NO992838L - Benzotiofenkarboksamid-derivater og PGD2 antagonister omfattende disse - Google Patents

Benzotiofenkarboksamid-derivater og PGD2 antagonister omfattende disse

Info

Publication number: NO992838L
Authority: NO; Norway
Prior art keywords: pgd2; pgd2 antagonists; systemic; benzothiophenecarboxamide; derivatives
Prior art date: 1996-12-13

Application number

NO992838A

Other languages

English (en)

Norwegian (no)

Other versions

NO992838D0 (no

Inventor

Tsunetoshi Honma

Yoshiharu Hiramatsu

Akinori Arimura

Original Assignee

Shionogi & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-13

Filing date

1999-06-10

Publication date

1999-07-20

1999-06-10 Application filed by Shionogi & Co filed Critical Shionogi & Co

1999-06-10 Publication of NO992838D0 publication Critical patent/NO992838D0/no

1999-07-20 Publication of NO992838L publication Critical patent/NO992838L/no

Links

102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 title abstract 2
101000988802 Homo sapiens Hematopoietic prostaglandin D synthase Proteins 0.000 title abstract 2
BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 title abstract 2
BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 title abstract 2
GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical class C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
206010010744 Conjunctivitis allergic Diseases 0.000 abstract 1
206010012438 Dermatitis atopic Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
206010063837 Reperfusion injury Diseases 0.000 abstract 1
206010039085 Rhinitis allergic Diseases 0.000 abstract 1
201000008736 Systemic mastocytosis Diseases 0.000 abstract 1
208000024780 Urticaria Diseases 0.000 abstract 1
208000002205 allergic conjunctivitis Diseases 0.000 abstract 1
201000010105 allergic rhinitis Diseases 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
208000024998 atopic conjunctivitis Diseases 0.000 abstract 1
201000008937 atopic dermatitis Diseases 0.000 abstract 1
230000020411 cell activation Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
210000003979 eosinophil Anatomy 0.000 abstract 1
210000003630 histaminocyte Anatomy 0.000 abstract 1
230000008595 infiltration Effects 0.000 abstract 1
238000001764 infiltration Methods 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000000302 ischemic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1
230000009284 tracheal contraction Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO992838A 1996-12-13 1999-06-10 Benzotiofenkarboksamid-derivater og PGD2 antagonister omfattende disse NO992838L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP33349596		1996-12-13
JP25400197		1997-09-19
PCT/JP1997/004527 WO1998025919A1 (fr)	1996-12-13	1997-12-10	Derives du benzothiophenecarboxamide, et antagonistes de la pgd2 les comprenant

Publications (2)

Publication Number	Publication Date
NO992838D0 NO992838D0 (no)	1999-06-10
NO992838L true NO992838L (no)	1999-07-20

Family

ID=26541496

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO992838A NO992838L (no)	1996-12-13	1999-06-10	Benzotiofenkarboksamid-derivater og PGD2 antagonister omfattende disse

Country Status (25)

Country	Link
US (1)	US6083974A (fr)
EP (1)	EP0944614B1 (fr)
JP (1)	JP3215441B2 (fr)
KR (1)	KR100433568B1 (fr)
CN (2)	CN1105112C (fr)
AR (1)	AR008939A1 (fr)
AT (1)	ATE223911T1 (fr)
AU (1)	AU718958B2 (fr)
BR (1)	BR9714016A (fr)
CA (1)	CA2274591C (fr)
CZ (1)	CZ297324B6 (fr)
DE (1)	DE69715448T2 (fr)
DK (1)	DK0944614T3 (fr)
ES (1)	ES2181039T3 (fr)
HU (1)	HU226458B1 (fr)
ID (1)	ID22753A (fr)
IL (1)	IL130660A (fr)
NO (1)	NO992838L (fr)
NZ (1)	NZ336143A (fr)
PL (1)	PL191760B1 (fr)
PT (1)	PT944614E (fr)
RU (1)	RU2161617C1 (fr)
TR (1)	TR199901280T2 (fr)
TW (1)	TW438790B (fr)
WO (1)	WO1998025919A1 (fr)

