IL91664A - Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release - Google Patents

Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release

Info

Publication number
IL91664A
IL91664A IL8991664A IL9166489A IL91664A IL 91664 A IL91664 A IL 91664A IL 8991664 A IL8991664 A IL 8991664A IL 9166489 A IL9166489 A IL 9166489A IL 91664 A IL91664 A IL 91664A
Authority
IL
Israel
Prior art keywords
liposomes
ammonium
controlled release
efficient loading
gradient system
Prior art date
Application number
IL8991664A
Other languages
English (en)
Other versions
IL91664A0 (en
Original Assignee
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co filed Critical Yissum Res Dev Co
Publication of IL91664A0 publication Critical patent/IL91664A0/xx
Publication of IL91664A publication Critical patent/IL91664A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL8991664A 1988-09-28 1989-09-18 Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release IL91664A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25068788A 1988-09-28 1988-09-28

Publications (2)

Publication Number Publication Date
IL91664A0 IL91664A0 (en) 1990-04-29
IL91664A true IL91664A (en) 1993-05-13

Family

ID=22948747

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8991664A IL91664A (en) 1988-09-28 1989-09-18 Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release

Country Status (11)

Country Link
US (2) US5192549A (fr)
EP (1) EP0361894B1 (fr)
JP (1) JP2659136B2 (fr)
AT (1) ATE113830T1 (fr)
CA (1) CA1335565C (fr)
DE (2) DE19675049I2 (fr)
ES (1) ES2067551T3 (fr)
HK (1) HK26197A (fr)
IL (1) IL91664A (fr)
LU (1) LU88856I2 (fr)
NL (1) NL960033I2 (fr)

Families Citing this family (268)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622713A (en) * 1985-09-17 1997-04-22 The Regents Of The University Of California Method of detoxifying animal suffering from overdose
US5252263A (en) * 1986-06-16 1993-10-12 The Liposome Company, Inc. Induction of asymmetry in vesicles
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US20020150539A1 (en) * 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5705187A (en) 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5334381A (en) * 1989-12-22 1994-08-02 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5228446A (en) * 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5230882A (en) * 1989-12-22 1993-07-27 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
WO1992002244A1 (fr) * 1990-07-31 1992-02-20 The Liposome Company, Inc. Accumulation d'acides amines et de peptides dans des liposomes
IS1685B (is) * 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
US20030113369A1 (en) * 1991-01-16 2003-06-19 Martin Francis J. Liposomes with enhanced circulation time and method of treatment
JPH04356421A (ja) * 1991-03-06 1992-12-10 Green Cross Corp:The プロスタグランジン類含有脂肪小体組成物
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
WO1993000888A1 (fr) * 1991-07-03 1993-01-21 Vestar, Inc. Technique de remplissage permettant de preparer des liposomes contenant un medicament
US5325860A (en) * 1991-11-08 1994-07-05 Mayo Foundation For Medical Education And Research Ultrasonic and interventional catheter and method
US20050181021A1 (en) * 1992-02-14 2005-08-18 Robert Lamb Vitamin E phosphate/phosphatidycholine liposomes to protect from or ameliorate cell damage
US5665381A (en) * 1992-02-25 1997-09-09 Nexstar Pharmaceuticals, Inc. Inhibition of aggregation of drug containing particles
DE4208527A1 (de) * 1992-03-17 1993-09-23 Max Planck Gesellschaft Liposomen mit negativer ueberschussladung
CA2150463A1 (fr) * 1992-12-02 1994-06-09 Donald F. H. Wallach Antiacide a action prolongee
DE4244122C1 (de) * 1992-12-24 1994-06-01 Sanol Arznei Schwarz Gmbh Lyophilisierte, wirkstoffhaltige Emulsion zur intravenösen Applikation
