PL371346A1 - Kwasy bisfosfonowe do leczenia i profilaktyki osteoporozy - Google Patents

Kwasy bisfosfonowe do leczenia i profilaktyki osteoporozy

Info

Publication number
PL371346A1
PL371346A1 PL03371346A PL37134603A PL371346A1 PL 371346 A1 PL371346 A1 PL 371346A1 PL 03371346 A PL03371346 A PL 03371346A PL 37134603 A PL37134603 A PL 37134603A PL 371346 A1 PL371346 A1 PL 371346A1
Authority
PL
Poland
Prior art keywords
osteoporosis
prevention
treatment
bisphosphonic acid
bisphosphonic
Prior art date
Application number
PL03371346A
Other languages
English (en)
Inventor
Frieder Bauss
Bernhard Pichler
Stephen Turley
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29414669&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL371346(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of PL371346A1 publication Critical patent/PL371346A1/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
PL03371346A 2002-05-10 2003-05-02 Kwasy bisfosfonowe do leczenia i profilaktyki osteoporozy PL371346A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02010136 2002-05-10

Publications (1)

Publication Number Publication Date
PL371346A1 true PL371346A1 (pl) 2005-06-13

Family

ID=29414669

Family Applications (2)

Application Number Title Priority Date Filing Date
PL399493A PL399493A1 (pl) 2002-05-10 2003-05-02 Kwasy bisfosfonowe do leczenia i profilaktyki osteoporozy
PL03371346A PL371346A1 (pl) 2002-05-10 2003-05-02 Kwasy bisfosfonowe do leczenia i profilaktyki osteoporozy

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL399493A PL399493A1 (pl) 2002-05-10 2003-05-02 Kwasy bisfosfonowe do leczenia i profilaktyki osteoporozy

Country Status (32)

