NO308301B1 - FremgangsmÕte for fremstilling av enantiomer-rene cykloalkanoindol- og azaindol- og pyrimido[1,2a]- indolkarboksylsyrer og deres aktiverte derivater, mellomprodukter samt anvendelse av disse - Google Patents

FremgangsmÕte for fremstilling av enantiomer-rene cykloalkanoindol- og azaindol- og pyrimido[1,2a]- indolkarboksylsyrer og deres aktiverte derivater, mellomprodukter samt anvendelse av disse

Info

Publication number: NO308301B1
Authority: NO; Norway
Prior art keywords: cycloalkanoindole; azaindole; pyrimido; intermediates; preparation
Prior art date: 1996-04-04

Application number

NO971513A

Other languages

English (en)

Norwegian (no)

Other versions

NO971513L (no

NO971513D0 (no

Inventor

Jan-Bernd Lenfers

Peter Fey

Paul Naab

Kai Van Laak

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-04

Filing date

1997-04-03

Publication date

2000-08-28

1997-04-03 Application filed by Bayer Ag filed Critical Bayer Ag

1997-04-03 Publication of NO971513D0 publication Critical patent/NO971513D0/no

1997-10-06 Publication of NO971513L publication Critical patent/NO971513L/no

2000-08-28 Publication of NO308301B1 publication Critical patent/NO308301B1/no

Links

BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title 1
239000002253 acid Substances 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
HBBKFNCURJQICW-UHFFFAOYSA-N pyrimido[1,2-a]indole Chemical compound C1=CC=NC2=CC3=CC=CC=C3N21 HBBKFNCURJQICW-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
- C07C69/616—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO971513A 1996-04-04 1997-04-03 FremgangsmÕte for fremstilling av enantiomer-rene cykloalkanoindol- og azaindol- og pyrimido[1,2a]- indolkarboksylsyrer og deres aktiverte derivater, mellomprodukter samt anvendelse av disse NO308301B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19613549A DE19613549A1 (de)	1996-04-04	1996-04-04	Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate

Publications (3)

Publication Number	Publication Date
NO971513D0 NO971513D0 (no)	1997-04-03
NO971513L NO971513L (no)	1997-10-06
NO308301B1 true NO308301B1 (no)	2000-08-28

Family

ID=7790501

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO971513A NO308301B1 (no)	1996-04-04	1997-04-03	FremgangsmÕte for fremstilling av enantiomer-rene cykloalkanoindol- og azaindol- og pyrimido[1,2a]- indolkarboksylsyrer og deres aktiverte derivater, mellomprodukter samt anvendelse av disse
NO20003784A NO20003784D0 (no)	1996-04-04	2000-07-24	FremgangsmÕte for fremstilling av enansiomert rene cykloalkanoindolkarboksylsyre og azaindolkarboksylsyrer og pyrimido 1,2a indolkarboksylsyrer og derivater derav

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20003784A NO20003784D0 (no)	1996-04-04	2000-07-24	FremgangsmÕte for fremstilling av enansiomert rene cykloalkanoindolkarboksylsyre og azaindolkarboksylsyrer og pyrimido 1,2a indolkarboksylsyrer og derivater derav

Country Status (27)