US5739020A (en) * 1995-01-10 1998-04-14 Pope; Edward J. A. Encapsulation of animal and microbial cells in an inorganic gel prepared from an organosilicon
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US5534499A (en) * 1994-05-19 1996-07-09 The University Of British Columbia Lipophilic drug derivatives for use in liposomes
US5736121A (en) 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US5741516A (en) * 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5543152A (en) * 1994-06-20 1996-08-06 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5714163A (en) * 1994-06-27 1998-02-03 Nexstar Pharmaceuticals, Inc. Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties
CA2152765A1 (fr) 1994-06-30 1995-12-31 Jeroen Elisabeth-Joseph Knops Methodes pour traiter un trouble physiologique associe a un peptide amyloide beta
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5827531A (en) * 1994-12-02 1998-10-27 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Microcapsules and methods for making
US6387399B1 (en) 1994-12-02 2002-05-14 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Microencapsulated bioactive agents and method of making
WO1996025147A1 (fr) * 1995-02-14 1996-08-22 Sequus Pharmaceuticals, Inc. Composition de liposomes et procede d'administration de medicaments par liposomes
US5972379A (en) * 1995-02-14 1999-10-26 Sequus Pharmaceuticals, Inc. Liposome composition and method for administering a quinolone
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5800833A (en) * 1995-02-27 1998-09-01 University Of British Columbia Method for loading lipid vesicles
EP0825852B1 (fr) * 1995-04-18 2004-07-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Procede de chargement de medicaments dans des liposomes et composition
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US20040208922A1 (en) * 1995-06-07 2004-10-21 The Regents Of The University Of California Method for loading lipid like vesicles with drugs or other chemicals
US6447800B2 (en) 1996-01-18 2002-09-10 The University Of British Columbia Method of loading preformed liposomes using ethanol
AU736301B2 (en) 1996-05-01 2001-07-26 Imarx Therapeutics, Inc. Methods for delivering compounds into a cell
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
PT977597E (pt) 1996-09-11 2003-06-30 Imarx Pharmaceutical Corp Metodos melhorados para imagiologia de diagnosticoutilizando um agente de contraste e um vasodil atador
US6056973A (en) * 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
US5837282A (en) * 1996-10-30 1998-11-17 University Of British Columbia Ionophore-mediated liposome loading
US5827532A (en) * 1997-01-31 1998-10-27 The Reagents Of The University Of California Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US20050019266A1 (en) * 1997-05-06 2005-01-27 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6045824A (en) 1997-09-18 2000-04-04 Skyepharma Inc. Sustained-release liposomal anesthetic compositions
US6120800A (en) * 1997-09-25 2000-09-19 Nexstar Pharmaceuticals, Inc. Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties
WO1999016425A1 (fr) * 1997-09-30 1999-04-08 The Ohio State University Liposomes a insuline modifiee par lipides incorporee permettant de delivrer des agents cytotoxiques aux cellules d'un hepatome
AU752802C (en) 1997-11-14 2006-04-13 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
US6787132B1 (en) 1997-12-04 2004-09-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combined chemo-immunotherapy with liposomal drugs and cytokines
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
AU4574199A (en) * 1998-06-16 2000-01-05 Jackie R. See Method for introducing a chemical agent into the systemic circulation
WO2000003660A1 (fr) 1998-07-17 2000-01-27 Skyepharma, Inc. Compositions biodegradables utilisees pour la liberation regulee de substances encapsulees
