NO20054311L - HIV-repliksjonsinhiberende pyrimidiner og triaziner - Google Patents

HIV-repliksjonsinhiberende pyrimidiner og triaziner

Info

Publication number
NO20054311L
NO20054311L NO20054311A NO20054311A NO20054311L NO 20054311 L NO20054311 L NO 20054311L NO 20054311 A NO20054311 A NO 20054311A NO 20054311 A NO20054311 A NO 20054311A NO 20054311 L NO20054311 L NO 20054311L
Authority
NO
Norway
Prior art keywords
triazines
hiv replication
replication inhibitory
pyrimidines
inhibitory pyrimidines
Prior art date
Application number
NO20054311A
Other languages
English (en)
Norwegian (no)
Other versions
NO20054311D0 (no
Inventor
Jan Heeres
Kurt Hertogs
Marc Rene De Jonge
Lucien Maria Henricus Koymans
Eva Bettens
Jerome Emile George Guillemont
Elisabeth Therese Jea Pasquier
Paulus Joannes Lewi
Frederik Frans Desire Daeyaert
Hendrik Maarten Vinkers
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of NO20054311D0 publication Critical patent/NO20054311D0/no
Publication of NO20054311L publication Critical patent/NO20054311L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20054311A 2003-02-20 2005-09-19 HIV-repliksjonsinhiberende pyrimidiner og triaziner NO20054311L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03100411 2003-02-20
US47501203P 2003-06-02 2003-06-02
PCT/EP2004/050175 WO2004074261A1 (en) 2003-02-20 2004-02-20 Hiv replication inhibiting pyrimidines and triazines

Publications (2)

Publication Number Publication Date
NO20054311D0 NO20054311D0 (no) 2005-09-19
NO20054311L true NO20054311L (no) 2005-10-27

Family

ID=32910137

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20054311A NO20054311L (no) 2003-02-20 2005-09-19 HIV-repliksjonsinhiberende pyrimidiner og triaziner
NO20054312A NO20054312L (no) 2003-02-20 2005-09-19 HIV-replikasjonsinhiberende pyrimidiner og triaziner

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20054312A NO20054312L (no) 2003-02-20 2005-09-19 HIV-replikasjonsinhiberende pyrimidiner og triaziner

Country Status (27)

Country Link
US (2) US7442705B2 (pt)
EP (2) EP1603887B1 (pt)
JP (2) JP4586014B2 (pt)
KR (2) KR20050094896A (pt)
CN (2) CN100572364C (pt)
AP (1) AP2005003373A0 (pt)
AR (2) AR044500A1 (pt)
AT (2) ATE361915T1 (pt)
AU (2) AU2004213186B2 (pt)
BR (2) BRPI0407732A (pt)
CA (2) CA2516699C (pt)
CL (2) CL2004000303A1 (pt)
CY (1) CY1106788T1 (pt)
DE (2) DE602004032321D1 (pt)
DK (1) DK1597238T3 (pt)
EA (2) EA010423B1 (pt)
ES (1) ES2287734T3 (pt)
HR (2) HRP20050821A2 (pt)
IL (2) IL169596A (pt)
MX (2) MXPA05008866A (pt)
MY (1) MY138308A (pt)
NO (2) NO20054311L (pt)
NZ (2) NZ541601A (pt)
PL (2) PL227295B1 (pt)
PT (1) PT1597238E (pt)
TW (2) TW200500346A (pt)
WO (2) WO2004074261A1 (pt)