Country	Link
US (1)	US5952498A (fr)
EP (1)	EP0799829B1 (fr)
JP (2)	JP4235268B2 (fr)
KR (1)	KR970069988A (fr)
CN (2)	CN1067394C (fr)
AR (2)	AR006544A1 (fr)
AT (1)	ATE246193T1 (fr)
AU (1)	AU722592B2 (fr)
BR (1)	BR9701672A (fr)
CA (1)	CA2201435C (fr)
CZ (1)	CZ102197A3 (fr)
DE (2)	DE19613549A1 (fr)
DZ (1)	DZ2202A1 (fr)
EE (1)	EE9700079A (fr)
ES (1)	ES2202506T3 (fr)
HR (1)	HRP970178A2 (fr)
HU (1)	HU218494B (fr)
ID (1)	ID16794A (fr)
IL (1)	IL120591A (fr)
MA (1)	MA24130A1 (fr)
NO (2)	NO308301B1 (fr)
NZ (1)	NZ314498A (fr)
PL (1)	PL319269A1 (fr)
SG (1)	SG60050A1 (fr)
SK (1)	SK42897A3 (fr)
TN (1)	TNSN97060A1 (fr)
ZA (1)	ZA972831B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4435477A1 (de) *	1994-10-04	1996-04-11	Bayer Ag	Cycloalkano-indol- und -azaindol-derivate
AU2001244635A1 (en) *	2000-03-30	2001-10-15	Yamanouchi Pharmaceutical Co..Ltd.	Hydrazide derivatives
WO2005051382A1 (fr) *	2003-11-28	2005-06-09	Astellas Pharma Inc.	Agent renforçant l'effet hypolipidemiant
PT1725234E (pt)	2004-03-05	2013-03-04	Univ Pennsylvania	Métodos com efeitos secundários reduzidos para tratamento de patologias ou doenças associadas a hiperlipidemia e hipercolesterolemia
EP1737460A2 (fr) *	2004-04-09	2007-01-03	Janssen Pharmaceutica N.V.	Mode d'administration intermittent pour le traitement de l'obésité avec des inhibiteurs de mtp
EP1951220A2 (fr) *	2005-10-18	2008-08-06	Aegerion Pharmaceuticals	Compositions destinees a l'abbaissement du cholesterol serique et/ou des triglycerides
JP2009537505A (ja) *	2006-05-18	2009-10-29	バイエル・ヘルスケア・アクチェンゲゼルシャフト	インプリタピドを含む薬学的組成物およびこの薬学的組成物の使用方法
JP2010513534A (ja) *	2006-12-21	2010-04-30	エージェリオンファーマシューティカルズ，インコーポレイテッド	Ｍｔｐインヒビターおよびコレステロール吸収インヒビターを含む組み合わせを用いて肥満症を処置する方法
WO2008124384A2 (fr) *	2007-04-03	2008-10-16	Aegerion Pharmaceuticals, Inc.	Méthodes de traitement de l'hépatite c
SI2968284T1 (sl)	2013-03-14	2021-08-31	Osteoqc Inc.	Alkil-amin harmin derivati za pospeševanje rasti kosti
JP7695496B2 (ja)	2018-08-14	2025-06-19	オシフィセラピューティクスリミティドライアビリティカンパニー	フルオロβ－カルボリン化合物
EP3836923B1 (fr)	2018-08-14	2024-10-16	OssiFi Therapeutics LLC	Composés pyrrolo-dipyridine pour le traitement de perte osseuse
BR112023000808A2 (pt)	2020-07-29	2023-02-07	Amryt Pharmaceuticals Inc	Lomitapida para uso em métodos para tratar hiperlipidemia e hipercolesterolemia em pacientes pediátricos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3900261A1 (de) *	1988-05-31	1989-12-07	Bayer Ag	Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate
DE4200954A1 (de) *	1991-04-26	1992-10-29	Bayer Ag	Heterocyclisch substituierte phenylessigsaeurederivate
DE4208051A1 (de) *	1992-03-13	1993-09-16	Bayer Ag	Substituierte phenylessigsaeureamide
DE4302956A1 (de) *	1993-02-03	1994-08-04	Bayer Ag	Substituierte Imidazo(4,5-b)pyridine und Benzimidazole
DE4435477A1 (de) *	1994-10-04	1996-04-11	Bayer Ag	Cycloalkano-indol- und -azaindol-derivate

