|
US3894037A
(en)
|
1971-05-24 |
1975-07-08 |
Ciba Geigy Corp |
Certain isothiocyanobenzimidazoles
|
|
US4197307A
(en)
|
1977-04-12 |
1980-04-08 |
Ciba-Geigy Corporation |
2-Alkylthio-, 2-alkylsulphinyl- and 2-alkylsulfonyl-6-phenylbenzimidazoles as anthelmintic agents
|
|
US4319039A
(en)
|
1979-06-15 |
1982-03-09 |
Merck & Co., Inc. |
Preparation of ammonium salt of hypocholesteremic fermentation product
|
|
US4294926A
(en)
|
1979-06-15 |
1981-10-13 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
|
US4231938A
(en)
|
1979-06-15 |
1980-11-04 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
|
US4444784A
(en)
|
1980-08-05 |
1984-04-24 |
Merck & Co., Inc. |
Antihypercholesterolemic compounds
|
|
DK149080C
(da)
|
1980-06-06 |
1986-07-28 |
Sankyo Co |
Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
|
|
JPS5889191A
(ja)
|
1981-11-20 |
1983-05-27 |
Sankyo Co Ltd |
３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
|
|
US4430502A
(en)
|
1982-08-13 |
1984-02-07 |
The Upjohn Company |
Pyridinyl substituted benzimidazoles and quinoxalines
|
|
US5354772A
(en)
|
1982-11-22 |
1994-10-11 |
Sandoz Pharm. Corp. |
Indole analogs of mevalonolactone and derivatives thereof
|
|
HU204253B
(en)
|
1982-11-22 |
1991-12-30 |
Sandoz Ag |
Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them
|
|
US4911165A
(en)
|
1983-01-12 |
1990-03-27 |
Ethicon, Inc. |
Pliabilized polypropylene surgical filaments
|
|
GB8307865D0
(en)
|
1983-03-22 |
1983-04-27 |
Fujisawa Pharmaceutical Co |
Benzimidazole derivatives
|
|
US4681893A
(en)
|
1986-05-30 |
1987-07-21 |
Warner-Lambert Company |
Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
|
|
US4782084A
(en)
|
1987-06-29 |
1988-11-01 |
Merck & Co., Inc. |
HMG-COA reductase inhibitors
|
|
US4885314A
(en)
|
1987-06-29 |
1989-12-05 |
Merck & Co., Inc. |
Novel HMG-CoA reductase inhibitors
|
|
US4820850A
(en)
|
1987-07-10 |
1989-04-11 |
Merck & Co., Inc. |
Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
|
|
US5180589A
(en)
|
1988-03-31 |
1993-01-19 |
E. R. Squibb & Sons, Inc. |
Pravastatin pharmaceuatical compositions having good stability
|
|
US5030447A
(en)
|
1988-03-31 |
1991-07-09 |
E. R. Squibb & Sons, Inc. |
Pharmaceutical compositions having good stability
|
|
US4916239A
(en)
|
1988-07-19 |
1990-04-10 |
Merck & Co., Inc. |
Process for the lactonization of mevinic acids and analogs thereof
|
|
US5290946A
(en)
|
1988-10-13 |
1994-03-01 |
Sandoz Ltd. |
Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
|
|
US5118853A
(en)
|
1988-10-13 |
1992-06-02 |
Sandoz Ltd. |
Processes for the synthesis of 3-disubstituted aminoacroleins
|
|
US4929437A
(en)
|
1989-02-02 |
1990-05-29 |
Merck & Co., Inc. |
Coenzyme Q10 with HMG-CoA reductase inhibitors
|
|
US5189164A
(en)
|
1989-05-22 |
1993-02-23 |
Sandoz Ltd. |
Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof
|
|
FI94339C
(fi)
|
1989-07-21 |
1995-08-25 |
Warner Lambert Co |
Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
|
|
PH27357A
(en)
|
1989-09-22 |
1993-06-21 |
Fujisawa Pharmaceutical Co |
Pyrazole derivatives and pharmaceutical compositions comprising the same
|
|
JPH06759B2
(ja)
|
1989-09-22 |
1994-01-05 |
ファイザー製薬株式会社 |
新規なベンゾイミダゾール化合物
|
|
US5420245A
(en)
|
1990-04-18 |
1995-05-30 |
Board Of Regents, The University Of Texas |
Tetrapeptide-based inhibitors of farnesyl transferase
|
|
US5041453A
(en)
|
1990-05-30 |
1991-08-20 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4
|
|
FR2677020B1
(fr)
|
1991-05-31 |
1993-08-27 |
Cird Galderma |
Composes derives de benzimidazole, leur procede de preparation et leur utilisation dans les domaines therapeutique et cosmetique.
