PL4106876T3 - Związki przeciwwirusowe - Google Patents

Związki przeciwwirusowe

Info

Publication number
PL4106876T3
PL4106876T3 PL21710377.9T PL21710377T PL4106876T3 PL 4106876 T3 PL4106876 T3 PL 4106876T3 PL 21710377 T PL21710377 T PL 21710377T PL 4106876 T3 PL4106876 T3 PL 4106876T3
Authority
PL
Poland
Prior art keywords
antiviral compounds
antiviral
compounds
Prior art date
Application number
PL21710377.9T
Other languages
English (en)
Inventor
Daniel H. BYUN
Gregory F. CHIN
Michael O. Clarke
Bindu Goyal
Petr Jansa
Richard L. Mackman
Michael R. Mish
Dustin S. SIEGEL
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of PL4106876T3 publication Critical patent/PL4106876T3/pl

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
PL21710377.9T 2020-02-18 2021-02-17 Związki przeciwwirusowe PL4106876T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062978199P 2020-02-18 2020-02-18
PCT/US2021/018410 WO2021168004A1 (en) 2020-02-18 2021-02-17 Antiviral compounds

Publications (1)

Publication Number Publication Date
PL4106876T3 true PL4106876T3 (pl) 2026-02-23

Family

ID=74859526

Family Applications (1)

Application Number Title Priority Date Filing Date
PL21710377.9T PL4106876T3 (pl) 2020-02-18 2021-02-17 Związki przeciwwirusowe

Country Status (14)

Country Link
US (2) US12030903B2 (pl)
EP (2) EP4644394A3 (pl)
JP (2) JP7429799B2 (pl)
KR (2) KR20250133471A (pl)
CN (2) CN115135383B (pl)
AR (1) AR121356A1 (pl)
AU (2) AU2021224588B2 (pl)
CA (1) CA3171648A1 (pl)
ES (1) ES3052691T3 (pl)
PL (1) PL4106876T3 (pl)
PT (1) PT4106876T (pl)
SI (1) SI4106876T1 (pl)
TW (1) TWI777411B (pl)
WO (1) WO2021168004A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
AU2022256476B2 (en) 2021-04-16 2025-06-05 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides
CA3228162A1 (en) 2021-08-18 2023-02-23 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same
CN120916999A (zh) * 2023-03-24 2025-11-07 巴斯夫欧洲公司 用于由烷氧基化醇制备作为有机醚硫酸盐的氨基酸酯的方法

Family Cites Families (487)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361306A (en) 1966-03-31 1968-01-02 Merck & Co Inc Aerosol unit dispensing uniform amounts of a medically active ingredient
US3565070A (en) 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
FR2224175B1 (pl) 1973-04-04 1978-04-14 Isf Spa
US4069819A (en) 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
IT1017153B (it) 1974-07-15 1977-07-20 Isf Spa Apparecchio per inalazioni
NL7606413A (en) 1976-06-14 1977-12-16 Kowa Co Adenosine-5'-phosphoric acid derivs. and their salts - prepd. by acylating adenosine-5'-phosphate and opt. desalting or salt exchanging
DE2626792A1 (de) 1976-06-15 1977-12-29 Kowa Co Acylderivate von adenosin-5'-monophosphorsaeure, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung
FR2354774A1 (fr) 1976-06-15 1978-01-13 Kowa Co Derives de l'acide adenosine-5'-monophosphorique et medicament contenant ces substances
SE438261B (sv) 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
US4805811A (en) 1985-03-29 1989-02-21 Aktiebolaget Draco Dosage device
SE448277B (sv) 1985-04-12 1987-02-09 Draco Ab Indikeringsanordning vid en doseringsanordning for lekemedel
JPS6286363A (ja) 1985-10-11 1987-04-20 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料
DE3528753A1 (de) 1985-08-10 1987-02-19 Bayer Ag Substituierte pyrazolin-5-one
US4707540A (en) 1986-10-29 1987-11-17 Morton Thiokol, Inc. Nitramine oxetanes and polyethers formed therefrom
US4871758A (en) 1987-03-18 1989-10-03 Schulman Jerome M Pharmacologically active cholinergic compositions, and methods for making same and use thereof in treating disease
DE3711345A1 (de) 1987-04-03 1988-10-20 Bayer Ag Substituierte propylamine
IN167775B (pl) 1988-06-24 1990-12-22 Hoechst India
IT1228459B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
US4955371A (en) 1989-05-08 1990-09-11 Transtech Scientific, Inc. Disposable inhalation activated, aerosol device for pulmonary medicine
US5674998A (en) 1989-09-15 1997-10-07 Gensia Inc. C-4' modified adenosine kinase inhibitors
DE3932052A1 (de) 1989-09-26 1991-04-04 Basf Ag Oxazol- bzw. thiazolcarbonsaeureamide
KR927003044A (ko) 1990-01-11 1992-12-17 크리스토퍼 케이. 미라벨리 Rna 활성과 유전자 발현을 검출하고 조절하는 조성물 및 그 방법
YU84791A (sh) 1990-05-19 1994-06-10 Boehringer Ingelheim Kg. Biciklicni 1-aza-cikloalkalni
MY106399A (en) 1990-07-24 1995-05-30 Pfizer Cephalosporins and homologeus, preparation and pharmaceutical composition
FR2669639A1 (fr) 1990-11-27 1992-05-29 Atochem Cocatalyseur de polymerisation du propylene a base de silane et de monoether.