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BR9909290A (pt)	1998-03-31	2000-12-05	Shinogi Co	Processo para preparar derivados de ácido 5-hidroxibenzo [b] tiofeno-3-carboxìlico
WO1999050261A1 (fr)	1998-03-31	1999-10-07	Shionogi & Co., Ltd.	PROCEDE DE PRODUCTION DE DERIVES D'AMIDE DE L'ACIDE BENZOTHIOPHENECARBOXYLIQUE$i()
CN1198649C (zh) *	1998-06-03	2005-04-27	盐野义制药株式会社	用于治疗瘙痒的含pgd2受体拮抗剂的药物组合物
WO2001002334A1 (fr)	1999-07-02	2001-01-11	Shionogi & Co., Ltd.	Nouveau procede de production d'amino-alcool bicyclique
MXPA02008801A (es)	2000-03-09	2003-07-07	Ono Pharmaceutical Co	Derivados de indol, proceso para la preparacion de los mismos y su uso.
WO2001078697A2 (fr) *	2000-04-12	2001-10-25	Merck Frosst Canada & Co.	Procede et compositions destines au traitement d'etats allergiques faisant appel a des antagonistes du recepteur pgd2
US6410583B1 (en) *	2000-07-25	2002-06-25	Merck Frosst Canada & Co.	Cyclopentanoindoles, compositions containing such compounds and methods of treatment
US7217725B2 (en)	2000-09-14	2007-05-15	Allergan, Inc.	Prostaglandin D2 antagonist
US7273883B2 (en)	2000-09-14	2007-09-25	Allergan, Inc.	Prostaglandin EP4 antagonist
ATE287399T1 (de) *	2000-10-17	2005-02-15	Shionogi & Co	Verfahren zur herstellung eines pgd2-antagonisten
EP1338594A4 (fr) *	2000-11-01	2004-06-16	Shionogi & Co	Compositions pharmaceutiques antagonistes du recepteur de pgd2
AR038136A1 (es)	2002-01-24	2004-12-29	Merck Frosst Canada Inc	Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
MXPA04009095A (es) *	2002-03-19	2004-12-06	Ono Pharmaceutical Co	Compuesto de acido carboxilico y agente farmaceutico que comprende el compuesto como ingrediente activo.
AU2003252499B2 (en) *	2002-07-12	2007-11-08	Japan Science And Technology Agency	Drugs for improving the prognosis of brain injury and a method of screening the same
WO2004030674A1 (fr) *	2002-09-30	2004-04-15	Shionogi & Co., Ltd.	Nouvelles utilisations de la prostaglandine d2, agoniste de la prostaglandine d2 et antagoniste de la prostaglandine d2
MXPA05004715A (es)	2002-10-30	2005-08-03	Merck Frosst Canada Inc	Derivados de piridopirrolizina y piridoindolizina.
RU2387652C2 (ru)	2004-03-11	2010-04-27	Актелион Фармасьютиклз Лтд	Производные тетрагидропиридоиндола
WO2006068162A1 (fr) *	2004-12-24	2006-06-29	Shionogi & Co., Ltd.	Agent thérapeutique pour le traitement de la bronchopneumopathie chronique obstructive
TW200716093A (en) *	2005-04-28	2007-05-01	Shionogi & Co	An antiasthmatic agent containing PGD2 receptor antagonist and leukotriene receptor antagonist
TWI410410B (zh)	2007-08-10	2013-10-01	Ono Pharmaceutical Co	Phenylacetic acid compounds
CN102822163B (zh)	2009-12-23	2016-01-20	艾恩伍德医药品股份有限公司	Crth2调节剂
US20130178475A1 (en)	2010-03-17	2013-07-11	Ironwood Pharmaceuticals, Inc.	sGC STIMULATORS
EA026692B1 (ru)	2010-06-30	2017-05-31	Айронвуд Фармасьютикелз, Инк.	Стимуляторы sgc
WO2012009137A1 (fr)	2010-07-12	2012-01-19	Ironwood Pharmaceuticals, Inc.	Modulateurs de crth2
US20130259830A1 (en)	2010-07-12	2013-10-03	Ironwood Pharmaceuticals, Inc.	Crth2 modulators
WO2012064559A1 (fr)	2010-11-09	2012-05-18	Ironwood Pharmaceuticals, Inc.	Stimulateurs de sgc
EP2797915B1 (fr)	2011-12-27	2016-07-13	Ironwood Pharmaceuticals, Inc.	Dérivés de 2-bénzyl-3-(oxazole/thiazole)-5-(pyrimidin-2-yl)-1(H)-pyrazole en tant que stimulateurs de la cyclase de guanylate soluble (sGC) pour le traitement de la hypertension ou de l'insuffisance cardiaque
WO2014047111A1 (fr)	2012-09-18	2014-03-27	Ironwood Pharmaceuticals, Inc.	Stimulateurs de la sgc
CA2885645A1 (fr)	2012-09-19	2014-03-27	Ironwood Pharmaceuticals, Inc.	Stimulateurs de sgc
RS63108B1 (sr)	2013-03-15	2022-04-29	Cyclerion Therapeutics Inc	Sgc stimulatori
US20160311826A1 (en)	2013-12-11	2016-10-27	Ironwood Pharmaceuticals, Inc.	Sgc stimulators
EP3094327A1 (fr)	2014-01-13	2016-11-23	Ironwood Pharmaceuticals, Inc.	Utilisation de stimulateurs de la sgc pour le traitement de troubles neuromusculaires
US20170298055A1 (en)	2014-09-17	2017-10-19	Ironwood Pharmaceuticals, Inc.	sGC STIMULATORS
US20170291889A1 (en)	2014-09-17	2017-10-12	Ironwood Pharmaceuticals, Inc.	Pyrazole derivatives as sgc stimulators
MX2017003518A (es)	2014-09-17	2017-07-28	Ironwood Pharmaceuticals Inc	Estimuladores de guanilato ciclasa soluble (sgc).
ES2991300T3 (es)	2015-02-13	2024-12-03	Inserm Institut Nat De La Sante Et De Larecherche Medicale	Antagonistas de PTGDR-1 y/o PTGDR-2 para prevenir y/o tratar lupus eritematoso sistémico
JP2019524710A (ja)	2016-07-07	2019-09-05	アイアンウッドファーマシューティカルズインコーポレイテッド	Ｓｇｃ刺激剤の固体形態
MA45592A (fr)	2016-07-07	2019-05-15	Ironwood Pharmaceuticals Inc	Promédicaments à base de phosphore de stimulateurs de sgc

