JPS5854157B2 - セフアロスポリン化合物の新規誘導体ならびにその製造方法 - Google Patents

セフアロスポリン化合物の新規誘導体ならびにその製造方法

Info

Publication number
JPS5854157B2
JPS5854157B2 JP52068699A JP6869977A JPS5854157B2 JP S5854157 B2 JPS5854157 B2 JP S5854157B2 JP 52068699 A JP52068699 A JP 52068699A JP 6869977 A JP6869977 A JP 6869977A JP S5854157 B2 JPS5854157 B2 JP S5854157B2
Authority
JP
Japan
Prior art keywords
group
lower alkyl
general formula
hydrogen atom
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP52068699A
Other languages
English (en)
Japanese (ja)
Other versions
JPS543090A (en
Inventor
勝 岩波
敦城 山崎
哲哉 前田
嘉信 長野
憲昭 長野
正治 藤本
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP52068699A priority Critical patent/JPS5854157B2/ja
Priority to GB24853/80A priority patent/GB1604740A/en
Priority to CH6107/78A priority patent/CH648317A5/de
Priority to DE2857816A priority patent/DE2857816C2/de
Priority to DE2824559A priority patent/DE2824559C2/de
Priority to NLAANVRAGE7806208,A priority patent/NL185622C/xx
Priority to US05/913,500 priority patent/US4263432A/en
Priority to CA305,045A priority patent/CA1103659A/fr
Priority to FR7817303A priority patent/FR2405952A1/fr
Priority to AU36988/78A priority patent/AU518620B2/en
Priority to SE7806711A priority patent/SE438338B/sv
Priority to BE188469A priority patent/BE867994A/fr
Priority to HU801504A priority patent/HU184788B/hu
Priority to ES470689A priority patent/ES470689A1/es
Priority to DK258078A priority patent/DK164224C/da
Priority to MX1051378U priority patent/MX7170E/es
Priority to MX1051478U priority patent/MX7171E/es
Priority to MX787141U priority patent/MX5137E/es
Priority to IT68369/78A priority patent/IT1159721B/it
Priority to FR7834349A priority patent/FR2405953A1/fr
Publication of JPS543090A publication Critical patent/JPS543090A/ja
Priority to ES479166A priority patent/ES479166A1/es
Priority to ES479168A priority patent/ES479168A1/es
Priority to ES479167A priority patent/ES479167A1/es
Priority to UA2781814A priority patent/UA5924A1/uk
Priority to SU792781814A priority patent/SU843752A3/ru
Priority to AT0685679A priority patent/AT363187B/de
Priority to SU802893654A priority patent/SU904525A3/ru
Priority to UA2893654A priority patent/UA5922A1/uk
Priority to AT345780A priority patent/AT367062B/de
Priority to US06/208,298 priority patent/US4404373A/en
Priority to SE8306298A priority patent/SE454512B/sv
Publication of JPS5854157B2 publication Critical patent/JPS5854157B2/ja
Priority to US06/727,233 priority patent/USRE32491E/en
Priority to NL8901120A priority patent/NL8901120A/nl
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP52068699A 1977-06-10 1977-06-10 セフアロスポリン化合物の新規誘導体ならびにその製造方法 Expired JPS5854157B2 (ja)

Priority Applications (33)