Country Link
US (5) US7410957B2 (pl)
EP (4) EP2308563A1 (pl)
JP (5) JP2005522526A (pl)
KR (7) KR20150053811A (pl)
CN (2) CN1939314A (pl)
AR (2) AR039978A1 (pl)
AT (1) ATE376444T1 (pl)
AU (2) AU2003229770B2 (pl)
BR (1) BR0308901A (pl)
CA (2) CA2481142C (pl)
CY (2) CY1108105T1 (pl)
DE (1) DE60317061T2 (pl)
DK (2) DK1880744T3 (pl)
EC (1) ECSP045335A (pl)
ES (2) ES2532393T3 (pl)
GT (1) GT200300107A (pl)
HR (1) HRP20040906B1 (pl)
IL (3) IL164371A0 (pl)
MX (1) MXPA04009586A (pl)
MY (2) MY146809A (pl)
NO (2) NO328734B1 (pl)
NZ (2) NZ535705A (pl)
PA (1) PA8573101A1 (pl)
PE (1) PE20040440A1 (pl)
PL (2) PL399493A1 (pl)
PT (2) PT1880744E (pl)
RU (2) RU2387451C2 (pl)
SI (2) SI1880744T1 (pl)
TW (1) TWI347188B (pl)
UY (1) UY27802A1 (pl)
WO (1) WO2003095029A1 (pl)
ZA (1) ZA200407950B (pl)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US8119159B2 (en) * 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US20070148228A1 (en) * 1999-02-22 2007-06-28 Merrion Research I Limited Solid oral dosage form containing an enhancer
NZ532994A (en) * 2001-12-21 2008-05-30 Procter & Gamble Method for the treatment of bone disorders using a bisphosphonate regimen, risedronate in particular
US20050070504A1 (en) * 2001-12-21 2005-03-31 The Procter & Gamble Co. Risedronate compositions and their methods of use
AU2003226148A1 (en) * 2002-04-05 2003-10-27 Merck & Co., Inc. Method for inhibiting bone resorption with an alendronate and vitamin d formulation
KR20150053811A (ko) * 2002-05-10 2015-05-18 에프. 호프만-라 로슈 아게 골다공증 치료 및 예방용 비스포스폰산
RU2315603C2 (ru) † 2002-12-20 2008-01-27 Ф.Хоффманн-Ля Рош Аг Композиция с высокой дозой ибандроната
US20050261250A1 (en) * 2004-05-19 2005-11-24 Merck & Co., Inc., Compositions and methods for inhibiting bone resorption
ATE495747T1 (de) * 2004-08-23 2011-02-15 Teva Pharma Kristalline form des ibandronat-natriums und herstellungsverfahren dafür
EP2610261A1 (en) * 2005-02-01 2013-07-03 F. Hoffmann-La Roche AG Ibandronate polymorph B
WO2006081963A1 (en) * 2005-02-01 2006-08-10 F.Hoffmann-La Roche Ag Ibandronate polymorph a
US20070049557A1 (en) * 2005-08-24 2007-03-01 Hashim Ahmed Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers
CN105232482A (zh) * 2006-04-07 2016-01-13 默里昂研究Iii有限公司 包含增强剂的固体口服剂型
RU2439065C2 (ru) 2006-04-20 2012-01-10 Ф.Хоффманн-Ля Рош Аг Производные диазепана в качестве модуляторов хемокиновых рецепторов
US20100120723A1 (en) * 2006-12-20 2010-05-13 Mostafa Akbarieh Pharmaceutical composition comprising a hot-melt granulated lubricant
AU2009244799B2 (en) * 2008-05-07 2014-11-20 Merrion Research Iii Limited Compositions of GnRH related compounds and processes of preparation
EP2210596A1 (en) 2009-01-22 2010-07-28 Laboratorios Liconsa, S.A. Pharmaceutical composition of ibandronate sodium salt or a hydrate thereof
TWI480286B (zh) * 2009-02-25 2015-04-11 Merrion Res Iii Ltd 雙膦酸鹽類組合物及藥物遞送
US9169279B2 (en) 2009-07-31 2015-10-27 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
WO2011014766A2 (en) 2009-07-31 2011-02-03 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US20160016982A1 (en) 2009-07-31 2016-01-21 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
US9089484B2 (en) * 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
US9340565B2 (en) 2010-11-24 2016-05-17 Thar Pharmaceuticals, Inc. Crystalline forms
AU2012204213A1 (en) 2011-01-07 2013-06-13 Merrion Research Iii Limited Pharmaceutical compositions of iron for oral administration
JP5874545B2 (ja) * 2011-06-20 2016-03-02 アステラス製薬株式会社 経口投与用医薬組成物
US10265384B2 (en) 2015-01-29 2019-04-23 Novo Nordisk A/S Tablets comprising GLP-1 agonist and enteric coating
CN107011380A (zh) * 2016-01-28 2017-08-04 臧伟 一种二膦酸衍生物及含二膦酸衍生物的组合物治疗骨折的应用
US10195218B2 (en) 2016-05-31 2019-02-05 Grunenthal Gmbh Crystallization method and bioavailability
CN114230610B (zh) * 2021-11-26 2023-05-23 西南医科大学附属医院 放射性标记物、其前体化合物、及制法和应用