|
|
HU9203780D0
(en)
|
1991-12-12 |
1993-03-29 |
Sandoz Ag |
Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
|
|
US5612360A
(en)
|
1992-06-03 |
1997-03-18 |
Eli Lilly And Company |
Angiotensin II antagonists
|
|
US5604260A
(en)
|
1992-12-11 |
1997-02-18 |
Merck Frosst Canada Inc. |
5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
|
|
CA2111902A1
(en)
|
1992-12-21 |
1994-06-22 |
Jack Beuford Campbell |
Antitumor compositions and methods of treatment
|
|
EP0679157B1
(en)
|
1993-01-15 |
1997-11-19 |
G.D. Searle & Co. |
Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
|
|
WO1994019357A1
(en)
|
1993-02-23 |
1994-09-01 |
Merrell Dow Pharmaceuticals Inc. |
Farnesyl:protein transferase inhibitors as anticancer agents
|
|
US5298627A
(en)
|
1993-03-03 |
1994-03-29 |
Warner-Lambert Company |
Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
|
|
US5409944A
(en)
|
1993-03-12 |
1995-04-25 |
Merck Frosst Canada, Inc. |
Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
|
|
CA2118985A1
(en)
|
1993-04-02 |
1994-10-03 |
Dinesh V. Patel |
Heterocyclic inhibitors of farnesyl protein transferase
|
|
AU6909194A
(en)
|
1993-05-14 |
1994-12-12 |
Board Of Regents, The University Of Texas System |
Preparation of n-cyanodithioimino-carbonates and 3-mercapto-5-amino-1h-1,2,4-triazole
|
|
US5602098A
(en)
|
1993-05-18 |
1997-02-11 |
University Of Pittsburgh |
Inhibition of farnesyltransferase
|
|
US5380738A
(en)
|
1993-05-21 |
1995-01-10 |
Monsanto Company |
2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
|
|
US5436265A
(en)
|
1993-11-12 |
1995-07-25 |
Merck Frosst Canada, Inc. |
1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
|
|
GB9602877D0
(en)
|
1996-02-13 |
1996-04-10 |
Merck Frosst Canada Inc |
3,4-Diaryl-2-hydroxy-2,5- dihydrofurans as prodrugs to cox-2 inhibitors
|
|
US5474995A
(en)
|
1993-06-24 |
1995-12-12 |
Merck Frosst Canada, Inc. |
Phenyl heterocycles as cox-2 inhibitors
|
|
US5852046A
(en)
|
1993-08-03 |
1998-12-22 |
Hoechst Aktiengesellschaft |
Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
|
|
EP0639573A1
(de)
|
1993-08-03 |
1995-02-22 |
Hoechst Aktiengesellschaft |
Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament
|
|
US5728830A
(en)
|
1993-09-22 |
1998-03-17 |
Kyowa Hakko Kogyo Co., Ltd. |
Farnesyltransferase inhibitor
|
|
CA2174105C
(en)
|
1993-10-15 |
2002-02-12 |
W. Robert Bishop |
Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
IL111235A
(en)
|
1993-10-15 |
2001-03-19 |
Schering Plough Corp |
Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
|
|
US5721236A
(en)
|
1993-10-15 |
1998-02-24 |
Schering Corporation |
Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
US5661152A
(en)
|
1993-10-15 |
1997-08-26 |
Schering Corporation |
Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
IL111257A0
(en)
|
1993-10-15 |
1994-12-29 |
Schering Corp |
Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
US5719148A
(en)
|
1993-10-15 |
1998-02-17 |
Schering Corporation |
Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
KR100378615B1
(ko)
|
1993-10-25 |
2003-10-10 |
파크데이비스앤드캄파니 |
단백질:파르네실트랜스퍼라제의치환된테트라및펜타펩티드억제제
|
|
US5344991A
(en)
|
1993-10-29 |
1994-09-06 |
G.D. Searle & Co. |
1,2 diarylcyclopentenyl compounds for the treatment of inflammation
