LU92678I2 - Tobramycine ou un sel pharmaceutiquement acceptable qui en dérive - Google Patents

Tobramycine ou un sel pharmaceutiquement acceptable qui en dérive Download PDF

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Publication number
LU92678I2
LU92678I2 LU92678C LU92678C LU92678I2 LU 92678 I2 LU92678 I2 LU 92678I2 LU 92678 C LU92678 C LU 92678C LU 92678 C LU92678 C LU 92678C LU 92678 I2 LU92678 I2 LU 92678I2
Authority
LU
Luxembourg
Prior art keywords
tobramycin
pharmaceutically acceptable
acceptable salt
salt
pharmaceutically
Prior art date
Application number
LU92678C
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of LU92678I2 publication Critical patent/LU92678I2/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LU92678C 2000-05-10 2015-03-11 Tobramycine ou un sel pharmaceutiquement acceptable qui en dérive LU92678I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/568,818 US7871598B1 (en) 2000-05-10 2000-05-10 Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use

Publications (1)

Publication Number Publication Date
LU92678I2 true LU92678I2 (fr) 2015-11-02

Family

ID=24272868

Family Applications (1)

Application Number Title Priority Date Filing Date
LU92678C LU92678I2 (fr) 2000-05-10 2015-03-11 Tobramycine ou un sel pharmaceutiquement acceptable qui en dérive

Country Status (9)

Country Link
US (5) US7871598B1 (fr)
EP (2) EP1282405A2 (fr)
JP (2) JP2003533449A (fr)
KR (2) KR20080031532A (fr)
AU (1) AU2001259637A1 (fr)
CA (1) CA2408464C (fr)
LU (1) LU92678I2 (fr)
MX (1) MXPA02011003A (fr)
WO (1) WO2001085137A2 (fr)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
WO2002009674A2 (fr) * 2000-07-28 2002-02-07 Inhale Therapeutic Systems, Inc. Nouveaux procedes et compositions destines a reguler positivement, a rediriger ou a limiter les reponses immunitaires aux peptides, proteines et autres composes bioactifs et aux vecteurs exprimant ces derniers
US7141236B2 (en) 2000-07-28 2006-11-28 Nektar Therapeutics Methods and compositions for delivering macromolecules to or via the respiratory tract
ES2587135T3 (es) 2000-11-30 2016-10-20 Vectura Limited Procedimiento de fabricación de partículas para su uso en una composición farmacéutica
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
JP2004528339A (ja) * 2001-04-26 2004-09-16 ネクター セラピューティクス 気道に対して又は気道を介して高分子を送達するための新規方法及び組成物
JP2005514393A (ja) * 2001-12-19 2005-05-19 ネクター セラピューティクス アミノグリコシドの肺への供給
JP4739672B2 (ja) 2001-12-21 2011-08-03 ネクター セラピューティクス 湿気のバリアを有するカプセルパッケージ
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
WO2006002178A1 (fr) 2004-06-18 2006-01-05 Novartis Vaccines And Diagnostics Inc. Methodes de traitement d'infections endobronchiques
US8513204B2 (en) 2004-06-21 2013-08-20 Novartis Ag Compositions comprising amphotericin B, mehods and systems
EP1773301A2 (fr) 2004-06-21 2007-04-18 Nektar Therapeutics Compositions renfermant de l'amphotericine b, procedes et systemes correspondants
WO2006071102A1 (fr) 2004-12-30 2006-07-06 Dobeel Co., Ltd. Préparation séchée par atomisation contenant des protéines de la famille de la collectine ou des variantes desdites protéines, et procédé d'élaboration de ladite préparation
ITMI20051999A1 (it) 2005-10-21 2007-04-22 Eratech S R L Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita'
JP2009537570A (ja) * 2006-05-18 2009-10-29 ティカ レーケメデル アーベー アルブテロールの吸入可能溶液を有する単位用量製剤
RU2463085C2 (ru) 2006-10-25 2012-10-10 Новартис Аг Аппарат для распыления порошка, способ его изготовления и применения и его компоненты
US12370352B2 (en) 2007-06-28 2025-07-29 Cydex Pharmaceuticals, Inc. Nasal and ophthalmic delivery of aqueous corticosteroid solutions
WO2009120619A2 (fr) * 2008-03-24 2009-10-01 Novartis Ag Compositions de nucléase, procédés de préparation et d’utilisation de ces compositions, et systèmes d’administration pulmonaire de ces compositions
JP5207359B2 (ja) * 2008-03-28 2013-06-12 独立行政法人産業技術総合研究所 金属配位型有機ナノチューブの大量製造法
JP5727927B2 (ja) 2008-05-15 2015-06-03 ノバルティス アーゲー フルオロキノロンの肺送達
DK2413902T3 (da) 2009-03-18 2019-10-07 Incarda Therapeutics Inc Enhedsdoser, aerosoler, kits og fremgangsmåder til behandling af hjertetilstande ved pulmonal indgivelse
WO2010111641A2 (fr) * 2009-03-26 2010-09-30 Pulmatrix, Inc. Méthodes de traitement et de prévention de la pneumonie et de la trachéo-bronchite associée à la mise sous respirateur
US20100310660A1 (en) * 2009-06-08 2010-12-09 Taipei Medical University Dry powder microparticles for pulmonary delivery
KR101214778B1 (ko) 2009-10-01 2012-12-21 주식회사 바이오드 철 이온/바이러스 벡터의 복합체를 이용한 세포 내 바이러스 벡터의 전달방법
US8822663B2 (en) 2010-08-06 2014-09-02 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2611438B1 (fr) 2010-08-30 2020-04-01 Pulmatrix Operating Company, Inc. Formulations de poudre sèche et méthodes de traitement de maladies pulmonaires
WO2012030647A1 (fr) 2010-08-30 2012-03-08 Pulmatrix, Inc. Méthodes de traitement de la mucoviscidose
JP5877204B2 (ja) 2010-09-29 2016-03-02 パルマトリックス，インコーポレイテッド 吸入用の一価金属カチオン乾燥粉末
DK2621488T3 (en) 2010-09-29 2019-03-04 Pulmatrix Operating Co Inc CATIONIC DRY POWDER
DK4108671T3 (da) 2010-10-01 2025-01-06 Modernatx Inc Modificerede nukleosider, nukleotider og nukleinsyrer samt anvendelser deraf
JOP20120023B1 (ar) 2011-02-04 2022-03-14 Novartis Ag صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
EP2790761B1 (fr) 2011-12-16 2022-05-11 Novartis AG Appareil passif d'aérosolisation de poudre
CN107596518B (zh) 2012-02-29 2021-04-23 普马特里克斯营业公司 可吸入干粉剂
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
EP2834259A4 (fr) 2012-04-02 2016-08-24 Moderna Therapeutics Inc Polynucléotides modifiés
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
WO2014028429A2 (fr) 2012-08-14 2014-02-20 Moderna Therapeutics, Inc. Enzymes et polymérases destinées à la synthèse d'arn
US9597380B2 (en) 2012-11-26 2017-03-21 Modernatx, Inc. Terminally modified RNA
NZ710557A (en) * 2013-01-15 2020-08-28 Glanbia Nutritionals Ireland Ltd Method for improving viscosity, solubility, and particle size of milk protein concentrates
WO2014159813A1 (fr) 2013-03-13 2014-10-02 Moderna Therapeutics, Inc. Molécules polynucléotidiques à longue durée de vie
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
CA2898700C (fr) 2013-03-14 2022-07-19 Novartis Ag Desamorphisation de formulations sechees par pulverisation par l'intermediaire d'un melange par pulverisation
US10258698B2 (en) 2013-03-14 2019-04-16 Modernatx, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
WO2014165303A1 (fr) 2013-04-01 2014-10-09 Pulmatrix, Inc. Poudres sèches de tiotropium
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
EP3725311A1 (fr) 2014-02-10 2020-10-21 Respivant Sciences GmbH Procédés de traitement de maladies pulmonaires à l'aide de stabilisateurs de mastocytes
EP3653207A1 (fr) 2014-02-10 2020-05-20 Respivant Sciences GmbH Traitement de troubles systémiques par stabilisateurs de mastocytes
CN112656780A (zh) * 2014-02-20 2021-04-16 奥迪托皮克股份有限公司 用于吸入的干粉制剂
PL3179986T3 (pl) * 2014-07-31 2023-06-26 Vectura Inc. Suche formulacje w proszku do inhalacji
CA2965759C (fr) 2014-10-31 2023-12-12 Glaxosmithkline Intellectual Property Development Limited Polypeptides en poudre presentant moins d'impuretes de disulfide comprenant des materiaux cationiques divalents
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
US9968125B2 (en) 2015-01-09 2018-05-15 Philip Morris Products S.A. Nicotine—diketopiperazine microparticle formulations and methods of making the same
WO2016142708A2 (fr) 2015-03-10 2016-09-15 Cipla Limited Composition pharmaceutique
WO2016145192A1 (fr) 2015-03-11 2016-09-15 University Of Cincinnati Compositions et méthodes de traitement d'une infection bactérienne
US11793783B2 (en) 2015-08-05 2023-10-24 Cmpd Licensing, Llc Compositions and methods for treating an infection
US11684567B2 (en) 2015-08-05 2023-06-27 Cmpd Licensing, Llc Compositions and methods for treating an infection
US11446236B2 (en) 2015-08-05 2022-09-20 Cmpd Licensing, Llc Topical antimicrobial compositions and methods of formulating the same
US10265296B2 (en) 2015-08-07 2019-04-23 Respivant Sciences Gmbh Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
EP3331522A1 (fr) 2015-08-07 2018-06-13 Patara Pharma LLC Méthodes de traitement de troubles liés aux mastocytes par des stabilisateurs de mastocytes
US20170071248A1 (en) 2015-09-16 2017-03-16 Sansa Corporation (Barbados) Inc. System and Method for Controlling the Harshness of Nicotine-Based Dry Powder Formulations
US10149844B2 (en) 2015-09-16 2018-12-11 Philip Morris Products S.A. Inhalable nicotine formulations, and methods of making and using thereof
US11224594B2 (en) 2015-09-16 2022-01-18 Philip Morris Products S.A. Nicotine formulations and methods of making and using the same
US9585835B1 (en) 2015-09-16 2017-03-07 Sansa Corporation (Barbados) Inc. Inhalable nicotine formulations and methods of making and using the same
AU2016336344A1 (en) 2015-10-05 2018-04-19 Modernatx, Inc. Methods for therapeutic administration of messenger ribonucleic acid drugs
RU2727239C2 (ru) 2016-01-19 2020-07-21 Новартис Аг Многодозовый ингалятор
SG10202012584UA (en) 2016-02-01 2021-01-28 Incarda Therapeutics Inc Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation
KR101938870B1 (ko) * 2016-05-04 2019-04-10 고려대학교 산학협력단 생물복합물질로서 분리 정제에 이용 가능한 실리카 코팅된 탄산칼슘입자
CN110139646A (zh) 2016-08-31 2019-08-16 瑞思皮万特科学有限责任公司 用于治疗由特发性肺纤维化引起的慢性咳嗽的色甘酸组合物
WO2018067341A1 (fr) 2016-10-07 2018-04-12 Patara Pharma, LLC Compositions à base de cromolyne pour le traitement d'une fibrose pulmonaire
CN110300588A (zh) * 2017-03-07 2019-10-01 菲利普莫里斯生产公司 可吸入尼古丁调配物及其制造和使用方法
CA3060702A1 (fr) 2017-05-10 2018-11-15 Incarda Therapeutics, Inc. Doses unitaires, aerosols, trousses, et methodes pour traiter des affections cardiaques par administration pulmonaire
WO2018229626A1 (fr) 2017-06-12 2018-12-20 Novartis Ag Matériaux pharmaceutiques nanostructurés amorphes
EP3768378B1 (fr) 2018-03-22 2025-08-06 InCarda Therapeutics, Inc. Nouvelle méthode pour ralentir le rythme ventriculaire
EP3833964B1 (fr) 2018-08-07 2023-07-26 Norton (Waterford) Limited Application de spectroscopie raman pour la fabrication de poudres à inhaler
CN109350747B (zh) * 2018-10-31 2022-03-01 南京医科大学 一种zl006环己酯聚合物纳米递药系统及其制备方法
US11020384B2 (en) 2019-08-01 2021-06-01 Incarda Therapeutics, Inc. Antiarrhythmic formulation
IL290088B2 (en) 2019-08-01 2023-10-01 Incarda Therapeutics Inc A pharmaceutical preparation containing flacainide, cyclodextrin and acid, a dosage unit of the preparation and a kit containing the preparation
US20240033222A1 (en) 2020-08-14 2024-02-01 Norton (Waterford) Limited An inhalable formulation of fluticasone propionate and albuterol sulfate
EP4304582A1 (fr) 2021-03-12 2024-01-17 Alvarius Pharmaceuticals Ltd. Compositions et méthodes pour traiter des addictions comprenant de la 5-meo-dmt
WO2023158286A1 (fr) * 2022-02-21 2023-08-24 주식회사 툴바이오 Particule réactive aux ions métalliques à base de calséquestrine et ses utilisations
KR102674935B1 (ko) * 2023-12-18 2024-06-13 피투케이바이오 주식회사 폐 전달을 위한 인슐린을 포함하는 점액투과 고분자 미셀의 제조 및 평가
WO2025137495A1 (fr) * 2023-12-20 2025-06-26 The Board Of Regents Of The University Of Texas System Microparticules inhalables comprenant un phospholipide et un anticorps ou un fragment d'anticorps

Family Cites Families (593)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE471490C (de) 1931-08-12 Karl Zeyen Vorrichtung zum Zerstaeuben mehlfoermiger Stoffe
US979993A (en) 1910-03-24 1910-12-27 Joseph Francis O'byrne Projectile.