Family Cites Families (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US124314A (en) * 1872-03-05 Improvement in preparing paper for buildings
US500937A (en) * 1893-07-04 Conduit railway insulator
DE2405254C2 (de) 1974-02-04 1982-05-27 Henkel KGaA, 4000 Düsseldorf Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper
DE2534391C2 (de) 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2745083C2 (de) 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
US4252742A (en) 1979-07-13 1981-02-24 Ciba-Geigy Corporation Chemical process for the preparation of 2,6-dialkylcyclohexylamines from 2,6-dialkylphenols
DE2943498C2 (de) 1979-10-27 1983-01-27 Henkel KGaA, 4000 Düsseldorf Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure
DE3016289A1 (de) 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
IT1201087B (it) 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
FR2531088B1 (fr) 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
US4509612A (en) 1982-09-28 1985-04-09 Applied Power Inc. Latch mechanism for a tilt-cab truck
JPS59145179A (ja) 1983-01-11 1984-08-20 Ricoh Co Ltd 補充交換用部品を検知可能にした事務機器
IT1195993B (it) 1984-01-12 1988-11-03 Gentili Ist Spa Forme farmaceutiche a base di difosfonati
DE3428524A1 (de) 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3434667A1 (de) 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US4812311A (en) 1984-12-21 1989-03-14 The Procter & Gamble Company Kit for use in the treatment of osteoporosis
DE3512536A1 (de) 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4761406A (en) 1985-06-06 1988-08-02 The Procter & Gamble Company Regimen for treating osteoporosis
DE3540150A1 (de) 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3623397A1 (de) 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3626058A1 (de) 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3640938A1 (de) 1986-11-29 1988-06-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel
HU199151B (en) 1987-03-10 1990-01-29 Yamanouchi Pharma Co Ltd Process for producing bis-phosphonic acid derivatives
CA1339805C (en) 1988-01-20 1998-04-07 Yasuo Isomura (cycloalkylamino)methylenebis(phosphonic acid) and medicines containing the same as an active
DE3822650A1 (de) 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4958839A (en) 1988-07-12 1990-09-25 Guzik Technical Enterprises, Inc. Disc clamp employing resilient cone for spreading balls
DE3825654A1 (de) * 1988-07-28 1990-02-01 Bosch Gmbh Robert Sicherheitseinrichtung an einer handwerkzeugmaschine
JP2691914B2 (ja) 1988-09-09 1997-12-17 株式会社リコー 画像形成装置
US5018651A (en) * 1988-12-27 1991-05-28 Hull Harold L Side or end dump article carrier
US4922077A (en) 1989-01-31 1990-05-01 Raytheon Company Method of laser marking metal packages
DE3917153A1 (de) * 1989-05-26 1990-11-29 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
JP2985205B2 (ja) 1990-01-25 1999-11-29 ミノルタ株式会社 画像形成装置
US5335048A (en) * 1990-01-30 1994-08-02 Minolta Camera Kabushiki Kaisha Efficient control system of image forming apparatus
JPH03226767A (ja) 1990-01-31 1991-10-07 Minolta Camera Co Ltd 画像形成装置管理システム
US5356887A (en) * 1990-01-31 1994-10-18 Merck & Co., Inc. Pharmaceutical compositions containing insoluble calcium salts of amino-hydroxybutylidene bisphoshonic acids
US5019651A (en) 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
JPH04151765A (ja) 1990-10-16 1992-05-25 Fujitsu Ltd ファクシミリ装置の消耗品自動発注方式
RU2120798C1 (ru) * 1991-11-22 1998-10-27 Проктер энд Гэмбл Фармасьютикалз, Инк. Твердая фармацевтическая композиция для перорального введения
CA2124792C (en) 1991-12-17 2000-07-04 Ann D. Geddes Methods for the treatment of osteoporosis using bisphosphonates and parathyroid hormone
JPH05224479A (ja) 1992-02-10 1993-09-03 Toshiba Corp 画像形成装置
