NO322072B1 - Anvendelse av 1-hydroksy-2-pyridoner for fremstilling av et legemiddel til behandling av hudinfeksjoner - Google Patents

Anvendelse av 1-hydroksy-2-pyridoner for fremstilling av et legemiddel til behandling av hudinfeksjoner Download PDF

Info

Publication number: NO322072B1
Authority: NO; Norway
Prior art keywords: hydroxy; pyridone; atoms; formula; treatment
Prior art date: 1996-09-27

Application number

NO19991459A

Other languages

English (en)

Norwegian (no)

Other versions

NO991459D0 (no

NO991459L (no

Inventor

Astrid Markus

Manfred Bohn

Karl Theodor Kraemer

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-27

Filing date

1999-03-25

Publication date

2006-08-07

1999-03-25 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

1999-03-25 Publication of NO991459D0 publication Critical patent/NO991459D0/no

1999-03-25 Publication of NO991459L publication Critical patent/NO991459L/no

2006-08-07 Publication of NO322072B1 publication Critical patent/NO322072B1/no

Links

206010040872 skin infection Diseases 0.000 title claims description 12
SNUSZUYTMHKCPM-UHFFFAOYSA-N 1-hydroxypyridin-2-one Chemical class ON1C=CC=CC1=O SNUSZUYTMHKCPM-UHFFFAOYSA-N 0.000 title claims description 6
239000003814 drug Substances 0.000 title claims description 4
238000002360 preparation method Methods 0.000 title description 13
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150000001875 compounds Chemical class 0.000 claims description 9
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229910052717 sulfur Inorganic materials 0.000 claims description 5
125000004434 sulfur atom Chemical group 0.000 claims description 5
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 4
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 4
229910052794 bromium Inorganic materials 0.000 claims description 4
239000000460 chlorine Substances 0.000 claims description 4
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ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 4
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239000002674 ointment Substances 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
229940055019 propionibacterium acne Drugs 0.000 description 1
125000001453 quaternary ammonium group Chemical group 0.000 description 1
238000011160 research Methods 0.000 description 1
238000007790 scraping Methods 0.000 description 1
230000008313 sensitization Effects 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000000725 suspension Substances 0.000 description 1
229940073455 tetraethylammonium hydroxide Drugs 0.000 description 1
LRGJRHZIDJQFCL-UHFFFAOYSA-M tetraethylazanium;hydroxide Chemical compound [OH-].CC[N+](CC)(CC)CC LRGJRHZIDJQFCL-UHFFFAOYSA-M 0.000 description 1
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
241001148471 unidentified anaerobic bacterium Species 0.000 description 1
229960003165 vancomycin Drugs 0.000 description 1
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1
150000003754 zirconium Chemical class 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO19991459A 1996-09-27 1999-03-25 Anvendelse av 1-hydroksy-2-pyridoner for fremstilling av et legemiddel til behandling av hudinfeksjoner NO322072B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19639817A DE19639817A1 (de)	1996-09-27	1996-09-27	Verwendung von 1-Hydroxy-2-pyridonen zur Behandlung von Hautinfektionen
PCT/EP1997/005069 WO1998013043A1 (de)	1996-09-27	1997-09-16	Verwendung von 1-hydroxy-2-pyridonen zur behandlung von hautinfektionen

Publications (3)

Publication Number	Publication Date
NO991459D0 NO991459D0 (no)	1999-03-25
NO991459L NO991459L (no)	1999-03-25
NO322072B1 true NO322072B1 (no)	2006-08-07

Family

ID=7807117

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19991459A NO322072B1 (no)	1996-09-27	1999-03-25	Anvendelse av 1-hydroksy-2-pyridoner for fremstilling av et legemiddel til behandling av hudinfeksjoner

Country Status (32)

Country	Link
US (1)	US6469033B1 (cs)
EP (1)	EP0928193B1 (cs)
JP (1)	JP4203125B2 (cs)
KR (1)	KR100457851B1 (cs)
CN (1)	CN1141096C (cs)
AR (1)	AR008859A1 (cs)
AT (1)	ATE218862T1 (cs)
AU (1)	AU717333B2 (cs)
BG (1)	BG64370B1 (cs)
BR (1)	BR9712141A (cs)
CA (1)	CA2267309C (cs)
CZ (1)	CZ290701B6 (cs)
DE (2)	DE19639817A1 (cs)
DK (1)	DK0928193T3 (cs)
ES (1)	ES2178761T3 (cs)
HU (1)	HU226911B1 (cs)
ID (1)	ID21948A (cs)
IL (1)	IL129144A0 (cs)
MA (1)	MA24332A1 (cs)
MY (1)	MY117381A (cs)
NO (1)	NO322072B1 (cs)
NZ (1)	NZ334848A (cs)
OA (1)	OA11027A (cs)
PL (1)	PL190298B1 (cs)
PT (1)	PT928193E (cs)
RU (1)	RU2203059C2 (cs)
TR (1)	TR199900661T2 (cs)
TW (1)	TW531418B (cs)
UA (1)	UA56192C2 (cs)
WO (1)	WO1998013043A1 (cs)
YU (1)	YU49494B (cs)
ZA (1)	ZA978639B (cs)