US1855591A (en) 1926-02-03 1932-04-26 Wallerstein Co Inc Invertase preparation and method of making the same
US2457036A (en) 1946-04-10 1948-12-21 Albert A Epstein Coffee concentrate and the process of producing it
US2797201A (en) 1953-05-11 1957-06-25 Standard Oil Co Process of producing hollow particles and resulting product
BE556587A (fr) 1957-01-31 1957-04-11
DE1080265B (de) 1958-09-30 1960-04-21 Bayer Ag Verfahren zur Herstellung von oral anzuwendenden Arzneimittel-zubereitungen mit protrahierter Wirkung aus Wirkstoffen und Schutzstoffen
US3362405A (en) 1964-04-06 1968-01-09 Hamilton O. Hazel Method and apparatus for admixing gas with solid particles
US3619294A (en) 1968-07-15 1971-11-09 Penick & Ford Ltd Method of combining crystalline sugar with impregnating agents and products produced thereby
US3555717A (en) 1968-10-24 1971-01-19 Victor Comptometer Corp Artificial fishing lure
DE1812574A1 (de) 1968-12-04 1970-06-11 Riedel De Haen Ag Verfahren zur Herstellung biozider Granulate
GB1263780A (en) 1969-05-13 1972-02-16 Matsushita Electric Industrial Co Ltd Piezoelectric ceramic compositions
US3632357A (en) 1969-07-29 1972-01-04 Standard Brands Inc Method of producing hard candy
US3655442A (en) 1969-08-27 1972-04-11 California & Hawaiian Sugar Method of making sugar and sugar products
GB1265615A (fr) 1970-09-10 1972-03-01
US3975512A (en) 1970-12-21 1976-08-17 University Of Illinois Foundation Non-toxic brominated perfluorocarbons radiopaque agents
GB1410588A (en) 1971-08-10 1975-10-22 Fisons Ltd Composition
US3745682A (en) 1971-09-28 1973-07-17 Pneu Dart Inc Gun for propelling a drug or medicine projectile
US3811124A (en) 1972-06-12 1974-05-14 Ibm Solid state gas panel display circuits with non-inductive solid state isolation between low level logic and high level drive signal functions
DE2246013A1 (de) 1972-09-20 1974-03-28 Boehringer Mannheim Gmbh Verfahren zur herstellung von poroesen tabletten
US3812854A (en) 1972-10-20 1974-05-28 A Michaels Ultrasonic nebulizer
FR2238476A1 (en) 1973-07-23 1975-02-21 Aries Robert Double esters of zeranol and natural hormones - and their implants for livestock, have protein anabolism props
US3957964A (en) 1974-01-30 1976-05-18 Colgate-Palmolive Company Dentifrice containing encapsulated flavoring
DE2415159A1 (de) 1974-03-29 1975-10-09 Hoechst Ag Alkalialkansulfonathaltige spruehprodukte und verfahren zu ihrer herstellung
US3948263A (en) 1974-08-14 1976-04-06 Minnesota Mining And Manufacturing Company Ballistic animal implant
JPS5134879A (en) 1974-09-19 1976-03-24 Eisai Co Ltd Bishochukuryushinoseizoho
US3964483A (en) 1975-01-13 1976-06-22 Syntex Puerto Rico, Inc. Inhalation device
US4005711A (en) 1975-01-13 1977-02-01 Syntex Puerto Rico, Inc. Inhalation device
FR2299011A1 (fr) 1975-01-29 1976-08-27 Obert Jean Claude Generateur d'aerosols de part
US4102999A (en) 1975-02-10 1978-07-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for producing stable macromomycin powder
US4161516A (en) 1975-07-25 1979-07-17 Fisons Limited Composition for treating airway disease
JPS5733509Y2 (fr) 1976-04-19 1982-07-23
US4147766A (en) 1976-06-09 1979-04-03 Armour Pharmaceutical Company Macrospherical particles of anti-perspirants
GB1533012A (en) 1976-12-20 1978-11-22 Lloyd C Confectionery machines
NL7704348A (nl) 1977-04-21 1978-10-24 Philips Nv Werkwijze voor het bereiden van een geattenueer- de transmissible gastroenteritis(tge)-virusstam voor toepassing in levende vaccins.
US4180593A (en) 1977-04-29 1979-12-25 Cohan Allan N Process for producing round spherical free flowing blown bead food products of controlled bulk density
US4127502A (en) 1977-06-10 1978-11-28 Eastman Kodak Company Stabilizers for reconstituted, lyophilized samples
US4211769A (en) 1977-08-24 1980-07-08 Takeda Chemical Industries, Ltd. Preparations for vaginal administration
JPS5492951A (en) 1977-12-29 1979-07-23 Shionogi & Co Ltd Novel aminoglycoside derivative
US4244949A (en) 1978-04-06 1981-01-13 The Population Council, Inc. Manufacture of long term contraceptive implant
IT1108132B (it) 1978-07-12 1985-12-02 Fiat Trattori Spa Dispositivo atto a migliorare il controllo di attrezzi portati da trattori agricoli
US4158544A (en) 1978-07-17 1979-06-19 Beckman Instruments, Inc. Process for preparing a biological composition for use as a reference control in diagnostic analysis
US4253468A (en) 1978-08-14 1981-03-03 Steven Lehmbeck Nebulizer attachment
US4588744A (en) 1978-09-19 1986-05-13 Mchugh John E Method of forming an aqueous solution of 3-3-Bis(p-hydroxyphenyl)-phthalide
GB2037735B (en) 1978-12-21 1983-11-09 Standard Telephones Cables Ltd Glass composition
DE3061384D1 (en) 1979-02-21 1983-01-27 Ici Plc A process for the extraction of poly-3-hydroxy-butyric acid from microbial cells
US4281031A (en) 1979-07-25 1981-07-28 Machine Technology, Inc. Method and apparatus for processing workpieces
GB2065659A (en) * 1979-12-21 1981-07-01 Nattermann A & Cie Calciumphosphatidylchlorine- chloride, process for producing the same and pharmaceutical preparations containing the same
DE2952115C2 (de) * 1979-12-22 1982-05-06 A. Nattermann & Cie GmbH, 5000 Köln Rosmarinsäure-Phospholipid-Komplex
ZA811942B (en) 1980-03-25 1983-02-23 H Malem Nebulising apparatus
EP0111216A3 (fr) 1980-03-31 1985-01-16 Takeda Chemical Industries, Ltd. Méthode pour essai immunoenzymatique, conjugué peptide-enzyme, son lyophilisat, anticorps et trousse de réactifs
US4326524A (en) 1980-09-30 1982-04-27 Minnesota Mining And Manufacturing Company Solid dose ballistic projectile
US4327076A (en) 1980-11-17 1982-04-27 Life Savers, Inc. Compressed chewable antacid tablet and method for forming same
JPS5795920A (en) 1980-12-04 1982-06-15 Teijin Ltd Remedy for respiratory disease
SE439599B (sv) 1981-01-14 1985-06-24 Kema Nord Ab Sett att torka och expandera i vetska dispergerade, termoplastiska mikrosferer innehallande, flyktiga, flytande jesmedel
US4371557A (en) 1981-01-21 1983-02-01 General Foods Corporation Maintenance of protein quality in foods containing reducing sugars
DE3266590D1 (en) 1981-01-21 1985-11-07 Unilever Plc Lipid and protein containing material in particulate form and process therefor
US5366734A (en) 1981-02-16 1994-11-22 Zeneca Limited Continuous release pharmaceutical compositions
US4327077A (en) 1981-05-29 1982-04-27 Life Savers, Inc. Compressed chewable antacid tablet and method for forming same
ATE23272T1 (de) 1981-07-08 1986-11-15 Draco Ab Pulverinhalator.