TW237386B (pl) 1992-04-15 1995-01-01 Ciba Geigy
DK0648120T3 (da) 1992-06-30 1998-01-19 Procter & Gamble Pharma Anvendelse af phosphonater til behandling af osteoporose
JPH06111039A (ja) 1992-09-25 1994-04-22 Toray Ind Inc 光学読み取り識別マークの記録方法
US5358941A (en) * 1992-12-02 1994-10-25 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids with lactose
JPH06250802A (ja) 1993-02-22 1994-09-09 Ricoh Co Ltd プリンタ
FR2703590B1 (fr) 1993-04-05 1995-06-30 Sanofi Elf Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
US5431920A (en) * 1993-09-21 1995-07-11 Merck Frosst, Canada, Inc. Enteric coated oral compositions containing bisphosphonic acid antihypercalcemic agents
JPH07239825A (ja) 1994-02-28 1995-09-12 Canon Inc 状態通報方法およびそれを用いたネットワークシステム
TW390813B (en) 1994-04-29 2000-05-21 Merck & Co Inc Wet granulation formulation for bisphosphonic acids
US20010007863A1 (en) 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
GB9408775D0 (en) * 1994-05-04 1994-06-22 Ciba Geigy Ag Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration
US5462932A (en) * 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations
JPH07325514A (ja) 1994-05-30 1995-12-12 Ricoh Co Ltd サプライ発注システム
ZA956029B (en) * 1994-07-22 1997-01-20 Lilly Co Eli Combination treatment for inhibiting bone loss
JPH08152825A (ja) 1994-11-30 1996-06-11 Mita Ind Co Ltd 画像形成装置の管理システム
JPH08152814A (ja) 1994-11-30 1996-06-11 Mita Ind Co Ltd 画像形成装置の管理システム
FR2727629A1 (fr) 1994-12-06 1996-06-07 Sanofi Sa Trousse pour cycle de traitement de l'osteoporose
JP3261900B2 (ja) 1994-12-13 2002-03-04 村田機械株式会社 ファクシミリ装置
JP3796693B2 (ja) 1994-12-28 2006-07-12 ガドール エス アー オルパドロネートからなる骨塊同化組成物
JPH08211792A (ja) 1995-02-03 1996-08-20 Mita Ind Co Ltd 画像形成装置の管理システム
AU690431B2 (en) * 1995-02-17 1998-04-23 Merck & Co., Inc. Method of lessening the risk of non-vertebral bone fractures
US20010051616A1 (en) * 1995-02-17 2001-12-13 David B. Karpf Method of lessening the risk of vertebral fractures
JPH08315052A (ja) 1995-05-18 1996-11-29 Ricoh Co Ltd 自動発注システム
JPH08310007A (ja) * 1995-05-19 1996-11-26 Oki Data:Kk シリアルプリンタ
JPH09120238A (ja) 1995-10-25 1997-05-06 Canon Inc 出力装置
JPH09156123A (ja) 1995-12-04 1997-06-17 Brother Ind Ltd プリンタ
JPH09185474A (ja) 1995-12-27 1997-07-15 Fuji Xerox Co Ltd 印刷管理装置
JP3363680B2 (ja) 1995-12-28 2003-01-08 ブラザー工業株式会社 カートリッジの真偽判別方法及びそれを利用した出力装置
JPH09259355A (ja) 1996-03-21 1997-10-03 Oki Electric Ind Co Ltd 梱包された商品の確認処理システム
DE19615812A1 (de) * 1996-04-20 1997-10-23 Boehringer Mannheim Gmbh Pharmazeutische Zubereitung enthaltend Diphosphonsäuren zur oralen Applikation
US5930553A (en) * 1997-04-25 1999-07-27 Hewlett-Packard Company Image forming and office automation device consumable with memory
US5730715A (en) * 1996-06-14 1998-03-24 Becton Dickinson And Company Method for the iontophoretic administration of bisphosphonates
JPH1052964A (ja) 1996-08-09 1998-02-24 Canon Inc 画像形成装置および画像形成装置の消耗材管理方法
JP3266002B2 (ja) 1996-08-29 2002-03-18 オムロン株式会社 純正交換部品識別装置及び純正交換部品識別方法
JPH10105011A (ja) 1996-09-25 1998-04-24 Ricoh Co Ltd 記録出力サービス課金装置
US5781405A (en) * 1996-09-30 1998-07-14 Gateway 2000, Inc. Electronic device having rotatably mounted infrared device with a pair of pegs fitting into a pair of holes
JPH10234825A (ja) 1997-02-20 1998-09-08 Cosmo Yakuhin:Kk 配置薬箱システム
JPH10264968A (ja) 1997-03-26 1998-10-06 Funai Electric Co Ltd 梱包構造
US6572874B1 (en) * 1998-05-15 2003-06-03 Umd, Inc. Vaginal delivery of bisphosphonates
US6905701B2 (en) 1997-06-11 2005-06-14 Umd, Inc. Formulations for transmucosal vaginal delivery of bisphosphonates
US5994329A (en) * 1997-07-22 1999-11-30 Merck & Co., Inc. Method for inhibiting bone resorption
AU8493698A (en) * 1997-07-22 1999-02-16 Merck & Co., Inc. Method for inhibiting bone resorption