TW239158B (pl) 1991-02-15 1995-01-21 Lubrizol Corp
ES2141108T3 (es) 1991-07-02 2000-03-16 Inhale Inc Metodo y dispositivo para proporcionar medicamentos en aerosol.
GB9202791D0 (en) 1992-02-11 1992-03-25 British Bio Technology Compounds
US5261538A (en) 1992-04-21 1993-11-16 Glaxo Inc. Aerosol testing method
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
DE4232852A1 (de) 1992-09-30 1994-03-31 Bayer Ag Imidazolinyl-pyridazine
US5388572A (en) 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5446137B1 (en) 1993-12-09 1998-10-06 Behringwerke Ag Oligonucleotides containing 4'-substituted nucleotides
DE69522494T2 (de) 1994-04-14 2002-04-25 Canon K.K., Tokio/Tokyo Flüssigkristallzusammensetzung, Anzeigevorrichtung und Verfahren diese verwendend
US5522385A (en) 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5681940A (en) 1994-11-02 1997-10-28 Icn Pharmaceuticals Sugar modified nucleosides and oligonucleotides
US5622163A (en) 1994-11-29 1997-04-22 Iep Group, Inc. Counter for fluid dispensers
US5544647A (en) 1994-11-29 1996-08-13 Iep Group, Inc. Metered dose inhalator
JP3822925B2 (ja) 1995-07-18 2006-09-20 興和株式会社 ２’−３’−ジ−ｏ−アシルａｔｐの製造法
JPH09328497A (ja) 1996-04-12 1997-12-22 Yamasa Shoyu Co Ltd ４’−フルオロメチルヌクレオシド
AU727177B2 (en) 1996-10-16 2000-12-07 Icn Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses thereof
UA63956C2 (uk) 1997-06-30 2004-02-16 Ай-Сі-Ен Фармасьютикалз, Інк. Спосіб одержання нуклеозидів
EP1015469B2 (en) 1997-09-12 2015-11-18 Exiqon A/S Bi- and tri-cyclic nucleoside, nucleotide and oligonucleoide analogues
WO1999026933A1 (en) 1997-11-26 1999-06-03 Axys Pharmaceuticals, Inc. Substituted amidinoaryl derivatives and their use as anticoagulants
US6150379A (en) 1997-11-26 2000-11-21 Axys Pharmaceuticals, Inc. Compounds and compositions as anticoagulants
US5972099A (en) 1997-12-17 1999-10-26 Bayer Corporation Process for preparing organic pigment compositions
CO5040088A1 (es) 1998-04-03 2001-05-29 Advanced Medicine Inc Nuevos compuestos y usos anestesicos locales
WO1999061583A2 (en) 1998-05-28 1999-12-02 Incara Pharmaceuticals Corp. Carbohydrate-based scaffold compounds, combinatorial libraries and methods for their construction
JP2002519375A (ja) 1998-07-03 2002-07-02 リューコサイト インク 酸素脂環化合物置換体、及びその合成法
WO2000032152A2 (en) 1998-12-02 2000-06-08 Princeton University Compositions and methods for regulating bacterial pathogenesis
US6432975B1 (en) 1998-12-11 2002-08-13 Targacept, Inc. Pharmaceutical compositions and methods for use
US6116234A (en) 1999-02-01 2000-09-12 Iep Pharmaceutical Devices Inc. Metered dose inhaler agitator
GB9908934D0 (en) 1999-04-19 1999-06-16 Rolic Ag Liquid crystalline compounds
EP1046631A1 (en) 1999-04-19 2000-10-25 Rolic AG Liquid crystalline compounds
ATE356824T1 (de) 1999-05-04 2007-04-15 Santaris Pharma As L-ribo-lna analoge
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
BR0012135A (pt) 1999-06-29 2002-07-02 Uab Research Foundation Métodos de tratamento de infecções de fungos com inibidores de enzima sintetase nad
DE19934799B4 (de) 1999-07-28 2008-01-24 Az Electronic Materials (Germany) Gmbh Chiral-smektische Flüssigkristallmischung und ihre Verwendung in Aktivmatrix-Displays mit hohen Kontrastwerten
WO2001010842A2 (en) 1999-08-04 2001-02-15 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