US4484577A (en) 1981-07-23 1984-11-27 Key Pharmaceuticals, Inc. Drug delivery method and inhalation device therefor
US5260306A (en) 1981-07-24 1993-11-09 Fisons Plc Inhalation pharmaceuticals
GB2105189B (en) 1981-07-24 1985-03-20 Fisons Plc Inhalation drugs
EP0072046B1 (fr) 1981-07-24 1986-01-15 FISONS plc Médicaments pour inhalation, méthodes pour leur production et formulations pharmaceutiques les contenant
KR890000664B1 (ko) 1981-10-19 1989-03-22 바리 안소니 뉴우샘 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법
DE3141498A1 (de) 1981-10-20 1983-04-28 Bayer Ag, 5090 Leverkusen Arzneimittel enthaltend kallikrein und verfahren zu seiner herstellung
US4713249A (en) 1981-11-12 1987-12-15 Schroeder Ulf Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof
JPS58164683A (ja) 1982-03-25 1983-09-29 Takeda Chem Ind Ltd 安定化された固体組成物
US4659696A (en) 1982-04-30 1987-04-21 Takeda Chemical Industries, Ltd. Pharmaceutical composition and its nasal or vaginal use
JPS58216695A (ja) 1982-06-07 1983-12-16 Otsuka Shokuhin Kogyo Kk トレハロ−スの製造方法
JPS58215695A (ja) 1982-06-09 1983-12-15 株式会社デンソー 電気式警音器
US4457916A (en) 1982-08-31 1984-07-03 Asahi Kasei Kogyo Kabushiki Kaisha Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same
CA1221689A (fr) 1982-09-10 1987-05-12 Mark E. Thompson Derives de substitution ortho-alcoyle et ortho- alcenyle de benzenesulfonamides, herbicides
US4591552A (en) 1982-09-29 1986-05-27 New York Blood Center, Inc. Detection of hepatitis B surface antigen (or antibody to same) with labeled synthetic peptide
JPS5995885U (ja) 1982-12-17 1984-06-29 日本擬餌鈎工業株式会社 うき
ES519619A0 (es) 1983-02-08 1984-03-16 Gandariasbeitia Aguirreche Man Procedimiento continuo para la produccion de enzimas proteoliticas y aminoliticas a partir de microorganismos vegetales.
JPS59163313A (ja) 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
JPS59168679U (ja) 1983-04-27 1984-11-12 三菱重工業株式会社 空気調和機
US4883762A (en) 1983-06-06 1989-11-28 Ciba Corning Diagnostics Corp. Stabilized isoenzyme control products
JPS6035263A (ja) 1983-08-05 1985-02-23 Wako Pure Chem Ind Ltd 不溶性担体に固定化された免疫活性物質の安定化法及び該物質を構成単位として含む生理活性物質測定用試薬
US4865871A (en) 1983-08-23 1989-09-12 Board Of Regents The University Of Texas System Method for cryopreparing biological tissue
GB8323094D0 (en) 1983-08-26 1983-09-28 Franks F Preservation of cells
EP0139286B1 (fr) 1983-10-14 1991-08-21 Sumitomo Pharmaceuticals Company, Limited Préparation à libération prolongée de longue durée
ATE93384T1 (de) 1983-11-14 1993-09-15 Univ Kentucky Res Found Poroese mikrokugeln zur arzneistoffabgabe sowie verfahren zu deren herstellung.
US4818542A (en) 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4534343A (en) 1984-01-27 1985-08-13 Trutek Research, Inc. Metered dose inhaler
WO1987000196A1 (fr) 1985-07-09 1987-01-15 Quadrant Bioresources Limited Protection des proteines et similaires
GB2187191B (en) 1984-01-30 1989-11-01 Quadrant Bioresources Ltd Protection of proteins and the like
US4758583A (en) 1984-03-19 1988-07-19 The Rockefeller University Method and agents for inhibiting protein aging
DD238305A3 (de) 1984-04-23 1986-08-20 Maisan Werke Barby Veb Verfahren zur herstellung von d-glucose und staerkehydrolysaten
US4617272A (en) 1984-04-25 1986-10-14 Economics Laboratory, Inc. Enzyme drying process
US4963367A (en) 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
JPS60244288A (ja) 1984-05-18 1985-12-04 Ookura Seiyaku Kk 安定なセラペプタ−ゼ粉末の製造方法
JPH0239237B2 (ja) 1984-05-21 1990-09-04 Noda Sangyo Kagaku Kenkyusho Shusanokishidaazenoseizoho
US4620847A (en) 1984-06-01 1986-11-04 Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh Polimerov Device for administering powdered substances
JPS60258195A (ja) 1984-06-05 1985-12-20 Ss Pharmaceut Co Ltd α．α―トレハロース脂肪酸ジエステル誘導体
JPS60258125A (ja) 1984-06-06 1985-12-20 Hayashibara Biochem Lab Inc 蛋白性生理活性物質を含有する水溶性乾燥物
US4721709A (en) 1984-07-26 1988-01-26 Pyare Seth Novel pharmaceutical compositions containing hydrophobic practically water-insoluble drugs adsorbed on pharmaceutical excipients as carrier; process for their preparation and the use of said compositions
GB8421282D0 (en) 1984-08-22 1984-09-26 Connaught Lab Multispecific antigenic proteins
US4971787A (en) 1984-08-27 1990-11-20 Warner-Lambert Company Antacid chewing gum
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
DE3445010A1 (de) 1984-12-10 1986-06-19 Boehringer Mannheim Gmbh Kontroll- bzw. eichserum fuer die lipid-diagnostik
GB8500698D0 (en) 1985-01-11 1985-02-13 Unilever Plc Preparation of reagents
FR2575923B1 (fr) 1985-01-15 1988-02-05 Jouveinal Sa Composition laxative a base de lactulose, et son procede de fabrication
US4830858A (en) 1985-02-11 1989-05-16 E. R. Squibb & Sons, Inc. Spray-drying method for preparing liposomes and products produced thereby
US4942544A (en) 1985-02-19 1990-07-17 Kenneth B. McIntosh Medication clock
GB8508173D0 (en) 1985-03-28 1985-05-01 Standard Telephones Cables Ltd Controlled delivery device
FR2580087B1 (fr) 1985-04-03 1988-12-02 Hispano Suiza Sa
US4847079A (en) 1985-07-29 1989-07-11 Schering Corporation Biologically stable interferon compositions comprising thimerosal
FR2586587B1 (fr) 1985-08-30 1987-10-23 Adir Nouveaux surfactants artificiels, leur preparation et les compositions pharmaceutiques qui les contiennent.
GR862412B (en) 1985-09-25 1987-01-23 Oncogen Vaccines and immuinoassays for acquired immune deficiency syndrome
US4680027A (en) 1985-12-12 1987-07-14 Injet Medical Products, Inc. Needleless hypodermic injection device
JPS62174094A (ja) 1985-12-16 1987-07-30 Ss Pharmaceut Co Ltd α．α―トレハロース誘導体
JPH0710344B2 (ja) 1985-12-26 1995-02-08 株式会社林原生物化学研究所 無水グリコシルフルクト−スによる含水物の脱水方法
DE3600567C1 (de) 1986-01-10 1987-05-07 Automatik App Maschb Gmbh Vorrichtung zum Granulieren von Straengen aus thermoplastischen Kunststoffen
GB8601100D0 (en) 1986-01-17 1986-02-19 Cosmas Damian Ltd Drug delivery system
GB8604983D0 (en) 1986-02-28 1986-04-09 Biocompatibles Ltd Protein preservation
SE453566B (sv) 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
JPS62228272A (ja) 1986-03-27 1987-10-07 Amano Pharmaceut Co Ltd 安定なペルオキシダ−ゼ製剤
US5017372A (en) 1986-04-14 1991-05-21 Medicis Corporation Method of producing antibody-fortified dry whey
IL82245A (en) 1986-04-25 1990-07-26 Basf Ag Preparation of spray-dried granules of active ingredients
JPH0655678B2 (ja) 1986-04-26 1994-07-27 不二製油株式会社 オリゴペプチド輸液
US4739754A (en) 1986-05-06 1988-04-26 Shaner William T Suction resistant inhalator
US5160745A (en) 1986-05-16 1992-11-03 The University Of Kentucky Research Foundation Biodegradable microspheres as a carrier for macromolecules
US4762857A (en) 1986-05-30 1988-08-09 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
DE3779221D1 (de) 1986-08-19 1992-06-25 Genentech Inc Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und -zytokinen.