US6432932B1 (en) * 1997-07-22 2002-08-13 Merck & Co., Inc. Method for inhibiting bone resorption
US6015801A (en) * 1997-07-22 2000-01-18 Merck & Co., Inc. Method for inhibiting bone resorption
JPH1185657A (ja) 1997-09-10 1999-03-30 Toshiba Corp サーバクライアントシステム及びカード作成装置の消耗品集中管理システム
SE9703691D0 (sv) 1997-10-10 1997-10-10 Astra Ab Pharmaceutical compositions
US6124314A (en) * 1997-10-10 2000-09-26 Pfizer Inc. Osteoporosis compounds
JPH11126008A (ja) 1997-10-24 1999-05-11 Canon Inc カートリッジおよびリサイクルシステム
JPH11239926A (ja) 1997-12-22 1999-09-07 Canon Inc 部品の再利用システム及び分解を容易にした製品及び分解方法
JP3065053B2 (ja) * 1998-01-06 2000-07-12 セイコーエプソン株式会社 機器監視システム、ローカル監視装置、統合監視装置、機器監視方法、及び、プログラムを格納したコンピュータ可読媒体
JP4274332B2 (ja) 1998-02-20 2009-06-03 東芝テック株式会社 画像形成装置
JP3919375B2 (ja) 1998-03-20 2007-05-23 キヤノン株式会社 画像形成装置及び画像形成装置の制御方法
JPH11272350A (ja) 1998-03-20 1999-10-08 Canon Inc 課金管理装置及び方法及び印刷装置
JP3720584B2 (ja) 1998-06-05 2005-11-30 株式会社リコー 事務機器の管理システムとそのホストコンピュータ
CA2336201A1 (en) 1998-06-24 1999-12-29 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
JP2000019803A (ja) 1998-07-01 2000-01-21 Canon Inc 消耗品ユニット及びこれを用いた画像形成装置及びその再利用システムとその方法
US6816968B1 (en) * 1998-07-10 2004-11-09 Silverbrook Research Pty Ltd Consumable authentication protocol and system
JP3200037B2 (ja) 1998-07-16 2001-08-20 株式会社ダスキン レンタル商品管理システム
IT1303672B1 (it) 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
JP3476122B2 (ja) 1998-08-26 2003-12-10 株式会社沖データ 状態通知装置
JP2968791B1 (ja) 1998-08-28 1999-11-02 新潟日本電気株式会社 印刷システム
US6494562B1 (en) * 1998-09-03 2002-12-17 Hewlett-Packard Company Method and apparatus for identifying a sales channel
FR2784031B1 (fr) * 1998-10-02 2002-02-01 Sanofi Elf Utilisation de derives de l'acide bisphosphonique pour la preparation d'un medicament destine au traitement des boiteries
EP0998932A1 (de) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung
EP0998933A1 (de) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation
JP2000206752A (ja) 1998-11-10 2000-07-28 Ricoh Co Ltd 電子写真記録装置
US6331533B1 (en) * 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
EP1135140B1 (en) * 1998-12-04 2005-08-31 Roche Diagnostics GmbH iBANDRONIC ACID FOR THE PROMOTION OF THE OSSEOINTEGRATION OF ENDOPROSTHESES
TW442666B (en) * 1998-12-22 2001-06-23 Minolta Co Ltd Zoom lens system
JP2000194767A (ja) 1998-12-24 2000-07-14 Ricoh Co Ltd 自動発注システム
JP4297579B2 (ja) 1998-12-28 2009-07-15 日立マクセル株式会社 管理システム
KR100415490B1 (ko) * 1999-01-11 2004-01-24 프라운호퍼-게젤샤프트 츄어 푀르더룽 데어 안게반텐 포르슝에.파우. 파워 모스 소자 및 그 제조 방법
US6204763B1 (en) 1999-03-22 2001-03-20 Jujitsu Limited Household consumable item automatic replenishment system including intelligent refrigerator
SE9901272D0 (sv) 1999-04-09 1999-04-09 Astra Ab New improved formulation
EP1165184B1 (en) 1999-04-09 2003-12-03 Karo Bio Ab Estrogen receptor-beta antagonism and bone diseases
CA2308532C (en) 1999-05-12 2005-11-29 Gador S.A. Use of bisphosphonates for the treatment of osteogenesis imperfecta
CN1202828C (zh) 1999-05-21 2005-05-25 诺瓦提斯公司 二膦酸在制备抑制或逆转血管发生的药物中的用途
JP2000347503A (ja) 1999-06-04 2000-12-15 Nec Corp 記録装置、記録装置におけるトナーカートリッジの適合性判別方法及びトナーカートリッジ
US6965411B1 (en) * 1999-06-24 2005-11-15 Jones Richard A Remote camera positioner
AR024462A1 (es) 1999-07-01 2002-10-02 Merck & Co Inc Tabletas farmaceuticas
US6903836B2 (en) * 1999-09-10 2005-06-07 Hewlett-Packard Development Company, L.P. Hard copy cost recovery systems, an apparatus for tracking usage information for a hard copy device, hard copy devices, and a usage accounting method
US6458387B1 (en) 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
US6793934B1 (en) * 1999-12-08 2004-09-21 Shire Laboratories, Inc. Solid oral dosage form