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HRP20050089B1 (hr) 2002-07-29 2015-06-19 Rigel Pharmaceuticals Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti
CL2004000303A1 (es) * 2003-02-20 2005-04-08 Tibotec Pharm Ltd Compuestos derivados de pirimidinas y triazinas; proceso de preparacion; composicion farmaceutica; y su uso para inhibir la replicacion del vih.
JP4886511B2 (ja) 2003-07-30 2012-02-29 ライジェル ファーマシューティカルズ, インコーポレイテッド 2,4−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法
EP2543376A1 (en) 2004-04-08 2013-01-09 Targegen, Inc. Benzotriazine inhibitors of kinases
AU2005276974B2 (en) 2004-08-25 2012-08-02 Targegen, Inc. Heterocyclic compounds and methods of use
ATE540035T1 (de) 2004-11-24 2012-01-15 Rigel Pharmaceuticals Inc Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen
CN101115761B (zh) 2005-01-19 2012-07-18 里格尔药品股份有限公司 2,4-嘧啶二胺化合物的前药及其应用
AU2006254840B2 (en) 2005-06-08 2012-08-02 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
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US8133900B2 (en) 2005-11-01 2012-03-13 Targegen, Inc. Use of bi-aryl meta-pyrimidine inhibitors of kinases
NZ567851A (en) 2005-11-01 2011-09-30 Targegen Inc Bi-aryl meta-pyrimidine inhibitors of kinases
US8604042B2 (en) 2005-11-01 2013-12-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
ES2622493T3 (es) 2006-02-24 2017-07-06 Rigel Pharmaceuticals, Inc. Composiciones y métodos para la inhibición de la ruta de JAK
ES2523863T3 (es) * 2006-12-29 2014-12-02 Janssen R&D Ireland Pirimidinas 5,6-sustituidas inhibidoras del VIH
BRPI0720858B8 (pt) * 2006-12-29 2021-05-25 Janssen R & D Ireland pirimidinas 6-substituídas inibidoras de hiv e composição farmacêutica que as compreende
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US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
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AR074209A1 (es) 2008-11-24 2010-12-29 Boehringer Ingelheim Int Derivados de pirimidina utiles para el tratamiento del cancer
TWI491605B (zh) 2008-11-24 2015-07-11 Boehringer Ingelheim Int 新穎化合物
DK2406253T3 (da) 2009-03-11 2013-08-12 Pfizer Benzofuranylderivater anvendt som glucokinase-inhibitorer
WO2012060847A1 (en) 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
US9249124B2 (en) 2011-03-30 2016-02-02 H. Lee Moffitt Cancer Center And Research Institute, Inc. Aurora kinase inhibitors and methods of making and using thereof
BR112013027734A2 (pt) 2011-05-04 2017-08-08 Ariad Pharma Inc compostos para a inibição de proliferação celular em cânceres impulsionados pelo egfr, método e composição farmacêutica
GB201119358D0 (en) 2011-11-10 2011-12-21 Lewi Paulus J Disubstituted triazine dimers for treatment and/or prevention of infectious diseases
GB201204756D0 (en) 2012-03-19 2012-05-02 Lewi Paulus J Triazines with suitable spacers for treatment and/or prevention of HIV infections
AU2013204563B2 (en) 2012-05-05 2016-05-19 Takeda Pharmaceutical Company Limited Compounds for inhibiting cell proliferation in EGFR-driven cancers
WO2014072419A1 (en) 2012-11-08 2014-05-15 Universiteit Antwerpen Novel anti-hiv compounds
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
CN108602802B (zh) * 2016-07-26 2020-01-21 深圳市塔吉瑞生物医药有限公司 用于抑制蛋白酪氨酸激酶活性的氨基嘧啶类化合物
CN106749203B (zh) * 2016-11-28 2020-04-10 洛阳聚慧医药科技有限公司 一种嘧啶类杂环化合物、嘧啶类杂环化合物盐以及制备方法和应用
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HRP20050089B1 (hr) * 2002-07-29 2015-06-19 Rigel Pharmaceuticals Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti
CL2004000303A1 (es) 2003-02-20 2005-04-08 Tibotec Pharm Ltd Compuestos derivados de pirimidinas y triazinas; proceso de preparacion; composicion farmaceutica; y su uso para inhibir la replicacion del vih.

Also Published As

Publication number Publication date
CL2004000306A1 (es) 2005-04-08
EA200501326A1 (ru) 2006-02-24
CY1106788T1 (el) 2012-05-23
BRPI0407732A (pt) 2006-02-14
IL169596A0 (en) 2007-07-04
JP2006518357A (ja) 2006-08-10
EA011256B1 (ru) 2009-02-27
WO2004074261A1 (en) 2004-09-02
EP1603887A1 (en) 2005-12-14
JP4586014B2 (ja) 2010-11-24
CN1751031A (zh) 2006-03-22
HRP20050820A2 (en) 2006-11-30
JP2006518356A (ja) 2006-08-10
US7585870B2 (en) 2009-09-08
EP1603887B1 (en) 2011-04-20
CN1751031B (zh) 2010-07-21
US20060194804A1 (en) 2006-08-31
TW200510339A (en) 2005-03-16
DK1597238T3 (da) 2007-09-10
IL169596A (en) 2017-02-28
IL169647A0 (en) 2007-07-04
AU2004213187A1 (en) 2004-09-02
US7442705B2 (en) 2008-10-28
AU2004213186B2 (en) 2009-10-01
CL2004000303A1 (es) 2005-04-08
TW200500346A (en) 2005-01-01
CA2516699C (en) 2011-07-12
NO20054311D0 (no) 2005-09-19
BRPI0407741A (pt) 2006-02-14
NZ541601A (en) 2007-09-28
CN100572364C (zh) 2009-12-23
EP1597238A1 (en) 2005-11-23
NO20054312L (no) 2005-11-16
KR20050099994A (ko) 2005-10-17
BRPI0407741B8 (pt) 2021-05-25
CA2516699A1 (en) 2004-09-02
IL169647A (en) 2013-05-30
AR044499A1 (es) 2005-09-14
ATE361915T1 (de) 2007-06-15
WO2004074262A1 (en) 2004-09-02
DE602004006383D1 (de) 2007-06-21
EP1597238B1 (en) 2007-05-09
DE602004032321D1 (de) 2011-06-01
MXPA05008867A (es) 2005-10-05
MXPA05008866A (es) 2005-10-05
NO20054312D0 (no) 2005-09-19
CA2516589A1 (en) 2004-09-02
EA010423B1 (ru) 2008-08-29
PL378064A1 (pl) 2006-02-20
US20060142571A1 (en) 2006-06-29
PL378136A1 (pl) 2006-03-06
AU2004213186A1 (en) 2004-09-02
HRP20050821A2 (en) 2006-11-30
NZ542428A (en) 2007-11-30
PT1597238E (pt) 2007-08-08
ATE506353T1 (de) 2011-05-15
ES2287734T3 (es) 2007-12-16
AP2005003373A0 (en) 2005-09-30
DE602004006383T2 (de) 2008-01-10
CA2516589C (en) 2012-04-17
JP4586013B2 (ja) 2010-11-24
BRPI0407741B1 (pt) 2018-05-29
MY138308A (en) 2009-05-29
KR20050094896A (ko) 2005-09-28
AR044500A1 (es) 2005-09-14
PL226954B1 (pl) 2017-10-31
EA200501327A1 (ru) 2006-02-24
AU2004213187B2 (en) 2009-11-05
CN1751030A (zh) 2006-03-22
PL227295B1 (pl) 2017-11-30

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