pure Chemical Industries, Ltd. Polymere d'acide lactique et son procede de preparation
US6362308B1 (en) * 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
EP1335661B1 (fr) 2000-10-27 2009-05-06 Baxter Healthcare S.A. Production de microspheres
US8470359B2 (en) 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
EP1343478B1 (fr) 2000-12-21 2007-10-10 Alrise Biosystems GmbH Procede de transition de phase induite permettant de produire des microparticules contenant des agents actifs hydrophiles
WO2003000156A1 (fr) 2001-06-22 2003-01-03 Southern Biosystems, Inc. Implants coaxiaux a liberation prolongee d'ordre 0
AR034641A1 (es) † 2001-06-29 2004-03-03 Takeda Pharmaceutical Composicion de liberacion controlada y metodo para producirla
TWI225416B (en) 2001-06-29 2004-12-21 Takeda Chemical Industries Ltd Sustained-release composition and process for producing the same
JP4612239B2 (ja) * 2001-07-18 2011-01-12 三井化学株式会社 生体吸収性ポリヒドロキシカルボン酸の製造方法
US20080026068A1 (en) * 2001-08-16 2008-01-31 Baxter Healthcare S.A. Pulmonary delivery of spherical insulin microparticles
ATE395042T1 (de) * 2001-08-16 2008-05-15 Baxter Int Darreichungsformen welche mikropartikel und treibgas enthalten
JP2003192773A (ja) * 2001-12-26 2003-07-09 Mitsui Chemicals Inc 生体吸収性ポリヒドロキシカルボン酸及びその製造法
US6849600B2 (en) * 2002-03-25 2005-02-01 The Regents Of The University Of California, Berkeley Corticotropin-releasing hormone analogs
US20050112087A1 (en) * 2003-04-29 2005-05-26 Musso Gary F. Pharmaceutical formulations for sustained drug delivery
US20060193825A1 (en) * 2003-04-29 2006-08-31 Praecis Phamaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
RU2426590C2 (ru) * 2003-07-18 2011-08-20 Бакстер Интернэшнл Инк. Способы изготовления, применение и композиции небольших сферических частиц, приготовленных регулируемым фазовым разделением
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
US20070092452A1 (en) * 2003-07-18 2007-04-26 Julia Rashba-Step Methods for fabrication, uses, compositions of inhalable spherical particles
US20050048127A1 (en) * 2003-07-22 2005-03-03 Larry Brown Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof
US20060210614A1 (en) * 2003-12-26 2006-09-21 Nastech Pharmaceutical Company Inc. Method of treatment of a metabolic disease using intranasal administration of exendin peptide
US20060074025A1 (en) * 2003-12-26 2006-04-06 Nastech Pharmaceutical Company Inc. Therapeutic formulations for transmucosal administration that increase glucagon-like peptide-1 bioavailability
US20050143303A1 (en) * 2003-12-26 2005-06-30 Nastech Pharmaceutical Company Inc. Intranasal administration of glucose-regulating peptides
US20080318837A1 (en) * 2003-12-26 2008-12-25 Nastech Pharmaceutical Company Inc. Pharmaceutical Formation For Increased Epithelial Permeability of Glucose-Regulating Peptide
TW200529890A (en) * 2004-02-10 2005-09-16 Takeda Pharmaceutical Sustained-release preparations
JP4403846B2 (ja) * 2004-03-22 2010-01-27 東レ株式会社 ポリ乳酸のラクチド除去法
JP4403845B2 (ja) * 2004-03-22 2010-01-27 東レ株式会社 ラクチド含有量が少ないポリ乳酸の製造方法
US8728525B2 (en) * 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
WO2005112885A2 (fr) * 2004-05-12 2005-12-01 Baxter International Inc. Administration de microspheres d'oligonucleotides antisens pour induire une tolerance de cellules dendritiques pour le traitement du diabete de type 1 insulino-dependant
DK2072040T3 (da) * 2004-05-12 2013-07-29 Baxter Healthcare Sa Terapeutisk anvendelse af nukleinsyremikrokugler
US8333995B2 (en) * 2004-05-12 2012-12-18 Baxter International, Inc. Protein microspheres having injectable properties at high concentrations
JP2007537007A (ja) * 2004-05-12 2007-12-20 マサチューセッツ インスティテュート オブ テクノロジー 溶剤蒸気膜形成を含んだ立体印刷法等の製法
TW200613012A (en) * 2004-07-02 2006-05-01 Takeda Pharmaceuticals Co Sustained-release composition, process for producing the same and use of the same
CN101035512B (zh) 2004-08-12 2012-01-18 昌达生物科技公司 用于生物活性化合物可控制释放递送的药物组合物