JP2001246822A (ja) 1999-12-27 2001-09-11 Canon Inc 印刷装置、印刷装置における報知方法、印刷装置の制御方法、外部装置、外部装置の制御方法、及び記録媒体
US6285060B1 (en) * 1999-12-30 2001-09-04 Siliconix Incorporated Barrier accumulation-mode MOSFET
JP2000325554A (ja) 2000-01-01 2000-11-28 Samii Kk スロットマシン
JP2001228762A (ja) 2000-02-14 2001-08-24 Canon Inc 消耗品管理システム及び消耗品管理方法
JP2001228761A (ja) 2000-02-14 2001-08-24 Canon Inc 消耗品管理方法及び消耗品管理システム
JP2001253827A (ja) * 2000-02-15 2001-09-18 Pfizer Prod Inc 骨粗鬆症を治療するための組成物および方法
JP3799210B2 (ja) 2000-03-07 2006-07-19 株式会社リコー 画像形成装置
US20020004218A1 (en) * 2000-03-31 2002-01-10 Rodan Gideon A. Methods for identifying compounds useful for inhibiting geranylgeranyl diphosphate synthase
AU2001251391A1 (en) 2000-04-06 2001-10-23 Acorda Therapeutics, Inc. Compositions and methods for promoting neural regeneration
US6468559B1 (en) * 2000-04-28 2002-10-22 Lipocine, Inc. Enteric coated formulation of bishosphonic acid compounds and associated therapeutic methods
JP3302985B2 (ja) 2000-05-12 2002-07-15 株式会社ハイパーマーケティング 消耗品提供システム
GB0012209D0 (en) 2000-05-19 2000-07-12 Novartis Ag Organic compounds
MXPA02012682A (es) * 2000-06-20 2003-04-25 Novartis Ag Metodo para administrar bisfosfonatos.
US6476006B2 (en) 2000-06-23 2002-11-05 Teva Pharmaceutical Industries, Ltd. Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
AU7105501A (en) * 2000-07-17 2002-01-30 Yamanouchi Pharma Co Ltd Pharmaceutical composition improved in peroral absorbability
US6638920B2 (en) * 2000-07-21 2003-10-28 Merck & Co., Inc. Compositions and methods of preventing or reducing the risk or incidence of skeletal injuries in horses
US6750213B2 (en) * 2000-10-19 2004-06-15 Merck & Co., Inc. Estrogen receptor modulators
MXPA03003485A (es) 2000-10-19 2003-07-14 Merck & Co Inc Moduladores del receptor de estrogenos.
US7560490B2 (en) 2001-01-23 2009-07-14 Gador S.A. Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition and use thereof
AR034199A1 (es) 2001-02-01 2004-02-04 Riderway Corp Composicion farmacologica liquida para el tratamiento de enfermedades oseas y procedimientos para su elaboracion
PL361909A1 (pl) 2001-02-06 2004-10-04 The Royal Alexandra Hospital For Children Lek do leczenia osteonekrozy i prowadzenia pacjentów u których występuje ryzyko rozwoju osteonekrozy
JP4354698B2 (ja) 2001-03-01 2009-10-28 エミスフェアー・テクノロジーズ・インク ビスホスホネートデリバリー用組成物
JP2004530684A (ja) 2001-05-10 2004-10-07 メルク　エンド　カムパニー　インコーポレーテッド エストロゲン受容体モジュレーター
US6998678B2 (en) * 2001-05-17 2006-02-14 Infineon Technologies Ag Semiconductor arrangement with a MOS-transistor and a parallel Schottky-diode
AU2002346583A1 (en) 2001-12-13 2003-06-30 Merck & Co., Inc. Liquid bisphosphonate formulations for bone disorders
US20050070504A1 (en) * 2001-12-21 2005-03-31 The Procter & Gamble Co. Risedronate compositions and their methods of use
NZ532994A (en) * 2001-12-21 2008-05-30 Procter & Gamble Method for the treatment of bone disorders using a bisphosphonate regimen, risedronate in particular
DE10262418B3 (de) * 2002-02-21 2015-10-08 Infineon Technologies Ag MOS-Transistoreinrichtung
US7488496B2 (en) * 2002-03-06 2009-02-10 Christer Rosen Effervescent compositions comprising bisphosphonates and methods related thereto
US7186838B2 (en) * 2002-03-13 2007-03-06 Merck & Co., Inc. Fluorinated 4-azasteroid derivatives as androgen receptor modulators
AU2003226148A1 (en) 2002-04-05 2003-10-27 Merck & Co., Inc. Method for inhibiting bone resorption with an alendronate and vitamin d formulation
KR20150053811A (ko) * 2002-05-10 2015-05-18 에프. 호프만-라 로슈 아게 골다공증 치료 및 예방용 비스포스폰산
RU2315603C2 (ru) 2002-12-20 2008-01-27 Ф.Хоффманн-Ля Рош Аг Композиция с высокой дозой ибандроната
GB0424543D0 (en) * 2004-11-05 2004-12-08 Varintelligent Bvi Ltd Driving method for high frame rate display system

