LU81985A1 - Nouveaux derives d'imidazole,leur procede de production et composition pharmaceutique les contenant - Google Patents

Nouveaux derives d'imidazole,leur procede de production et composition pharmaceutique les contenant Download PDF

Info

Publication number
LU81985A1
LU81985A1 LU81985A LU81985A LU81985A1 LU 81985 A1 LU81985 A1 LU 81985A1 LU 81985 A LU81985 A LU 81985A LU 81985 A LU81985 A LU 81985A LU 81985 A1 LU81985 A1 LU 81985A1
Authority
LU
Luxembourg
Prior art keywords
compound
imidazole
solution
group
compound according
Prior art date
Application number
LU81985A
Other languages
English (en)
French (fr)
Inventor
R Dickinson
P Cross
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10501705&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU81985(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of LU81985A1 publication Critical patent/LU81985A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LU81985A 1978-12-13 1979-12-12 Nouveaux derives d'imidazole,leur procede de production et composition pharmaceutique les contenant LU81985A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7848367 1978-12-13
GB7848367 1978-12-13

Publications (1)

Publication Number Publication Date
LU81985A1 true LU81985A1 (fr) 1980-04-22

Family

ID=10501705

Family Applications (1)

Application Number Title Priority Date Filing Date
LU81985A LU81985A1 (fr) 1978-12-13 1979-12-12 Nouveaux derives d'imidazole,leur procede de production et composition pharmaceutique les contenant

Country Status (34)

