NO992838L - Benzotiofenkarboksamid-derivater og PGD2 antagonister omfattende disse - Google Patents

Benzotiofenkarboksamid-derivater og PGD2 antagonister omfattende disse

Info

Publication number: NO992838L
Authority: NO; Norway
Prior art keywords: pgd2; pgd2 antagonists; systemic; benzothiophenecarboxamide; derivatives
Prior art date: 1996-12-13

Application number

NO992838A

Other languages

English (en)

Norwegian (no)

Other versions

NO992838D0 (no

Inventor

Tsunetoshi Honma

Yoshiharu Hiramatsu

Akinori Arimura

Original Assignee

Shionogi & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-13

Filing date

1999-06-10

Publication date

1999-07-20

1999-06-10 Application filed by Shionogi & Co filed Critical Shionogi & Co

1999-06-10 Publication of NO992838D0 publication Critical patent/NO992838D0/no

1999-07-20 Publication of NO992838L publication Critical patent/NO992838L/no

Links

102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 title abstract 2
101000988802 Homo sapiens Hematopoietic prostaglandin D synthase Proteins 0.000 title abstract 2
BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 title abstract 2
BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 title abstract 2
GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical class C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
206010010744 Conjunctivitis allergic Diseases 0.000 abstract 1
206010012438 Dermatitis atopic Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
206010063837 Reperfusion injury Diseases 0.000 abstract 1
206010039085 Rhinitis allergic Diseases 0.000 abstract 1
201000008736 Systemic mastocytosis Diseases 0.000 abstract 1
208000024780 Urticaria Diseases 0.000 abstract 1
208000002205 allergic conjunctivitis Diseases 0.000 abstract 1
201000010105 allergic rhinitis Diseases 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
208000024998 atopic conjunctivitis Diseases 0.000 abstract 1
201000008937 atopic dermatitis Diseases 0.000 abstract 1
230000020411 cell activation Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
210000003979 eosinophil Anatomy 0.000 abstract 1
210000003630 histaminocyte Anatomy 0.000 abstract 1
230000008595 infiltration Effects 0.000 abstract 1
238000001764 infiltration Methods 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000000302 ischemic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1
230000009284 tracheal contraction Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO992838A 1996-12-13 1999-06-10 Benzotiofenkarboksamid-derivater og PGD2 antagonister omfattende disse NO992838L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP33349596		1996-12-13
JP25400197		1997-09-19
PCT/JP1997/004527 WO1998025919A1 (fr)	1996-12-13	1997-12-10	Derives du benzothiophenecarboxamide, et antagonistes de la pgd2 les comprenant

Publications (2)

Publication Number	Publication Date
NO992838D0 NO992838D0 (no)	1999-06-10
NO992838L true NO992838L (no)	1999-07-20

Family

ID=26541496

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO992838A NO992838L (no)	1996-12-13	1999-06-10	Benzotiofenkarboksamid-derivater og PGD2 antagonister omfattende disse

Country Status (25)