US20070254314A1 (en) * 2004-09-16 2007-11-01 Geier Mark R Methods of treating autism and autism spectrum disorders
US8541413B2 (en) * 2004-10-01 2013-09-24 Ramscor, Inc. Sustained release eye drop formulations
US20080038316A1 (en) * 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
US9993558B2 (en) 2004-10-01 2018-06-12 Ramscor, Inc. Sustained release eye drop formulations
EP2452670A1 (fr) * 2004-10-01 2012-05-16 Ramscor, Inc. Compositions de médicaments à libération prolongée parfaitement implantable
US8394410B2 (en) * 2005-01-20 2013-03-12 Massachusetts Institute Of Technology Soft polylactides
AU2006241145B2 (en) * 2005-04-27 2011-04-28 Baxter Healthcare S. A. Surface-modified microparticles and methods of forming and using the same
ATE382337T1 (de) * 2005-04-28 2008-01-15 Nipro Corp Bioabsorbierbare pharmazeutische zusammensetzung enthaltend einen plga-copolymer
US8840876B2 (en) * 2005-05-19 2014-09-23 Ethicon, Inc. Antimicrobial polymer compositions and the use thereof
US7942867B2 (en) * 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
RU2008124109A (ru) * 2005-12-08 2010-01-20 МДРНА, Инк. (US) Чресслизистая доставка стабилизированных композиций эксендина
US20070154546A1 (en) * 2005-12-30 2007-07-05 Zhang Jack Y Sustained release pharmaceutical compositions
MX2008009125A (es) 2006-01-18 2008-10-23 Qps Llc Composiciones farmaceuticas con estabilidad mejorada.
WO2007088135A1 (fr) * 2006-01-31 2007-08-09 Purac Biochem Bv Procede de purification de polymeres resorbables a partir de monomeres residuels
US20070179276A1 (en) * 2006-01-31 2007-08-02 Purac Biochem Bv Method for the purification of resorbable polymers from residual monomers
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
EP2054073B1 (fr) * 2006-07-11 2014-11-26 Foresee Pharmaceuticals, Inc. Compositions pharmaceutiques pour délivrance à libération prolongée de peptides
JP5118139B2 (ja) * 2006-08-04 2013-01-16 バクスター・インターナショナル・インコーポレイテッド 新規発症自己免疫性糖尿病を予防および／または逆転させるためのマイクロスフィアに基づく組成物
EP2068845A2 (fr) * 2006-10-06 2009-06-17 Baxter International Inc. Microcapsules contenant des microparticules modifiées en surface et leurs procédés de formation et d'utilisation
US8076448B2 (en) * 2006-10-11 2011-12-13 Tolmar Therapeutics, Inc. Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction
WO2008063378A2 (fr) 2006-11-01 2008-05-29 Ventana Medical Systems, Inc. Haptènes, conjugués de haptène, compositions de haptène, procédé de fabrication et utilisation
NO347209B1 (no) 2006-12-18 2023-07-03 Takeda Pharmaceutical Sammensetning med forlenget frigjøring og fremgangsmåte for å produsere det samme
HUE025842T2 (en) * 2007-02-15 2016-04-28 Tolmar Therapeutics Inc Poly (lactide / glycolide) with reduced fracture properties and methods for producing polymers
US8367427B2 (en) * 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US8323685B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US20100047292A1 (en) * 2008-08-20 2010-02-25 Baxter International Inc. Methods of processing microparticles and compositions produced thereby
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
US8741259B2 (en) 2008-10-20 2014-06-03 Marvin C. Gershengorn Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists
AU2009308454A1 (en) 2008-10-21 2010-04-29 Oregon Health & Science University Naphthamides as anticancer agents
US20100256746A1 (en) * 2009-03-23 2010-10-07 Micell Technologies, Inc. Biodegradable polymers
EP2246063A1 (fr) 2009-04-29 2010-11-03 Ipsen Pharma S.A.S. Formulations à libération prolongée contenant des analogues de GnRH
US20120108514A1 (en) 2009-07-09 2012-05-03 University Of Iowa Research Foundation Long acting atrial natriuretic peptide (la-anp) and methods for use thereof
WO2011094426A1 (fr) 2010-01-29 2011-08-04 The United State Of America, As Represented By The Secretary, Department Of Health & Human Services Inhibiteurs de caspases