IL140892A0 (en) * 1998-08-12 2002-02-10 Yissum Res Dev Co Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
CA2346879A1 (fr) * 1998-09-16 2000-04-27 Alza Corporation Inhibiteurs de topoisomerase pieges dans des liposomes
US6159931A (en) * 1998-09-29 2000-12-12 The Ohio State University Lipid-modified insulin incorporated liposomes for selectively delivering cytotoxic agents to hepatoma cells
AU780194B2 (en) * 1999-06-24 2005-03-10 Kyowa Hakko Kirin Co., Ltd. Method of regulating leakage of drug encapsulated in liposomes
US7094423B1 (en) * 1999-07-15 2006-08-22 Inex Pharmaceuticals Corp. Methods for preparation of lipid-encapsulated therapeutic agents
CA2424619C (fr) * 2000-10-04 2010-05-18 Kyowa Hakko Kirin Co., Ltd. Procede de revetement de particules fines avec un film de lipides
JP4623931B2 (ja) * 2000-12-07 2011-02-02 エンセラデュス、ファーマシューティカルズ、ベスローテン、フェンノートシャップ 炎症性疾患の治療用組成物
HUP0303616A3 (en) * 2001-03-26 2006-07-28 Alza Corp Mountain View Liposome composition for improved intracellular delivery of a therapeutic agent
AU2002312777B2 (en) * 2001-03-27 2007-07-05 Phares Pharmaceutical Research N.V. Method and composition for solubilising a biologically active compound with low water solubility
DE10117043A1 (de) * 2001-04-05 2002-11-07 Gerhard Puetz Verfahren zur Eliminierung von potentiell toxischen und/oder schädlichen Stoffen
WO2002096368A2 (fr) * 2001-05-31 2002-12-05 Skyepharma Inc. Encapsulation de nanosuspensions dans des liposomes et des microspheres
AU2002334358B2 (en) * 2001-09-06 2008-02-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem A method for preparing liposome formulations with a predefined release profile
US20040219201A1 (en) * 2001-12-06 2004-11-04 Yechezkel Barenholz Tempamine compositions and methods of use
DE10214983A1 (de) 2002-04-04 2004-04-08 TransMIT Gesellschaft für Technologietransfer mbH Vernebelbare Liposomen und ihre Verwendung zur pulmonalen Applikation von Wirkstoffen
US20050152962A1 (en) * 2002-06-12 2005-07-14 Metselaar Josbert M. Composition for treatment of inflammatory disorders
EP1393720A1 (fr) * 2002-08-27 2004-03-03 Universiteit Utrecht Vesicules encapsulant des corticosteroides pour le traitement du cancer
ES2402270T3 (es) 2002-10-10 2013-04-30 Visualsonics Inc. Sistema de formación de imágenes por ultrasonidos de alta frecuencia y de alta frecuencia de fotogramas
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
AU2003304204B2 (en) * 2002-10-29 2009-12-24 Insmed Incorporated Sustained release of antiinfectives
AU2003298738A1 (en) * 2002-11-26 2004-06-18 Su-Ming Chiang Liposomal formulations
CA2510780A1 (fr) * 2002-12-19 2004-07-08 Alza Corporation Methode de traitement de la croissance de tissu angiogenique
US8980310B2 (en) * 2002-12-31 2015-03-17 Bharat Serums and Vaccines, Ltd. Non-pegylated long-circulating liposomes
DE60330745D1 (de) * 2002-12-31 2010-02-11 Bharat Serums & Vaccines Ltd Nicht-pegylierte lang-zirkulierende Liposome
WO2004087097A2 (fr) * 2003-03-31 2004-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ensembles de lipides contenant des amphiphiles de formation non liposomique
KR20060015534A (ko) 2003-04-25 2006-02-17 더 펜 스테이트 리서치 파운데이션 성장 억제, 지질 유래된 생활성 화합물의 전신 전달을 위한방법 및 시스템
EP1628637A2 (fr) * 2003-05-30 2006-03-01 Alza Corporation Methode d'administration pulmonaire d'un agent
NZ543635A (en) * 2003-06-25 2008-05-30 Crucell Holland Bv Human C-type lectin: a suitable target molecule for binding molecules, particularly immunoconjugates, in the diagnosis, prevention and/or treatment of myeloid neoplastic diseases such as AML and CML
EP1643972A4 (fr) * 2003-06-27 2010-01-20 Smithkline Beecham Corp Compositions liposomales stabilisee de topotecane et procedes
US20050175683A1 (en) * 2003-10-24 2005-08-11 Yuanpeng Zhang Preparation of lipid particles
US20050129753A1 (en) * 2003-11-14 2005-06-16 Gabizon Alberto A. Method for drug loading in liposomes