1996
- 1996-04-04 DE DE19613549A patent/DE19613549A1/de not_active Withdrawn
1997
- 1997-03-24 EP EP97104941A patent/EP0799829B1/fr not_active Expired - Lifetime
- 1997-03-24 DE DE59710487T patent/DE59710487D1/de not_active Expired - Lifetime
- 1997-03-24 AT AT97104941T patent/ATE246193T1/de not_active IP Right Cessation
- 1997-03-24 ES ES97104941T patent/ES2202506T3/es not_active Expired - Lifetime
- 1997-03-27 AU AU16602/97A patent/AU722592B2/en not_active Ceased
- 1997-03-27 NZ NZ314498A patent/NZ314498A/en unknown
- 1997-03-28 HR HR19613549.4A patent/HRP970178A2/xx not_active Application Discontinuation
- 1997-03-31 US US08/829,566 patent/US5952498A/en not_active Expired - Lifetime
- 1997-03-31 ID IDP971060A patent/ID16794A/id unknown
- 1997-04-01 SG SG1997001028A patent/SG60050A1/en unknown
- 1997-04-01 CA CA002201435A patent/CA2201435C/fr not_active Expired - Fee Related
- 1997-04-01 JP JP09635197A patent/JP4235268B2/ja not_active Expired - Fee Related
- 1997-04-01 MA MA24543A patent/MA24130A1/fr unknown
- 1997-04-02 DZ DZ970049A patent/DZ2202A1/fr active
- 1997-04-02 IL IL12059197A patent/IL120591A/xx not_active IP Right Cessation
- 1997-04-02 TN TNTNSN97060A patent/TNSN97060A1/fr unknown
- 1997-04-03 SK SK428-97A patent/SK42897A3/sk unknown
- 1997-04-03 ZA ZA9702831A patent/ZA972831B/xx unknown
- 1997-04-03 PL PL97319269A patent/PL319269A1/xx unknown
- 1997-04-03 HU HU9700698A patent/HU218494B/hu not_active IP Right Cessation
- 1997-04-03 CZ CZ971021A patent/CZ102197A3/cs unknown
- 1997-04-03 NO NO971513A patent/NO308301B1/no not_active IP Right Cessation
- 1997-04-03 EE EE9700079A patent/EE9700079A/xx unknown
- 1997-04-03 KR KR1019970012291A patent/KR970069988A/ko not_active Withdrawn
- 1997-04-04 BR BR9701672A patent/BR9701672A/pt active Search and Examination
- 1997-04-04 AR ARP970101366A patent/AR006544A1/es unknown
- 1997-04-04 CN CN97110276A patent/CN1067394C/zh not_active Expired - Fee Related
1998
- 1998-03-06 AR ARP980101029A patent/AR012048A2/es unknown
2000
- 2000-07-24 NO NO20003784A patent/NO20003784D0/no not_active Application Discontinuation
- 2000-10-12 CN CN00133103A patent/CN1330065A/zh active Pending
2008
- 2008-01-31 JP JP2008021569A patent/JP2008169218A/ja active Pending

Also Published As

Publication number	Publication date
AR012048A2 (es)	2000-09-27
JPH1045759A (ja)	1998-02-17
CN1330065A (zh)	2002-01-09
DZ2202A1 (fr)	2002-12-03
EE9700079A (et)	1997-10-15
IL120591A0 (en)	1997-08-14
US5952498A (en)	1999-09-14
CN1184109A (zh)	1998-06-10
HUP9700698A1 (hu)	1998-01-28
NZ314498A (en)	1999-09-29
JP4235268B2 (ja)	2009-03-11
DE19613549A1 (de)	1997-10-09
SG60050A1 (en)	1999-02-22
CN1067394C (zh)	2001-06-20
PL319269A1 (en)	1997-10-13
ES2202506T3 (es)	2004-04-01
NO971513L (no)	1997-10-06
BR9701672A (pt)	1998-11-03
IL120591A (en)	2000-11-21
AU722592B2 (en)	2000-08-10
TNSN97060A1 (fr)	2005-03-15
EP0799829B1 (fr)	2003-07-30
MX9702446A (es)	1997-10-31
CA2201435C (fr)	2006-12-12
NO20003784D0 (no)	2000-07-24
NO971513D0 (no)	1997-04-03
MA24130A1 (fr)	1997-10-01
KR970069988A (ko)	1997-11-07
EP0799829A1 (fr)	1997-10-08
ID16794A (id)	1997-11-13
CZ102197A3 (en)	1997-10-15
JP2008169218A (ja)	2008-07-24
ZA972831B (en)	1997-10-31
DE59710487D1 (de)	2003-09-04
HU9700698D0 (en)	1997-05-28
SK42897A3 (en)	1997-10-08
AR006544A1 (es)	1999-09-08
ATE246193T1 (de)	2003-08-15
HU218494B (hu)	2000-09-28
HRP970178A2 (en)	1998-04-30
AU1660297A (en)	1997-10-09
NO20003784L (no)	1997-10-06
CA2201435A1 (fr)	1997-10-04

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Legal Events

Date	Code	Title	Description
2002-12-09	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN OCTOBER 2002