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US20030228340A1 (en) *	2002-04-04	2003-12-11	Gans Eugene H.	Methods for treating rosacea with pyridones
ITMI20022447A1 (it) *	2002-11-19	2004-05-20	Carlo Ghisalberti	Uso di piridinoni nel trattamento della purpura capillare ed affezioni cutanee correlate.
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US20070071705A1 (en) *	2005-09-29	2007-03-29	De Oliveira Monica A M	Topical anti-microbial compositions
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1996
- 1996-09-27 DE DE19639817A patent/DE19639817A1/de not_active Withdrawn
1997
- 1997-09-16 EP EP97910293A patent/EP0928193B1/de not_active Expired - Lifetime
- 1997-09-16 CA CA002267309A patent/CA2267309C/en not_active Expired - Fee Related
- 1997-09-16 KR KR10-1999-7002622A patent/KR100457851B1/ko not_active Expired - Fee Related
- 1997-09-16 AT AT97910293T patent/ATE218862T1/de active
- 1997-09-16 WO PCT/EP1997/005069 patent/WO1998013043A1/de not_active Ceased
- 1997-09-16 TR TR1999/00661T patent/TR199900661T2/xx unknown
- 1997-09-16 BR BR9712141-0A patent/BR9712141A/pt not_active Application Discontinuation
- 1997-09-16 NZ NZ334848A patent/NZ334848A/xx not_active IP Right Cessation
- 1997-09-16 HU HU9904317A patent/HU226911B1/hu not_active IP Right Cessation
- 1997-09-16 ES ES97910293T patent/ES2178761T3/es not_active Expired - Lifetime
- 1997-09-16 UA UA99042350A patent/UA56192C2/uk unknown
- 1997-09-16 AU AU47745/97A patent/AU717333B2/en not_active Ceased
- 1997-09-16 IL IL12914497A patent/IL129144A0/xx not_active IP Right Cessation
- 1997-09-16 RU RU99108754/14A patent/RU2203059C2/ru not_active IP Right Cessation
- 1997-09-16 DK DK97910293T patent/DK0928193T3/da active
- 1997-09-16 CN CNB971982651A patent/CN1141096C/zh not_active Expired - Fee Related
- 1997-09-16 ID IDW990128A patent/ID21948A/id unknown
- 1997-09-16 YU YU13699A patent/YU49494B/sh unknown
- 1997-09-16 PL PL97332579A patent/PL190298B1/pl not_active IP Right Cessation
- 1997-09-16 PT PT97910293T patent/PT928193E/pt unknown
- 1997-09-16 CZ CZ19991074A patent/CZ290701B6/cs not_active IP Right Cessation
- 1997-09-16 US US09/077,191 patent/US6469033B1/en not_active Expired - Lifetime
- 1997-09-16 JP JP51522298A patent/JP4203125B2/ja not_active Expired - Fee Related
- 1997-09-16 DE DE59707519T patent/DE59707519D1/de not_active Expired - Lifetime
- 1997-09-25 AR ARP970104431A patent/AR008859A1/es not_active Application Discontinuation
- 1997-09-25 TW TW086113945A patent/TW531418B/zh not_active IP Right Cessation
- 1997-09-26 ZA ZA9708639A patent/ZA978639B/xx unknown
- 1997-09-26 MY MYPI97004502A patent/MY117381A/en unknown
- 1997-09-29 MA MA24813A patent/MA24332A1/fr unknown
1999
- 1999-03-17 BG BG103261A patent/BG64370B1/bg unknown
- 1999-03-25 NO NO19991459A patent/NO322072B1/no not_active IP Right Cessation
- 1999-03-26 OA OA9900070A patent/OA11027A/fr unknown

Also Published As

Publication number	Publication date
YU13699A (sh)	1999-12-27
YU49494B (sh)	2006-08-17
AU717333B2 (en)	2000-03-23
HU226911B1 (en)	2010-03-01
OA11027A (fr)	2003-03-06
PT928193E (pt)	2002-11-29
HUP9904317A2 (hu)	2000-05-28
CZ290701B6 (cs)	2002-09-11
EP0928193B1 (de)	2002-06-12
DE59707519D1 (de)	2002-07-18
CN1141096C (zh)	2004-03-10
TW531418B (en)	2003-05-11
BG103261A (en)	1999-09-30
WO1998013043A1 (de)	1998-04-02
BR9712141A (pt)	1999-08-31
NO991459D0 (no)	1999-03-25
EP0928193A1 (de)	1999-07-14
IL129144A0 (en)	2000-02-17
KR20000048674A (ko)	2000-07-25
DE19639817A1 (de)	1998-04-02
US6469033B1 (en)	2002-10-22
UA56192C2 (uk)	2003-05-15
PL190298B1 (pl)	2005-11-30
RU2203059C2 (ru)	2003-04-27
HUP9904317A3 (en)	2001-07-30
CA2267309A1 (en)	1998-04-02
BG64370B1 (bg)	2004-12-30
ATE218862T1 (de)	2002-06-15
MA24332A1 (fr)	1998-04-01
PL332579A1 (en)	1999-09-27
JP4203125B2 (ja)	2008-12-24
AU4774597A (en)	1998-04-17
ZA978639B (en)	1998-03-27
MY117381A (en)	2004-06-30
DK0928193T3 (da)	2002-10-07
JP2001501200A (ja)	2001-01-30
CN1231610A (zh)	1999-10-13
KR100457851B1 (ko)	2004-11-18
TR199900661T2 (xx)	1999-06-21
CZ107499A3 (cs)	1999-07-14
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