Application Number Priority Date Filing Date Title
JP52068699A JPS5854157B2 (ja) 1977-06-10 1977-06-10 セフアロスポリン化合物の新規誘導体ならびにその製造方法
GB24853/80A GB1604740A (en) 1977-06-10 1978-05-31 7-isothiazolylthioacetamido-7-methoxycephalosporanic acid derivatives
CH6107/78A CH648317A5 (de) 1977-06-10 1978-06-05 7alpha-methoxy-7betha-(1,3-dithietan-2- carboxamido)cephalosporansaeurederivate und verfahren zu ihrer herstellung.
DE2857816A DE2857816C2 (de) 1977-06-10 1978-06-05 7ß-(substituierte-Isothiazol)thioacetamido-7-methoxy(alkylsubstituierte-tetraz olyl)thiomethyl-Δ↑3↑-cephem-4-carbonsäuren, Verfahren zu ihrer Herstellung und deren Verwendung
DE2824559A DE2824559C2 (de) 1977-06-10 1978-06-05 7α-Methoxy-7β-(4-substituierte-methylen-1,3-dithietan-2-yl)-carboxamido-3-Δ↑3↑-cephem-4-carbonsäuren, Verfahren zu deren Herstellung sowie ihre Verwendung
NLAANVRAGE7806208,A NL185622C (nl) 1977-06-10 1978-06-07 Farmaceutisch preparaat met antibacteriele werking, alsmede 7beta-acylamino-7alfa-methoxy-3-heterocyclylthiomethyl-3-cefem-4-carbonzuur.
US05/913,500 US4263432A (en) 1977-06-10 1978-06-07 7α-Methoxy-7β-(1,3-dithietane-2-carboxamido)cephalosporanic acid derivatives
CA305,045A CA1103659A (fr) 1977-06-10 1978-06-08 Traduction non-disponible
FR7817303A FR2405952A1 (fr) 1977-06-10 1978-06-09 Derives de l'acide methoxy-7a-(dithietane-1,3-carboxamido-2)-cephalosporanique, presentant une activite anti-bacterienne et leurs procedes de preparation
AU36988/78A AU518620B2 (en) 1977-06-10 1978-06-09 7d-methoxy-7b-(1,3-dithietane-2-carboxamido)cephalosporanic acid derivatives
SE7806711A SE438338B (sv) 1977-06-10 1978-06-09 7alfa-metoxi-7beta-(1,3-ditietan-2-karboxamido)-cefalosporansyraderivat med antibakteriell verkan
BE188469A BE867994A (fr) 1977-06-10 1978-06-09 Procede de preparation de derives de l'acide methoxy-7,alpha-(dithietane-1,3-carboxamido-2)-cephalosporanique
HU801504A HU184788B (en) 1977-06-10 1978-06-09 Process for the preparation of 7alfa-methoxy-ceph-3-em-4-carboxylic acid derivatives
ES470689A ES470689A1 (es) 1977-06-10 1978-06-09 Un procedimiento para la preparacion de acido 7-metoxi-7- (4-metilen sustituido-1,3-ditietan-2-il-carboxamido)-3-hete-rociclotiometil-3-cefem-4-carboxilico
DK258078A DK164224C (da) 1977-06-10 1978-06-09 Analogifremgangsmaade til fremstilling af 7alfa-methoxy-7beta-(4-methylen-1,3-dithietan-2-yl)carboxamido-3-heterocyclylthiomethyl-delta3-cephem-4-carboxylsyre-forbindelser eller salte deraf og mellemprodukter til anvendelse herved
MX1051478U MX7171E (es) 1977-06-10 1978-06-12 Procedimiento para la preparacion del acido tio-metil-delta3-cefem-4-carboxilico,7alfa-metoxi-7beta-(metilen-1,3-ditietan-2-il,4-substituido)carboxamido-3-heterociclico
IT68369/78A IT1159721B (it) 1977-06-10 1978-06-12 Derivati dell'acido 7 alfa metossi-7 beta-(1,3-ditietane-2-carbossiamido)-cefalosporanico e procedimento per la loro preparazione
MX1051378U MX7170E (es) 1977-06-10 1978-06-12 Procedimiento para la preparacion del acido tiometil-delta3-cefem-4-carboxilico,7 alfa-metoxi-7beta-(metilen-1,3-ditietan-2-il 4-substituido)-carboxamido-3-heterociclico
MX787141U MX5137E (es) 1977-06-10 1978-06-12 Procedimiento para la preparacion del acido tio-metil-delta3-cefem-carboxilico,7 alfa metoxi-7 beta(metilen-1,3-ditietan-2-il-carboxamido-4-substituido)-3-heterociclico
FR7834349A FR2405953A1 (fr) 1977-06-10 1978-12-06 Derives de la methoxy-7a-thiomethylheterocyclique-3-cephalosporine representant une activite anti-bacterienne
ES479166A ES479166A1 (es) 1977-06-10 1979-03-31 Un procedimiento para la preparacion de acido 7&-metoxi-7b-(4-metilen sustituido 1,3-ditietan-2il) carboxamido-3-hetero-ciclotiometil-3-cefem-4-carboxilico.
ES479168A ES479168A1 (es) 1977-06-10 1979-03-31 Un procedimiento para la preparacion de derivados de acido 7&-metoxicefalosporanico.
ES479167A ES479167A1 (es) 1977-06-10 1979-03-31 Un procedimiento para la preparacion de acido 7&-metoxi-7b( 4-metilen sustituido-1,3-ditietan-2-il)carboxamido-3-hete- ro-ciclotiometil-3-cefem-4-carboxilico.
UA2781814A UA5924A1 (uk) 1977-06-10 1979-06-25 СПОСІБ ОДЕРЖАННЯ 7alРha-МЕТОКСІЦЕФАЛОСПОРІНІВ
SU792781814A SU843752A3 (ru) 1977-06-10 1979-06-25 Способ получени -метоксицефало-СпОРиНОВ
AT0685679A AT363187B (de) 1977-06-10 1979-10-22 Verfahren zur herstellung von neuen 7alpha-methoxycephalosporansaeurederivaten
SU802893654A SU904525A3 (ru) 1977-06-10 1980-03-11 Способ получени 7 @ -метоксицефалоспоринов
UA2893654A UA5922A1 (uk) 1977-06-10 1980-03-11 СПОСІБ ОДЕРЖАННЯ 7alРha-МЕТОКСІЦЕФАЛОСПОРІНІВ
AT345780A AT367062B (de) 1977-06-10 1980-07-02 Verfahren zur herstellung von neuen 7alphamethoxy-cephalosporansaeurederivaten
US06/208,298 US4404373A (en) 1977-06-10 1980-11-19 Process for the preparation of 7α-methoxy-7β-(1,3-diethietane-2-carboxamido)cephalosporanic acid derivatives
SE8306298A SE454512B (sv) 1977-06-10 1983-11-16 7beta-isotiazolyltioacetamido-7alfa-metoxicefalosporansyraderivat
US06/727,233 USRE32491E (en) 1977-06-10 1985-04-25 Process for the preparation of 7α-methoxy-7β-(1,3-diethietane-2-carboxyamido)cephalosporanic acid derivatives
NL8901120A NL8901120A (nl) 1977-06-10 1989-05-02 Farmaceutisch preparaat met anti-bacteriele werking alsmede 7beta-acylamino 7alfa-methoxy-3-heterocyclylthiomethyl-3-cefem-4-carbonzuur.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52068699A JPS5854157B2 (ja) 1977-06-10 1977-06-10 セフアロスポリン化合物の新規誘導体ならびにその製造方法