US20050129752A1 (en) * 2003-12-15 2005-06-16 Tty Biopharm Limited Company Use and manufacturing process for liposomal doxorubicin pharmaceutical composition
US20050129750A1 (en) * 2003-12-15 2005-06-16 Yu-Fang Hu Process for producing liposome suspension and product containing liposome suspension produced thereby
US7842289B2 (en) * 2003-12-24 2010-11-30 Aduro Biotech Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
EP1715897B2 (fr) 2004-01-20 2013-10-30 Sunnybrook and Women's College Health Sciences Centre Imagerie a ultrasons haute frequence utilisant des agents de contraste
US8772013B2 (en) * 2004-02-02 2014-07-08 Engeneic Molecular Delivery Pty Ltd Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
EP1718338B1 (fr) 2004-02-02 2015-05-06 EnGeneIC Molecular Delivery Pty Ltd. Compositions et procedes de liberation de medicaments in vitro et in vivo ciblee dans des cellules mammiferes par le biais de minicellules intactes derivees de bacteries
CN101002107B (zh) * 2004-03-01 2010-06-23 阳光溪流女子学院健康科学中心 用于心电图触发的回溯彩色血流超声成像的系统和方法
WO2005092388A1 (fr) * 2004-03-26 2005-10-06 Terumo Kabushiki Kaisha Preparation de liposome
AT500143A1 (de) * 2004-04-22 2005-11-15 Sanochemia Pharmazeutika Ag Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung
US8658203B2 (en) * 2004-05-03 2014-02-25 Merrimack Pharmaceuticals, Inc. Liposomes useful for drug delivery to the brain
KR101462825B1 (ko) 2004-05-03 2014-11-21 헤르메스 바이오사이언스, 인코포레이티드 약물 전달에 유용한 리포좀
NZ551748A (en) * 2004-06-01 2010-02-26 Yakult Honsha Kk Irinotecan formulation
AU2005281352B2 (en) * 2004-09-09 2011-01-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal compositions of glucocorticoid and glucocorticoid derivatives
US20080063702A1 (en) * 2004-09-09 2008-03-13 Yechezkel Barenholz Liposomal Formulations Comprising an Amphipathic Weak Base Like Tempamine for Treatment of Neurodegenerative Conditions
CN101072588B (zh) 2004-10-06 2012-11-28 不列颠哥伦比亚抗癌机构 用于治疗癌症的具有改善的药物保留的脂质体
ATE454884T1 (de) * 2004-10-18 2010-01-15 Polymun Scient Immunbio Forsch Liposomale zusammensetzung einen wirkstoff zur relaxierung glatter muskulatur enthaltend, die herstellung dieser zusammensetzung und deren therapeutische verwendung
CA2584583A1 (fr) * 2004-10-28 2006-05-11 Alza Corporation Formulations de liposomes lyophilises et methode associee
AU2005304914B2 (en) * 2004-11-05 2012-02-16 Tekmira Pharmaceuticals Corporation Compositions and methods for stabilizing liposomal camptothecin formulations
TW200618820A (en) * 2004-11-05 2006-06-16 Alza Corp Liposome formulations of boronic acid compounds
AU2005303389A1 (en) * 2004-11-15 2006-05-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combination therapy associating preferably a ceramide with a cytotoxic drug
WO2006071659A1 (fr) * 2004-12-29 2006-07-06 Trustees Of Boston University Delivrance d'antagonistes h2
US20060228395A1 (en) * 2005-04-11 2006-10-12 Robert Lamb Vitamin E phosphate/phosphatidylcholine liposomes to protect from or ameliorate cell damage
KR20080028361A (ko) * 2005-05-03 2008-03-31 뮤추얼 파마슈티컬 컴퍼니 아이엔씨. 퀴닌-함유 제어-방출형 제제
US8275449B2 (en) * 2005-11-11 2012-09-25 Visualsonics Inc. Overlay image contrast enhancement
ES2798263T3 (es) 2005-12-08 2020-12-10 Insmed Inc Composiciones a base de lípidos de antiinfecciosos para tratar infecciones pulmonares
US20090175930A1 (en) 2006-01-11 2009-07-09 Nobuhiro Yagi Composition Suppressing The Expression of Target Gene in Eyeball and Medicament For Treating of Disease in Eyeball
WO2007117550A2 (fr) 2006-04-06 2007-10-18 Transave, Inc. Procédés d'encapsulation liposomale induite par coacervation et formulations associées
JP5080779B2 (ja) 2006-10-25 2012-11-21 テルモ株式会社 リポソーム製剤の製造方法
EP1932517A3 (fr) * 2006-12-11 2008-07-16 Universiteit Utrecht Holding B.V. Liposomes contenant des dérivés de polyphénols et son procédé de post-chargement