US9206154B2 (en) 2010-04-08 2015-12-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inverse agonists and neutral antagonists for the TSH receptor
WO2012125486A1 (fr) 2011-03-11 2012-09-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Polychimiothérapie pour le traitement du cancer
WO2012125787A1 (fr) 2011-03-17 2012-09-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Méthodes de traitement de la leucémie et de troubles à médiation par les protéines cbfβ et runx1
CN107090028A (zh) 2011-08-30 2017-08-25 梅约医学教育与研究基金会 利钠多肽
WO2013039792A1 (fr) 2011-09-12 2013-03-21 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Immunogènes à base d'un épitope vih-1 gp120 v1v2
WO2013049535A2 (fr) 2011-09-30 2013-04-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Vaccin antigrippal
US9611305B2 (en) 2012-01-06 2017-04-04 Mayo Foundation For Medical Education And Research Treating cardiovascular or renal diseases
US9249103B2 (en) 2012-01-13 2016-02-02 Oregon Health & Science University Compounds, compositions and associated methods comprising 3-aryl quinolines
PT2858975T (pt) 2012-06-08 2019-07-16 Univ Pittsburgh Commonwealth Sys Higher Education Inibidores de fbxo3
EP2919779B1 (fr) 2012-11-13 2021-01-06 The U.S.A. as represented by the Secretary, Department of Health and Human Services Composés pour la médiation d'un récepteur des cannabinoïdes
US9775895B2 (en) 2012-12-12 2017-10-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HIV therapeutics and methods of making and using same
FI2970398T3 (fi) 2013-03-13 2024-08-06 Us Health Rsv f -prefuusioproteiineja ja niiden käyttö
JP2016524607A (ja) 2013-05-16 2016-08-18 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ Ｈｉｖ−１インテグラーゼの薬物耐性株を阻害するための化合物
CN103300120B (zh) * 2013-06-25 2015-04-22 南京工业大学 一种绿色家禽家畜脱毛剂及其制备方法
CA2924527C (fr) 2013-09-20 2022-07-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Composes destines au traitement du cancer de la prostate
WO2015106003A1 (fr) 2014-01-08 2015-07-16 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Voies de ras en tant que marqueurs de protection contre le vih et méthode d'amélioration d'efficacité de vaccin
AU2015255765A1 (en) 2014-05-09 2016-11-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Pyrazole derivatives and their use as cannabinoid receptor mediators
DK3185868T3 (da) 2014-08-25 2022-05-23 Salk Inst For Biological Studi Hidtil ukendte ULK1-inhibitorer og fremgangsmåder til anvendelse af samme
WO2016037154A1 (fr) 2014-09-04 2016-03-10 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Protéines de l'enveloppe du vih-1 recombinantes et leur utilisation
WO2016064716A1 (fr) 2014-10-20 2016-04-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Polythérapie basée sur un antagoniste du tshr et un inhibiteur de l'igfr
EP3236998A1 (fr) 2014-12-24 2017-11-01 The U.S.A. as represented by the Secretary, Department of Health and Human Services Protéines du métapneumovirus f recombinant et leur utilisation
EP3242661B1 (fr) 2015-01-05 2019-08-21 The U.S.A. as represented by the Secretary, Department of Health and Human Services Petites molécules de stabilisation de la structure g-quadruplexe du gène myc et leur utilisation
EP3259246B1 (fr) 2015-02-20 2023-03-22 Oregon Health & Science University Dérivés de sobétirome
US20180273485A1 (en) 2015-06-04 2018-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Cannabinoid receptor mediating compounds
CN107848932B (zh) 2015-06-11 2025-09-02 解向群 p62-ZZ化学抑制剂
US10799580B2 (en) 2015-09-09 2020-10-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Expression vector delivery system and use thereof for inducing an immune response
WO2017151802A1 (fr) 2016-03-04 2017-09-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Composés de médiation des récepteurs cannabinoïdes