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GB8406906D0 (en) *	1984-03-16	1984-04-18	Akzo Nv	Benzo-thiazole and benzothiophene derivatives
US4560343A (en) *	1984-06-11	1985-12-24	Honeywell Inc.	Functional check for a hot surface ignitor element
JPS6149A (ja) *	1984-06-12	1986-01-06	Ono Pharmaceut Co Ltd	新規な１３―アザ―１４―オキソ―ＴｘＡ２類似化合物およびそれらを有効成分として含有するトロンボキサン起因疾患治療剤
CA1278577C (fr) *	1985-11-18	1991-01-02	Tatsuo Tsuri	Derives bicycliques de sulfonamides
CA1294974C (fr) *	1987-05-08	1992-01-28	Sanji Hagishita	Derives de sulfonamide bicycliques et leur procede de preparation
US5356926A (en) *	1992-02-24	1994-10-18	Warner-Lambert Company	3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion
CA2113787A1 (fr) *	1993-01-29	1994-07-30	Nobuyuki Hamanaka	Sulfonamides carbocycliques
DE4317076A1 (de) *	1993-05-21	1994-11-24	Bayer Ag	Benzthiophencarbonsäureamid-S-oxide
US5863936A (en) *	1995-04-18	1999-01-26	Geron Corporation	Telomerase inhibitors
MX9710256A (es) *	1995-06-21	1998-03-31	Shionogi & Co	Derivados de amino biciclicos y antagonistas pgd2 que contienen los mismos.
US5792763A (en) *	1996-10-08	1998-08-11	Eli Lilly And Company	Serotonin 5-HT1F agonists