|
|
CA2152822A1
(en)
|
1993-11-04 |
1995-05-11 |
William R. Baker |
Cyclobutane derivatives as inhibitors of squalene synthetase and protein farnesyltransferase
|
|
US5783593A
(en)
|
1993-11-04 |
1998-07-21 |
Abbott Laboratories |
Inhibitors of squalene synthetase and protein farnesyltransferase
|
|
CA2170766A1
(en)
|
1993-11-05 |
1995-05-11 |
Gary Louis Bolton |
Substituted di- and tripeptide inhibitors of protein:farnesyl transferase
|
|
US5466823A
(en)
|
1993-11-30 |
1995-11-14 |
G.D. Searle & Co. |
Substituted pyrazolyl benzenesulfonamides
|
|
US5484799A
(en)
|
1993-12-09 |
1996-01-16 |
Abbott Laboratories |
Antifungal dorrigocin derivatives
|
|
US5393790A
(en)
|
1994-02-10 |
1995-02-28 |
G.D. Searle & Co. |
Substituted spiro compounds for the treatment of inflammation
|
|
HUT77406A
(hu)
|
1994-03-15 |
1998-04-28 |
Eisai Co., Ltd., |
1-(4-Amino-5-tio-pent-2-en)-il oldalláncot tartalmazó peptidomimetikumok és az ezeket tartalmazó gyógyszerkészítmények
|
|
AU1615895A
(en)
|
1994-03-31 |
1995-10-12 |
Bristol-Myers Squibb Company |
Imidazole-containing inhibitors of farnesyl protein transferase
|
|
US5523430A
(en)
|
1994-04-14 |
1996-06-04 |
Bristol-Myers Squibb Company |
Protein farnesyl transferase inhibitors
|
|
US5510510A
(en)
|
1994-05-10 |
1996-04-23 |
Bristol-Meyers Squibb Company |
Inhibitors of farnesyl protein transferase
|
|
US6358932B1
(en)
|
1994-05-31 |
2002-03-19 |
Isis Pharmaceticals, Inc. |
Antisense oligonucleotide inhibition of raf gene expression
|
|
US6391636B1
(en)
|
1994-05-31 |
2002-05-21 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
|
US5563255A
(en)
|
1994-05-31 |
1996-10-08 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
|
DE69507476D1
(de)
|
1994-06-10 |
1999-03-04 |
Rhone Poulenc Rorer Sa |
Farnesyl-transferase-inhibitoren, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen
|
|
US5571792A
(en)
|
1994-06-30 |
1996-11-05 |
Warner-Lambert Company |
Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
|
|
WO1996005529A1
(en)
|
1994-08-09 |
1996-02-22 |
Micron Optics, Inc. |
Temperature compensated fiber fabry-perot filters
|
|
EP0776884B1
(en)
|
1994-08-11 |
2000-01-05 |
Banyu Pharmaceutical Co., Ltd. |
Substituted amide derivative
|
|
CA2155448A1
(en)
|
1994-08-11 |
1996-02-12 |
Katerina Leftheris |
Inhibitors of farnesyl protein transferase
|
|
EP0805154A1
(en)
|
1994-08-12 |
1997-11-05 |
Banyu Pharmaceutical Co., Ltd. |
N,n-disubstituted amic acid derivative
|
|
DE4429506B4
(de)
|
1994-08-19 |
2007-09-13 |
Degussa Gmbh |
Verfahren zur Extraktion natürlicher Carotinoid-Farbstoffe
|
|
DE4429653C2
(de)
|
1994-08-20 |
1997-04-03 |
Anton Dr More |
Konverter und Verfahren zum Frischen von Metallschmelzen insbesondere von Roheisen zu Stahl
|
|
EP0701907A1
(en)
|
1994-09-13 |
1996-03-20 |
Agfa-Gevaert N.V. |
A dye donor element for use in a thermal dye transfer process
|
|
US6037136A
(en)
|
1994-10-24 |
2000-03-14 |
Cold Spring Harbor Laboratory |
Interactions between RaF proto-oncogenes and CDC25 phosphatases, and uses related thereto
|
|
JP4319251B2
(ja)
|
1994-11-22 |
2009-08-26 |
エヌエックスピー ビー ヴィ |
半導体素子を有し導体トラックが形成されている基板が接着層により結合されている支持本体を有する半導体装置
|
|
CA2204144A1
(en)
|
1994-12-09 |
1996-06-13 |
Francis J. Tinney |
Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase
|
|
WO1996021701A2
(en)
|
1995-01-09 |
1996-07-18 |
Magla International Ltd. |
Wear resistant image printing on latex surfaces
|
|
AU4915796A
(en)
|
1995-01-12 |
1996-07-31 |
University Of Pittsburgh |
Inhibitors of prenyl transferases
|
|
US5741789A
(en)
|
1995-01-17 |
1998-04-21 |
Eli Lilly And Company |
Compounds having effects on serotonin-related systems
|
|
FR2729390A1
(fr)
|
1995-01-18 |
1996-07-19 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
FR2730492B1
(fr)
|
1995-02-09 |
1997-03-14 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
FR2730491B1
(fr)
|
1995-02-09 |
1997-03-14 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
US5633272A
(en)
|
1995-02-13 |
1997-05-27 |
Talley; John J. |
Substituted isoxazoles for the treatment of inflammation
|
|
US5684013A
(en)
|
1995-03-24 |
1997-11-04 |
Schering Corporation |
Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
US5700806A
(en)
|
1995-03-24 |
1997-12-23 |
Schering Corporation |
Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
IL117580A0
(en)
|
1995-03-29 |
1996-07-23 |
Merck & Co Inc |
Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them
|
|
US5891872A
(en)
|
1995-04-07 |
1999-04-06 |
Schering Corporation |
Tricyclic compounds
|
|
DE69628559T2
(de)
|
1995-04-07 |
2004-04-29 |
Schering Corp. |
Carbonyl-piperaznyl und piperidinyl derivate zur hemmung farnesyl protein transferase
|
|
US5712280A
(en)
|
1995-04-07 |
1998-01-27 |
Schering Corporation |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
IL117798A
(en)
|
1995-04-07 |
2001-11-25 |
Schering Plough Corp |
Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
|
|
US5831115A
(en)
|
1995-04-21 |
1998-11-03 |
Abbott Laboratories |
Inhibitors of squalene synthase and protein farnesyltransferase
|
|
IL118101A0
(en)
|
1995-05-03 |
1996-09-12 |
Abbott Lab |
Inhibitors of farnesyltransferase
|
|
AU6034296A
(en)
|
1995-06-16 |
1997-01-15 |
Warner-Lambert Company |
Tricyclic inhibitors of protein farnesyltransferase
|
|
FR2736641B1
(fr)
|
1995-07-10 |
1997-08-22 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
AT402617B
(de)
|
1995-07-11 |
1997-07-25 |
Datacon Schweitzer & Zeindl Gm |
Anlage zum automatisierten, hermetischen anlage zum automatisierten, hermetischen verschliessen von gehäusen verschliessen von gehäusen
|
|
FR2736638B1
(fr)
|
1995-07-12 |
1997-08-22 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
GB9514265D0
(en)
|
1995-07-13 |
1995-09-13 |
Wellcome Found |
Hetrocyclic compounds
|
|
CH690163A5
(fr)
|
1995-07-28 |
2000-05-31 |
Symphar Sa |
Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
|
|
US6001866A
(en)
|
1995-10-05 |
1999-12-14 |
Warner-Lambert Company |
Method for treating and preventing inflammation and atherosclerosis
|
|
AU6966696A
(en)
|
1995-10-05 |
1997-04-28 |
Warner-Lambert Company |
Method for treating and preventing inflammation and atherosclerosis
|
|
US5717100A
(en)
|
1995-10-06 |
1998-02-10 |
Merck & Co., Inc. |
Substituted imidazoles having anti-cancer and cytokine inhibitory activity
|
|
US6020343A
(en)
|
1995-10-13 |
2000-02-01 |
Merck Frosst Canada, Inc. |
(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
|
|
EP0873123B1