Also Published As

Publication number Publication date
EP1506041B1 (en) 2007-10-24
JP2014058554A (ja) 2014-04-03
CA2763775C (en) 2014-01-07
TWI347188B (en) 2011-08-21
CN100551377C (zh) 2009-10-21
US20100197637A1 (en) 2010-08-05
EP2308563A1 (en) 2011-04-13
KR20140021045A (ko) 2014-02-19
ECSP045335A (es) 2004-11-26
MY140080A (en) 2009-11-30
DE60317061D1 (de) 2007-12-06
AU2003229770A1 (en) 2003-11-11
RU2329809C2 (ru) 2008-07-27
WO2003095029A1 (en) 2003-11-20
EP1880744A1 (en) 2008-01-23
JP2005522526A (ja) 2005-07-28
RU2008103617A (ru) 2009-08-10
MY146809A (en) 2012-09-28
SI1880744T1 (sl) 2015-04-30
US20030225039A1 (en) 2003-12-04
JP2013166773A (ja) 2013-08-29
DE60317061T2 (de) 2008-07-24
GT200300107A (es) 2006-02-23
AU2003229770B2 (en) 2009-11-05
US7192938B2 (en) 2007-03-20
NZ535705A (en) 2007-08-31
KR20150053811A (ko) 2015-05-18
NO331024B1 (no) 2011-09-12
NO20100477L (no) 2004-10-01
CY1116233T1 (el) 2017-02-08
CY1108105T1 (el) 2014-02-12
PL399493A1 (pl) 2012-11-05
NO20044195L (no) 2004-10-01
SI1506041T1 (sl) 2008-02-29
IL205262A (en) 2015-03-31
KR20040097267A (ko) 2004-11-17
PT1880744E (pt) 2015-02-13
EP2851105A1 (en) 2015-03-25
JP5813911B2 (ja) 2015-11-17
ATE376444T1 (de) 2007-11-15
CN1939314A (zh) 2007-04-04
IL164371A0 (en) 2005-12-18
KR20060058151A (ko) 2006-05-29
EP1880744B1 (en) 2015-01-21
US20050075319A1 (en) 2005-04-07
MXPA04009586A (es) 2005-01-11
CA2481142C (en) 2012-11-13
CN1646193A (zh) 2005-07-27
RU2004129324A (ru) 2006-01-27
EP1506041A1 (en) 2005-02-16
HRP20040906B1 (en) 2013-01-31
PE20040440A1 (es) 2004-08-07
TW200404553A (en) 2004-04-01
AR039978A1 (es) 2005-03-09
CA2763775A1 (en) 2003-11-20
ES2532393T3 (es) 2015-03-26
NO328734B1 (no) 2010-05-03
DK1880744T3 (en) 2015-02-09
KR20090029312A (ko) 2009-03-20
DK1506041T3 (da) 2008-01-28
KR100642961B9 (ko) 2021-11-12
JP2015083592A (ja) 2015-04-30
IL164371A (en) 2010-11-30
AR061845A2 (es) 2008-09-24
AU2010200438A1 (en) 2010-02-25
PT1506041E (pt) 2007-12-28
RU2387451C2 (ru) 2010-04-27
HRP20040906A2 (en) 2005-06-30
US7410957B2 (en) 2008-08-12
US20060166938A1 (en) 2006-07-27
JP2009132709A (ja) 2009-06-18
PA8573101A1 (es) 2004-02-07
US7718634B2 (en) 2010-05-18
HK1080409A1 (zh) 2006-04-28
AU2010200438B2 (en) 2012-02-02
JP5837552B2 (ja) 2015-12-24
JP6067466B2 (ja) 2017-01-25
NZ556278A (en) 2009-06-26
US20080249069A1 (en) 2008-10-09
KR100642961B1 (ko) 2006-11-10
ZA200407950B (en) 2005-12-28
KR20120065435A (ko) 2012-06-20
UY27802A1 (es) 2003-11-28
KR20090106663A (ko) 2009-10-09
ES2294277T3 (es) 2008-04-01
CA2481142A1 (en) 2003-11-20
BR0308901A (pt) 2005-01-04