SE8603812D0 (sv) 1986-09-12 1986-09-12 Draco Ab Administration of liposomes to mammals
US6024983A (en) 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
DE3636669C2 (de) 1986-10-28 2001-08-16 Siemens Ag Anordnung zur Zufuhr von Aerosol zu den Luftwegen und/oder Lungen eines Patienten
US5049388A (en) 1986-11-06 1991-09-17 Research Development Foundation Small particle aerosol liposome and liposome-drug combinations for medical use
US4851211A (en) 1986-11-25 1989-07-25 Abbott Laboratories LHRH analog formulations
US4906463A (en) 1986-12-22 1990-03-06 Cygnus Research Corporation Transdermal drug-delivery composition
US5032585A (en) 1987-02-17 1991-07-16 Board Of Regents, The University Of Texas System Methods and compositions employing unique mixtures of polar and neutral lipids for surfactant replacement therapy
US5089181A (en) 1987-02-24 1992-02-18 Vestar, Inc. Method of dehydrating vesicle preparations for long term storage
FR2611501B1 (fr) 1987-03-04 1991-12-06 Corbiere Jerome Nouvelles compositions pharmaceutiques pour la voie buccale a base d'acetylsalielylate de lysine et leur procede d'obtention
CA1337268C (fr) 1987-03-09 1995-10-10 Edmund P. Bass Vaccin contre le virus de la maladie de carre
US5718921A (en) 1987-03-13 1998-02-17 Massachusetts Institute Of Technology Microspheres comprising polymer and drug dispersed there within
US4855326A (en) 1987-04-20 1989-08-08 Fuisz Pharmaceutical Ltd. Rapidly dissoluble medicinal dosage unit and method of manufacture
US5387431A (en) 1991-10-25 1995-02-07 Fuisz Technologies Ltd. Saccharide-based matrix
JP2656944B2 (ja) 1987-04-30 1997-09-24 クーパー ラボラトリーズ タンパク質性治療剤のエアロゾール化
US4861627A (en) 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
GB8712176D0 (en) 1987-05-22 1987-06-24 Cosmas Damian Ltd Drug delivery system
US5690954A (en) 1987-05-22 1997-11-25 Danbiosyst Uk Limited Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US5571499A (en) 1987-06-24 1996-11-05 Autoimmune, Inc. Treatment of autoimmune diseases by aerosol administration of autoantigens
US5069936A (en) 1987-06-25 1991-12-03 Yen Richard C K Manufacturing protein microspheres
GB8715238D0 (en) 1987-06-29 1987-08-05 Quadrant Bioresources Ltd Food process
US5240712A (en) 1987-07-17 1993-08-31 The Boots Company Plc Therapeutic agents
US5043158A (en) 1987-08-21 1991-08-27 Chembiomed, Ltd. Immunogenic compositions containing ordered carriers
CA1327161C (fr) 1987-09-01 1994-02-22 Mitsugu Kobayashi Composition pharmaceutique lyophilisee d'un derive de neocarzinostatine
GB8722622D0 (en) 1987-09-25 1987-11-04 Halo Retail Systems Ltd Dot-matrix printers
GB8723846D0 (en) 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system
EP0325936A3 (fr) 1988-01-16 1990-01-17 Ono Pharmaceutical Co., Ltd. Dérivés d'aminoguanidine et agents inhibiteurs pour la réaction de maillard les contenant comme ingrédient actives
GB8801338D0 (en) 1988-01-21 1988-02-17 Quadrant Bioresources Ltd Preservation of viruses
GB8802174D0 (en) 1988-02-01 1988-03-02 Quadrant Bioresources Ltd Method of drying macromolecules
DE3815221C2 (de) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
US5045446A (en) 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
US4950477A (en) 1988-08-23 1990-08-21 Memorial Hospital For Cancer And Allied Dieseas Method of preventing and treating pulmonary infection by fungi using aerosolized polyenes
US5049664A (en) 1988-08-26 1991-09-17 Sawai Pharmaceutical Co., Ltd. Trehalose derivatives
US5342625A (en) 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
EP0360340A1 (fr) 1988-09-19 1990-03-28 Akzo N.V. Composition pour administration par voie nasale contenant un peptide
JP2733259B2 (ja) 1988-09-20 1998-03-30 旭化成工業株式会社 多孔性微小セルロース粒子
IT1230508B (it) 1988-10-11 1991-10-25 Italiana Sali C I S S P A Comp Composizione autodisperdente in acqua particolarmente adatta per il trattamento della cute
US4984158A (en) 1988-10-14 1991-01-08 Hillsman Dean Metered dose inhaler biofeedback training and evaluation system
GB8824897D0 (en) 1988-10-24 1988-11-30 Ici Plc Biocatalysts
GB8826429D0 (en) 1988-11-11 1988-12-14 Univ Leeds Ind Service Ltd Enzyme stabilisation systems
US5776434A (en) 1988-12-06 1998-07-07 Riker Laboratories, Inc. Medicinal aerosol formulations
GB8828477D0 (en) 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
US5225183A (en) 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
US5043165A (en) 1988-12-14 1991-08-27 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs
US4906476A (en) 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US5006343A (en) 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
CA2008176A1 (fr) 1989-01-25 1990-07-25 John W. Palmour Diode de schottky au carbure de silicium et methode de fabrication de cette diode
US5011678A (en) 1989-02-01 1991-04-30 California Biotechnology Inc. Composition and method for administration of pharmaceutically active substances
GB8903593D0 (en) 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
IT1228459B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
US5744166A (en) 1989-02-25 1998-04-28 Danbiosyst Uk Limited Drug delivery compositions
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
FR2645021A1 (fr) 1989-03-30 1990-10-05 Sanofi Sa Utilisation d'un agoniste potassique dans le traitement du glaucome
AU5414990A (en) 1989-04-12 1990-11-05 Aberdeen University Slow release vitreous systems
US5270048A (en) 1989-04-21 1993-12-14 Borden (Uk) Limited Controlled delivery devices
JPH0739339B2 (ja) 1989-05-01 1995-05-01 アルカーメス コントロールド セラピューティクス，インコーポレイテッド 生物活性を有する分子の小粒子の製造方法
US4955371A (en) 1989-05-08 1990-09-11 Transtech Scientific, Inc. Disposable inhalation activated, aerosol device for pulmonary medicine
US5069786A (en) 1989-06-15 1991-12-03 Cuno, Incorporated Filter apparatus snap lock cartridge retainer
FI84698C (fi) 1989-06-16 1992-01-10 Huhtamaeki Oy Anordning foer finfoerdelning av agglomerat av en enkeldos av ett laekemedelpreparat i pulverform.
JP2783848B2 (ja) * 1989-07-04 1998-08-06 晟 八木 新規ホスファチジルコリンカルシウムとその製法
US5174988A (en) 1989-07-27 1992-12-29 Scientific Development & Research, Inc. Phospholipid delivery system
GB8917470D0 (en) 1989-07-31 1989-09-13 Quadrant Bioresources Ltd Composition and method
US5725871A (en) 1989-08-18 1998-03-10 Danbiosyst Uk Limited Drug delivery compositions comprising lysophosphoglycerolipid
US5240846A (en) 1989-08-22 1993-08-31 The Regents Of The University Of Michigan Gene therapy vector for cystic fibrosis
US5562608A (en) 1989-08-28 1996-10-08 Biopulmonics, Inc. Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation
US5208226A (en) 1989-09-08 1993-05-04 Glaxo Group Limited Medicaments
FR2651680B1 (fr) 1989-09-14 1991-12-27 Medgenix Group Sa Nouveau procede de preparation de microparticules lipidiques.
GB8921222D0 (en) 1989-09-20 1989-11-08 Riker Laboratories Inc Medicinal aerosol formulations
FR2652497A1 (fr) 1989-09-29 1991-04-05 Mendolia Georges Prothese femoro-patellaire et ses dispositifs de mise en place.
US5013557A (en) 1989-10-03 1991-05-07 Warner-Lambert Company Taste masking compositions comprising spray dried microcapsules containing sucralfate and methods for preparing same
IT1237118B (it) 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
US5707644A (en) 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
GB2237510B (en) 1989-11-04 1993-09-15 Danbiosyst Uk Small particle drug compositions for nasal administration
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
JPH03161441A (ja) 1989-11-20 1991-07-11 Senjiyu Seiyaku Kk メイラード反応阻害剤
JP2854631B2 (ja) 1989-11-21 1999-02-03 千寿製薬株式会社 糖尿病合併症および老化によって引き起こされる疾患の予防・治療剤
GB8926643D0 (en) 1989-11-24 1990-01-17 Unilever Plc Cleaning composition
CA2030718C (fr) 1989-11-28 1998-05-12 Jacob Berger Composes tricycliques
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
GB9001635D0 (en) 1990-01-24 1990-03-21 Ganderton David Aerosol carriers
NL9000207A (fr) 1990-01-29 1991-08-16 Duphar Int Res
IL97065A (en) 1990-02-02 1994-01-25 Fisons Plc Repellent preparations for aerosol
KR920700632A (ko) 1990-02-19 1992-08-10 요시다 쇼오지 메일라드 반응저해제
GB9003821D0 (en) 1990-02-20 1990-04-18 Danbiosyst Uk Diagnostic aid
FR2658418B1 (fr) 1990-02-20 1994-09-02 Synthelabo Compositions pharmaceutiques a base de phospholipides.
CA2036844A1 (fr) 1990-02-22 1991-08-23 Hua-Pin Huang Aerosol permettant une liberation reglee de microspheres de procaterol
US5925337A (en) 1990-03-01 1999-07-20 L'oreal Waterproof composition for covering the eyelashes, and process for the preparation thereof
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
JP2859919B2 (ja) 1990-03-15 1999-02-24 旭化成工業株式会社 難溶性薬物の溶出性改善方法
US5118494A (en) 1990-03-23 1992-06-02 Minnesota Mining And Manufacturing Company Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
US5312909A (en) 1990-03-28 1994-05-17 Gist Brocades, N.V. Recombinant DNA encoding neutral trehalase
IN172208B (fr) 1990-04-02 1993-05-01 Sint Sa
JPH05963A (ja) 1990-04-13 1993-01-08 Toray Ind Inc ポリペプチド類組成物
ES2132780T3 (es) * 1990-04-17 1999-08-16 Liposome Co Inc Sintesis enzimatica de fosfatidos solubles a partir de fosfolipidos.
US5112596A (en) 1990-04-23 1992-05-12 Alkermes, Inc. Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
US5145369A (en) 1990-04-23 1992-09-08 L. Paul Lustig Dental tool driving apparatus having rotating and roto-reciprocating motions
AU7908791A (en) 1990-05-08 1991-11-27 Liposome Technology, Inc. Direct spray-dried drug/lipid powder composition
GB9010742D0 (en) 1990-05-14 1990-07-04 Quadrant Bioresources Ltd Stabilization of biological macromolecular substances
US5621094A (en) 1990-05-14 1997-04-15 Quadrant Holdings Cambridge Limited Method of preserving agarose gel structure during dehydration by adding a non-reducing glycoside of a straight-chain sugar alcohol
GB9012663D0 (en) 1990-06-07 1990-08-01 Erba Carlo Spa Galenic formulations containing cyclodextrins
CA2086096A1 (fr) 1990-06-27 1991-12-28 Robert A. Moris Utilisation de fluorosurfactants pour la preparation de formulations pour inhalateurs doseurs en aerosol
US5126123A (en) 1990-06-28 1992-06-30 Glaxo, Inc. Aerosol drug formulations
PT98105B (pt) 1990-06-28 1998-11-30 Glaxo Inc Processo para a preparacao de formulacoes em aerossol contendo como propulsor 1,1,1,2-tetrafluoroetano
DE69124374T2 (de) 1990-06-29 1997-06-19 Fisons Plc, Ipswich, Suffolk Druckaerosolzusammensetzung
IT1246350B (it) 1990-07-11 1994-11-17 Eurand Int Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili
EP0539522B1 (fr) 1990-07-19 1998-12-30 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Procede immunotherapeutique ameliore pour la prevention ou le traitement des maladies virales des voies respiratoires
WO1992002133A1 (fr) 1990-08-10 1992-02-20 Analytical Control Systems, Inc. Compositions diagnostiques et therapeutiques ameliorees
US4999384A (en) 1990-08-14 1991-03-12 General Electric Company Foamed blends of nylon 6,I/T and polycarbonate
US5230884A (en) 1990-09-11 1993-07-27 University Of Wales College Of Cardiff Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations
CA2051092C (fr) 1990-09-12 2002-07-23 Stephen A. Livesey Methode et appareillage pour la cryopreservation, la stabilisation a sec et la rehydratation de suspensions biologiques
US5200399A (en) 1990-09-14 1993-04-06 Boyce Thompson Institute For Plant Research, Inc. Method of protecting biological materials from destructive reactions in the dry state
FR2667072B1 (fr) * 1990-09-24 1993-08-13 Bioetica Sa Complexe ternaire de chitosane, d'ions calcium et de lipides, procede de preparation et leurs applications.