DE19939910A1 (de) 1999-08-23 2001-03-01 Morphochem Ag Neue Verbindungen, die Tryptase-Aktivität hemmen
EP1214332A1 (en) 1999-09-17 2002-06-19 Amersham Biosciences Corp. Charge-modified nucleic acid terminators
US7115750B1 (en) 1999-09-20 2006-10-03 Takeda Pharmaceutical Company Limited Melanin concentrating hormone antagonist
US6514964B1 (en) 1999-09-27 2003-02-04 Amgen Inc. Fused cycloheptane and fused azacycloheptane compounds and their methods of use
GB9930557D0 (en) 1999-12-23 2000-02-16 Rolic Ag Optically active materials
WO2001064642A2 (en) 2000-02-29 2001-09-07 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
US20090124690A1 (en) 2000-04-03 2009-05-14 Alberte Randall S Generation of Combinatorial Synthetic Libraries and Screening for Novel Proadhesins and Nonadhesins
WO2001077091A2 (en) 2000-04-05 2001-10-18 Tularik Inc. Ns5b hcv polymerase inhibitors
US6696081B2 (en) 2000-06-09 2004-02-24 Duke University Carbohydrate based lipid compositions and supramolecular structures comprising same
US6875483B2 (en) 2000-07-06 2005-04-05 Fuji Photo Film Co., Ltd. Liquid crystal composition comprising liquid crystal molecules and alignment promoter
CA2415900A1 (en) 2000-07-14 2002-01-31 The Uab Research Foundation Uses for nad synthetase inhibitors
AU2001279955A1 (en) 2000-08-18 2002-03-04 Sterix Limited 2-substituted estradiol derivative for inhibiting superoxid dismutase
WO2002028813A1 (en) 2000-09-30 2002-04-11 Loctite Low shrinkage thermosetting resin compositions and methods of use therefor
CA2426430C (en) 2000-10-20 2014-10-07 Biocryst Pharmaceuticals, Inc. Biaryl compounds as serine protease inhibitors
AUPR105700A0 (en) 2000-10-27 2000-11-23 Monash University Process for preparation of bicyclic and polycyclic molecules
AU2002223492A1 (en) 2000-11-14 2002-05-27 Neurosearch A/S Use of malaria parasite anion channel blockers for treating malaria
AUPR213700A0 (en) 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
DE10064823A1 (de) 2000-12-22 2002-06-27 Knoll Ag Integrinrezeptorliganden
EP1363890A4 (en) 2001-02-07 2009-06-10 Ore Pharmaceuticals Inc MELANOCORTIN-4-RECEPTOR BINDING COMPOUNDS AND METHOD FOR THEIR APPLICATION
JP4161291B2 (ja) 2001-03-02 2008-10-08 東レ・ファインケミカル株式会社 光学活性体の製造法
JP2002326996A (ja) 2001-03-02 2002-11-15 Toray Ind Inc 光学活性体の製造法
DE60139510D1 (de) 2001-04-06 2009-09-17 Biocryst Pharm Inc Biarylverbindungen als serinproteaseinhibitoren
EP3231445A1 (en) 2001-05-18 2017-10-18 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
US20030170891A1 (en) 2001-06-06 2003-09-11 Mcswiggen James A. RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA)
US20030175950A1 (en) 2001-05-29 2003-09-18 Mcswiggen James A. RNA interference mediated inhibition of HIV gene expression using short interfering RNA
GB0114286D0 (en) 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
AU2002368274A1 (en) 2001-09-13 2004-06-03 Genesoft, Inc. Methods of treating infection by drug resistant bacteria
WO2003039523A2 (en) 2001-11-05 2003-05-15 Exiqon A/S OLIGONUCLEOTIDES MODIFIED WITH NOVEL α-L-RNA ANALOGUES
DE60225316T2 (de) 2001-11-13 2009-02-26 AXYS Pharmaceuticals, Inc., South San Francisco Cyanoalkylamino-derivate als protease-hemmer
MXPA04005611A (es) 2001-12-11 2005-04-19 Cellgate Inc Reactivos y conjugados de transporte de guanidinio.