US8278415B2 (en) 2006-12-21 2012-10-02 Centocor, Inc. Dimeric high affinity EGFR constructs and uses thereof
WO2008079973A2 (fr) * 2006-12-21 2008-07-03 Centocor, Inc. Peptides de liaison au récepteur egf et utilisations de ces derniers
WO2008079982A2 (fr) 2006-12-21 2008-07-03 Centocor, Inc. Composition de liposome utilisée pour cibler le récepteur egf
US7964580B2 (en) * 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
WO2008137717A1 (fr) 2007-05-04 2008-11-13 Transave, Inc. Compositions de médicaments multicationiques pour réduire des interactions avec des biomolécules polyanioniques et leurs procédés et utilisations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
WO2009076323A2 (fr) 2007-12-06 2009-06-18 Genalyte Inc. Surveillance d'un procédé enzymatique
WO2009072136A1 (fr) * 2007-12-06 2009-06-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Vecteurs de médicaments particulaires en tant qu'agents de désensibilisation
US20090281054A1 (en) * 2008-05-06 2009-11-12 Venkata Reddy Compositions and methods comprising capuramycin analogues
JP5542804B2 (ja) 2008-05-23 2014-07-09 ザ ユニヴァーシティ オブ ブリティッシュ コロンビア リポソームナノ粒子中で使用するための修飾薬物
US8173621B2 (en) * 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2299953B1 (fr) * 2008-07-14 2017-04-12 Polypid Ltd. Composition de véhicule de médicament à libération prolongée
CN103585107A (zh) 2008-08-01 2014-02-19 协和发酵麒麟株式会社 组合物在制备癌症或炎症疾病的治疗剂中的应用
WO2010041255A2 (fr) 2008-10-07 2010-04-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Systèmes liposomiques comprenant de la sphingomyéline
EP2347247B1 (fr) 2008-10-27 2019-06-26 Genalyte, Inc. Biocapteurs basés sur des sondes et capteurs optiques
JPWO2010058840A1 (ja) * 2008-11-20 2012-04-19 テルモ株式会社 リポソームからの薬物放出手段および放出性評価法
AR076634A1 (es) 2008-11-21 2011-06-29 Medgenesis Therapeutix Inc Composiciones y metodo para tratar desordenes del sistema nervioso central
CL2009002206A1 (es) 2008-12-23 2011-08-26 Gilead Pharmasset Llc Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
CN101756902B (zh) * 2008-12-23 2011-10-05 上海医药工业研究院 一种可乐定多囊脂质体及其制备方法
AR074897A1 (es) 2008-12-23 2011-02-23 Pharmasset Inc Fosforamidatos de nucleosidos
MX2011006890A (es) 2008-12-23 2011-07-20 Pharmasset Inc Analogos de nucleosidos.
US20100209348A1 (en) * 2009-02-18 2010-08-19 Arondo Pharma, Inc. Methods for determining liposome bioequivalence
WO2010113983A1 (fr) 2009-03-30 2010-10-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 Procédé de mise au point d'une composition liposomique
RU2476216C1 (ru) * 2009-03-30 2013-02-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Липосомальная композиция
PE20120923A1 (es) 2009-03-30 2012-08-27 Eisai Randd Man Co Ltd Composiciones farmaceuticas comprendiendo liposomas que contiene eribulina o una sal del mismo
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
DE102009031274A1 (de) 2009-06-30 2011-01-13 Justus-Liebig-Universität Giessen Liposomen zur pulmonalen Applikation
CN102470105B (zh) 2009-07-14 2015-07-29 波利皮得有限公司 持续释放药物载体组合物
WO2012098692A1 (fr) 2011-01-19 2012-07-26 協和発酵キリン株式会社 Composition pour l'inhibition de l'expression d'un gène cible
CA2781529C (fr) 2009-09-23 2017-10-24 Indu Javeri Methodes de preparation de liposomes contenant du docetaxel
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes
JP5860409B2 (ja) 2010-01-19 2016-02-16 ポリピッド リミテッド 徐放性核酸マトリックス組成物
WO2011092708A2 (fr) 2010-02-01 2011-08-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Liposomes comprenant des médicaments amphipathiques et procédé pour leur préparation
AP2012006535A0 (en) 2010-03-31 2012-10-31 Gilead Pharmasset Llc Stereoselective synthesis of phosphorous containing actives
TW201136945A (en) 2010-03-31 2011-11-01 Pharmasset Inc Purine nucleoside phosphoramidate
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
