JPS63255268A - ドーパミン−β−ヒドロキシラーゼ抑制剤 - Google Patents

ドーパミン−β−ヒドロキシラーゼ抑制剤

Info

Publication number
JPS63255268A
JPS63255268A JP63070850A JP7085088A JPS63255268A JP S63255268 A JPS63255268 A JP S63255268A JP 63070850 A JP63070850 A JP 63070850A JP 7085088 A JP7085088 A JP 7085088A JP S63255268 A JPS63255268 A JP S63255268A
Authority
JP
Japan
Prior art keywords
carbon atoms
formula
alkyl
compound
mercaptoimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP63070850A
Other languages
English (en)
Japanese (ja)
Inventor
ジョセフ・アラン・フィンケルスタイン
ロウレンス・アイバン・クルス
トーマス・ブレント・レオナルド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of JPS63255268A publication Critical patent/JPS63255268A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP63070850A 1987-03-24 1988-03-24 ドーパミン−β−ヒドロキシラーゼ抑制剤 Pending JPS63255268A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US029512 1987-03-24
US07/029,512 US4762850A (en) 1987-03-24 1987-03-24 Dopamine-beta-hydroxylase inhibitors

Publications (1)

Publication Number Publication Date
JPS63255268A true JPS63255268A (ja) 1988-10-21

Family

ID=21849416

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63070850A Pending JPS63255268A (ja) 1987-03-24 1988-03-24 ドーパミン−β−ヒドロキシラーゼ抑制剤

Country Status (7)

Country Link
US (1) US4762850A (de)
EP (1) EP0284375A1 (de)
JP (1) JPS63255268A (de)
AU (1) AU1370688A (de)
DK (1) DK163088A (de)
PT (1) PT87079B (de)
ZA (1) ZA882100B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882348A (en) * 1987-12-29 1989-11-21 Smithkline Beckman Corporation 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
JP2568315B2 (ja) * 1989-06-30 1997-01-08 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 縮合環アリール置換イミダゾール
CA2032289A1 (en) * 1989-12-29 1991-06-30 Joseph A. Finkelstein Substituted 5-(alkyl) carboxamide imidazoles
DE4200954A1 (de) * 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate
PT2822936T (pt) 2012-03-07 2021-12-02 Univ Of Delhi Derivados da aminoquinolina e suas utilizações

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3217094A1 (de) * 1982-05-07 1983-11-10 Hoechst Ag, 6230 Frankfurt 1-substituierte imidazol-5-carbonsaeurederivate, ihre herstellung sowie ihre verwendung als biozide
PT78388B (en) * 1983-04-12 1986-09-15 Smithkline Beckman Corp Dopamine-beta-hydroxylase inhibitors
US4532331A (en) * 1983-04-12 1985-07-30 Smithkline Beckman Corporation 1-Benzyl-2-aminomethyl imidazole derivatives
US4743613A (en) * 1986-04-08 1988-05-10 Smithkline Beckman Corporation Ester prodrugs of dopamine-β-hydroxylase, inhibitors, composition containing them, and method of using them to inhibit dopamine-β-hydroxylase activity

Also Published As

Publication number Publication date
PT87079A (pt) 1988-04-01
EP0284375A1 (de) 1988-09-28
ZA882100B (en) 1989-10-25
DK163088D0 (da) 1988-03-24
PT87079B (pt) 1992-07-31
US4762850A (en) 1988-08-09
AU1370688A (en) 1988-09-22
DK163088A (da) 1988-09-25

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