PE20160179A1 - Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido - Google Patents

Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido

Info

Publication number
PE20160179A1
PE20160179A1 PE2016000022A PE2016000022A PE20160179A1 PE 20160179 A1 PE20160179 A1 PE 20160179A1 PE 2016000022 A PE2016000022 A PE 2016000022A PE 2016000022 A PE2016000022 A PE 2016000022A PE 20160179 A1 PE20160179 A1 PE 20160179A1
Authority
PE
Peru
Prior art keywords
free base
metoxy
benzaldehyde
pyridin
isopropyl
Prior art date
Application number
PE2016000022A
Other languages
English (en)
Inventor
Zhe Li
Travis Houston
Stephan D Parent
Original Assignee
Global Blood Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53774359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20160179(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Global Blood Therapeutics Inc filed Critical Global Blood Therapeutics Inc
Publication of PE20160179A1 publication Critical patent/PE20160179A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A FORMAS DE ANSOLVATOS DE LA BASE LIBRE CRISTALINA DE 2-HIDROXI-6-((2-(1-ISOPROPIL-1H-PIRAZOL-5-IL)PIRIDIN-3-IL)METOXI)BENZALDEHIDO (COMPUESTO 1) TALES COMO: A) LA FORMA I CUYOS PICOS DE DIFRACCION DE RAYOS X EN POLVO SE SELECCIONAN DE 12.82°, 15.74°, 16.03°, 16.63°, 17.60°, 25.14°, 25.82° Y 26.44° (±0.2 °2THETA); B) LA FORMA II CUYOS PICOS DE DIFRACCION DE RAYOS X EN POLVO SE SELECCIONAN DE 13.37°, 14.37°, 19.95° Y 23.92° (±0.2 °2THETA); ENTRE OTROS. TAMBIEN SE REFIERE A SOLVATOS DE LA BASE LIBRE CRISTALINA DEL COMPUESTO 1. DICHAS FORMAS SON UTILES EN EL TRATAMIENTO DE TRASTORNOS MEDIADOS POR LA HEMOGLOBINA DREPANOCITICA
PE2016000022A 2014-02-07 2015-02-05 Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido PE20160179A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461937393P 2014-02-07 2014-02-07
US201461937404P 2014-02-07 2014-02-07

Publications (1)

Publication Number Publication Date
PE20160179A1 true PE20160179A1 (es) 2016-05-20

Family

ID=53774359

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2020000511A PE20201444A1 (es) 2014-02-07 2015-02-05 Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido
PE2016000022A PE20160179A1 (es) 2014-02-07 2015-02-05 Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2020000511A PE20201444A1 (es) 2014-02-07 2015-02-05 Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido

Country Status (31)

Country Link
US (7) US9447071B2 (es)
EP (2) EP3102208B2 (es)
JP (4) JP6809681B2 (es)
KR (2) KR102588476B1 (es)
CN (4) CN105431147A (es)
AP (1) AP2016009261A0 (es)
AU (3) AU2015214182B2 (es)
BR (1) BR112015032160B1 (es)
CA (1) CA2916564C (es)
CY (1) CY1124097T1 (es)
DK (1) DK3102208T4 (es)
EA (1) EA028529B1 (es)
ES (1) ES2860648T5 (es)
FI (1) FI3102208T4 (es)
HR (1) HRP20210388T4 (es)
HU (1) HUE053706T2 (es)
IL (2) IL243214B (es)
LT (1) LT3102208T (es)
MX (2) MX361810B (es)
MY (1) MY189995A (es)
PE (2) PE20201444A1 (es)
PL (1) PL3102208T5 (es)
PT (1) PT3102208T (es)
RS (1) RS61653B2 (es)
SA (1) SA516370358B1 (es)
SG (4) SG10201911662YA (es)
SI (1) SI3102208T2 (es)
SM (1) SMT202100160T1 (es)
TW (4) TWI799115B (es)
WO (1) WO2015120133A1 (es)
ZA (1) ZA202401707B (es)

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