EP2374470A1 (fr) * 2010-04-08 2011-10-12 Beta Innov Utilisation thérapeutique de la protéine Beta2m
KR101773643B1 (ko) 2010-04-28 2017-08-31 교와 핫꼬 기린 가부시키가이샤 양이온성 지질
US20130129811A1 (en) 2010-04-28 2013-05-23 Takeshi Kuboyama Cationic lipid
WO2012021107A2 (fr) * 2010-08-12 2012-02-16 Nanyang Technological University Formulation de liposomes pour l'administration d'un médicament dans l'œil
EP2635710B1 (fr) 2010-11-05 2017-08-09 Genalyte, Inc. Systèmes optiques de détection d'analytes et leurs procédés d'utilisation
ES2716158T3 (es) 2010-11-30 2019-06-10 Gilead Pharmasset Llc 2'-spiro-nucleótidos para el tratamiento de hepatitis C
US20130337051A1 (en) * 2011-03-01 2013-12-19 To-Bbb Holding B.V. Advanced active liposomal loading of poorly water-soluble substances
PL226015B1 (pl) 2011-03-03 2017-06-30 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Liposomowy preparat zawierajacy przeciwnowotworowa substancje aktywna, sposob jego wytwarzania i zawierajaca go kompozycja farmaceutyczna
RU2571077C2 (ru) 2011-03-25 2015-12-20 Терумо Кабусики Кайся Липосомальная композиция длительного действия с контролируемым высвобождением и способ ее получения
JP2013095755A (ja) 2011-11-02 2013-05-20 Kyowa Hakko Kirin Co Ltd カチオン性脂質
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
EP2787977A4 (fr) * 2011-12-09 2015-05-06 Univ California Encapsulation liposomale de médicaments
CN104159615B (zh) 2011-12-12 2017-08-18 协和发酵麒麟株式会社 含有阳离子性脂质的组合的脂质纳米粒子
JP6182457B2 (ja) 2011-12-12 2017-08-16 協和発酵キリン株式会社 カチオン性脂質を含有するドラックデリバリーシステムのための脂質ナノ粒子
WO2013114377A1 (fr) 2012-02-02 2013-08-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd Liposomes stables pour l'administration de médicament
US20130261010A1 (en) 2012-03-12 2013-10-03 The Board Of Trustees Of The University Of Illinois Optical analyte detection systems with magnetic enhancement and methods of use
PL2852391T3 (pl) 2012-05-21 2022-04-11 Insmed Incorporated Układy do leczenia infekcji płuc
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
EP2682106A1 (fr) 2012-07-03 2014-01-08 Phares Pharmaceutical Research N.V. Procédé pour la solubilisation de composés biologiquement actifs
TW201726599A (zh) 2012-07-06 2017-08-01 協和醱酵麒麟有限公司 陽離子性脂質
AU2013291125A1 (en) 2012-07-16 2015-01-22 Dicerna Pharmaceuticals, Inc. RNAi pharmaceutical composition capable of suppressing expression of KRAS gene
ES2442450B1 (es) * 2012-08-09 2014-12-12 Enoc Solutions, S.L. Liposomas vacíos como adyuvante de diferentes principios activos, administrados independientemente y en su forma galénica convencional
WO2014046191A1 (fr) 2012-09-21 2014-03-27 テルモ株式会社 Préparation d'un liposome à libération prolongée à longue durée anesthésique locale
WO2014081887A1 (fr) 2012-11-20 2014-05-30 Spectrum Pharmaceuticals Méthode améliorée pour la préparation de vincristine encapsulée dans des liposomes à usage thérapeutique
CA2891487A1 (fr) 2012-11-29 2014-06-05 Insmed Incorporated Formulations de vancomycine stabilisees
AU2013360302C1 (en) 2012-12-12 2019-01-24 Temple University - Of The Commonwealth System Of Higher Education Compositions and methods for treatment of cancer
WO2014100379A1 (fr) 2012-12-19 2014-06-26 The Research Foundation For The State University Of New York Compositions et procédé pour libération déclenchée par lumière de matières depuis des nanovésicules
KR102310786B1 (ko) 2013-02-01 2021-10-12 존원 파마, 인코포레이티드 리포좀 내로 난수용성 약물의 원격 부하
US10220095B2 (en) * 2013-03-15 2019-03-05 Taiwan Liposome Company, Ltd Controlled drug release liposome compositions and methods thereof
US9693958B2 (en) 2013-03-15 2017-07-04 Cureport, Inc. Methods and devices for preparation of lipid nanoparticles
EA201690473A1 (ru) 2013-08-27 2017-03-31 ГАЙЛИД ФАРМАССЕТ ЭлЭлСи Комбинированный состав двух противовирусных соединений
MX384843B (es) 2014-05-15 2025-03-14 Insmed Inc Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas.