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP17426082A Division JPS5850206B2 (ja) 1982-10-04 1982-10-04 セフアロスポリン化合物の新規誘導体
JP9035283A Division JPS603399B2 (ja) 1983-05-23 1983-05-23 セファロスポリン化合物の新規な誘導体

Publications (2)

Publication Number Publication Date
JPS543090A JPS543090A (en) 1979-01-11
JPS5854157B2 true JPS5854157B2 (ja) 1983-12-02

Family

ID=13381266

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52068699A Expired JPS5854157B2 (ja) 1977-06-10 1977-06-10 セフアロスポリン化合物の新規誘導体ならびにその製造方法

Country Status (10)

Country Link
JP (1) JPS5854157B2 (fr)
AU (1) AU518620B2 (fr)
BE (1) BE867994A (fr)
DE (1) DE2857816C2 (fr)
FR (1) FR2405953A1 (fr)
GB (1) GB1604740A (fr)
HU (1) HU184788B (fr)
SE (1) SE454512B (fr)
SU (2) SU843752A3 (fr)
UA (2) UA5924A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187355A1 (fr) 1981-09-23 1986-07-16 E.R. Squibb & Sons, Inc. Procédé de préparation d'antibiotiques bêta-lactames
ZA874696B (en) 1986-07-03 1988-01-04 F. Hoffmann-La Roche & Co. Aktiengesellschaft Acyl derivatives
PT620225E (pt) 1993-04-16 2003-03-31 Basilea Pharmaceutica Ag Derivados de cefalosporina
US5811419A (en) * 1996-01-16 1998-09-22 Hoffmann-La Roche Inc. Isooxacephem-derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL29235A (en) * 1967-01-05 1971-10-20 Bristol Myers Co 7-(pyridylthioacetamido)cephalosporanic acid derivatives and their preparation
JPS5165789A (en) * 1974-11-30 1976-06-07 Sankyo Co 77 metokishisefuarosuhorinkagobutsuno seiho
CA1088049A (fr) * 1975-06-03 1980-10-21 Takashi Masugi Procedes d'obtention de derives d'acides alcanamido substitues en 3 et substitues en 7-3-cephem-4 carboxyliques
DE2539214C2 (de) * 1975-09-03 1984-03-29 E.R. Squibb & Sons, Inc., 08540 Princeton, N.J. 7-Methoxythienyl-ureido-cephalosporin und dieses enthaltendes Arzneimittel

Also Published As

Publication number Publication date
UA5922A1 (uk) 1994-12-29
SU843752A3 (ru) 1981-06-30
SE8306298L (sv) 1983-11-16
GB1604740A (en) 1981-12-16
SE454512B (sv) 1988-05-09
HU184788B (en) 1984-10-29
SU904525A3 (ru) 1982-02-07
UA5924A1 (uk) 1994-12-29
SE8306298D0 (sv) 1983-11-16
BE867994A (fr) 1978-12-11
FR2405953A1 (fr) 1979-05-11
JPS543090A (en) 1979-01-11
FR2405953B1 (fr) 1983-07-18
DE2857816C2 (de) 1985-05-09
AU3698878A (en) 1979-12-13
AU518620B2 (en) 1981-10-08

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