JP2003246770A (ja) 2002-02-25 2003-09-02 Toray Ind Inc 光学活性体の製造法
TW200403058A (en) 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
US20050245537A1 (en) 2002-04-24 2005-11-03 Noboru Tsuchimori Use of compounds having ccr antagonism
US6841502B2 (en) 2002-04-24 2005-01-11 Symyx Technologies, Inc. Bridged bi-aromatic ligands, catalysts, processes for polymerizing and polymers therefrom
AU2003247084B9 (en) 2002-06-28 2018-07-26 Centre National De La Recherche Scientifique Modified 2' and 3'-nucleoside prodrugs for treating flaviridae infections
WO2004007472A1 (ja) 2002-07-10 2004-01-22 Ono Pharmaceutical Co., Ltd. Ｃｃｒ４アンタゴニストおよびその医薬用途
AU2003259735A1 (en) 2002-08-08 2004-02-25 Sirna Therapeutics, Inc. Small-mer compositions and methods of use
WO2004037159A2 (en) 2002-10-23 2004-05-06 Obetherapy Biotechnology Compounds, compositions and methods for modulating fat metabolism
US20040229840A1 (en) 2002-10-29 2004-11-18 Balkrishen Bhat Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
US20040146941A1 (en) 2002-11-04 2004-07-29 Biliang Zhang Chemical encoding technology for combinatorial synthesis
US7329658B2 (en) 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7176210B2 (en) 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
JP4736043B2 (ja) 2003-03-14 2011-07-27 小野薬品工業株式会社 含窒素複素環誘導体およびそれらを有効成分とする薬剤
US7135469B2 (en) 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
GB0306430D0 (en) 2003-03-20 2003-04-23 Bp Chem Int Ltd Polymerisation and oligomerisation catalysts
WO2004087153A2 (en) 2003-03-28 2004-10-14 Chiron Corporation Use of organic compounds for immunopotentiation
WO2004091499A2 (en) 2003-04-09 2004-10-28 Neose Technologies, Inc. Intracellular formation of peptide conjugates
JP2004315613A (ja) 2003-04-14 2004-11-11 Fuji Photo Film Co Ltd セルロースアシレートフィルム、その製造方法、偏光板保護膜、液晶表示装置、及びハロゲン化銀写真感光材料
US7268133B2 (en) 2003-04-23 2007-09-11 Pfizer, Inc. Patent Department Cannabinoid receptor ligands and uses thereof
US20040229839A1 (en) 2003-05-14 2004-11-18 Biocryst Pharmaceuticals, Inc. Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
CN102584813B (zh) 2003-05-14 2016-07-06 Ngc药物公司 化合物及其在调节淀粉样蛋白β中的用途
WO2005020885A2 (en) 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
WO2004106356A1 (en) 2003-05-27 2004-12-09 Syddansk Universitet Functionalized nucleotide derivatives
WO2005021568A2 (en) 2003-08-27 2005-03-10 Biota, Inc. Novel tricyclic nucleosides or nucleotides as therapeutic agents
EP1661889A4 (en) 2003-09-05 2009-08-05 Ono Pharmaceutical Co ANTAGONIST OF THE CHEMOKINE RECEPTOR AND ITS USE FOR MEDICAL PURPOSES
WO2005025515A2 (en) 2003-09-12 2005-03-24 California Institute Of Technology Proteasome pathway inhibitors and related methods
JP4231379B2 (ja) 2003-10-15 2009-02-25 富士フイルム株式会社 潤滑剤組成物
JPWO2005040135A1 (ja) 2003-10-24 2007-03-08 小野薬品工業株式会社 抗ストレス薬およびその医薬用途
EP1692110A1 (en) 2003-12-10 2006-08-23 MERCK PATENT GmbH Diacylhydrazine derivatives
JP2007530470A (ja) 2004-03-25 2007-11-01 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 液晶化合物、液晶媒体および液晶ディスプレイ
KR101202227B1 (ko) 2004-03-25 2012-11-16 후지필름 가부시키가이샤 투명 필름 및 광학 보상 필름, 편광판 및 그것을 사용하는액정 표시 장치
US7306631B2 (en) 2004-03-30 2007-12-11 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
