MA49578A - Incorporation de nucléotides non naturels et procédés associés - Google Patents

Incorporation de nucléotides non naturels et procédés associés

Info

Publication number
MA49578A
MA49578A MA049578A MA49578A MA49578A MA 49578 A MA49578 A MA 49578A MA 049578 A MA049578 A MA 049578A MA 49578 A MA49578 A MA 49578A MA 49578 A MA49578 A MA 49578A
Authority
MA
Morocco
Prior art keywords
incorporation
related processes
natural nucleotides
nucleotides
natural
Prior art date
Application number
MA049578A
Other languages
English (en)
Inventor
Hans Aerni
Carolina Caffaro
Vivian T Dien
Aaron W Feldman
Emil C Fischer
Jerod Ptacin
Floyd E Romesberg
Yorke Zhang
Original Assignee
Synthorx Inc
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthorx Inc, Scripps Research Inst filed Critical Synthorx Inc
Publication of MA49578A publication Critical patent/MA49578A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
    • C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
    • C12Y601/01026—Pyrrolysine-tRNAPyl ligase (6.1.1.26)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
MA049578A 2017-07-11 2018-07-10 Incorporation de nucléotides non naturels et procédés associés MA49578A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762531325P 2017-07-11 2017-07-11

Publications (1)

Publication Number Publication Date
MA49578A true MA49578A (fr) 2021-04-07

Family

ID=65002471

Family Applications (1)

Application Number Title Priority Date Filing Date
MA049578A MA49578A (fr) 2017-07-11 2018-07-10 Incorporation de nucléotides non naturels et procédés associés

Country Status (14)

Country Link
US (5) US20200131555A1 (fr)
EP (1) EP3652316A4 (fr)
JP (3) JP7325341B2 (fr)
KR (3) KR102890562B1 (fr)
CN (1) CN111051512A (fr)
AR (1) AR112756A1 (fr)
AU (2) AU2018300069C1 (fr)
CA (1) CA3069321A1 (fr)
EA (1) EA202090090A1 (fr)
IL (2) IL316833A (fr)
MA (1) MA49578A (fr)
SG (1) SG11202000167SA (fr)
TW (2) TWI821192B (fr)
WO (1) WO2019014267A1 (fr)

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TWI638047B (zh) 2014-04-09 2018-10-11 史基普研究協會 藉由核酸三磷酸酯轉運子將非天然或經修飾的核苷三磷酸酯輸入至細胞中
WO2017106767A1 (fr) 2015-12-18 2017-06-22 The Scripps Research Institute Production de nucléotides non naturels par l'utilisation d'un système crispr/cas9
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JP7325341B2 (ja) 2017-07-11 2023-08-14 シンソークス，インク． 非天然ヌクレオチドの組み込み及びその方法
WO2019014262A1 (fr) 2017-07-11 2019-01-17 The Scripps Research Institute Incorporation de nucléotides non naturels et procédés d'utilisation in vivo de ceux-ci
KR20240141853A (ko) 2017-08-03 2024-09-27 신톡스, 인크. 자가면역 질환의 치료를 위한 사이토카인 접합체
SG11202006101WA (en) 2017-12-29 2020-07-29 Scripps Research Inst Unnatural base pair compositions and methods of use
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EP3923974A4 (fr) 2019-02-06 2023-02-08 Synthorx, Inc. Conjugués d'il-2 et méthodes d'utilisation de ceux-ci
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EP4017540A1 (fr) 2019-08-23 2022-06-29 Synthorx, Inc. Conjugués d'il-15 et leurs utilisations
US12234271B2 (en) 2019-09-10 2025-02-25 Synthorx, Inc. Il-2 conjugates and methods of use to treat autoimmune diseases
EP4041247A4 (fr) * 2019-09-30 2024-03-06 The Scripps Research Institute Organismes eucaryotes semi-synthétiques
TW202128996A (zh) * 2019-10-10 2021-08-01 美商史基普研究協會 用於活體內合成非天然多肽的組合物及方法
WO2021091986A1 (fr) 2019-11-04 2021-05-14 Synthorx, Inc. Conjugués d'interleukine 10 et leurs utilisations
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IL299074A (en) 2020-06-25 2023-02-01 Synthorx Inc Immuno-oncology therapeutic combination with IL-2 and anti-AGFR antibody conjugates
JP2023546010A (ja) 2020-10-09 2023-11-01 シンソークス， インコーポレイテッド Ｉｌ－２コンジュゲートを用いた免疫腫瘍療法
IL301611A (en) 2020-10-09 2023-05-01 Synthorx Inc Immuno oncology combination therapy with il-2 conjugates and pembrolizumab
WO2022098160A1 (fr) * 2020-11-06 2022-05-12 한국과학기술원 Protéine éditée par un gène dans laquelle un acide aminé non naturel est incorporé spécifiquement à un site, et procédé d'édition de gène l'utilisant
CN114807154B (zh) * 2020-12-10 2024-05-28 深圳瑞吉生物科技有限公司 一种修饰的核酸及其应用
TW202245843A (zh) 2021-02-12 2022-12-01 美商欣爍克斯公司 Ｉｌ－２接合物及西米普利單抗（ｃｅｍｉｐｌｉｍａｂ）之皮膚癌組合療法
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WO2022258678A1 (fr) 2021-06-09 2022-12-15 Innate Pharma Protéines multispécifiques se liant à nkp30, un récepteur de cytokine, un antigène tumoral et cd16a
BR112023025331A2 (pt) 2021-06-09 2024-02-27 Innate Pharma Proteína multiespecífica, composição farmacêutica, célula recombinante, ácido nucleico ou conjunto de ácidos nucleicos, uso de uma proteína ou composição, métodos ou uso
WO2022258691A1 (fr) 2021-06-09 2022-12-15 Innate Pharma Protéines multispécifiques se liant à nkg2d, récepteur de cytokine, antigène tumoral et cd16a
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EP4370680A4 (fr) 2021-07-16 2025-08-13 Aptah Bio Inc Compositions polynucléotidiques et procédés de régulation de l'expression génique
CN114196714B (zh) * 2021-11-04 2023-09-29 华南理工大学 利用末端脱氧核糖核苷酸转移酶无模板合成含非天然碱基寡核苷酸链的方法及其应用
EP4452327A1 (fr) 2021-12-20 2024-10-30 Synthorx, Inc. Polythérapie contre le cancer de la tête et du cou comprenant un conjugué d'il-2 et du pembrolizumab
WO2023122750A1 (fr) 2021-12-23 2023-06-29 Synthorx, Inc. Polythérapie contre le cancer avec des conjugués d'il-2 et du cétuximab
CN115960152A (zh) * 2022-10-11 2023-04-14 河南师范大学 一种炔丙醚基取代tpt3型非天然碱基三磷酸及其合成方法和应用
WO2024136899A1 (fr) 2022-12-21 2024-06-27 Synthorx, Inc. Thérapie anticancéreuse avec des conjugués d'il-2 et des thérapies par récepteur antigénique chimérique
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WO2024251884A1 (fr) 2023-06-09 2024-12-12 Innate Pharma Protéines d'activation de cellules nk comprenant un anticorps anti-cd20 et ant-nkp46, liées à il-2 dans le traitement de lnh-b r/r
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WO2025199099A1 (fr) * 2024-03-18 2025-09-25 The Regents Of The University Of Coloradoa Body Corporate Régulation post-traductionnelle dépendante d'un ligand de mutants d'arn polymérase (rnap) modifiés à partir d'un bactériophage t7
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