PL1913004T3 - 8-metoksy-9H-izotiazolo[5,4-B] chinolino-3,4-diony i pokrewne związki jako środki przeciwzakaźne - Google Patents
8-metoksy-9H-izotiazolo[5,4-B] chinolino-3,4-diony i pokrewne związki jako środki przeciwzakaźneInfo
- Publication number
- PL1913004T3 PL1913004T3 PL06800428T PL06800428T PL1913004T3 PL 1913004 T3 PL1913004 T3 PL 1913004T3 PL 06800428 T PL06800428 T PL 06800428T PL 06800428 T PL06800428 T PL 06800428T PL 1913004 T3 PL1913004 T3 PL 1913004T3
- Authority
- PL
- Poland
- Prior art keywords
- formula
- compounds
- compound
- isothiazolo
- diones
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 8
- TYDQUACGVFCRFY-UHFFFAOYSA-N 8-methoxy-9h-[1,2]thiazolo[5,4-b]quinoline-3,4-dione Chemical class COC1=CC=CC(C2=O)=C1NC1=C2C(=O)NS1 TYDQUACGVFCRFY-UHFFFAOYSA-N 0.000 title 1
- 229960005475 antiinfective agent Drugs 0.000 title 1
- 239000004599 antimicrobial Substances 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 2
- 230000000845 anti-microbial effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 108020000946 Bacterial DNA Proteins 0.000 abstract 1
- 230000006820 DNA synthesis Effects 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70281105P | 2005-07-27 | 2005-07-27 | |
| EP06800428A EP1913004B1 (en) | 2005-07-27 | 2006-07-27 | 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents |
| PCT/US2006/029302 WO2007014308A1 (en) | 2005-07-27 | 2006-07-27 | 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1913004T3 true PL1913004T3 (pl) | 2011-03-31 |
Family
ID=37106335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06800428T PL1913004T3 (pl) | 2005-07-27 | 2006-07-27 | 8-metoksy-9H-izotiazolo[5,4-B] chinolino-3,4-diony i pokrewne związki jako środki przeciwzakaźne |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8044204B2 (pl) |
| EP (1) | EP1913004B1 (pl) |
| JP (1) | JP5143000B2 (pl) |
| KR (1) | KR101272263B1 (pl) |
| CN (1) | CN101263146B (pl) |
| AT (1) | ATE482219T1 (pl) |
| AU (1) | AU2006272571B2 (pl) |
| BR (1) | BRPI0614456B8 (pl) |
| CA (1) | CA2616768C (pl) |
| DE (1) | DE602006017082D1 (pl) |
| DK (1) | DK1913004T3 (pl) |
| EA (1) | EA013244B1 (pl) |
| ES (1) | ES2352799T3 (pl) |
| IL (1) | IL189017A (pl) |
| NO (1) | NO343376B1 (pl) |
| NZ (1) | NZ566209A (pl) |
| PL (1) | PL1913004T3 (pl) |
| PT (1) | PT1913004E (pl) |
| WO (1) | WO2007014308A1 (pl) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008021491A2 (en) * | 2006-08-16 | 2008-02-21 | Achillion Pharmaceuticals, Inc. | Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones |
| US8173636B2 (en) * | 2009-04-03 | 2012-05-08 | Achillion Pharmaceuticals, Inc. | Hydroxylthienoquinolones and related compounds as anti-infective agents |
| WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
| NZ623384A (en) * | 2009-10-16 | 2016-06-24 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
| JP6274723B2 (ja) * | 2009-10-16 | 2018-02-07 | メリンタ セラピューティクス，インコーポレイテッド | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| JP2013508299A (ja) | 2009-10-16 | 2013-03-07 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| TN2010000566A1 (en) * | 2010-12-03 | 2012-05-24 | Rekik Raouf | Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs |
| CN103819401B (zh) * | 2012-11-19 | 2016-04-13 | 浙江中欣氟材股份有限公司 | 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法 |