EP1593713A1 (en) 2004-05-04 2005-11-09 Rolic AG Polymerizable dichromophoric dichroic azo dyes
GB0410604D0 (en) 2004-05-12 2004-06-16 Bp Chem Int Ltd Ethylene copolymers
WO2006001463A1 (ja) 2004-06-23 2006-01-05 Ono Pharmaceutical Co., Ltd. Ｓ１ｐ受容体結合能を有する化合物およびその用途
WO2006006490A1 (ja) 2004-07-08 2006-01-19 Ono Pharmaceutical Co., Ltd. スピロ化合物
GB0415879D0 (en) 2004-07-15 2004-08-18 Bp Chem Int Ltd Polymerisation catalyst
GB0418022D0 (en) 2004-08-12 2004-09-15 Bp Chem Int Ltd Polymerisation and oligomerisation catalyst
GB0420396D0 (en) 2004-09-14 2004-10-13 Bp Chem Int Ltd Polyolefins
WO2006038594A1 (ja) 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. Ｎ型カルシウムチャネル阻害薬
GB0424422D0 (en) 2004-11-04 2004-12-08 Bp Chem Int Ltd Polymerisation catalysts
JP4429149B2 (ja) 2004-11-26 2010-03-10 キヤノン株式会社 フルオレン化合物及び有機発光素子
WO2006061094A1 (en) 2004-12-11 2006-06-15 Merck Patent Gmbh Liquid crystal compounds, liquid crystal medium and liquid crystal display
WO2006063717A2 (en) 2004-12-16 2006-06-22 Febit Biotech Gmbh Polymerase-independent analysis of the sequence of polynucleotides
US8101745B2 (en) 2004-12-16 2012-01-24 The Regents Of The University Of California Lung-targeted drugs
JP4749000B2 (ja) 2005-02-22 2011-08-17 富士フイルム株式会社 グリース組成物
US7622240B2 (en) 2005-02-28 2009-11-24 International Business Machines Corporation Low blur molecular resist
AU2006222563A1 (en) 2005-03-08 2006-09-14 Biota Scientific Management Pty Ltd. Bicyclic nucleosides and nucleotides as therapeutic agents
EP1867704B1 (en) 2005-03-15 2010-09-15 FUJIFILM Corporation Surface treatment method using disc-like compound, (lubricating) composition for surface treatment, and surface-treated article
EP2805719A1 (en) 2005-03-30 2014-11-26 Glaxosmithkline LLC Nicotinamide riboside and analogues thereof
US20090156545A1 (en) 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
JP2008538354A (ja) 2005-04-08 2008-10-23 キメリクス，インコーポレイテッド ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
WO2006119800A1 (en) 2005-05-09 2006-11-16 Technische Universität Braunschweig Light emitting compound for electroluminescent applications
US7576205B2 (en) 2005-06-13 2009-08-18 Agency For Science, Technology & Research Detectable threading intercalator
WO2007007588A1 (ja) 2005-07-08 2007-01-18 Ono Pharmaceutical Co., Ltd. 平面性を有する環状基を母核とする化合物
WO2007011759A2 (en) 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
JP2007056213A (ja) 2005-08-26 2007-03-08 Fujifilm Corp 焼結含油軸受油用組成物、並びにそれを用いた軸受け装置及び摺動部材
DE102005043165A1 (de) 2005-09-12 2007-03-22 Merck Patent Gmbh Metallkomplexe
EP1945222B1 (en) 2005-11-02 2012-12-26 Bayer Pharma Aktiengesellschaft Pyrrolo[2,1-f] [1,2,4]-triazin-4-ylamines as igf-1r kinase inhibitors for the treatment of cancer and other hyperproliferative diseases
EP1942732A2 (en) 2005-11-02 2008-07-16 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
ATE541844T1 (de) 2005-12-21 2012-02-15 Abbott Lab Antivirale verbindungen
WO2007084667A2 (en) 2006-01-19 2007-07-26 Osi Pharmaceutical, Inc. Fused heterobicyclic kinase inhibitors
ATE479434T1 (de) 2006-02-14 2010-09-15 Vertex Pharma Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine
MX2008012574A (es) 2006-03-29 2008-10-10 Schering Corp Derivados de himbacina monociclitos y biciclicos utiles como antagonistas del receptor de trombina.