US5518731A (en) 1990-09-27 1996-05-21 Allergan, Inc. Nonaqueous fluorinated drug delivery vehicle suspensions
US5173298A (en) 1990-09-27 1992-12-22 Allergan, Inc. Nonaqueous fluorinated drug delivery vehicle suspensions
US5304125A (en) 1990-10-05 1994-04-19 The University Of North Carolina Apparatus for administering solid particulate aerosols to the lungs
US5149543A (en) 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
JP2769925B2 (ja) 1990-10-18 1998-06-25 ミネソタ マイニング アンド マニュファクチャリング カンパニー ベクロメタゾン１７，２１ジプロピオネートを含んで成るエアロゾル製剤
GB9024365D0 (en) 1990-11-09 1991-01-02 Glaxo Group Ltd Medicaments
EP0563120B1 (fr) 1990-12-17 1997-10-01 Minnesota Mining And Manufacturing Company Inhalateur
JPH04230625A (ja) 1990-12-27 1992-08-19 Standard Chem & Pharmaceut Corp Ltd 噴霧乾燥したジクロフェナクナトリウムを含み腸溶性の被覆を有するマイクロカプセルからなる微分散した錠剤組成物の製造方法
US5616311A (en) 1991-01-15 1997-04-01 Hemosphere, Inc. Non-crosslinked protein particles for therapeutic and diagnostic use
DK0495187T3 (da) 1991-01-15 1997-08-11 Hemosphere Inc Protein-nanomatricer og fremstillingsmetode.
US5552160A (en) 1991-01-25 1996-09-03 Nanosystems L.L.C. Surface modified NSAID nanoparticles
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
DE69233479T2 (de) 1991-02-08 2006-03-16 Scion Pharmaceuticals, Inc., Medford Substituierte Guanidine und Derivate hiervon als Modulatoren der Freisetzung von Neurotransmittern und neue Methode zur Identifizierung von Inhibitoren der Neurotransmitter-Freisetzung
DE69229070T2 (de) 1991-02-09 1999-11-18 B.S.D. Bio Science Development Snc Di Omini C. & Zuccari G., Bussero Antireaktive antiasthmatische Wirkung von Acetylsalicylsäure durch Inhalation
US5182097A (en) 1991-02-14 1993-01-26 Virginia Commonwealth University Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
US5190029A (en) 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
AU1442592A (en) 1991-02-20 1992-09-15 Nova Pharmaceutical Corporation Controlled release microparticulate delivery system for proteins
JP3532204B2 (ja) 1991-03-05 2004-05-31 アラダイム コーポレーション 流量計の圧力センサのドリフトオフセットを補正する方法および装置
US5450336A (en) 1991-03-05 1995-09-12 Aradigm Corporation Method for correcting the drift offset of a transducer
US5404871A (en) 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
AU643141B2 (en) 1991-03-15 1993-11-04 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
DE59107894D1 (de) 1991-03-21 1996-07-11 Ritzau Pari Werk Gmbh Paul Vernebler insbesondere zur Anwendung in Geräten für die Inhalationstherapie
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5993805A (en) 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
SE9101090D0 (sv) 1991-04-11 1991-04-11 Astra Ab Process for conditioning of water-soluble substances
US5874063A (en) 1991-04-11 1999-02-23 Astra Aktiebolag Pharmaceutical formulation
US5437272A (en) 1991-05-01 1995-08-01 Alliance Pharmaceutical Corp. Perfluorocarbon associated gas exchange
EP0908178A1 (fr) 1991-05-03 1999-04-14 Alliance Pharmaceutical Corporation Respiration liquide partielle des fluorocarbones
DE69228332T2 (de) 1991-05-07 1999-09-16 The Liposome Co.,Inc. Liposomale Prostaglandinformulierungen
US6060069A (en) 1991-05-20 2000-05-09 Dura Pharmaceuticals, Inc. Pulmonary delivery of pharmaceuticals
US5474759A (en) 1991-06-10 1995-12-12 Schering Corporation Non-chlorofluorocarbon aerosol formulations
ES2180592T3 (es) 1991-06-10 2003-02-16 Schering Corp Formulaciones en aerosol libres de clorofluorocarbonos.
AU659645B2 (en) 1991-06-26 1995-05-25 Inhale Therapeutic Systems Storage of materials
US6681767B1 (en) 1991-07-02 2004-01-27 Nektar Therapeutics Method and device for delivering aerosolized medicaments
DE69230613T2 (de) 1991-07-02 2000-12-28 Inhale Inc Verfahren und vorrichtung zum abgeben von medikamenten in aerosolform
CA2112905A1 (fr) 1991-07-05 1993-01-21 Michael R. Violante Particules poreuses ultra petites, non solidarisees, a bulles de gaz piegees
ATE126115T1 (de) 1991-07-31 1995-08-15 Blatter Farros Ag Schleifgerät zum schleifen einer zylindrischen oder sphärischen oberfläche einer walze, insbesondere einer walze einer papiermaschine.
GB9116610D0 (en) 1991-08-01 1991-09-18 Danbiosyst Uk Preparation of microparticles
TW221689B (fr) 1991-08-27 1994-03-11 Otsuka Pharma Co Ltd
GB9120005D0 (en) 1991-09-19 1991-11-06 Wellcome Found Method of administering phospholipid dispersions
US6123924A (en) 1991-09-25 2000-09-26 Fisons Plc Pressurized aerosol inhalation compositions
IL103238A (en) 1991-09-25 1995-07-31 Fisons Plc Pressurised aerosol compositions
US6013638A (en) 1991-10-02 2000-01-11 The United States Of America As Represented By The Department Of Health And Human Services Adenovirus comprising deletions on the E1A, E1B and E3 regions for transfer of genes to the lung
GB9123953D0 (en) 1991-11-12 1992-01-02 Minnesota Mining & Mfg Inhalation device
EP0808636A1 (fr) 1991-11-14 1997-11-26 Alliance Pharmaceutical Corporation Procédé de respiration artificielle partielle de liquide au moyen de fluorocarbones
ES2090714T3 (es) 1991-12-05 1996-10-16 Mallinckrodt Veterinary Inc Matriz de vidrio de carbohidrato para la liberacion prolongada de un agente terapeutico.
DE4140689B4 (de) 1991-12-10 2007-11-22 Boehringer Ingelheim Kg Inhalationspulver und Verfahren zu ihrer Herstellung
IL104068A (en) 1991-12-12 1998-10-30 Glaxo Group Ltd Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant
US5658549A (en) 1991-12-12 1997-08-19 Glaxo Group Limited Aerosol formulations containing propellant 134a and fluticasone propionate
US5744123A (en) 1991-12-12 1998-04-28 Glaxo Group Limited Aerosol formulations containing P134a and particulate medicaments
US5736124A (en) 1991-12-12 1998-04-07 Glaxo Group Limited Aerosol formulations containing P134a and particulate medicament
DE69205177T2 (de) 1991-12-12 1996-03-21 Glaxo Group Ltd., Greenford, Middlesex Pharmazeutische Aerosolformulierung.
DE69227257T2 (de) 1991-12-12 1999-03-25 Glaxo Group Ltd Arzneimittel
US5674471A (en) 1991-12-12 1997-10-07 Glaxo Group Limited Aerosol formulations containing P134a and salbutamol
US5653962A (en) 1991-12-12 1997-08-05 Glaxo Group Limited Aerosol formulations containing P134a and particulate medicaments
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
CA2083676A1 (fr) 1991-12-17 1993-06-18 Paul E. Naton Compositions contenant des microspheres creuses
EP0625207A1 (fr) 1991-12-17 1994-11-23 The Regents Of The University Of California Therapie des genes pour activite regulatrice de la conductance transmembranaire de la fibrose cystique
AU675633B2 (en) * 1991-12-18 1997-02-13 Minnesota Mining And Manufacturing Company Suspension aerosol formulations
US5849700A (en) 1991-12-20 1998-12-15 Novo Nordisk A/S Pharmaceutical formulation
FR2685857A1 (fr) 1992-01-06 1993-07-09 Jean Marcel Bombe a aerosols contenant des micro-capsules.
DE69306755T2 (de) 1992-01-21 1997-04-10 Stanford Res Inst Int Verbessertes verfahren zur herstellung von mikronisierter polypeptidarzneimitteln
GB9202519D0 (en) 1992-02-06 1992-03-25 Glaxo Group Ltd Medicaments
KR950700083A (ko) 1992-03-03 1995-01-16 스즈키 다다시 경구용 백신(oral vaccine)
US5607662A (en) 1992-03-10 1997-03-04 Fisons, Plc Pharmaceutical inhalation compositions
US5912015A (en) * 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US5656297A (en) 1992-03-12 1997-08-12 Alkermes Controlled Therapeutics, Incorporated Modulated release from biocompatible polymers
AU2088992A (en) 1992-05-05 1993-11-11 Research Foundation For Microbial Diseases Of Osaka University, The Stabilized live vaccine
IT1254359B (it) 1992-05-11 1995-09-14 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti il-6
NL9200844A (nl) 1992-05-13 1993-12-01 De Wijdeven Gijsbertus G P Van Inrichting en werkwijze voor het injecteren met een vaste stof.
US5292513A (en) 1992-05-18 1994-03-08 Anthony G. Gristina Method for nonspecific cellular immune stimulation
US5215079A (en) 1992-05-19 1993-06-01 Armstrong Pharmaceuticals, Inc. Single dose metered dose inhaler for delivery of vaccines and other drugs
US5711968A (en) 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
WO1993025198A1 (fr) 1992-06-12 1993-12-23 Teijin Limited Poudre ultra-fine pour inhalation et production de cette poudre
GB9213874D0 (en) 1992-06-30 1992-08-12 Fisons Plc Process to novel medicament form
US5376359A (en) 1992-07-07 1994-12-27 Glaxo, Inc. Method of stabilizing aerosol formulations
US6673335B1 (en) 1992-07-08 2004-01-06 Nektar Therapeutics Compositions and methods for the pulmonary delivery of aerosolized medicaments
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US5284133A (en) 1992-07-23 1994-02-08 Armstrong Pharmaceuticals, Inc. Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means
MX9304585A (es) 1992-07-31 1994-03-31 Glaxo Group Ltd Formulacion farmaceutica en aerosol, lata adecuada para liberar la formulacion e inhalador de dosis dosificada que comprende la lata.