CN106999419A (zh) 2014-08-04 2017-08-01 佐尼奥尼制药股份有限公司 远程装载略微水溶性药物至脂质膜泡
EP3271057B1 (fr) 2015-03-19 2019-09-04 The University of Connecticut Systèmes et procédés pour la fabrication continue de formulations de médicament liposomales
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
TWI678213B (zh) * 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物
SG10201913073YA (en) 2015-08-20 2020-03-30 Ipsen Biopharm Ltd Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment
EP3791876A1 (fr) 2015-08-21 2021-03-17 Ipsen Biopharm Ltd. Méthodes permettant de traiter le cancer du pancréas métastatique au moyen de traitements d'association comprenant de l'irinotécan liposomal et de l'oxaliplatine
US10617672B2 (en) 2015-10-15 2020-04-14 Lipomedix Pharmaceuticals Ltd. Liposome composition co-encapsulating doxorubicin and a prodrug of mitomycin C
ES3036518T3 (en) 2015-10-16 2025-09-19 Ipsen Biopharm Ltd Stabilizing camptothecin pharmaceutical compositions
US10525138B2 (en) 2015-12-25 2020-01-07 Kyowa Hakko Kirin Co., Ltd. Compound as cationic lipid
WO2017188350A1 (fr) 2016-04-28 2017-11-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 Procédé d'inhibition de croissance tumorale
CN106220562B (zh) * 2016-07-29 2019-10-01 上海璃道医药科技有限公司 两种喹啉环类药物的新用途
RU2761953C2 (ru) 2016-11-02 2021-12-14 Ипсен Биофарм Лтд. Лечение рака желудка с применением комбинационных видов терапии, содержащих липосомальный иринотекан, оксалиплатин, 5-фторурацил (и лейковорин)
WO2018181963A1 (fr) 2017-03-31 2018-10-04 富士フイルム株式会社 Composition de liposome et composition pharmaceutique
EP3658134A4 (fr) 2017-07-24 2021-05-05 Pharmosa Biopharm Inc. Compositions de liposomes comprenant des médicaments à base d'acide faible et utilisations de celles-ci
US10864161B2 (en) 2017-10-13 2020-12-15 American University Of Sharjah Systems and methods for targeted breast cancer therapies
EP3727333A1 (fr) 2017-12-21 2020-10-28 Taiwan Liposome Company Ltd Compositions de triptan à libération prolongée et procédé d'utilisation de celles-ci par voie sous-dermale ou similaire
EP3773505B1 (fr) 2018-03-30 2026-04-29 Insmed Incorporated Procédés pour la fabrication continue de produits médicamenteux liposomaux
WO2019213101A1 (fr) * 2018-04-30 2019-11-07 Purdue Research Foundation Nano-formulation liposomale d'antibiotiques combinatoires et ses utilisations
EP3787602A4 (fr) 2018-05-02 2022-03-23 Insmed Incorporated Procédés de fabrication de formulations de médicament liposomal
SG11202011045VA (en) * 2018-05-07 2020-12-30 Pharmosa Biopharm Inc Pharmaceutical composition for controlled release of treprostinil
PL3811931T3 (pl) 2018-06-20 2024-11-18 Fujifilm Corporation Skojarzony środek leczniczy zawierający kompozycję liposomową z kapsułkowanym lekiem i inhibitor punktu kontroli immunologicznej
WO2020023445A1 (fr) 2018-07-24 2020-01-30 Taiwan Liposome Co., Ltd. Compositions pharmaceutiques à libération prolongée comprenant un agent thérapeutique permettant le traitement de la démence, et leurs utilisations
EP3829539A4 (fr) 2018-08-02 2022-05-04 Taiwan Liposome Company, Ltd. Compositions à libération prolongée comprenant un agent thérapeutique de traitement de la dépression ou de l'anxiété et leurs utilisations
US20200085741A1 (en) * 2018-09-14 2020-03-19 Pharmosa Biopharm Inc. Pharmaceutical composition for controlled release of weak acid drugs and uses thereof
WO2020071349A1 (fr) 2018-10-01 2020-04-09 富士フイルム株式会社 Médicament combiné comprenant une composition de liposome encapsulant un médicament et préparation à base de platine
EP3866764A4 (fr) * 2018-10-17 2022-07-13 Taiwan Liposome Company, Ltd. Compositions pharmaceutiques à libération prolongée comprenant un agent immunomodulateur et leurs utilisations
AU2020269626B2 (en) 2019-05-07 2026-01-22 Universidade Do Minho Method for production of liposomes
US11083705B2 (en) 2019-07-26 2021-08-10 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
ES3075649T3 (en) 2019-07-26 2026-08-06 Eisai R&D Man Co Ltd Pharmaceutical composition for treating tumor