JP2009534454A (ja) 2006-04-25 2009-09-24 アステックス、セラピューティックス、リミテッド 医薬化合物
ES2600792T3 (es) 2006-05-03 2017-02-10 Chimerix, Inc. Alcoxialquilésteres metabólicamente estables de fosfonatos, fosfonatos nucleosídicos y fosfatos nucleosídicos antivirales o antiproliferativos
EP2035395A2 (en) 2006-06-27 2009-03-18 Glenmark Pharmaceuticals S.A. Novel processes for the preparation of dpp iv inhibitors
JP2008007634A (ja) 2006-06-29 2008-01-17 Fujifilm Corp 潤滑剤組成物
BRPI0713187A2 (pt) 2006-07-20 2012-10-16 Mehmet Kahraman método de inibir rho-quinase, método de tratamento de doença mediada por rho-quinase, composto e composição farmacêutica
GB0614947D0 (en) 2006-07-27 2006-09-06 Isis Innovation Epitope reduction therapy
PE20080906A1 (es) 2006-08-17 2008-07-05 Kemia Inc Derivados heteroarilo como inhibidores de citocina
WO2008024364A2 (en) 2006-08-22 2008-02-28 Redpoint Bio Corporation Heterocyclic compounds as sweetener enhancers
US7951789B2 (en) 2006-12-28 2011-05-31 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
NZ598927A (en) 2007-01-12 2013-09-27 Biocryst Pharm Inc Antiviral nucleoside analogs
WO2008092006A2 (en) 2007-01-24 2008-07-31 Cernofina, Llc Antimicrobial compositions
US20080207554A1 (en) 2007-01-31 2008-08-28 Alios Biopharma, Inc. 2-5A Analogs and their Methods of Use
AU2008223348A1 (en) 2007-03-07 2008-09-12 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors containing a heterocyclic moiety
US8088566B2 (en) 2007-03-26 2012-01-03 Fujifilm Corporation Surface-treating agent for pattern formation and pattern-forming method using the surface-treating agent
WO2008117047A1 (en) 2007-03-27 2008-10-02 Astrazeneca Ab Pyrazolo[3, 4-d]pyrimidine derivatives as antibacterial compounds
US7956020B2 (en) 2007-03-29 2011-06-07 Fujifilm Corporation Lubricant composition, mechanical element, and method for producing triazine derivatives
US8088940B2 (en) 2007-03-30 2012-01-03 Momentive Performance Materials Inc. Hydrolyzable silanes of low VOC-generating potential and resinous compositions containing same
CN101678122A (zh) 2007-04-27 2010-03-24 奇默里克斯公司 在核苷给药的受体中降低肾中毒性的方法
DK2155758T3 (da) 2007-05-10 2012-11-05 Biocryst Pharm Inc Tetrahydrofuro[3,4-d]dioxolanforbindelser til anvendelse i behandlingen af virusinfektioner og cancer
WO2008151437A1 (en) 2007-06-14 2008-12-18 Osta Biotechnologies Heme-oxygenase inhibitors and use of the same in the treatment of cancer and diseases of the central nervous system
US20110319459A1 (en) 2007-06-14 2011-12-29 Osta Biotechnologies Compounds and Methods for Treating Cancer and Diseases of the Central Nervous System
GB0712494D0 (en) 2007-06-27 2007-08-08 Isis Innovation Substrate reduction therapy
CN100532388C (zh) 2007-07-16 2009-08-26 郑州大学 2’-氟-4’-取代-核苷类似物、其制备方法及应用
WO2009011228A1 (ja) 2007-07-19 2009-01-22 Konica Minolta Opto, Inc. セルロースエステルフィルム、セルロースエステルフィルムの製造方法、それを用いた偏光板、及び液晶表示装置
WO2009011229A1 (ja) 2007-07-19 2009-01-22 Konica Minolta Opto, Inc. セルロースエステルフィルム、セルロースエステルフィルムの製造方法、それを用いた偏光板保護フィルム、偏光板、及び液晶表示装置
US9340506B2 (en) 2007-10-08 2016-05-17 Advinus Therapeutics Limited Acetamide derivatives as glucokinase activators, their process and medicinal applications
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
TW200936146A (en) 2007-11-29 2009-09-01 Metabasis Therapeutics Inc Antiviral nucleoside compounds
ES2422741T3 (es) 2007-12-13 2013-09-13 Vertex Pharma Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