Country	Link
US (1)	US6083974A (fr)
EP (1)	EP0944614B1 (fr)
JP (1)	JP3215441B2 (fr)
KR (1)	KR100433568B1 (fr)
CN (2)	CN1105112C (fr)
AR (1)	AR008939A1 (fr)
AT (1)	ATE223911T1 (fr)
AU (1)	AU718958B2 (fr)
BR (1)	BR9714016A (fr)
CA (1)	CA2274591C (fr)
CZ (1)	CZ297324B6 (fr)
DE (1)	DE69715448T2 (fr)
DK (1)	DK0944614T3 (fr)
ES (1)	ES2181039T3 (fr)
HU (1)	HU226458B1 (fr)
ID (1)	ID22753A (fr)
IL (1)	IL130660A (fr)
NO (1)	NO992838L (fr)
NZ (1)	NZ336143A (fr)
PL (1)	PL191760B1 (fr)
PT (1)	PT944614E (fr)
RU (1)	RU2161617C1 (fr)
TR (1)	TR199901280T2 (fr)
TW (1)	TW438790B (fr)
WO (1)	WO1998025919A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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RU2185380C1 (ru)	1998-03-31	2002-07-20	Сионоги Энд Ко., Лтд.	Способ получения производных бензотиофенкарбоксамида и аминоспиртов (варианты)
ID26346A (id)	1998-03-31	2000-12-14	Shionogi & Co	PROSES PEMBUATAN TURUNAN ASAM 5-HIDROKSIBENZO (b)TIOFEN-3-KARBOKSILAT
ES2241283T3 (es) *	1998-06-03	2005-10-16	SHIONOGI & CO., LTD.	Remedios para el tratamiento del prurito que contienen antagonistas de pgd2.
EP1808427A3 (fr) *	1999-07-02	2008-06-25	Shionogi & Co., Ltd.	Nouveaux processus de préparation d'amino-alcools bicycliques
KR20030010589A (ko)	2000-03-09	2003-02-05	오노 야꾸힝 고교 가부시키가이샤	인돌 유도체, 그 제조 방법 및 용도
ATE311200T1 (de) *	2000-04-12	2005-12-15	Merck Frosst Canada Inc	Verfahren und zusammensetzungen zur behandlung von allergischen zuständen mit pgd2 rezeptor antagonisten
US6410583B1 (en) *	2000-07-25	2002-06-25	Merck Frosst Canada & Co.	Cyclopentanoindoles, compositions containing such compounds and methods of treatment
US7273883B2 (en)	2000-09-14	2007-09-25	Allergan, Inc.	Prostaglandin EP4 antagonist
US7217725B2 (en)	2000-09-14	2007-05-15	Allergan, Inc.	Prostaglandin D2 antagonist
WO2002032892A1 (fr) *	2000-10-17	2002-04-25	Shionogi & Co., Ltd	Procede de preparation d'antagoniste pgd2
JPWO2002036583A1 (ja) *	2000-11-01	2004-03-11	塩野義製薬株式会社	Ｐｇｄ２受容体拮抗性医薬組成物
AR038136A1 (es)	2002-01-24	2004-12-29	Merck Frosst Canada Inc	Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
CN100378083C (zh)	2002-03-19	2008-04-02	小野药品工业株式会社	羧酸化合物和含有所述化合物作为活性成分的药物制剂
JPWO2004006956A1 (ja) *	2002-07-12	2005-11-10	独立行政法人科学技術振興機構	脳損傷の予後改善薬とそのスクリーニング方法
AU2003242485A1 (en) *	2002-09-30	2004-04-23	Shionogi And Co., Ltd.	Novel uses of prostaglandin d2, prostaglandin d2 agonist and prostaglandin d2 antagonist
EP1558614B1 (fr)	2002-10-30	2010-09-01	Merck Frosst Canada Ltd.	Pyridopyrrolizine et derives de pyridoindolizine
JP4051398B2 (ja)	2004-03-11	2008-02-20	アクテリオンファマシューティカルズリミテッド	テトラヒドロピリドインドール誘導体
JPWO2006068162A1 (ja) *	2004-12-24	2008-06-12	塩野義製薬株式会社	慢性閉塞性肺疾患の治療剤
TW200716093A (en) *	2005-04-28	2007-05-01	Shionogi & Co	An antiasthmatic agent containing PGD2 receptor antagonist and leukotriene receptor antagonist
TWI410410B (zh)	2007-08-10	2013-10-01	Ono Pharmaceutical Co	Phenylacetic acid compounds
CN102822163B (zh)	2009-12-23	2016-01-20	艾恩伍德医药品股份有限公司	Crth2调节剂
US20130178475A1 (en)	2010-03-17	2013-07-11	Ironwood Pharmaceuticals, Inc.	sGC STIMULATORS
TWI532737B (zh)	2010-06-30	2016-05-11	艾諾屋製藥公司	可溶性鳥苷酸環化酶（ｓＧＣ）刺激物
US20130259830A1 (en)	2010-07-12	2013-10-03	Ironwood Pharmaceuticals, Inc.	Crth2 modulators
WO2012009137A1 (fr)	2010-07-12	2012-01-19	Ironwood Pharmaceuticals, Inc.	Modulateurs de crth2
JP5878546B2 (ja)	2010-11-09	2016-03-08	アイアンウッドファーマシューティカルズインコーポレイテッド	ｓＧＣ刺激剤
CA2861804C (fr)	2011-12-27	2021-10-26	Ironwood Pharmaceuticals, Inc.	Pyrazoles 2-benzyle, 3-(pyrimidin-2-yle)-substitues utiles comme stimulateurs de scg
WO2014047111A1 (fr)	2012-09-18	2014-03-27	Ironwood Pharmaceuticals, Inc.	Stimulateurs de la sgc
EP2897953B8 (fr)	2012-09-19	2019-06-26	Cyclerion Therapeutics, Inc.	Stimulateurs de sgc
ES2911276T3 (es)	2013-03-15	2022-05-18	Cyclerion Therapeutics Inc	Estimuladores de sGC
JP2016540017A (ja)	2013-12-11	2016-12-22	アイアンウッドファーマシューティカルズインコーポレイテッド	ｓＧＣ刺激物質
WO2015106268A1 (fr)	2014-01-13	2015-07-16	Ironwood Pharmaceuticals, Inc.	Utilisation de stimulateurs de la sgc pour le traitement de troubles neuromusculaires
EP3194382B1 (fr)	2014-09-17	2021-09-08	Cyclerion Therapeutics, Inc.	Dérivés de pyrazole utilisés comme stimulateurs de sgc
WO2016044445A2 (fr)	2014-09-17	2016-03-24	Ironwood Pharmaceuticals, Inc.	Stimulateurs de sgc
US10844064B2 (en)	2014-09-17	2020-11-24	Cyclerion Therapeutics, Inc.	sGC stimulators
JP6770522B2 (ja)	2015-02-13	2020-10-14	アンスティチュナショナルドゥラサンテエドゥラルシェルシュメディカル	全身性エリテマトーデスを予防し、及び／又は、治療するためのｐｔｇｄｒ−１及び／又はｐｔｇｄｒ−２アンタゴニスト
KR102513343B1 (ko)	2016-07-07	2023-03-22	사이클리온 테라퓨틱스, 인크.	sGC 자극제의 인 전구약물
EA039753B1 (ru)	2016-07-07	2022-03-10	Сайклерион Терапьютикс, Инк.	ТВЕРДЫЕ ФОРМЫ СТИМУЛЯТОРА sGC