GB2269992A (en) 1992-08-14 1994-03-02 Rh Ne Poulenc Rorer Limited Powder inhalation formulations
US5239993A (en) 1992-08-26 1993-08-31 Glaxo Inc. Dosage inhalator providing optimized compound inhalation trajectory
DE69332105T2 (de) 1992-09-29 2003-03-06 Inhale Therapeutic Systems, San Carlos Pulmonale abgabe von aktiven fragmenten des parathormons
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
WO1994008599A1 (fr) 1992-10-14 1994-04-28 The Regents Of The University Of Colorado Appariement d'ions de medicaments pour ameliorer l'efficacite et l'administration
ATE174804T1 (de) 1992-10-19 1999-01-15 Dura Pharma Inc Trockenpulverinhalator
US5380473A (en) 1992-10-23 1995-01-10 Fuisz Technologies Ltd. Process for making shearform matrix
US5422384A (en) 1992-11-25 1995-06-06 Battelle Memorial Institute Glass/polymer composites and methods of making
JP3168550B2 (ja) 1992-12-02 2001-05-21 株式会社林原生物化学研究所 脱水剤およびそれを用いる含水物の脱水方法並びにその方法で得られる脱水物品
JPH08503950A (ja) 1992-12-02 1996-04-30 アルカーメス・コントロールド・セラピユーテイクス・インコーポレーテツド 徐放性成長ホルモン含有マイクロスフェア
SE9203743D0 (sv) 1992-12-11 1992-12-11 Astra Ab Efficient use
US5453514A (en) 1992-12-25 1995-09-26 Yamanouchi Pharmaceutical Co., Ltd. Pyrazole derivatives and compositions and methods of use as maillard reaction inhibitors
JPH08505625A (ja) 1993-01-11 1996-06-18 ダナ−ファーバー キャンサー インスティチュート 細胞毒性ｔリンパ球応答の誘導
JP3264537B2 (ja) 1993-01-22 2002-03-11 キヤノン株式会社 通信装置及びその制御方法
US5694919A (en) 1993-01-29 1997-12-09 Aradigm Corporation Lockout device for controlled release of drug from patient-activated dispenser
US5743250A (en) 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US5507277A (en) 1993-01-29 1996-04-16 Aradigm Corporation Lockout device for controlled release of drug from patient-activateddispenser
US5724957A (en) 1993-01-29 1998-03-10 Aradigm Corporation Intrapulmonary delivery of narcotics
US6131567A (en) 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US5354934A (en) 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
RU2075700C1 (ru) 1993-02-16 1997-03-20 Казанский инженерно-строительный институт Вентиляционное укрытие
DK0686045T3 (da) 1993-02-23 2001-03-05 Genentech Inc Stabilisering af med organisk opløsningsmiddel behandlede polypeptider med et hjælpestof
US5437274A (en) 1993-02-25 1995-08-01 Gholam A. Peyman Method of visualizing submicron-size vesicles and particles in blood circulation
AU679511B2 (en) 1993-03-17 1997-07-03 Minnesota Mining And Manufacturing Company Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid
WO1994022473A1 (fr) 1993-04-01 1994-10-13 University Of Washington Utilisation d'interleukine 7 pour ameliorer l'efficacite d'un vaccin
US5994314A (en) 1993-04-07 1999-11-30 Inhale Therapeutic Systems, Inc. Compositions and methods for nucleic acid delivery to the lung
US20020132787A1 (en) 1993-04-07 2002-09-19 Mohammed Eljamal Compositions and methods for nucleic acid delivery to the lung
DK42093D0 (da) 1993-04-07 1993-04-07 Bukh Meditec Administrationsmetode
TW404844B (en) 1993-04-08 2000-09-11 Oxford Biosciences Ltd Needleless syringe
US5492688A (en) 1993-04-28 1996-02-20 The Center For Innovative Technology Metered dose inhaler fomulations which include the ozone-friendly propellant HFC 134a and a pharmaceutically acceptable suspending, solubilizing, wetting, emulsifying or lubricating agent
US5497763A (en) 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
ES2068151B1 (es) 1993-06-23 1995-11-16 Cabrera Garrido Juan Microespuma inyectable para esclerosis.
US5747445A (en) 1993-06-24 1998-05-05 Astra Aktiebolag Therapeutic preparation for inhalation
IS1796B (is) 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
TW402506B (en) 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
US5830853A (en) 1994-06-23 1998-11-03 Astra Aktiebolag Systemic administration of a therapeutic preparation
US5506203C1 (en) 1993-06-24 2001-02-06 Astra Ab Systemic administration of a therapeutic preparation
GB9313642D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
GB9313650D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
GB9314886D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Production of a biological control agent
EP1550464A1 (fr) 1993-07-30 2005-07-06 IMCOR Pharmaceutical Co. Composition à microbulles stabilisées pour application mettant en oeuvre des ultrasons
SE9302550D0 (sv) 1993-07-30 1993-07-30 Ernst Hoerlin Powder inhaler
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US5508203A (en) * 1993-08-06 1996-04-16 Fuller; Milton E. Apparatus and method for radio frequency spectroscopy using spectral analysis
GB9316745D0 (en) 1993-08-12 1993-09-29 Medeva Holdings Bv Vaccine compositions
EP0714314B1 (fr) 1993-08-18 1998-10-14 FISONS plc Inhalateur pourvu d'un systeme de regulation du debit d'air
AU4953393A (en) 1993-08-24 1995-03-21 Mogen International N.V. Production of trehalose in plants
US5470885A (en) 1993-09-29 1995-11-28 The Research Foundation Of The State University Of New York Fluorocarbons as anti-inflammatory agents
US5994318A (en) * 1993-10-04 1999-11-30 Albany Medical College Cochleate delivery vehicles
DE4334071C1 (de) 1993-10-06 1995-02-09 Siemens Ag Verfahren zur Verminderung der Stickoxidkonzentration im Abgas einer Brennkraftmaschine oder einer Verbrennungsanlage
JP2828391B2 (ja) 1993-10-29 1998-11-25 東燃株式会社 オリゴ糖を表面に有するリポソーム
EP0655237A1 (fr) 1993-11-27 1995-05-31 Hoechst Aktiengesellschaft Composition d'aerosol medicinal
PT731688E (pt) 1993-12-02 2003-07-31 Abbott Lab Formulacoes de farmacos em aerossol para utilizacao com propulsores sem cfc
DE69424181T2 (de) 1993-12-20 2000-10-19 Minnesota Mining And Mfg. Co., Saint Paul Flunisolide aerosolformulierungen
JPH07203396A (ja) 1993-12-28 1995-08-04 Sony Corp 字幕データ復号化装置
PT101450B (pt) 1994-02-02 1999-11-30 Hovione Produtos Farmaceuticos Novo dispositivo para inalacao
JPH09511492A (ja) 1994-02-03 1997-11-18 ザ ピコワー インスティテュート フォア メディカル リサーチ アミロイドーシスの前進性グリコシル化終末産物仲介モジュレーション用組成物及び方法
US5502092A (en) 1994-02-18 1996-03-26 Minnesota Mining And Manufacturing Company Biocompatible porous matrix of bioabsorbable material
JP2986215B2 (ja) 1994-03-04 1999-12-06 ジェネンテック インコーポレイテッド Ｄｎアーゼ含有医薬製剤
US20030113273A1 (en) 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
EP0748213B1 (fr) 1994-03-07 2004-04-14 Nektar Therapeutics Procede et preparations pour l'administration d'insuline par voie pulmonaire
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
WO1995024892A1 (fr) 1994-03-14 1995-09-21 Abbott Laboratories Formule d'un aerosol medicamenteux contenant de la vitamine e
EP0803513B1 (fr) 1994-03-18 2002-07-03 Kao Corporation Particule poreuse fine et produit cosmetique
US5508023A (en) 1994-04-11 1996-04-16 The Center For Innovative Technology Pharmaceutically acceptable agents for solubilizing, wetting, emulsifying, or lubricating in metered dose inhaler formulations which use HFC-227 propellant
GB2288732B (en) 1994-04-13 1998-04-29 Quadrant Holdings Cambridge Pharmaceutical compositions
US5955448A (en) 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
GB9408053D0 (en) 1994-04-22 1994-06-15 Nat Heart & Lung Inst Pharmaceutical preparation
DE69518316T2 (de) 1994-05-10 2001-03-29 American Home Products Corp., Madison Modifizierter,verbesserter,lebender brsv impfstoff
WO1995031182A1 (fr) 1994-05-13 1995-11-23 Aradigm Corporation Formulation en aerosol contenant un narcotique
WO1995031479A1 (fr) 1994-05-18 1995-11-23 Inhale Therapeutic Systems, Inc. Procedes et compositions pour produire des interferons sous forme de poudre seche
GB9410222D0 (en) 1994-05-21 1994-07-06 Glaxo Wellcome Australia Ltd Medicaments
CN1188171C (zh) 1994-06-02 2005-02-09 廓德伦特控股剑桥有限公司 防止各种特质在再水化或熔化时聚集的方法以及由此获得的组合物
US5567439A (en) 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
CA2126034A1 (fr) 1994-06-16 1995-12-17 Amado Cordova Bobine de capteur de gyroscope a fibre optique a enrobage de protection contre les vibrations et la chaleur
US6142216A (en) 1994-07-27 2000-11-07 Bradford White Corporation Indirect water heater
US5591453A (en) 1994-07-27 1997-01-07 The Trustees Of The University Of Pennsylvania Incorporation of biologically active molecules into bioactive glasses
SK283026B6 (sk) 1994-08-04 2003-02-04 Quadrant Holdings Cambridge Limited Tuhý časticový prostriedok na terapeutické použitie a spôsob jeho prípravy
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US5635159A (en) 1994-08-26 1997-06-03 Abbott Laboratories Aerosol drug formulations containing polyglycolyzed glycerides
ES2151079T3 (es) 1994-09-09 2000-12-16 Takeda Chemical Industries Ltd Preparacion de liberacion sostenida que contiene una sal metalica de un peptido.