US20090181921A1 (en) 2007-12-21 2009-07-16 Alios Biopharma Inc. 2-5a analogs and their methods of use
WO2009086192A1 (en) 2007-12-21 2009-07-09 Alios Biopharma, Inc. Biodegradable phosphate protected nucleotide derivatives and their use as cancer, anti viral and anti parasitic agents
TW200942243A (en) 2008-03-05 2009-10-16 Biocryst Pharm Inc Antiviral therapeutic agents
EP2098226A1 (de) 2008-03-06 2009-09-09 Forschungsverbund Berlin e.V. AKAP-PKA-Interaktionshemmer zur Anwendung in der Behandlung von Herzkrankheiten
PL2280973T3 (pl) 2008-04-23 2013-05-31 Gilead Sciences Inc Analogi karba-nukleozydowe do leczenia przeciwwirusowego
WO2010036407A2 (en) 2008-05-15 2010-04-01 Biocryst Pharmaceuticals, Inc. Antiviral nucleoside analogs
JP5712125B2 (ja) 2008-05-27 2015-05-07 トリリンク バイオテクノロジーズ 高温で開始される核酸増幅のための、化学修飾されたヌクレオシド５’−三リン酸
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US7910019B2 (en) 2008-06-27 2011-03-22 Transitions Optical, Inc. Mesogen containing compounds
US7910020B2 (en) 2008-06-27 2011-03-22 Transitions Optical, Inc. Liquid crystal compositions comprising mesogen containing compounds
US8628685B2 (en) 2008-06-27 2014-01-14 Transitions Optical, Inc Mesogen-containing compounds
US7803285B2 (en) 2008-07-01 2010-09-28 Gentex Corporation Liquid crystal display device and associated liquid crystal media for use in the same
EP2313102A2 (en) 2008-07-03 2011-04-27 Biota Scientific Management Bycyclic nucleosides and nucleotides as therapeutic agents
GB0812297D0 (en) 2008-07-04 2008-08-13 Lucite Int Uk Ltd Novel carbonylation ligand sand thier use of in the carbonylation of ethylenically unsaturated compounds
UY31982A (es) 2008-07-16 2010-02-26 Boehringer Ingelheim Int Derivados de 1,2-dihidropiridin-3-carboxamidas n-sustituidas
GB0815968D0 (en) 2008-09-03 2008-10-08 Angeletti P Ist Richerche Bio Antiviral agents
JP5295692B2 (ja) 2008-09-10 2013-09-18 豊和工業株式会社 自動開閉防音サッシ
WO2010039548A2 (en) 2008-09-23 2010-04-08 Alnylam Pharmaceuticals, Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
US20100096603A1 (en) 2008-10-20 2010-04-22 Nitto Denko Corporation Optical devices responsive to near infrared laser and methods of modulating light
EP2384328B1 (en) 2008-11-27 2013-02-13 Boehringer Ingelheim International GmbH 6,7,8,9-tetrahydro-5h-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and process for preparing them
WO2010073126A2 (en) 2008-12-22 2010-07-01 The Governors Of The University Of Alberta Compounds useful in delivering anti-neoplastic therapy and diagnostic imaging to hypoxic cells and methods of use thereof
GB0900914D0 (en) 2009-01-20 2009-03-04 Angeletti P Ist Richerche Bio Antiviral agents
US9040718B2 (en) 2009-01-22 2015-05-26 The University Of Rochester Hybrid host materials for electrophosphorescent devices
KR20100087540A (ko) 2009-01-28 2010-08-05 삼성전자주식회사 잉크젯 기록용 잉크 조성물
CA2751458C (en) 2009-02-06 2018-06-05 Rfs Pharma, Llc Purine nucleoside monophosphate prodrugs for treatment of cancer and viral infections
US20100240604A1 (en) 2009-03-20 2010-09-23 Alios Biopharma, Inc. Protected nucleotide analogs
WO2010108140A1 (en) 2009-03-20 2010-09-23 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
EP2264169A1 (en) 2009-06-15 2010-12-22 Qiagen GmbH Modified siNA
US20110212994A1 (en) 2009-06-26 2011-09-01 Brian Clem Small Molecule Choline Kinase Inhibitors, Screening Assays, and Methods for Safe and Effective Treatment of Neoplastic Disorders