| MX2016002975A (es) | 2013-09-09 | 2016-10-21 | Melinta Therapeutics Inc | Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos. |
| US9937183B2 (en) | 2013-09-09 | 2018-04-10 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| WO2015114317A1 (en) * | 2014-01-28 | 2015-08-06 | Redx Pharma Plc | 5h-isothiazolo[4,5-c]pyridine-3,4-dione or 5h-pyrazolo[4,3-c]pyridin-3,4-dione as antibacterial compounds |
| WO2016145417A1 (en) | 2015-03-11 | 2016-09-15 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| US11098047B2 (en) | 2016-05-06 | 2021-08-24 | BioVersys AG | Antimicrobials and methods of making and using same |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| CN109562113A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| CN121974842A (zh) | 2016-05-10 | 2026-05-05 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| EP4717317A3 (en) | 2017-06-20 | 2026-06-03 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| AU2020216470B2 (en) * | 2019-02-01 | 2023-05-04 | Alcon Inc. | Compounds, compositions and methods for treatment of myopia |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767762A (en) | 1985-12-23 | 1988-08-30 | Abbott Laboratories | Tricyclic quinoline and naphthyride antibacterials |
| JPH01160985A (ja) | 1987-12-17 | 1989-06-23 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環化合物 |
| JPH01193275A (ja) | 1988-01-28 | 1989-08-03 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環化合物 |
| JP2681190B2 (ja) | 1988-04-13 | 1997-11-26 | 塩野義製薬株式会社 | ピリドン系抗菌剤 |
| CA2001203C (en) | 1988-10-24 | 2001-02-13 | Thomas P. Demuth, Jr. | Novel antimicrobial dithiocarbamoyl quinolones |
| US5328908A (en) | 1988-10-24 | 1994-07-12 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolone thioureas |
| JPH02174784A (ja) | 1988-12-27 | 1990-07-06 | Hokuriku Seiyaku Co Ltd | イソチアゾロキノリン誘導体 |
| JPH02243692A (ja) | 1989-03-16 | 1990-09-27 | Dainippon Pharmaceut Co Ltd | 三環式化合物 |
| JPH02255687A (ja) | 1989-03-27 | 1990-10-16 | Dainippon Pharmaceut Co Ltd | 三環式化合物 |
| FR2645862B1 (fr) | 1989-04-18 | 1991-07-12 | Esteve Labor Dr | Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments |
| JP2787713B2 (ja) | 1989-07-28 | 1998-08-20 | 富山化学工業株式会社 | 新規なイソチアゾローナフチリジンおよびイソチアゾローキノリン誘導体並びにそれらの塩 |
| US5071848A (en) | 1989-10-23 | 1991-12-10 | Abbott Laboratories | Tricyclic quinoline antineoplastic agents |
| JP2939280B2 (ja) | 1990-01-10 | 1999-08-25 | 三共株式会社 | フッ素置換メトキシキノロンカルボン酸誘導体 |
| US5580872A (en) | 1990-05-02 | 1996-12-03 | Abbott Laboratories | Quinolizinone type compounds |
| NO304832B1 (no) | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
| US5646163A (en) | 1992-10-30 | 1997-07-08 | The Procter & Gamble Company | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
| EP0878194A1 (en) | 1996-01-31 | 1998-11-18 | Sankyo Company Limited | Remedies or preventives for aids |
| JP3616454B2 (ja) | 1996-04-19 | 2005-02-02 | 栄研化学株式会社 | 生体成分測定用試薬 |
| JPH10130149A (ja) | 1996-07-12 | 1998-05-19 | Sankyo Co Ltd | Ｔｎｆ産生抑制剤 |
| DE19652219A1 (de) | 1996-12-16 | 1998-06-18 | Bayer Ag | Verwendung von 7-(1-Aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-chinolon- und naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen |
| ATE304539T1 (de) * | 2000-12-14 | 2005-09-15 | Procter & Gamble | Antimikrobielle chinolone |