Country Link
US (2) US4602016A (da)
JP (1) JPS585197B2 (da)
KR (1) KR830001243B1 (da)
AR (1) AR227637A1 (da)
AT (1) AT373879B (da)
AU (1) AU517892B2 (da)
BE (1) BE880584A (da)
CA (1) CA1108137A (da)
CH (1) CH644597A5 (da)
CS (1) CS216517B2 (da)
DD (1) DD147943A5 (da)
DE (1) DE2950019A1 (da)
DK (1) DK471479A (da)
EG (1) EG14227A (da)
ES (1) ES8101556A1 (da)
FI (1) FI70888C (da)
FR (1) FR2444031A1 (da)
GB (1) GB2038821B (da)
GR (1) GR73003B (da)
HU (1) HU183016B (da)
IE (1) IE49318B1 (da)
IL (1) IL58917A (da)
IT (1) IT1194900B (da)
LU (1) LU81985A1 (da)
NL (1) NL177749C (da)
NO (1) NO153135C (da)
NZ (1) NZ192360A (da)
PH (1) PH15056A (da)
PL (1) PL134005B1 (da)
PT (1) PT70571A (da)
SE (1) SE444937B (da)
SU (1) SU878195A3 (da)
YU (1) YU301879A (da)
ZA (1) ZA796708B (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350696A (en) * 1980-03-08 1982-09-21 Pfizer Inc. Imidazole derivatives, process for their preparation and pharmaceutical compositions thereof
US4444775A (en) * 1981-06-22 1984-04-24 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridines
DE3148291A1 (de) * 1981-12-05 1983-06-09 Basf Ag, 6700 Ludwigshafen Harnstoffderivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
JPS58113178A (ja) * 1981-12-28 1983-07-05 Yamanouchi Pharmaceut Co Ltd 「お」−（１−イミダゾリル）アルキルオキシ（またはチオ）ベンゼン誘導体
US4588732A (en) * 1982-12-21 1986-05-13 Ciba-Geigy Corporation Certain imidazo(1,5-a)pyridine derivatives and their use as thromboxane synthetase inhibitors
US4470986A (en) * 1982-12-21 1984-09-11 Ciba-Geigy Corporation Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid derivatives and their use as selective thromboxane inhibitors
NL8301550A (nl) * 1983-05-03 1984-12-03 Gist Brocades Nv Imidazolethanol esters.
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
PH22076A (en) * 1983-08-25 1988-05-20 Daiichi Seiyaku Co Benzocycloalkane derivative
IT1212791B (it) * 1983-11-24 1989-11-30 Medea Res Srl Derivato imidazolico adattivita' vasodilatatrice ed antitrombotica, sua preparazione e composizioni farmaceutiche che lo contengono.
ES539074A0 (es) * 1984-12-10 1985-11-16 Ferrer Int Procedimiento de obtencion de nuevos derivados imidazoliletoxiindanicos.
JPH0625141B2 (ja) * 1985-01-16 1994-04-06 三共株式会社 イミダゾ−ル誘導体およびその製法
KR920002129B1 (ko) 1986-01-27 1992-03-12 상꾜 가부시끼가이샤 티아나프텐 유도체의 제조방법
ATE90076T1 (de) 1986-03-27 1993-06-15 Merck Frosst Canada Inc Tetrahydrocarbazole ester.
JPS63179840A (ja) * 1986-07-24 1988-07-23 Yamanouchi Pharmaceut Co Ltd 新規化学物質
EP0284892B1 (de) * 1987-04-03 1990-10-31 Cl Pharma Aktiengesellschaft Neue 2-Thienyloxyessigsäurederivate, ein Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
JPH01125372A (ja) * 1988-09-12 1989-05-17 Yamanouchi Pharmaceut Co Ltd イミダゾリルアルキルオキシベンゼン誘導体
DE4204686A1 (de) * 1992-02-17 1993-08-19 Gruenenthal Gmbh Imidazolylphenolderivate, diese enthaltende arzneimittel sowie ein verfahren zur herstellung dieser verbindungen und arzneimitteln
WO1995029165A2 (en) * 1994-04-26 1995-11-02 Syntex (U.S.A.) Inc. Benzocycloalkylaz0lethione derivatives as dopamin beta-hydroxylase inhibitors
WO1999045905A2 (en) * 1998-03-13 1999-09-16 Pozen Inc. Prophylaxis and treatment of migraine headaches with thromboxane synthetase inhibitors and/or receptor antagonists
ES2172436B1 (es) 2000-10-31 2004-01-16 Almirall Prodesfarma Sa Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
AU2003244913A1 (en) * 2002-07-09 2004-01-23 B.M.R.A. Corporation B.V. Pharmaceutical combination of a thromboxane A2 receptor antagonist and a COX-2 inhibitor
EP1660076A1 (en) * 2003-08-07 2006-05-31 B.M.R.A. Corporation B.V. Compositions and methods involving the combination of a thromboxane a2 receptor antagonist and an inhibitor of cyclooxigenase-1
KR101275814B1 (ko) * 2006-06-23 2013-06-18 삼성에스디아이 주식회사 분산제 화합물 및 그의 제조방법
US20110015158A1 (en) 2007-12-11 2011-01-20 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
CN101811974B (zh) * 2010-04-15 2012-12-12 合肥医工医药有限公司 4-(3-(二甲氨基)丙氧基)-3,5-二甲氧基苯甲酸、其制法及医药用途
CN101851209B (zh) * 2010-06-21 2012-09-19 合肥医工医药有限公司 咪唑乙基香草酸醚、其制备方法及其医药用途
SG11201408284VA (en) * 2012-05-22 2015-02-27 Xenon Pharmaceuticals Inc N-substituted benzamides and their use in the treatment of pain
BR112015008987A2 (pt) 2012-10-26 2017-07-04 Merck Sharp & Dohme composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de uma composição farmacêutica
EP4538258A4 (en) * 2022-06-13 2025-07-30 Hefei Inst Of Pharmaceutical Industry Co Ltd IMIDAZOLIDINYL VANILLIC ACID ETHER DERIVATIVE AND ITS USE
CN114736161B (zh) * 2022-06-13 2022-09-13 南京医工医药技术有限公司 咪唑烷基香草酸醚衍生物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3534061A (en) * 1967-12-04 1970-10-13 Parke Davis & Co N-(alpha-(p-methoxyphenyl)-beta-nitrostyryl)-phenoxyalkyl pyrroles
US4085209A (en) * 1975-02-05 1978-04-18 Rohm And Haas Company Preparation and safening effect of 1-substituted imidazole metal salt complexes
US4078071A (en) * 1976-03-08 1978-03-07 Syntex (U.S.A.) Inc. Derivatives of substituted N-alkyl imidazoles
JPS5951943B2 (ja) * 1978-08-21 1984-12-17 キツセイ薬品工業株式会社 新規なイミダゾ−ル誘導体