EP3433239A4 (fr) 2016-03-24 2020-04-15 University of Pittsburgh- Of the Commonwealth System of Higher Education Inhibiteur de type petite molécule de la translocation nucléaire du récepteur aux androgènes pour le traitement du cancer de la prostate résistant à la castration
CN109475121B (zh) 2016-05-18 2021-06-25 俄勒冈健康科学大学 苏比替罗衍生物
EP3471828A1 (fr) 2016-06-16 2019-04-24 Acies Bio d.o.o. Compositions et méthodes utiles dans le traitement de maladies se caractérisant par une activité insuffisante de la pantothénate kinase
TWI648291B (zh) * 2016-10-13 2019-01-21 傑安生技股份有限公司 氧化性修飾改善細胞穿透性胜肽之成藥性以作為藥物載體
EP4595970A3 (fr) 2016-11-09 2025-10-29 Mayo Foundation for Medical Education and Research Analogues de manp
US11084850B2 (en) 2016-12-16 2021-08-10 The Pirbright Institute Recombinant prefusion RSV F proteins and uses thereof
CA3053388C (fr) 2017-02-22 2024-02-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Composes et procedes pour inhiber les voies emt pour traiter le cancer, la fibrose d'organe et les troubles metaboliques
JP7730640B2 (ja) 2017-11-01 2025-08-28 ザ スクリプス リサーチ インスティテュート 新規足場ｈｉｖ－１ワクチン免疫原
WO2019118803A1 (fr) 2017-12-14 2019-06-20 The United States Of America, As Represented By The Secretary,Department Of Health And Human Services Entités chimiques pour l'activation lytique de kshv et ciblage thérapeutique d'enzymes/protéines virales
RU2020134972A (ru) 2018-03-29 2022-04-29 Элекс Байотек, Инк. Соединения для лечения сердечных аритмий и сердечной недостаточности
JP7520822B2 (ja) 2018-09-25 2024-07-23 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ ２’－ハロゲン化－４’－チオ－２’－デオキシ－５－アザシチジンアナログおよびその使用
WO2020097421A1 (fr) 2018-11-09 2020-05-14 Mayo Foundation For Medical Education And Research Traitement combiné pour l'hypertension résistante
EP3894383A1 (fr) 2018-12-12 2021-10-20 Autobahn Therapeutics, Inc. Nouveaux thyromimétiques
CA3130371A1 (fr) 2019-03-01 2020-09-10 Autobahn Therapeutics, Inc. Nouveaux thyromimetiques
EP3937917B1 (fr) 2019-03-11 2023-11-15 Oregon State University Analogues et dérivés de céphalotaxine et procédés de fabrication et d'utilisation des composés
KR20220121239A (ko) 2019-11-29 2022-08-31 아우토반 쎄라퓨틱스, 인크. 신규한 갑상선 호르몬 모방제
US20210196648A1 (en) * 2019-12-31 2021-07-01 Industrial Technology Research Institute Drug-containing multilayer film and method for forming the same
KR20220153582A (ko) 2020-02-14 2022-11-18 솔크 인스티튜트 포 바이올로지칼 스터디즈 마크로시클릭 ulk1/2 억제제
JP7813730B2 (ja) 2020-06-17 2026-02-13 オートバーン セラピューティクス，インク． 甲状腺様作用剤
WO2021257851A1 (fr) 2020-06-17 2021-12-23 Autobahn Therapeutics, Inc. Thyromimétiques
CN112409765A (zh) * 2020-11-16 2021-02-26 深圳市正旺环保新材料有限公司 一种可降解环保塑料袋及其制备方法
WO2022261296A1 (fr) 2021-06-09 2022-12-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Composés qui se lient à des structures g-quadruplexes non canoniques et leurs procédés de fabrication et d'utilisation
GB2613656A (en) * 2021-12-13 2023-06-14 Pharmathen Sa Sustained release injectable pharmaceutical formulation of levothyroxine and process for preparation thereof
WO2023059867A1 (fr) 2021-10-08 2023-04-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Composés pour le traitement ou la prévention de la maladie d'alzheimer
US12325688B2 (en) 2022-01-25 2025-06-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gingerenone A prodrugs as sensotherapeutics and methods of use
EP4493547A1 (fr) 2022-03-14 2025-01-22 The United States of America, as represented by the Secretary, Department of Health and Human Services Composés modulant le récepteur cannabinoïde
WO2024151855A1 (fr) 2023-01-13 2024-07-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibiteurs de transfert de brins intégrase à base de carbamoyl pyridone bicyclique
WO2025054172A1 (fr) 2023-09-05 2025-03-13 E-Star Biotech, LLC Formulations de manp et leurs utilisations
WO2025196270A1 (fr) 2024-03-22 2025-09-25 Limmatech Biologics Ag Vaccins à vésicule de membrane externe pour la prévention de n. gonorrhoeae et leurs procédés de fabrication et d'utilisation