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GB8406906D0 (en) *	1984-03-16	1984-04-18	Akzo Nv	Benzo-thiazole and benzothiophene derivatives
US4560343A (en) *	1984-06-11	1985-12-24	Honeywell Inc.	Functional check for a hot surface ignitor element
JPS6149A (ja) *	1984-06-12	1986-01-06	Ono Pharmaceut Co Ltd	新規な１３―アザ―１４―オキソ―ＴｘＡ２類似化合物およびそれらを有効成分として含有するトロンボキサン起因疾患治療剤
NZ218115A (en) *	1985-11-18	1990-02-26	Shionogi & Co	Bicyclic sulphonamides and pharmaceutical compositions
CA1294974C (fr) *	1987-05-08	1992-01-28	Sanji Hagishita	Derives de sulfonamide bicycliques et leur procede de preparation
US5356926A (en) *	1992-02-24	1994-10-18	Warner-Lambert Company	3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion
CA2113787A1 (fr) *	1993-01-29	1994-07-30	Nobuyuki Hamanaka	Sulfonamides carbocycliques
DE4317076A1 (de) *	1993-05-21	1994-11-24	Bayer Ag	Benzthiophencarbonsäureamid-S-oxide
US5863936A (en) *	1995-04-18	1999-01-26	Geron Corporation	Telomerase inhibitors
PL185107B1 (pl) *	1995-06-21	2003-02-28	Shionogi & Co	Bicykliczne związki aminowe, kompozycja farmaceutyczna i jej stosowanie
JP2001501946A (ja) *	1996-10-08	2001-02-13	イーライ・リリー・アンド・カンパニー	新規セロトニン５―ｈｔ▲下１ｆ▼アゴニスト

