IL110430A - Dna sequence comprising a gene cluster encoding branched chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis - Google Patents

Dna sequence comprising a gene cluster encoding branched chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis

Info

Publication number
IL110430A
IL110430A IL11043094A IL11043094A IL110430A IL 110430 A IL110430 A IL 110430A IL 11043094 A IL11043094 A IL 11043094A IL 11043094 A IL11043094 A IL 11043094A IL 110430 A IL110430 A IL 110430A
Authority
IL
Israel
Prior art keywords
dehydrogenase complex
dna sequence
chain alpha
branched chain
gene cluster
Prior art date
Application number
IL11043094A
Other languages
English (en)
Other versions
IL110430A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL110430A0 publication Critical patent/IL110430A0/xx
Priority to IL15413603A priority Critical patent/IL154136A0/xx
Publication of IL110430A publication Critical patent/IL110430A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/04—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with a disulfide as acceptor (1.2.4)
    • C12Y102/04004—3-Methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (1.2.4.4), i.e. branched-chain-alpha-ketoacid dehydrogenase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL11043094A 1993-07-30 1994-07-25 Dna sequence comprising a gene cluster encoding branched chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis IL110430A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL15413603A IL154136A0 (en) 1993-07-30 2003-01-26 Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10051893A 1993-07-30 1993-07-30

Publications (2)

Publication Number Publication Date
IL110430A0 IL110430A0 (en) 1994-10-21
IL110430A true IL110430A (en) 2005-08-31

Family

ID=22280171

Family Applications (2)

Application Number Title Priority Date Filing Date
IL11043094A IL110430A (en) 1993-07-30 1994-07-25 Dna sequence comprising a gene cluster encoding branched chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis
IL15413603A IL154136A0 (en) 1993-07-30 2003-01-26 Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL15413603A IL154136A0 (en) 1993-07-30 2003-01-26 Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis

Country Status (22)

Country Link
US (1) US5728561A (pl)
EP (1) EP0711349B1 (pl)
JP (1) JP2807348B2 (pl)
KR (1) KR100221385B1 (pl)
CN (2) CN1104502C (pl)
AT (1) ATE248916T1 (pl)
AU (2) AU6657294A (pl)
BR (1) BR9407211A (pl)
CA (1) CA2167520C (pl)
CZ (3) CZ26096A3 (pl)
DE (1) DE69433112T2 (pl)
DK (1) DK0711349T3 (pl)
ES (1) ES2204914T3 (pl)
FI (1) FI960401L (pl)
HU (1) HU218964B (pl)
IL (2) IL110430A (pl)
NO (2) NO321077B1 (pl)
NZ (2) NZ266014A (pl)
PL (3) PL181916B1 (pl)
PT (1) PT711349E (pl)
WO (1) WO1995004150A1 (pl)
ZA (1) ZA945639B (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466102A (en) * 1993-12-16 1995-11-14 Kennametal Inc. System for coupling machine tools
WO1999000505A1 (en) * 1997-06-30 1999-01-07 The Curators Of The University Of Missouri Use of dna encoding plastid pyruvate dehydrogenase and branched chain oxoacid dehydrogenase components to enhance polyhydroxyalkanoate biosynthesis in plants
US6248579B1 (en) 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
US6197591B1 (en) 1998-09-14 2001-03-06 Pfizer Inc. Streptomyces avermitilis regulatory genes for increased avermectin production
BRPI0013119B8 (pt) * 1999-08-12 2021-05-25 Pah Usa 15 Llc molécula polinucleotídica isolada, vetor recombinante purificado, célula hospedeira procariótica e célula de streptomyces avermitilis mutada, método para obtenção de uma nova cepa de s. avermitilis e processo para produção de avermectinas
EP1210460B1 (en) * 1999-08-19 2007-05-23 Omniscience Pharmaceuticals Gene cloning
CN1321684A (zh) * 2000-04-29 2001-11-14 上海博德基因开发有限公司 一种新的多肽——人krab包含的锌指蛋白kraz2－12和编码这种多肽的多核苷酸
CN1321752A (zh) * 2000-04-29 2001-11-14 上海博德基因开发有限公司 一种新的多肽——人分支alpha－酮酸脱氢酶E1－beta亚单位9和编码这种多肽的多核苷酸
AT410217B (de) * 2000-06-15 2003-03-25 Cistem Biotechnologies Gmbh Vektor und ein verfahren zur expression und selektion randomisierter peptid-sequenzen
EP2141236A1 (en) 2008-07-03 2010-01-06 KRKA, D.D., Novo Mesto Process for production of lipstatin and microorganisms therefore
CN112410389B (zh) * 2019-08-23 2023-07-18 中国科学院微生物研究所 支链α-酮酸脱氢酶复合体在制备丙二酸单酰辅酶A中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN167980B (pl) * 1987-01-23 1991-01-19 Pfizer
IL85119A (en) * 1987-01-23 1993-01-14 Pfizer Streptomyces avermitilis strains, their preparation and use in production of avermectins

Also Published As

Publication number Publication date
PL181778B1 (pl) 2001-09-28
JPH08507931A (ja) 1996-08-27
HUT71323A (en) 1995-11-28
US5728561A (en) 1998-03-17
CZ289136B6 (cs) 2001-11-14
PL177922B1 (pl) 2000-01-31
DE69433112T2 (de) 2004-04-01
NZ328926A (en) 1998-02-26
HU218964B (hu) 2001-01-29
CN1104502C (zh) 2003-04-02
CZ289866B6 (cs) 2002-04-17
NO20052209D0 (no) 2005-05-04
JP2807348B2 (ja) 1998-10-08
CZ20002929A3 (cs) 2001-11-14
IL154136A0 (en) 2003-07-31
CA2167520A1 (en) 1995-02-09
IL110430A0 (en) 1994-10-21
WO1995004150A1 (en) 1995-02-09
CN1128046A (zh) 1996-07-31
PL312733A1 (en) 1996-05-13
PL181916B1 (en) 2001-10-31
ZA945639B (en) 1996-01-29
NO960372L (no) 1996-01-29
FI960401A7 (fi) 1996-01-29
CZ26096A3 (en) 1996-05-15
AU712442B2 (en) 1999-11-04
AU9421898A (en) 1999-03-04
FI960401A0 (fi) 1996-01-29
EP0711349B1 (en) 2003-09-03
ATE248916T1 (de) 2003-09-15
HU9402192D0 (en) 1994-10-28
NO321077B1 (no) 2006-03-13
KR100221385B1 (ko) 1999-10-01
BR9407211A (pt) 1996-09-17
AU6657294A (en) 1995-02-28
FI960401L (fi) 1996-01-29
DE69433112D1 (de) 2003-10-09
CA2167520C (en) 1999-07-27
PT711349E (pt) 2003-12-31
CN1208078A (zh) 1999-02-17
NO20052209L (no) 1996-01-29
EP0711349A1 (en) 1996-05-15
NO960372D0 (no) 1996-01-29
ES2204914T3 (es) 2004-05-01
DK0711349T3 (da) 2003-11-24
NZ266014A (en) 1997-11-24

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FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees