UA125962C2 - Біспецифічна антигензв'язуюча молекула до ox40 та фібробласт-активуючого білка (fap) - Google Patents

Біспецифічна антигензв'язуюча молекула до ox40 та фібробласт-активуючого білка (fap) Download PDF

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UA125962C2
UA125962C2 UAA201804698A UAA201804698A UA125962C2 UA 125962 C2 UA125962 C2 UA 125962C2 UA A201804698 A UAA201804698 A UA A201804698A UA A201804698 A UAA201804698 A UA A201804698A UA 125962 C2 UA125962 C2 UA 125962C2
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Ukraine
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amino acid
acid sequence
cells
domain
concentration
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UAA201804698A
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English (en)
Ukrainian (uk)
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Марія Аманн
Мария АМАНН
Петер Брюнкер
Крістіна Клаус
Кристина КЛАУС
Коллер Клаудіа Феррара
Коллер Клаудиа Феррара
Сандра Грау-Ріхардс
Сандра Грау-Рихардс
Ральф Хоссе
Крістіан Кляйн
Кристиан КЛЯЙН
Віктор Левітскі
Виктор ЛЕВИТСКИ
Пабло Умана
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Ф. Хоффманн-Ля Рош Аг
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Publication of UA125962C2 publication Critical patent/UA125962C2/uk

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/14—Dipeptidyl-peptidases and tripeptidyl-peptidases (3.4.14)
    • C12Y304/14005—Dipeptidyl-peptidase IV (3.4.14.5)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)
UAA201804698A 2015-10-02 2016-09-29 Біспецифічна антигензв'язуюча молекула до ox40 та фібробласт-активуючого білка (fap) UA125962C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15188095 2015-10-02
EP16170363 2016-05-19
PCT/EP2016/073185 WO2017055398A2 (fr) 2015-10-02 2016-09-29 Anticorps bispécifiques spécifiques d'un récepteur de co-stimulation du tnf

Publications (1)

Publication Number Publication Date
UA125962C2 true UA125962C2 (uk) 2022-07-20

Family

ID=57018141

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Application Number Title Priority Date Filing Date
UAA201804698A UA125962C2 (uk) 2015-10-02 2016-09-29 Біспецифічна антигензв'язуюча молекула до ox40 та фібробласт-активуючого білка (fap)

Country Status (22)

Country Link
US (2) US10526413B2 (fr)
EP (1) EP3356403A2 (fr)
JP (2) JP7034066B2 (fr)
KR (1) KR20180053674A (fr)
CN (3) CN115594765A (fr)
AU (1) AU2016329120B2 (fr)
BR (1) BR112018002570A2 (fr)
CA (1) CA2992863A1 (fr)
CL (1) CL2018000390A1 (fr)
CO (1) CO2018000710A2 (fr)
CR (1) CR20180163A (fr)
IL (1) IL257112A (fr)
MA (1) MA43017A (fr)
MX (2) MX2018003820A (fr)
MY (2) MY206406A (fr)
PE (2) PE20180950A1 (fr)
PH (1) PH12018500636A1 (fr)
RU (1) RU2761115C1 (fr)
TW (2) TWI757252B (fr)
UA (1) UA125962C2 (fr)
WO (1) WO2017055398A2 (fr)
ZA (1) ZA201800535B (fr)

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CN114929734A (zh) 2020-01-09 2022-08-19 豪夫迈·罗氏有限公司 新型含有4-1bbl三聚体的抗原结合分子
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CN108602887B (zh) 2022-06-21
TW202221040A (zh) 2022-06-01
KR20180053674A (ko) 2018-05-23
JP7034066B2 (ja) 2022-03-11
IL257112A (en) 2018-03-29
WO2017055398A2 (fr) 2017-04-06
PH12018500636A1 (en) 2018-09-24
WO2017055398A3 (fr) 2017-05-11
BR112018002570A2 (pt) 2018-10-16
ZA201800535B (en) 2018-12-19
CL2018000390A1 (es) 2018-07-06
PE20240096A1 (es) 2024-01-18
JP2018535662A (ja) 2018-12-06
MA43017A (fr) 2018-08-08
JP2022088367A (ja) 2022-06-14
MX2018003820A (es) 2018-12-10
CR20180163A (es) 2018-05-25
AU2016329120B2 (en) 2023-04-13
CO2018000710A2 (es) 2018-04-10
MX2023006482A (es) 2023-06-20
CA2992863A1 (fr) 2017-04-06
TW201718645A (zh) 2017-06-01
CN115746143A (zh) 2023-03-07
AU2016329120A1 (en) 2018-02-15
CN115594765A (zh) 2023-01-13
US20200071411A1 (en) 2020-03-05
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MY206406A (en) 2024-12-16
TWI757252B (zh) 2022-03-11
US12240911B2 (en) 2025-03-04
EP3356403A2 (fr) 2018-08-08
CN108602887A (zh) 2018-09-28
US10526413B2 (en) 2020-01-07
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US20170114141A1 (en) 2017-04-27

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