(en)
|
1995-11-06 |
2003-04-09 |
University Of Pittsburgh |
Inhibitors of protein isoprenyl transferases
|
|
JP4183099B2
(ja)
|
1995-11-17 |
2008-11-19 |
ゲゼルシャフト・フュア・ビオテヒノロジッシェ・フォルシュング・ミット・ベシュレンクテル・ハフツング（ゲー・ベー・エフ） |
エポチロンｃおよびｄ、製造法ならびに組成物
|
|
JP2000500502A
(ja)
|
1995-11-22 |
2000-01-18 |
メルク エンド カンパニー インコーポレーテッド |
ファルネシル―タンパク質トランスフェラーゼ阻害剤
|
|
SK283335B6
(sk)
|
1995-12-08 |
2003-06-03 |
Janssen Pharmaceutica N. V. |
(Imidazol-5-yl)metyl-2-chinolinónové deriváty, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické kompozície na ich báze
|
|
IL125062A
(en)
|
1995-12-22 |
2003-11-23 |
Schering Corp |
Tricyclic amides and pharmaceutical compositions containing them for inhibition of g-protein function and for treatment of proliferative diseases
|
|
WO1997024334A1
(en)
|
1995-12-28 |
1997-07-10 |
Fujisawa Pharmaceutical Co., Ltd. |
Benzimidazole derivatives
|
|
AU1529997A
(en)
|
1996-01-16 |
1997-08-11 |
Warner-Lambert Company |
Substituted histidine inhibitors of protein farnesyltransferase
|
|
GB9602029D0
(en)
|
1996-02-01 |
1996-04-03 |
Fujisawa Pharmaceutical Co |
New heterocyclic compounds
|
|
US6673927B2
(en)
|
1996-02-16 |
2004-01-06 |
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. |
Farnesyl transferase inhibitors
|
|
EP0944388A4
(en)
|
1996-04-03 |
2001-08-16 |
Merck & Co Inc |
INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
|
|
ATE233743T1
(de)
|
1996-04-12 |
2003-03-15 |
Searle & Co |
N-((4-(5-methyl-3-phenylisoxazol-4- yl)phenyl)sulphonylpropylamid und sein natriumsalz als pro-pharmakon von cox-2 inhibitoren
|
|
WO1997044350A1
(en)
|
1996-05-22 |
1997-11-27 |
Warner-Lambert Company |
Inhibitors of protein farnesyl transferase
|
|
JP2000511419A
(ja)
|
1996-05-23 |
2000-09-05 |
アプライド・リサーチ・システムズ・エイアールエス・ホールディング・ナムローゼ・フェンノートシャップ |
Ｒａｆ―１または１４―３―３タンパク質のＩＬ―２受容体β鎖への結合を阻害する化合物およびそれを含有する医薬組成物
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
WO1998002436A1
(en)
|
1996-07-15 |
1998-01-22 |
Bristol-Myers Squibb Company |
Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase
|
|
US5861419A
(en)
|
1996-07-18 |
1999-01-19 |
Merck Frosst Canad, Inc. |
Substituted pyridines as selective cyclooxygenase-2 inhibitors
|
|
FR2751649B1
(fr)
|
1996-07-26 |
1998-08-28 |
Adir |
Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
CA2273083C
(en)
|
1996-12-03 |
2012-09-18 |
Sloan-Kettering Institute For Cancer Research |
Synthesis of epothilones, intermediates thereto, analogues and uses thereof
|
|
EP0951285A1
(en)
|
1996-12-30 |
1999-10-27 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
CA2276081A1
(en)
|
1996-12-30 |
1998-07-09 |
Lekhanh O. Tran |
Inhibitors of farnesyl-protein transferase
|
|
US6127380A
(en)
|
1997-02-18 |
2000-10-03 |
American Home Products Corporation |
4-aminoalkoxy-1H-benzoimidazoles
|
|
US5932600A
(en)
|
1997-03-14 |
1999-08-03 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme
|
|
EP0966465B1
(en)
|
1997-03-14 |
2003-07-09 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of impdh enzyme
|
|
AR012634A1
(es)
|
1997-05-02 |
2000-11-08 |
Sugen Inc |
Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
|
|
US6187799B1
(en)
|
1997-05-23 |
2001-02-13 |
Onyx Pharmaceuticals |
Inhibition of raf kinase activity using aryl ureas
|