WO2025213007A1 (fr) 2024-04-04 2025-10-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services S-hydroxychloroquine, facultativement avec de l'acide tauro-ursodésoxycholique et/ou du 3,3'-diindolylméthane, pour le traitement et/ou la prévention de troubles neurologiques

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3297033A (en) * 1963-10-31 1967-01-10 American Cyanamid Co Surgical sutures
US3565869A (en) * 1968-12-23 1971-02-23 American Cyanamid Co Extrudable and stretchable polyglycolic acid and process for preparing same
US3755558A (en) * 1971-02-23 1973-08-28 Du Pont Polylactide drug mixtures for topical application atelet aggregation
US3839297A (en) * 1971-11-22 1974-10-01 Ethicon Inc Use of stannous octoate catalyst in the manufacture of l(-)lactide-glycolide copolymer sutures
US3912692A (en) * 1973-05-03 1975-10-14 American Cyanamid Co Process for polymerizing a substantially pure glycolide composition
US3890283A (en) * 1973-06-04 1975-06-17 American Cyanamid Co Process for post-polymerizing polyglycolic acid
US4249531A (en) * 1979-07-05 1981-02-10 Alza Corporation Bioerodible system for delivering drug manufactured from poly(carboxylic acid)
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
US4479911A (en) * 1982-01-28 1984-10-30 Sandoz, Inc. Process for preparation of microspheres and modification of release rate of core material
US4605730A (en) * 1982-10-01 1986-08-12 Ethicon, Inc. Surgical articles of copolymers of glycolide and ε-caprolactone and methods of producing the same
US4523591A (en) * 1982-10-22 1985-06-18 Kaplan Donald S Polymers for injection molding of absorbable surgical devices
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法

Also Published As

Publication number Publication date
DE3688213T2 (de) 1993-09-23
DE3688213D1 (de) 1993-05-13
US4849228A (en) 1989-07-18
ATE87946T1 (de) 1993-04-15
JP2551756B2 (ja) 1996-11-06
JP2660401B2 (ja) 1997-10-08
HUT43488A (en) 1987-11-30
CA1262005A (fr) 1989-09-26
US4728721A (en) 1988-03-01
JPH08169818A (ja) 1996-07-02
HU196703B (en) 1989-01-30
JPS6254760A (ja) 1987-03-10
EP0202065A2 (fr) 1986-11-20
EP0202065A3 (en) 1987-10-21
EP0202065B1 (fr) 1993-04-07

Similar Documents

Publication Publication Date Title
EP0202065B1 (fr) Polymère, sa préparation et son utilisation
US5585460A (en) Biodegradable high-molecular polymers, production and use thereof
EP0442671B1 (fr) Microcapsules à libération prolongée
NL194577C (nl) Preparaat voor de lang aanhoudende en gecontroleerde afgifte van medicamenteuze stoffen.
DE69333817T2 (de) Leuprorelinpräparat mit verzögerter Wirkstoffabgabe
EP0302582B2 (fr) Système pour la libération de drogues et son mode de préparation
US5575987A (en) Method of producing sustained-release microcapsules
Bodmeier et al. Pseudoephedrine HCl microspheres formulated into an oral suspension dosage form
DE3345314A1 (de) Oligomere hydroxycarbonsaeurederivate, deren herstellung und verwendung
EP0595030A2 (fr) Composition de microsphères à plusieurs noyaux à libération retardée et son procédé de préparation
HK1007490B (en) Drug delivery system and method of making the same
IE83404B1 (en) Polyethylene-polylactic acid block copolymer nanoparticles
LV10055B (en) Prolonged release preparation and polymers thereof
CH690491A5 (de) Mikroteilchen zur Injektion und ihre Herstellungsverfahren.
Yeh et al. Improving the delivery capacity of microparticle systems using blends of poly (DL-lactide co-glycolide) and poly (ethylene glycol)
EP0256726A2 (fr) Encapsulation de TRH ou de ses analogues
JP3200706B2 (ja) 生体内分解型高分子重合物
IE883110L (en) Polyester based compositions for controlled release
JP3254449B2 (ja) 生体内分解型高分子重合物
EP0724880A1 (fr) Procédé d'encapsulation de la chlorphéniramine

Legal Events

Date Code Title Description
PF Patent in force
CHPA Change of a particular in the register (except of change of ownership)
PE Patent expired

Effective date: 20060505