Also Published As

Publication number Publication date
NL177749C (nl) 1985-11-18
FI70888C (fi) 1986-10-27
SU878195A3 (ru) 1981-10-30
US4602016A (en) 1986-07-22
US4636500A (en) 1987-01-13
SE7910204L (sv) 1980-06-14
FI793868A7 (fi) 1980-06-14
JPS585197B2 (ja) 1983-01-29
ZA796708B (en) 1981-08-26
IL58917A (en) 1984-03-30
JPS5585572A (en) 1980-06-27
AR227637A1 (es) 1982-11-30
HU183016B (en) 1984-04-28
CH644597A5 (de) 1984-08-15
CS216517B2 (en) 1982-11-26
YU301879A (en) 1983-01-21
NZ192360A (en) 1982-02-23
KR830001243B1 (ko) 1983-06-27
DE2950019A1 (de) 1980-07-10
AU517892B2 (en) 1981-09-03
KR830001242A (ko) 1983-04-29
FR2444031A1 (fr) 1980-07-11
IE49318B1 (en) 1985-09-18
FI70888B (fi) 1986-07-18
PT70571A (en) 1980-01-01
PH15056A (en) 1982-06-03
IE792403L (en) 1980-06-13
GB2038821A (en) 1980-07-30
GR73003B (da) 1984-01-24
EG14227A (en) 1983-12-31
ATA783379A (de) 1983-07-15
DD147943A5 (de) 1981-04-29
PL134005B1 (en) 1985-07-31
PL220351A1 (da) 1980-12-01
ES486782A0 (es) 1980-12-16
AT373879B (de) 1984-02-27
CA1108137A (en) 1981-09-01
NL177749B (nl) 1985-06-17
GB2038821B (en) 1982-12-08
NO153135C (no) 1986-01-22
AU5372579A (en) 1980-06-19
IT1194900B (it) 1988-09-28
ES8101556A1 (es) 1980-12-16
BE880584A (fr) 1980-06-12
NL7908899A (nl) 1980-06-17
IT7941669A0 (it) 1979-12-11
IL58917A0 (en) 1980-03-31
NO153135B (no) 1985-10-14
FR2444031B1 (da) 1983-06-10
SE444937B (sv) 1986-05-20
NO794069L (no) 1980-06-16
DK471479A (da) 1980-06-14

Similar Documents

Publication Publication Date Title
LU81985A1 (fr) Nouveaux derives d'imidazole,leur procede de production et composition pharmaceutique les contenant
US4448781A (en) N-Benzyl-imidazoles as selective inhibitors of the thromboxane synthetase enzyme
LU82224A1 (fr) Nouveaux 3-(1-imidazolylalkyl)indoles, leur procede de production et composition pharmaceutique les contenant
MC1883A1 (fr) Derives de tetrahydronaphtalene
EP0003199A2 (fr) Nouveaux dérivés du tétrahydro pyridinyl indole et leurs sels, le procédé de préparation, l'application à titre de médicaments de ces nouveaux produits et les compositions pharmaceutiques les renfermant
GB2041363A (en) N-Benzyl-imidazoles
EP0382637A1 (fr) Dérivés de pyrimidinyl-piperazinyl-alkyl azolès avec activité anxiolytique et/ou tranquillisante
EP0037778A1 (fr) Benzodioxanne 1,4 méthoxy-2 propanolamines, leur préparation et leur application en tant que médicaments
GB2101992A (en) Indole derivatives
EP0021940B1 (fr) Nouveaux dérivés aminés du benzothiazole, leur procédé de préparation et leur application en thérapeutique
WO2001027088A1 (en) Lpl potentiators
EP0025727A1 (fr) Dérivés de l'indole, procédé pour leur préparation et médicaments les contenant
LU81598A1 (fr) Nouveaux derives d'imidazole,leur procede de production et composition pharmaceutique les contenant
EP0122827B1 (fr) (Carbéthoxy-2 benzalkylamido-4 phénoxy)-1 amino-3 propanols-2, leurs préparations et leurs utilisations en thérapeutique
JP2003505367A (ja) マトリックスメタロプロテイナーゼ阻害剤としての３−アリールスルホニル−２−（置換メチル）プロパン酸誘導体
EP0385848A1 (fr) Nouveaux dérivés benzoxazolinoniques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
EP0201400B1 (fr) Dérivés du 4-phénylpropyl indole et leurs sels, leur procédé de préparation, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant
BE861454A (fr) Derives d'acides thiazolidinecarboxyliques, leur preparation et leur utilisation
FR2460934A1 (fr) Derives d'isoquinoleine contenant du soufre, procedes pour leur preparation et compositions pharmaceutiques les contenant
JPH09227495A (ja) フェノール誘導体及びその製法
EP0395526B1 (fr) Nouveaux dérivés benzothiazolinoniques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP0210893B1 (fr) Benzamides, leur procédé de préparation et leur application dans le domaine thérapeutique
EP0994857A1 (fr) DERIVES DE (1$i(H)-IMIDAZOL-4-YL)PIPERIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
JP3839518B2 (ja) 抗真菌剤
EP0099822B1 (fr) Nouveaux 1-(2-carbalkoxy 4-(thiénylalkylamido)phénoxy) 3-amino 2-propanols, leur préparation et leurs applications en thérapeutique