LU88791I2 - Gemcitabine ou un sel pharmaceuticallement acceptable de celle-ci - Google Patents

Gemcitabine ou un sel pharmaceuticallement acceptable de celle-ci

Info

Publication number
LU88791I2
LU88791I2 LU88791C LU88791C LU88791I2 LU 88791 I2 LU88791 I2 LU 88791I2 LU 88791 C LU88791 C LU 88791C LU 88791 C LU88791 C LU 88791C LU 88791 I2 LU88791 I2 LU 88791I2
Authority
LU
Luxembourg
Prior art keywords
gemcitabine
pharmaceutically acceptable
acceptable salt
salt
pharmaceutically
Prior art date
Application number
LU88791C
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23881409&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU88791(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of LU88791I2 publication Critical patent/LU88791I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
LU88791C 1983-03-10 1984-03-06 Gemcitabine ou un sel pharmaceuticallement acceptable de celle-ci LU88791I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/473,883 US4526988A (en) 1983-03-10 1983-03-10 Difluoro antivirals and intermediate therefor

Publications (1)

Publication Number Publication Date
LU88791I2 true LU88791I2 (fr) 1996-11-05

Family

ID=23881409

Family Applications (1)

Application Number Title Priority Date Filing Date
LU88791C LU88791I2 (fr) 1983-03-10 1984-03-06 Gemcitabine ou un sel pharmaceuticallement acceptable de celle-ci

Country Status (36)

Country Link
US (5) US4526988A (fr)
EP (1) EP0122707B1 (fr)
JP (2) JPS59175498A (fr)
KR (1) KR860001283B1 (fr)
AR (1) AR243533A1 (fr)
AT (1) ATE29726T1 (fr)
AU (1) AU565856B2 (fr)
BG (1) BG40814A3 (fr)
CA (2) CA1218647A (fr)
CS (1) CS246075B2 (fr)
CY (1) CY1489A (fr)
DD (1) DD216468A5 (fr)
DE (2) DE19675003I2 (fr)
DK (2) DK162529C (fr)
ES (1) ES530364A0 (fr)
FI (1) FI77870C (fr)
GB (2) GB2136425B (fr)
GR (1) GR81845B (fr)
HK (1) HK44989A (fr)
HU (1) HU193893B (fr)
IE (1) IE57071B1 (fr)
IL (2) IL80463A (fr)
KE (1) KE3874A (fr)
LU (1) LU88791I2 (fr)
MX (1) MX9203246A (fr)
MY (1) MY102025A (fr)
NL (1) NL950018I2 (fr)
NZ (1) NZ207358A (fr)
PH (2) PH23240A (fr)
PL (1) PL142437B1 (fr)
PT (1) PT78181B (fr)
RO (1) RO89963A (fr)
SG (1) SG21889G (fr)
SU (1) SU1442076A3 (fr)
UA (1) UA5955A1 (fr)
ZA (1) ZA841605B (fr)

Families Citing this family (253)

* Cited by examiner, † Cited by third party
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US4994558A (en) * 1986-12-24 1991-02-19 Eli Lilly And Company Immunoglobulin conjugates
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US4814438A (en) * 1986-12-24 1989-03-21 Eli Lilly And Company Immunoglobulin conjugates of 2',2'-difluronucleosides
EP0277599A3 (fr) * 1987-01-30 1990-05-09 Asahi Glass Company Ltd. Dérivés de cyclopentane contenant du fluor et procédés pour leur préparation
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US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
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US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US4914028A (en) * 1988-02-10 1990-04-03 Eli Lilly And Company Method of preparing beta-2',2'-difluoronucleosides
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US5821357A (en) * 1992-06-22 1998-10-13 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
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PH23593A (en) 1989-09-11
IL71143A0 (en) 1984-06-29
DK114484A (da) 1984-09-11
ATE29726T1 (de) 1987-10-15
US5118820A (en) 1992-06-02
CA1218647A (fr) 1987-03-03
NZ207358A (en) 1987-03-06
MY102025A (en) 1992-02-29
PT78181A (en) 1984-04-01
US4692434A (en) 1987-09-08
BG40814A3 (bg) 1987-02-16
JPH06102655B2 (ja) 1994-12-14
PH23240A (en) 1989-06-06
ZA841605B (en) 1985-10-30
GB8610648D0 (en) 1986-06-04
DK190590D0 (da) 1990-08-10
JPH069602A (ja) 1994-01-18
CY1489A (en) 1989-12-08
IL80463A0 (en) 1987-01-30
DE3466224D1 (en) 1987-10-22
GB8405805D0 (en) 1984-04-11
DK170647B1 (da) 1995-11-20
PT78181B (en) 1986-08-05
GR81845B (fr) 1984-12-12
GB2172287B (en) 1987-05-20
KR840007883A (ko) 1984-12-11
FI840890L (fi) 1984-09-11
GB2172287A (en) 1986-09-17
EP0122707B1 (fr) 1987-09-16
FI77870B (fi) 1989-01-31
KR860001283B1 (ko) 1986-09-05
AU565856B2 (en) 1987-10-01
US5015743A (en) 1991-05-14
NL950018I1 (fr) 1995-11-01
DE19675003I2 (de) 2003-05-22
US4526988A (en) 1985-07-02
GB2136425A (en) 1984-09-19
IL71143A (en) 1988-07-31
PL246601A1 (en) 1985-08-13
UA5955A1 (uk) 1994-12-29
ES8602840A1 (es) 1985-12-01
DK162529B (da) 1991-11-11
AR243533A1 (es) 1993-08-31
NL950018I2 (nl) 1997-03-03
FI840890A0 (fi) 1984-03-06
GB2136425B (en) 1987-05-13
MX9203246A (es) 1992-07-31
IE840584L (en) 1984-09-10
DK114484D0 (da) 1984-02-28
DK190590A (da) 1990-08-10
JPH0542438B2 (fr) 1993-06-28
HU193893B (en) 1987-12-28
RO89963A (fr) 1986-09-30
AU2537484A (en) 1984-09-13
US4808614A (en) 1989-02-28
PL142437B1 (en) 1987-10-31
EP0122707A1 (fr) 1984-10-24
DD216468A5 (de) 1984-12-12
IE57071B1 (en) 1992-04-22
JPS59175498A (ja) 1984-10-04
IL80463A (en) 1988-07-31
FI77870C (fi) 1989-05-10
CS246075B2 (en) 1986-10-16
CA1223869A (fr) 1987-07-07
SU1442076A3 (ru) 1988-11-30
ES530364A0 (es) 1985-12-01
KE3874A (en) 1989-06-30
SG21889G (en) 1989-07-14
HK44989A (en) 1989-06-09
DK162529C (da) 1992-03-30

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