Similar Documents

Publication Publication Date Title
ZA200407950B (en) Bisphosphonic acid for the treatment and prevention of osteoporosis
HUS1600050I1 (hu) Eljárás szklerózis multiplex kezelésére
IL165950A0 (en) Compositions and method for the diagnosis and treatment of tumor
AU2003258145A8 (en) Substituted phenylindoles for the treatment of hiv
AU2003263760A1 (en) Methods for the treatment or prevention of obesity
AU2003211610A1 (en) Pharmaceutical compositions for the treatment or prevention of osteoporosis
GB0213869D0 (en) The treatment of pain
IL162818A0 (en) Combination therapy for the treatment of bacterialinfections
IL162053A0 (en) Method for the treatment of bone disorders
AU2003268939A1 (en) Bisphosphonates for the treatment of antheroscleorosis and devices comprising them
GB0201025D0 (en) The treatment of degenerative diseases
EP1573063A4 (en) TREATMENT OF LIVER DISEASES
AU2003240174A8 (en) Compositions for the treatment of edematous-firbrosclerotic panniculopathy
IL162492A0 (en) Use of alkylphosphocholines for the preventative treatment of protozoandiseases
GB0100092D0 (en) Treatment of degenerative diseases
HRP20041159A2 (en) Combination for the treatment of airway disorders
HUP0203741A3 (en) Treatment of osteoporosis
AU2003245211A1 (en) Treatment of osteoporosis
IL151658A0 (en) Methods and compositions for the treatment or prevention of cardiovascular diseases
TJ20010676A (en) Method treatment cirrosis of the liver
GB0213870D0 (en) The treatment of pain conditions
PL354698A1 (pl) Środek farmaceutyczny do zapobiegania lub leczeniaŚrodek farmaceutyczny do zapobiegania lub leczenia chorób o podłożu autoimmunizacyjnym chorób o podłożu autoimmunizacyjnym
GB0219706D0 (en) The treatment of neuropathic pain
GB0216978D0 (en) The treatment of pain
GB0325259D0 (en) Therapeutic agents for the treatment of bone conditions

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)