1997
- 1997-12-10 NZ NZ336143A patent/NZ336143A/en unknown
- 1997-12-10 RU RU99115766/04A patent/RU2161617C1/ru not_active IP Right Cessation
- 1997-12-10 ES ES97947866T patent/ES2181039T3/es not_active Expired - Lifetime
- 1997-12-10 WO PCT/JP1997/004527 patent/WO1998025919A1/fr not_active Ceased
- 1997-12-10 AT AT97947866T patent/ATE223911T1/de not_active IP Right Cessation
- 1997-12-10 PL PL334072A patent/PL191760B1/pl not_active IP Right Cessation
- 1997-12-10 ID IDW990472A patent/ID22753A/id unknown
- 1997-12-10 EP EP97947866A patent/EP0944614B1/fr not_active Expired - Lifetime
- 1997-12-10 IL IL13066097A patent/IL130660A/en not_active IP Right Cessation
- 1997-12-10 DK DK97947866T patent/DK0944614T3/da active
- 1997-12-10 DE DE69715448T patent/DE69715448T2/de not_active Expired - Lifetime
- 1997-12-10 CN CN97180628A patent/CN1105112C/zh not_active Expired - Fee Related
- 1997-12-10 CA CA002274591A patent/CA2274591C/fr not_active Expired - Fee Related
- 1997-12-10 AU AU54097/98A patent/AU718958B2/en not_active Ceased
- 1997-12-10 HU HU0002869A patent/HU226458B1/hu not_active IP Right Cessation
- 1997-12-10 JP JP52649298A patent/JP3215441B2/ja not_active Expired - Fee Related
- 1997-12-10 BR BR9714016-3A patent/BR9714016A/pt active Search and Examination
- 1997-12-10 KR KR10-1999-7005154A patent/KR100433568B1/ko not_active Expired - Fee Related
- 1997-12-10 CZ CZ0206599A patent/CZ297324B6/cs not_active IP Right Cessation
- 1997-12-10 PT PT97947866T patent/PT944614E/pt unknown
- 1997-12-10 TR TR1999/01280T patent/TR199901280T2/xx unknown
- 1997-12-10 US US09/308,176 patent/US6083974A/en not_active Expired - Lifetime
- 1997-12-11 TW TW086118667A patent/TW438790B/zh not_active IP Right Cessation
- 1997-12-12 AR ARP970105862A patent/AR008939A1/es active IP Right Grant
1999
- 1999-06-10 NO NO992838A patent/NO992838L/no unknown
2002
- 2002-06-11 CN CNB021227608A patent/CN1185226C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6083974A (en)	2000-07-04
HUP0002869A3 (en)	2003-01-28
IL130660A (en)	2002-03-10
AU718958B2 (en)	2000-05-04
NZ336143A (en)	2002-05-31
CN1445225A (zh)	2003-10-01
ATE223911T1 (de)	2002-09-15
NO992838D0 (no)	1999-06-10
CN1185226C (zh)	2005-01-19
CZ206599A3 (cs)	1999-11-17
KR100433568B1 (ko)	2004-05-31
HUP0002869A2 (hu)	2001-06-28
CN1240438A (zh)	2000-01-05
TR199901280T2 (xx)	1999-10-21
CN1105112C (zh)	2003-04-09
ID22753A (id)	1999-12-09
ES2181039T3 (es)	2003-02-16
DE69715448D1 (de)	2002-10-17
HU226458B1 (en)	2008-12-29
BR9714016A (pt)	2000-02-29
AR008939A1 (es)	2000-02-23
JP3215441B2 (ja)	2001-10-09
PT944614E (pt)	2003-01-31
TW438790B (en)	2001-06-07
PL191760B1 (pl)	2006-06-30
IL130660A0 (en)	2000-06-01
KR20000069402A (ko)	2000-11-25
RU2161617C1 (ru)	2001-01-10
AU5409798A (en)	1998-07-03
CA2274591C (fr)	2005-06-14
DK0944614T3 (da)	2003-01-13
EP0944614B1 (fr)	2002-09-11
JP2000514824A (ja)	2000-11-07
DE69715448T2 (de)	2003-08-07
EP0944614A1 (fr)	1999-09-29
CZ297324B6 (cs)	2006-11-15
WO1998025919A1 (fr)	1998-06-18
HK1020045A1 (en)	2000-03-10
PL334072A1 (en)	2000-01-31
CA2274591A1 (fr)	1998-06-18

Publication	Publication Date	Title
NO992838L (no)	1999-07-20	Benzotiofenkarboksamid-derivater og PGD2 antagonister omfattende disse
DE69733271D1 (de)	2005-06-16	Kondensierte heterocyclische benzolcarbonsäureamid-derivate und diese enthaltende pgd2 antagonisten
CZ285870B6 (cs)	1999-11-17	Bicyklické aminoderiváty a antagonist PGD2, který je obsahuje
CA2482551A1 (fr)	2003-12-18	1-(4-piperidinyl) benzimidazolones utilises en tant qu'antagonistes du recepteur h3 de l'histamine
DK1230243T3 (da)	2009-06-15	Polycycloalkylpuriner som adenosinreceptorantagonister
NO20044501L (no)	2005-01-18	[1,4] diazenino [6,7,1-IJ] kinolin-derivater som antipsykotis og antifedme-midler
NO981485L (no)	1998-06-02	Nye heterocykliske derivater og farmas÷ytisk anvendelse av disse
NO20020823L (no)	2002-04-17	Heteropolysykliske forbindelser og deres anvendelse som metabotropiske glutamatreseptorantagonister
NO20055565L (no)	2006-01-25	Anvendelse av derivater av 2,4-dihydro-[1,2,4]triazol-3-thion som inhibitorer av enzymet myeloperoksidase (MPO)
NO963706L (no)	1996-11-06	Benzenkondenserte heterosykliske derivater og deres anvendelse
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