| WO2006089054A1 (en) * | 2005-02-16 | 2006-08-24 | Achillion Pharmaceuticals, Inc. | New isothiazoloquinolones and related compounds as anti-infective agents |
| KR20060069836A (ko) * | 2003-08-12 | 2006-06-22 | 아칠리온 파르마세우티칼스 인코포레이티드 | 항-감염제로서의 이소티아졸로퀴놀론 및 관련 화합물 |
| EP1809639B1 (en) * | 2004-11-11 | 2009-10-14 | Achillion Pharmaceuticals, Inc. | 8a, 9-dihydro-4a-h-isothiazolo[5,4-b] quinoline-3, 4-diones and related compounds as anti-infective agents |
| US8173636B2 (en) | 2009-04-03 | 2012-05-08 | Achillion Pharmaceuticals, Inc. | Hydroxylthienoquinolones and related compounds as anti-infective agents |
-
2006
- 2006-07-27 ES ES06800428T patent/ES2352799T3/es not_active Expired - Lifetime
- 2006-07-27 WO PCT/US2006/029302 patent/WO2007014308A1/en not_active Ceased
- 2006-07-27 EP EP06800428A patent/EP1913004B1/en not_active Expired - Lifetime
- 2006-07-27 PL PL06800428T patent/PL1913004T3/pl unknown
- 2006-07-27 KR KR1020087004769A patent/KR101272263B1/ko not_active Expired - Lifetime
- 2006-07-27 US US11/494,205 patent/US8044204B2/en active Active
- 2006-07-27 CA CA2616768A patent/CA2616768C/en not_active Expired - Fee Related
- 2006-07-27 DE DE602006017082T patent/DE602006017082D1/de not_active Expired - Lifetime
- 2006-07-27 NZ NZ566209A patent/NZ566209A/en unknown
- 2006-07-27 CN CN200680033548XA patent/CN101263146B/zh not_active Expired - Fee Related
- 2006-07-27 JP JP2008524168A patent/JP5143000B2/ja not_active Expired - Fee Related
- 2006-07-27 AT AT06800428T patent/ATE482219T1/de active
- 2006-07-27 AU AU2006272571A patent/AU2006272571B2/en not_active Ceased
- 2006-07-27 PT PT06800428T patent/PT1913004E/pt unknown
- 2006-07-27 EA EA200800444A patent/EA013244B1/ru unknown
- 2006-07-27 DK DK06800428.2T patent/DK1913004T3/da active
- 2006-07-27 BR BRPI0614456A patent/BRPI0614456B8/pt not_active IP Right Cessation
-
2008
- 2008-01-24 IL IL189017A patent/IL189017A/en active IP Right Grant
- 2008-02-27 NO NO20081005A patent/NO343376B1/no unknown
-
2011
- 2011-10-24 US US13/279,852 patent/US8946422B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080035661A (ko) | 2008-04-23 |
| US8044204B2 (en) | 2011-10-25 |
| JP5143000B2 (ja) | 2013-02-13 |
| ES2352799T3 (es) | 2011-02-23 |
| CA2616768C (en) | 2014-05-06 |
| US20120040959A1 (en) | 2012-02-16 |
| DE602006017082D1 (de) | 2010-11-04 |
| AU2006272571A1 (en) | 2007-02-01 |
| EA013244B1 (ru) | 2010-04-30 |
| EP1913004B1 (en) | 2010-09-22 |
| EP1913004A1 (en) | 2008-04-23 |
| PT1913004E (pt) | 2010-12-09 |
| DK1913004T3 (da) | 2011-01-10 |
| BRPI0614456B1 (pt) | 2019-08-27 |
| BRPI0614456A2 (pt) | 2011-03-29 |
| KR101272263B1 (ko) | 2013-06-13 |
| IL189017A0 (en) | 2008-08-07 |
| CN101263146A (zh) | 2008-09-10 |
| US20070049586A1 (en) | 2007-03-01 |
| IL189017A (en) | 2014-01-30 |
| EA200800444A1 (ru) | 2008-06-30 |
| HK1122024A1 (en) | 2009-05-08 |
| NZ566209A (en) | 2011-03-31 |
| US8946422B2 (en) | 2015-02-03 |
| BRPI0614456B8 (pt) | 2021-05-25 |
| AU2006272571B2 (en) | 2012-03-08 |
| CA2616768A1 (en) | 2007-02-01 |
| ATE482219T1 (de) | 2010-10-15 |
| WO2007014308A1 (en) | 2007-02-01 |
| CN101263146B (zh) | 2012-12-05 |
| NO20081005L (no) | 2008-04-09 |
| JP2009502953A (ja) | 2009-01-29 |
| NO343376B1 (no) | 2019-02-11 |
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