JP3706136B2 (ja) 1994-09-21 2005-10-12 ネクター セラピューティクス 乾燥粉末薬剤の分散装置及び方法
DE4434629C1 (de) 1994-09-28 1996-06-27 Byk Gulden Lomberg Chem Fab Zusammensetzungen zur Behandlung von IRDS und ARDS
RU2147226C1 (ru) 1994-09-29 2000-04-10 Квадрант Хэлткэа (Ю Кей) Лимитед Высушенные распылением микрочастицы как терапевтические носители
US6117455A (en) 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
US5547696A (en) 1994-10-13 1996-08-20 Novo Nordisk A/S Pharmaceutical formulation
US5631225A (en) 1994-10-13 1997-05-20 Novo Nordisk A/S Pharmaceutical formulation
US5654278A (en) 1994-10-13 1997-08-05 Novo Nordisk A/S Composition and method comprising growth hormone and leucine
US5512547A (en) 1994-10-13 1996-04-30 Wisconsin Alumni Research Foundation Pharmaceutical composition of botulinum neurotoxin and method of preparation
US5535089A (en) 1994-10-17 1996-07-09 Jing Mei Industrial Holdings, Ltd. Ionizer
US5508269A (en) 1994-10-19 1996-04-16 Pathogenesis Corporation Aminoglycoside formulation for aerosolization
GB9423419D0 (en) 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
US5660854A (en) 1994-11-28 1997-08-26 Haynes; Duncan H Drug releasing surgical implant or dressing material
JPH08157491A (ja) 1994-11-30 1996-06-18 Hayashibara Biochem Lab Inc トレハロース誘導体の製造方法
CA2207077C (fr) 1994-12-16 2007-02-06 Andaris Limited Microparticules reticulees et utilisation de ces particules comme vehicules therapeutiques
CN1088580C (zh) 1994-12-22 2002-08-07 阿斯特拉公司 气溶胶药物制剂
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
SA95160463B1 (ar) 1994-12-22 2005-10-04 استرا أكتيبولاج مساحيق للاستنشاق
GB9426252D0 (en) 1994-12-24 1995-02-22 Glaxo Group Ltd Pharmaceutical composition
US5681746A (en) 1994-12-30 1997-10-28 Chiron Viagene, Inc. Retroviral delivery of full length factor VIII
US5705482A (en) 1995-01-13 1998-01-06 Novo Nordisk A/S Pharmaceutical formulation
US5569448A (en) 1995-01-24 1996-10-29 Nano Systems L.L.C. Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions
US5962424A (en) 1995-02-21 1999-10-05 Arch Development Corporation Methods and compositions for targeting selectins
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5747001A (en) 1995-02-24 1998-05-05 Nanosystems, L.L.C. Aerosols containing beclomethazone nanoparticle dispersions
WO1996027393A1 (fr) 1995-03-07 1996-09-12 University Of Pittsburgh Formulation de poudre seche pour therapie genique
DE19510690A1 (de) 1995-03-14 1996-09-19 Schering Ag Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie
US5659297A (en) 1995-03-27 1997-08-19 Eaton Corporation Display system
US5653961A (en) 1995-03-31 1997-08-05 Minnesota Mining And Manufacturing Company Butixocort aerosol formulations in hydrofluorocarbon propellant
US5612053A (en) 1995-04-07 1997-03-18 Edward Mendell Co., Inc. Controlled release insufflation carrier for medicaments
US5474059A (en) 1995-04-08 1995-12-12 Cooper; Guy F. Aerosol dispensing apparatus for dispensing a medicated vapor into the lungs of a patient
US6258341B1 (en) 1995-04-14 2001-07-10 Inhale Therapeutic Systems, Inc. Stable glassy state powder formulations
US6019968A (en) 1995-04-14 2000-02-01 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
US6309671B1 (en) 1995-04-14 2001-10-30 Inhale Therapeutic Systems Stable glassy state powder formulations
US5780014A (en) 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
KR19980703876A (ko) 1995-04-14 1998-12-05 스티븐 엘. 허스트 분산성이 개선된 분말화된 약학적 조성물
US6165463A (en) 1997-10-16 2000-12-26 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
US6190859B1 (en) 1995-04-17 2001-02-20 The United States Of America As Represented By The Secretary Of The Army Method and kit for detection of dengue virus
GB9508691D0 (en) 1995-04-28 1995-06-14 Pafra Ltd Stable compositions
US5770585A (en) 1995-05-08 1998-06-23 Kaufman; Robert J. Homogeneous water-in-perfluorochemical stable liquid dispersion for administration of a drug to the lung of an animal
US6428771B1 (en) 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
DE19518196A1 (de) 1995-05-22 1996-11-28 Zahnradfabrik Friedrichshafen Hilfskraftlenkung für Kraftfahrzeuge
ATE239451T1 (de) 1995-06-07 2003-05-15 Elan Drug Delivery Ltd Verfahren zur stabilen einarbeitung von substanzen in trockene geschäumte glasmatrizen und auf diese weise hergestellte zusammensetzungen
US5635161A (en) 1995-06-07 1997-06-03 Abbott Laboratories Aerosol drug formulations containing vegetable oils
US5904935A (en) 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US5667809A (en) 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
US5654007A (en) 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
US6129934A (en) 1995-06-07 2000-10-10 Ony, Inc. Modification of animal lung surfactant for treating respiratory disease due to lung surfactant deficiency or dysfunction
WO1996040066A1 (fr) 1995-06-07 1996-12-19 The Governors Of The University Of Alberta Procede pour induire une reaction immune specifique contre th1
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
EP0831932B1 (fr) 1995-06-07 2004-05-06 Imarx Pharmaceutical Corp. Nouvelles compositions ciblees, destinees a une utilisation diagnostique et therapeutique
US5811406A (en) 1995-06-07 1998-09-22 Regents Of The University Of California Dry powder formulations of polynucleotide complexes
WO1996040277A2 (fr) 1995-06-07 1996-12-19 Brown University Research Foundation Microparticules polymeres sechees par pulverisation contenant des agents d'imagerie
US6248720B1 (en) 1996-07-03 2001-06-19 Brown University Research Foundation Method for gene therapy using nucleic acid loaded polymeric microparticles
GB9515182D0 (en) 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
US5807552A (en) 1995-08-04 1998-09-15 Board Of Regents, The University Of Texas System Compositions for conferring immunogenicity to a substance and uses thereof
WO1997013503A1 (fr) 1995-10-13 1997-04-17 The Penn State Research Foundation Synthese de nanoparticules medicamenteuses par sechage par pulverisation
US6041777A (en) 1995-12-01 2000-03-28 Alliance Pharmaceutical Corp. Methods and apparatus for closed-circuit ventilation therapy
AU1354497A (en) 1995-12-21 1997-07-14 Drexel University Hollow polymer microcapsules and method of producing
CA2241880A1 (fr) 1996-01-03 1997-07-17 Glaxo Group Limited Dispositif d'inhalation
US5740064A (en) 1996-01-16 1998-04-14 Hewlett-Packard Co. Sampling technique for waveform measuring instruments
DE19601430C1 (de) 1996-01-17 1997-04-24 Lohmann Therapie Syst Lts Verfahren zur Wirkstoffapplikation an Pflanzen und dafür geeignete Zubereitung
CZ292186B6 (cs) 1996-01-24 2003-08-13 Altana Pharma Ag Způsob výroby práškového prostředku s obsahem plicní povrchově aktivní látky, práškový prostředek a jeho použití
DE19602332A1 (de) 1996-01-24 1997-07-31 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung von pulverförmigen Lungensurfactant-Zubereitungen
DK0904113T3 (da) 1996-03-05 2004-08-30 Acusphere Inc Mikroindkapslede fluorerede gasser til anvendelse som billeddannende midler
US5611344A (en) 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US5824133A (en) 1996-03-12 1998-10-20 Emr Microwave Technology Corporation Microwave treatment of metal bearing ores and concentrates
US5861175A (en) 1996-03-15 1999-01-19 Alliance Pharmaceutical Corp. Use of fluorocarbons for diagnosis and treatment of articular disorders
GB9605628D0 (en) 1996-03-18 1996-05-22 Univ North Wales Apparatus for carrying out reactions
GB9606188D0 (en) 1996-03-23 1996-05-29 Danbiosyst Uk Pollysaccharide microspheres for the pulmonary delivery of drugs
GB9606677D0 (en) 1996-03-29 1996-06-05 Glaxo Wellcome Inc Process and device
GB9607035D0 (en) 1996-04-03 1996-06-05 Andaris Ltd Spray-dried microparticles as therapeutic vehicles
US5875776A (en) 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
ATE247948T1 (de) 1996-04-29 2003-09-15 Dura Pharma Inc Verfahren zum inhalieren trockener pulver
GB9610341D0 (en) 1996-05-17 1996-07-24 Andaris Ltd Formulation for inhalation
WO1997044015A1 (fr) 1996-05-17 1997-11-27 Andaris Limited Microparticules et utilisation de ces dernieres pour soigner des plaies
US20020052310A1 (en) 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
USRE37053E1 (en) 1996-05-24 2001-02-13 Massachusetts Institute Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5855913A (en) 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US6503480B1 (en) 1997-05-23 2003-01-07 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US6254854B1 (en) 1996-05-24 2001-07-03 The Penn Research Foundation Porous particles for deep lung delivery
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US5766520A (en) 1996-07-15 1998-06-16 Universal Preservation Technologies, Inc. Preservation by foam formation
US5698537A (en) 1996-06-18 1997-12-16 Clarion Pharmaceuticals Inc. Method of lowering the viscosity of mucus
TW497974B (en) 1996-07-03 2002-08-11 Res Dev Foundation High dose liposomal aerosol formulations
DE69712108T2 (de) 1996-07-10 2002-12-12 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Ltd., Nottingham Gentherapiesystem zur zielung des endotheliums
GB9616237D0 (en) 1996-08-01 1996-09-11 Norton Healthcare Ltd Aerosol formulations
US5853740A (en) 1996-08-07 1998-12-29 Abbott Laboratories Delivery system for pharmaceutical agents encapsulated with oils
WO1998007414A1 (fr) 1996-08-22 1998-02-26 Research Triangle Pharmaceuticals Ltd. Compositions comprenant des microparticules de substances insolubles dans l'eau et procede de preparation associe
US5729948A (en) 1996-08-29 1998-03-24 Levy; Tzadok Apparatus and method for rigidly joining construction elements to one another
CN1162157C (zh) 1996-08-29 2004-08-18 先灵公司 无氯氟烃的糠酸莫米他松气溶胶制剂
US6017310A (en) 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
GB9620187D0 (en) 1996-09-27 1996-11-13 Minnesota Mining & Mfg Medicinal aerosol formulations
GB9621825D0 (en) 1996-10-19 1996-12-11 Andaris Ltd Microparticles and their use as therapeutic vehicles
SE507658C2 (sv) 1996-12-02 1998-06-29 Bofors Ab Sätt att lagra, transportera och leverera ammunition till artilleripjäser samt ett i enlighet därmed utformat transportfordon
US5875716A (en) 1996-12-05 1999-03-02 Markem Corporation Rotating ink cup
US6468782B1 (en) 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
US6068600A (en) 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
US6096291A (en) 1996-12-27 2000-08-01 Biovector Therapeutics, S.A. Mucosal administration of substances to mammals
US6517860B1 (en) 1996-12-31 2003-02-11 Quadrant Holdings Cambridge, Ltd. Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery
US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
JP2001507701A (ja) 1996-12-31 2001-06-12 インヘイル・セラピューティック・システムズ・インコーポレーテッド 親水性賦形剤を有する疎水性薬剤の溶液を噴霧乾燥するための方法及びその方法によって作製された組成物
GB9700624D0 (en) 1997-01-14 1997-03-05 Danbiosyst Uk Drug delivery composition
CA2277801C (fr) * 1997-01-16 2002-10-15 Massachusetts Institute Of Technology Preparation de particules pour inhalation
AU747577B2 (en) 1997-01-30 2002-05-16 Novartis Vaccines And Diagnostics, Inc. Use of microparticles with adsorbed antigen to stimulate immune responses
US5921447A (en) 1997-02-13 1999-07-13 Glaxo Wellcome Inc. Flow-through metered aerosol dispensing apparatus and method of use thereof
US5829435A (en) 1997-02-24 1998-11-03 Aradigm Corporation Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of undesirable particles
US5843193A (en) 1997-03-18 1998-12-01 Revlon Consumer Products Corporation Hair dye compositions and process
GB9705588D0 (en) 1997-03-18 1997-05-07 Anglia Research Foundation Stable particle in liquid formulations
US5898028A (en) 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US20020039594A1 (en) 1997-05-13 2002-04-04 Evan C. Unger Solid porous matrices and methods of making and using the same
BR9809149A (pt) 1997-05-20 2000-08-01 Galenica Pharmaceuticals Inc Análogos de triterpeno saponina dotados de adjuvante e atividade imonoestimulatória
WO1998058989A1 (fr) 1997-06-20 1998-12-30 Coloplast A/S Revetement hydrophile et procede de preparation dudit revetement
US20030035778A1 (en) 1997-07-14 2003-02-20 Robert Platz Methods and compositions for the dry powder formulation of interferon
FR2766706B1 (fr) 1997-07-30 2001-05-25 Biovector Therapeutics Sa Complexes particulaires stables de charge globale neutre ou negative de structure multilamellaire composes par au moins une substance biologiquement active globalement anionique et un constituant cationique, leur preparation et utilisation
US6048546A (en) 1997-07-31 2000-04-11 Sandia Corporation Immobilized lipid-bilayer materials
US5925334A (en) 1997-08-27 1999-07-20 Rubin; Bruce K. Use of surface active agents to promote mucus clearance
ES2248914T3 (es) 1997-08-29 2006-03-16 Corixa Corporation Agentes bioactivos encapsulados de liberacion rapida que permiten inducir o potenciar una respuesta inmunitaria y metodos para utilizar los mismos.