|
BR9810651A
(pt)
|
1997-07-03 |
2000-10-03 |
Neurogen Corp |
Certos derivados de diarilimidazol; uma nova classe de ligantes npy especìficos
|
|
SI9700186B
(sl)
|
1997-07-14 |
2006-10-31 |
Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. |
Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin
|
|
FR2766822B1
(fr)
|
1997-07-30 |
2001-02-23 |
Adir |
Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
GB9716557D0
(en)
|
1997-08-06 |
1997-10-08 |
Glaxo Group Ltd |
Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
|
|
US6022884A
(en)
|
1997-11-07 |
2000-02-08 |
Amgen Inc. |
Substituted pyridine compounds and methods of use
|
|
US6204467B1
(en)
|
1998-03-24 |
2001-03-20 |
Ford Global Technologies, Inc. |
Method and apparatus for resistive welding
|
|
JP2002516322A
(ja)
|
1998-05-22 |
2002-06-04 |
スミスクライン・ビーチャム・コーポレイション |
新規２−アルキル置換イミダゾール化合物
|
|
US6420555B1
(en)
|
1998-06-16 |
2002-07-16 |
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. |
Imidazolyl derivatives
|
|
FR2780973B1
(fr)
|
1998-07-09 |
2001-10-05 |
Hoechst Marion Roussel Inc |
Procede de preparation du 4-(3-pyridinyl)-1h-imidazole, et les intermediaires mis en oeuvre
|
|
DE19834751A1
(de)
|
1998-08-01 |
2000-02-03 |
Boehringer Ingelheim Pharma |
Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
|
|
US6576631B1
(en)
|
1998-11-17 |
2003-06-10 |
Kumiai Chemical Industry Co., Ltd. |
Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultural/horticultural bactericides
|
|
US6211177B1
(en)
|
1998-11-24 |
2001-04-03 |
Cell Pathways, Inc. |
Method for treating neoplasia by exposure to substituted 2-aryl-benzimidazole derivatives
|
|
US6339083B1
(en)
|
1998-12-14 |
2002-01-15 |
Bayer Aktiengesellschaft |
Multiheterocyclic pharmAceuticals
|
|
ME00275B
(me)
|
1999-01-13 |
2011-02-10 |
Bayer Corp |
ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE
|
|
JP2002536968A
(ja)
|
1999-01-29 |
2002-11-05 |
イムクローン システムズ インコーポレイティド |
Ｋｄｒに特異的な抗体およびその使用
|
|
GB9904387D0
(en)
|
1999-02-25 |
1999-04-21 |
Pharmacia & Upjohn Spa |
Antitumour synergistic composition
|
|
EP1187633A4
(en)
|
1999-04-08 |
2005-05-11 |
Arch Dev Corp |
USE OF ANTI-VEGF ANTIBODIES TO ENHANCE RADIATION IN ANTICANCER THERAPY
|
|
ES2231179T3
(es)
|
1999-04-12 |
2005-05-16 |
Aventis Pharma Limited |
Compuestos de heteroarilo biciclicos sustituidos como antagonistas de la integrina.
|
|
ES2260033T3
(es)
|
1999-07-02 |
2006-11-01 |
Stuart A. Lipton |
Uso de los inhibidores p38 mapk en efermadades oftalmicas.
|
|
CZ20021428A3
(cs)
|
1999-10-27 |
2002-11-13 |
Cytokinetics, Inc. |
Způsoby a kompozice vyuľívající chinazoliny
|
|
US6545004B1
(en)
|
1999-10-27 |
2003-04-08 |
Cytokinetics, Inc. |
Methods and compositions utilizing quinazolinones
|
|
ATE266022T1
(de)
|
2000-03-06 |
2004-05-15 |
Smithkline Beecham Plc |
Imidazol derivate als raf kinase inhibitoren
|
|
WO2001072712A1
(en)
|
2000-03-24 |
2001-10-04 |
Cor Therapeutics, Inc. |
ISOQUINOLONE INHIBITORS OF FACTOR Xa
|
|
EP1272483A2
(en)
|
2000-03-24 |
2003-01-08 |
Millenium Pharmaceuticals, Inc. |
OXINDOLE INHIBITORS OF FACTOR Xa
|
|
JP2001322903A
(ja)
|
2000-05-15 |
2001-11-20 |
Kumiai Chem Ind Co Ltd |
農園芸用殺菌剤組成物
|
|
AU7804501A
(en)
*
|
2000-07-27 |
2002-02-13 |
Pharmacia Corp |
Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure
|
|
US6756410B2
(en)
|
2000-08-30 |
2004-06-29 |
Kamal D. Mehta |
Induction of LDL receptor expression by extracellular-signal regulated kinase, ERK-1/2
|
|
JP4734705B2
(ja)
|
2000-10-31 |
2011-07-27 |
三菱化学株式会社 |
リチウム二次電池用正極材料、リチウム二次電池用正極及びリチウム二次電池
|
|
DE10060292A1
(de)
|
2000-12-05 |
2002-06-20 |
Aventis Pharma Gmbh |
Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament
|
|
DE60131015T2
(de)
|
2000-12-15 |
2008-07-10 |
Vertex Pharmaceuticals Inc., Cambridge |
Bakterielle gyrase-hemmer und deren verwendung
|
|
TW593278B
(en)
|
2001-01-23 |
2004-06-21 |
Wyeth Corp |
1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
|
|
JP2004531479A
(ja)
|
2001-02-08 |
2004-10-14 |
カロ バイオ アクチェブラーグ |
甲状腺受容体リガンドとしてのフェノキシ置換されたベンゾ縮合ヘテロアリール誘導体
|
|
US20050038022A1
(en)
|
2001-03-26 |
2005-02-17 |
Unisearch Limited |
Method for treatment of cancer and compositions for use therein
|
|
WO2002083139A1
(en)
|
2001-04-10 |
2002-10-24 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
US6958334B2
(en)
|
2001-04-10 |
2005-10-25 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
|
US7034026B2
(en)
|
2001-04-10 |
2006-04-25 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
|
US20040106540A1
(en)
|
2001-04-10 |
2004-06-03 |
Barnett Stanley F |
Method of treating cancer
|
|
CZ20032829A3
(cs)
|
2001-04-16 |
2005-03-16 |
Tanabe Seiyaku Co., Ltd. |
Heterocyklické sloučeniny
|
|
US6855714B2
(en)
|
2001-07-06 |
2005-02-15 |
Schering Aktiengesellschaft |
1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
|
|
WO2003013526A1
(en)
|
2001-08-08 |
2003-02-20 |
Merck & Co. Inc. |
Anticoagulant compounds
|
|
US6740649B2
(en)
|
2001-09-17 |
2004-05-25 |
Bristol-Myers Squibb Company |
Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF- α converting enzyme (TACE)
|
|
US7132438B2
(en)
|
2001-10-09 |
2006-11-07 |
Amgen Inc. |
Benzimidazole derivatives
|
|
US7039413B2
(en)
*
|
2001-10-24 |
2006-05-02 |
Ntt Docomo, Inc. |
Mobile station transfer control system, cell transfer control method, mobile station, cell transfer control method at mobile station, cell transfer control program, control apparatus, and allocating method of communication resources
|
|
JP2005511581A
(ja)
|
2001-11-07 |
2005-04-28 |
メルク エンド カムパニー インコーポレーテッド |
有糸分裂キネシン阻害剤
|
|
TW200300140A
(en)
|
2001-11-14 |
2003-05-16 |
Novartis Ag |
Organic compounds
|
|
TW200303742A
(en)
|
2001-11-21 |
2003-09-16 |
Novartis Ag |
Organic compounds
|
|
UA83620C2
(ru)
|
2001-12-05 |
2008-08-11 |
Уайт |
Замещенные бензоксазолы и их аналоги как эстрогенные агенты
|
|
CA2468156A1
(en)
|
2001-12-06 |
2003-06-19 |
Merck & Co., Inc. |
Azolopyrimidinone compounds and their use
|
|
US20050107404A1
(en)
|
2001-12-06 |
2005-05-19 |
Fraley Mark E. |
Mitotic kinesin inhibitors
|
|
CA2467722A1
(en)
|
2001-12-06 |
2003-06-19 |
Merck & Co., Inc. |
Thienopyrimidinone derivatives as mitotic kinesin inhibitors
|
|
WO2003049527A2
(en)
|
2001-12-06 |
2003-06-19 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
JP2005515208A
(ja)
|
2001-12-06 |
2005-05-26 |
メルク エンド カムパニー インコーポレーテッド |
有糸分裂性キネシン阻害剤
|
|
JP4136395B2
(ja)
|
2002-02-22 |
2008-08-20 |
クミアイ化学工業株式会社 |
農園芸用殺菌剤組成物
|
|
AU2003249597B2
(en)
|
2002-03-08 |
2007-06-28 |