1997
- 1997-12-10 BR BR9714016-3A patent/BR9714016A/pt active Search and Examination
- 1997-12-10 AU AU54097/98A patent/AU718958B2/en not_active Ceased
- 1997-12-10 KR KR10-1999-7005154A patent/KR100433568B1/ko not_active Expired - Fee Related
- 1997-12-10 PL PL334072A patent/PL191760B1/pl not_active IP Right Cessation
- 1997-12-10 EP EP97947866A patent/EP0944614B1/fr not_active Expired - Lifetime
- 1997-12-10 DK DK97947866T patent/DK0944614T3/da active
- 1997-12-10 NZ NZ336143A patent/NZ336143A/en unknown
- 1997-12-10 HU HU0002869A patent/HU226458B1/hu not_active IP Right Cessation
- 1997-12-10 DE DE69715448T patent/DE69715448T2/de not_active Expired - Lifetime
- 1997-12-10 PT PT97947866T patent/PT944614E/pt unknown
- 1997-12-10 JP JP52649298A patent/JP3215441B2/ja not_active Expired - Fee Related
- 1997-12-10 US US09/308,176 patent/US6083974A/en not_active Expired - Lifetime
- 1997-12-10 ES ES97947866T patent/ES2181039T3/es not_active Expired - Lifetime
- 1997-12-10 CA CA002274591A patent/CA2274591C/fr not_active Expired - Fee Related
- 1997-12-10 WO PCT/JP1997/004527 patent/WO1998025919A1/fr not_active Ceased
- 1997-12-10 AT AT97947866T patent/ATE223911T1/de not_active IP Right Cessation
- 1997-12-10 IL IL13066097A patent/IL130660A/en not_active IP Right Cessation
- 1997-12-10 CZ CZ0206599A patent/CZ297324B6/cs not_active IP Right Cessation
- 1997-12-10 RU RU99115766/04A patent/RU2161617C1/ru not_active IP Right Cessation
- 1997-12-10 TR TR1999/01280T patent/TR199901280T2/xx unknown
- 1997-12-10 ID IDW990472A patent/ID22753A/id unknown
- 1997-12-10 CN CN97180628A patent/CN1105112C/zh not_active Expired - Fee Related
- 1997-12-11 TW TW086118667A patent/TW438790B/zh not_active IP Right Cessation
- 1997-12-12 AR ARP970105862A patent/AR008939A1/es active IP Right Grant
1999
- 1999-06-10 NO NO992838A patent/NO992838L/no unknown
2002
- 2002-06-11 CN CNB021227608A patent/CN1185226C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6083974A (en)	2000-07-04
PL191760B1 (pl)	2006-06-30
HUP0002869A3 (en)	2003-01-28
AU5409798A (en)	1998-07-03
HK1020045A1 (en)	2000-03-10
CN1240438A (zh)	2000-01-05
ATE223911T1 (de)	2002-09-15
KR100433568B1 (ko)	2004-05-31
ID22753A (id)	1999-12-09
CA2274591A1 (fr)	1998-06-18
AU718958B2 (en)	2000-05-04
KR20000069402A (ko)	2000-11-25
TR199901280T2 (xx)	1999-10-21
DK0944614T3 (da)	2003-01-13
IL130660A0 (en)	2000-06-01
EP0944614A1 (fr)	1999-09-29
HUP0002869A2 (hu)	2001-06-28
CZ297324B6 (cs)	2006-11-15
AR008939A1 (es)	2000-02-23
TW438790B (en)	2001-06-07
CN1445225A (zh)	2003-10-01
RU2161617C1 (ru)	2001-01-10
EP0944614B1 (fr)	2002-09-11
CN1105112C (zh)	2003-04-09
JP2000514824A (ja)	2000-11-07
DE69715448T2 (de)	2003-08-07
CA2274591C (fr)	2005-06-14
NO992838D0 (no)	1999-06-10
HU226458B1 (en)	2008-12-29
PT944614E (pt)	2003-01-31
NZ336143A (en)	2002-05-31
WO1998025919A1 (fr)	1998-06-18
JP3215441B2 (ja)	2001-10-09
IL130660A (en)	2002-03-10
PL334072A1 (en)	2000-01-31
BR9714016A (pt)	2000-02-29
CN1185226C (zh)	2005-01-19
CZ206599A3 (cs)	1999-11-17
ES2181039T3 (es)	2003-02-16
DE69715448D1 (de)	2002-10-17

Publication	Publication Date	Title
CA2274591A1 (fr)	1998-06-18	Derives du benzothiophenecarboxamide, et antagonistes de la pgd2 les comprenant
DE69733271D1 (de)	2005-06-16	Kondensierte heterocyclische benzolcarbonsäureamid-derivate und diese enthaltende pgd2 antagonisten
MX9710256A (es)	1998-03-31	Derivados de amino biciclicos y antagonistas pgd2 que contienen los mismos.
CA2482551A1 (fr)	2003-12-18	1-(4-piperidinyl) benzimidazolones utilises en tant qu'antagonistes du recepteur h3 de l'histamine
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