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US20020017295A1 (en) 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
WO1999016420A1 (fr) 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Preparations stabilisees pour nebuliseurs
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
ATE239447T1 (de) 1997-09-29 2003-05-15 Inhale Therapeutic Syst In verneblern verwendbare, stabilisierte zubereitungen
US6423334B1 (en) 1997-10-01 2002-07-23 Elan Corporation, Plc Composition and method for enhancing transport across gastrointestinal tract cell layers
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
WO1999032098A2 (fr) 1997-12-19 1999-07-01 Janssen Pharmaceutica N.V. Combinaison d'un agent bloquant le metabolisme de l'acide retinoique (ramba) et de tocopherol
KR100295517B1 (ko) * 1997-12-19 2001-10-29 사까모도 마사모도 정전잠상현상용토너,정전잠상현상제및화상형성방법
GB9727102D0 (en) 1997-12-22 1998-02-25 Andaris Ltd Microparticles and their therapeutic use
US6086376A (en) 1998-01-30 2000-07-11 Rtp Pharma Inc. Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant
CA2322435A1 (fr) 1998-03-02 1999-09-10 Applied Vaccine Technologies Corp. Procedes et dispositifs modulant la reponse immunitaire
GB9805102D0 (en) 1998-03-10 1998-05-06 Ciba Geigy Ag Device
RO121834B1 (ro) 1998-03-16 2008-06-30 Inhale Therapeutic Systems, Inc. Dispozitiv pentru administrarea unui agent activ
US6284282B1 (en) 1998-04-29 2001-09-04 Genentech, Inc. Method of spray freeze drying proteins for pharmaceutical administration
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
CA2336139C (fr) 1998-06-24 2008-10-14 Advanced Inhalation Research, Inc. Grandes particules poreuses emises par un inhalateur
WO2000000215A1 (fr) 1998-06-29 2000-01-06 Inhale Therapeutic Systems, Inc. Systemes administration de particules et procedes d'utilisation
GB9814172D0 (en) 1998-06-30 1998-08-26 Andaris Ltd Formulation for inhalation
US6165597A (en) 1998-08-12 2000-12-26 Swagelok Company Selective case hardening processes at low temperature
US6334182B2 (en) 1998-08-18 2001-12-25 Intel Corp Scheduling operations using a dependency matrix
PT1107743E (pt) 1998-08-25 2007-10-01 Advanced Inhalation Res Inc Formulações proteicas estáveis secas por pulverização
UA73924C2 (en) 1998-10-09 2005-10-17 Nektar Therapeutics Device for delivering active agent formulation to lungs of human patient
ATE308976T1 (de) 1998-11-10 2005-11-15 Altana Pharma Ag Lungensurfactant zubereitungen enthaltendes behandlungset
AU778797B2 (en) 1998-12-17 2004-12-23 Novartis Vaccines And Diagnostics, Inc. Method for the treatment of severe chronic bronchitis (bronchiectasis) with an aerosolized antibiotic
US6265384B1 (en) 1999-01-26 2001-07-24 Dale L. Pearlman Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents
GB9906695D0 (en) 1999-03-24 1999-05-19 Secr Defence Vaccine composition
US6630169B1 (en) 1999-03-31 2003-10-07 Nektar Therapeutics Particulate delivery systems and methods of use
US20020090381A1 (en) 1999-04-09 2002-07-11 H. Kim Bottomly System for controlling immune system response to antigen
US6737066B1 (en) 1999-05-06 2004-05-18 The Immune Response Corporation HIV immunogenic compositions and methods
MXPA01012246A (es) 1999-05-28 2002-08-12 Inhale Therapeutic Syst Aparato y metodo para distribuir una cantidad medida de medicamento en aerosol.
US6858199B1 (en) 2000-06-09 2005-02-22 Advanced Inhalation Research, Inc. High efficient delivery of a large therapeutic mass aerosol
US6606992B1 (en) 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
CA2382821A1 (fr) 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Modulation de liberation a partir de formulations seches en poudre
CA2383491A1 (fr) * 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Formulation permettant le sechage par atomisation de grandes particules poreuses
CA2389652A1 (fr) 1999-10-12 2001-04-19 National Research Council Of Canada Archeosomes comme porteurs immunomodulateurs servant a faire induire par des vaccins acellulaires des reactions de lymphocytes t cytotoxiques (ctl) et a proteger l'hote vaccine contre des pathogenes intracelulaires et le cancer
CN1188111C (zh) 1999-10-29 2005-02-09 耐科塔医药公司 分散性得到改进的干粉组合物
US20010035184A1 (en) 1999-12-17 2001-11-01 Carlos Schuler Systems and methods for treating packaged powders
US20020103165A1 (en) 2000-02-29 2002-08-01 Alliance Pharmaceutical Corp., Engineered spray-dried lipid-based microparticles for cellular targeting
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
WO2001085136A2 (fr) 2000-05-10 2001-11-15 Alliance Pharmaceutical Corporation Poudres a base de phospholipides permettant de distribuer un medicament
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
GB0011807D0 (en) 2000-05-16 2000-07-05 Quadrant Holdings Cambridge Formulation for inhalation
WO2002009674A2 (fr) 2000-07-28 2002-02-07 Inhale Therapeutic Systems, Inc. Nouveaux procedes et compositions destines a reguler positivement, a rediriger ou a limiter les reponses immunitaires aux peptides, proteines et autres composes bioactifs et aux vecteurs exprimant ces derniers
KR20030038690A (ko) 2000-08-07 2003-05-16 인헤일 테라퓨틱 시스템즈 인크. 응집이 최소화된, 흡입성 분무 건조 4-나선 다발 단백질분말
US6514482B1 (en) 2000-09-19 2003-02-04 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US6475468B2 (en) 2001-02-15 2002-11-05 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
US6551578B2 (en) 2001-02-15 2003-04-22 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
US6804260B2 (en) 2001-02-16 2004-10-12 Qualcomm, Incorporated Method for selectively maintaining and applying PPP compression in a wireless communication system
WO2003002834A1 (fr) 2001-06-29 2003-01-09 Sentry Protection Products, Inc. Appareil de protection pour piliers de structure
JP3620479B2 (ja) 2001-07-31 2005-02-16 株式会社島津製作所 イオン蓄積装置におけるイオン選別の方法
US6752893B2 (en) 2001-09-28 2004-06-22 Gentex Corporation Rimless spectacles and method for making the same
US20030096774A1 (en) 2001-11-21 2003-05-22 Igor Gonda Compositions of nucleic acids and cationic aminoglycosides and methods of using and preparing the same
JP2006509716A (ja) 2002-03-12 2006-03-23 マイクロドース・テクノロジーズ・インコーポレーテッド 吸入で同時投与した薬剤を特定部位へ届ける方法
US7101576B2 (en) 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
EP1589947B2 (fr) 2002-12-31 2019-01-30 Novartis AG Formulation pharmaceutique ayant un agent actif insoluble
FR2853450B1 (fr) * 2003-04-04 2006-09-08 Thales Sa Grille de commande d'un tube electronique
US20050214224A1 (en) 2003-11-04 2005-09-29 Nektar Therapeutics Lipid formulations for spontaneous drug encapsulation
US7192919B2 (en) 2004-01-07 2007-03-20 Stelios Tzannis Sustained release compositions for delivery of pharmaceutical proteins
EP1773301A2 (fr) 2004-06-21 2007-04-18 Nektar Therapeutics Compositions renfermant de l'amphotericine b, procedes et systemes correspondants

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JP2013237681A (ja) 2013-11-28
EP1282405A2 (fr) 2003-02-12
US7871598B1 (en) 2011-01-18
KR100845445B1 (ko) 2008-07-10
US8877162B2 (en) 2014-11-04
KR20030038541A (ko) 2003-05-16
KR20080031532A (ko) 2008-04-08
MXPA02011003A (es) 2004-08-19
EP2851067A1 (fr) 2015-03-25
US20140212504A1 (en) 2014-07-31
US20140377361A1 (en) 2014-12-25
CA2408464C (fr) 2016-01-26
AU2001259637A1 (en) 2001-11-20
JP5952231B2 (ja) 2016-07-13
US20130095153A1 (en) 2013-04-18
US8349294B2 (en) 2013-01-08
CA2408464A1 (fr) 2001-11-15
US20110082076A1 (en) 2011-04-07
WO2001085137A2 (fr) 2001-11-15
JP2003533449A (ja) 2003-11-11
US9439862B2 (en) 2016-09-13
WO2001085137A3 (fr) 2002-04-18

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