Merck Sharp & Dohme Corp. |
Mitotic kinesin inhibitors
|
|
WO2003082272A1
(en)
*
|
2002-03-29 |
2003-10-09 |
Chiron Corporation |
Substituted benzazoles and use thereof as raf kinase inhibitors
|
|
US8299108B2
(en)
*
|
2002-03-29 |
2012-10-30 |
Novartis Ag |
Substituted benzazoles and methods of their use as inhibitors of raf kinase
|
|
CA2484261A1
(en)
|
2002-04-16 |
2003-10-23 |
Teijin Limited |
Piperidine derivatives having ccr3 antagonism
|
|
EP1505067A4
(en)
|
2002-04-25 |
2006-06-21 |
Teijin Ltd |
4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES WITH CCR3 ANTAGONISM
|
|
EP1517904A4
(en)
|
2002-05-23 |
2007-02-21 |
Merck & Co Inc |
INHIBITORS OF MITOTIC KINESINE
|
|
EP1509507A4
(en)
|
2002-05-23 |
2006-09-13 |
Merck & Co Inc |
INHIBITORS OF MITOTIC KINESINE
|
|
ATE356804T1
(de)
|
2002-06-14 |
2007-04-15 |
Merck & Co Inc |
Inhibitoren von mitotischem kinesin
|
|
EP1515724B1
(en)
|
2002-06-14 |
2009-10-21 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
TW200400816A
(en)
*
|
2002-06-26 |
2004-01-16 |
Lilly Co Eli |
Tricyclic steroid hormone nuclear receptor modulators
|
|
WO2004014881A2
(en)
|
2002-08-09 |
2004-02-19 |
Astra Zeneca Ab |
'1,2,4'oxadiazoles as modulators of metabotropic glutamate receptor-5
|
|
MXPA05002981A
(es)
|
2002-09-18 |
2005-06-22 |
Pfizer Prod Inc |
Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf).
|
|
AU2003271548A1
(en)
|
2002-10-13 |
2004-05-04 |
Neurosearch A/S |
Use of skca channel blocking drugs for combating parkinson's disease
|
|
JP4768265B2
(ja)
|
2002-10-15 |
2011-09-07 |
シンタ ファーマシューティカルズ コーポレーション |
新規化合物
|
|
US20050054705A1
(en)
|
2003-02-04 |
2005-03-10 |
Aventis Pharma Deutschland Gmbh |
N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
|
|
US7531553B2
(en)
|
2003-03-21 |
2009-05-12 |
Amgen Inc. |
Heterocyclic compounds and methods of use
|
|
WO2004087153A2
(en)
|
2003-03-28 |
2004-10-14 |
Chiron Corporation |
Use of organic compounds for immunopotentiation
|
|
CA2525764C
(en)
|
2003-05-20 |
2012-07-17 |
Novartis Ag |
N-acyl nitrogen heterocycles as ligands of peroxisome proliferator-activated receptors
|
|
WO2005000404A2
(en)
|
2003-05-29 |
2005-01-06 |
Synta Pharmaceuticals, Corp. |
Heterocyclic compounds for preventing and treating disorders associated with excessive bone loss
|
|
EP1646628A1
(en)
|
2003-07-08 |
2006-04-19 |
Novartis AG |
Benzenesulfonylamino compounds and pharmaceutical compositions containing these compounds
|
|
US20060205740A1
(en)
|
2003-08-14 |
2006-09-14 |
Reno Michael J |
Chemical compounds
|
|
EP2210607B1
(en)
|
2003-09-26 |
2011-08-17 |
Exelixis Inc. |
N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer
|
|
KR20060118472A
(ko)
|
2003-10-16 |
2006-11-23 |
카이론 코포레이션 |
치환 벤자졸 및 ｒａｆ 키나아제의 저해제로서 그것의 사용
|
|
US7470712B2
(en)
|
2004-01-21 |
2008-12-30 |
Bristol-Myers Squibb Company |
Amino-benzazoles as P2Y1 receptor inhibitors
|
|
JP2007518823A
(ja)
|
2004-01-23 |
2007-07-12 |
アムゲン インコーポレイテッド |
キノリン、キナゾリン、ピリジン、及びピリミジン化合物と炎症、血管新生、及び癌に対する治療におけるそれら化合物の用途
|
|
TWI387592B
(zh)
*
|
2005-08-30 |
2013-03-01 |
Novartis Ag |
經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法
|
|
PT2046292E
(pt)
*
|
2006-07-21 |
2010-04-26 |
Novartis Ag |
Formulações de éteres benzimidazolil-piridílicos
|