WO2021141963A1 (fr) 2020-01-10 2021-07-15 Pacira Pharmaceuticals, Inc. Traitement de la douleur par administration sous-arachnoïdienne de compositions anesthésiques liposomales à libération prolongée
WO2021141959A1 (fr) 2020-01-10 2021-07-15 Pacira Pharmaceuticals, Inc. Traitement de la douleur par administration de compositions anesthésiques liposomales à libération prolongée
CN111249223B (zh) * 2020-03-17 2022-08-05 中国人民解放军联勤保障部队第九〇〇医院 一种盐酸普萘洛尔立方液晶凝胶及其制备方法
AU2021292747A1 (en) 2020-06-18 2023-02-23 Akagera Medicines, Inc. Oxazolidinone compounds, liposome compositions comprising oxazolidinone compounds and methods of use thereof
CN117098541A (zh) 2020-11-25 2023-11-21 阿卡格拉医药公司 用于递送核酸的脂质纳米粒及相关使用方法
EP4274573A4 (fr) * 2021-01-11 2024-12-11 Pacira Pharmaceuticals, Inc. Traitement de la douleur de la hanche avec des compositions anesthésiques liposomales à libération prolongée
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12151024B2 (en) 2021-01-22 2024-11-26 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
EP4308084A4 (fr) 2021-03-19 2025-04-23 Pacira Pharmaceuticals, Inc. Traitement de la douleur chez des patients pédiatriques par administration de compositions anesthésiques liposomales à libération prolongée
US12285419B2 (en) 2021-10-14 2025-04-29 Pacira Pharmaceuticals, Inc. Bupivacaine multivesicular liposome formulations and uses thereof
WO2023108286A1 (fr) 2021-12-15 2023-06-22 Canam Bioresearch Inc. Analogues de pyridoxal-5-phosphate (p5p)
WO2023126947A1 (fr) * 2022-01-02 2023-07-06 Moebius Medical Ltd. Détermination du volume piégé d'un liposome
WO2023230587A2 (fr) 2022-05-25 2023-11-30 Akagera Medicines, Inc. Nanoparticules lipidiques pour l'administration d'acides nucléiques et leurs procédés d'utilisation
US11918565B1 (en) 2022-11-03 2024-03-05 Pacira Pharmaceuticals, Inc. Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions
US12226610B2 (en) 2022-11-03 2025-02-18 Pacira Pharmaceuticals, Inc. Treatment of pain associated with total knee arthroplasty with sustained-release liposomal anesthetic compositions
EP4743090A1 (fr) * 2023-07-10 2026-05-20 Liposome Holdings Limited Apomorphine encapsulée dans des liposomes
US12156940B1 (en) 2024-05-20 2024-12-03 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12280149B1 (en) 2024-05-20 2025-04-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12251472B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460577A (en) * 1977-09-30 1984-07-17 Farmitalia Carlo Erba S.P.A. Pharmaceutical compositions consisting or consisting essentially of liposomes, and processes for making same
ES8603459A1 (es) * 1983-09-29 1985-12-16 Akzo Nv Un procedimiento para la preparacion de nuevos derivados de quinazolina e isoquinolina.
CA1270198A (fr) * 1984-08-08 1990-06-12 Marcel B. Bally Encapsulation d'agents antineoplastiques dans des liposones
US4885172A (en) * 1985-06-26 1989-12-05 The Liposome Company, Inc. Composition for targeting, storing and loading of liposomes
US4796559A (en) * 1985-09-04 1989-01-10 Ulrich Steinemann Ag Apparatus for applying a liquid to a web of material
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
JPH0825869B2 (ja) * 1987-02-09 1996-03-13 株式会社ビタミン研究所 抗腫瘍剤包埋リポソ−ム製剤
CA1338702C (fr) * 1987-03-05 1996-11-12 Lawrence D. Mayer Formulations d'agents liposomiques-antineoplasiques a faible teneur en medicaments-lipides
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release

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ATE113830T1 (de) 1994-11-15
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US5192549A (en) 1993-03-09
DE68919321D1 (de) 1994-12-15
EP0361894A3 (fr) 1991-11-21
IL91664A0 (en) 1990-04-29
LU88856I2 (fr) 1997-01-31
HK26197A (en) 1997-03-06
EP0361894B1 (fr) 1994-11-09
JP2659136B2 (ja) 1997-09-30
NL960033I1 (nl) 1997-03-03
JPH02196713A (ja) 1990-08-03
DE19675049I2 (de) 2009-05-28
US5316771A (en) 1994-05-31
CA1335565C (fr) 1995-05-16
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