US8927513B2 (en) 2009-07-07 2015-01-06 Alnylam Pharmaceuticals, Inc. 5′ phosphate mimics
WO2011016430A1 (ja) 2009-08-04 2011-02-10 三菱化学株式会社 光電変換素子及びこれを用いた太陽電池
RU2012104214A (ru) 2009-08-05 2013-09-10 Верситек Лимитед Противовирусные соединения и способы их получения и применения
KR20120063515A (ko) 2009-09-09 2012-06-15 아빌라 테라퓨틱스, 인크. Ｐｉ３ 키나제 억제제 및 이들의 용도
US20120189670A1 (en) 2009-09-14 2012-07-26 Kirkpatrick D Lynn Pharmaceutical compositions and formulations including inhibitors of the pleckstrin homology domain and methods for using same
US8455451B2 (en) 2009-09-21 2013-06-04 Gilead Sciences, Inc. 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
DK2480552T3 (en) 2009-09-21 2017-02-20 Gilead Sciences Inc 2 'FLUOROUS-SUBSTITUTED CARBA NUCLEOSIDE ANALYSIS FOR ANTIVIRAL TREATMENT
NZ599404A (en) 2009-09-21 2014-02-28 Gilead Sciences Inc Processes and intermediates for the preparation of 1’-substituted carba-nucleoside analogs
US20120264810A1 (en) 2009-09-22 2012-10-18 The University Of British Columbia Compositions and methods for enhancing cellular uptake and intracellular delivery of lipid particles
WO2011038207A1 (en) 2009-09-25 2011-03-31 Metabasis Therapeutics, Inc. Phosphorus-containing thyroid hormone receptor agonists and methods of use
DE102010035730A1 (de) 2009-09-28 2011-04-07 Merck Patent Gmbh Polymerisierbare Verbindungen und ihre Verwendung in Flüssigkristallanzeigen
EP2499282B1 (en) 2009-11-09 2015-04-22 NeuroGenetic Pharmaceuticals, Inc. Gamma-secretase modulatory compounds, methods for identifying same, and uses therefor
CN102000103B (zh) 2009-12-21 2011-12-21 郑州大学 2’-氟-4’-叠氮-核苷类似物或其盐的药物应用
UY33176A (es) 2010-01-13 2011-08-31 Sanofi Aventis Derivados de oxazolopirimidina sustituida en 2, 5, 7.
US9198972B2 (en) 2010-01-28 2015-12-01 Alnylam Pharmaceuticals, Inc. Monomers and oligonucleotides comprising cycloaddition adduct(s)
WO2011094890A1 (en) 2010-02-02 2011-08-11 Argusina Inc. Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators
WO2011109799A1 (en) 2010-03-05 2011-09-09 Karyopharm Therapeutics, Inc. Nuclear transport modulatiors and uses thereof
US20130137728A1 (en) 2010-03-24 2013-05-30 MUSC Foundation for Research and Development Compositions and Methods for the Treatment of Degenerative Diseases
WO2011146401A1 (en) 2010-05-17 2011-11-24 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
FR2960234B1 (fr) 2010-05-18 2013-11-01 Inst Francais Du Petrole Procede de dimerisation de l'ethylene en butene-1 utilisant une composition comprenant un complexe a base de titane et un ligand alcoxy fonctionnalise par un hetero-atome.
FR2960235B1 (fr) 2010-05-18 2013-11-01 Inst Francais Du Petrole Procede d'oligomerisation des olefines utilisant une composition comprenant un complexe organometallique contenant un ligand alcoxy fonctionnalise par un hetero-atome.
TW201201815A (en) 2010-05-28 2012-01-16 Gilead Sciences Inc 1'-substituted-carba-nucleoside prodrugs for antiviral treatment
WO2011156632A2 (en) 2010-06-09 2011-12-15 Georgetown University Compositions and methods of treatment for tumors in the nervous system
US8614021B2 (en) 2010-06-10 2013-12-24 The United States Of America As Represented By The Secretary Of The Army Agents for enhanced charge transport across microbial membranes
EA025311B1 (ru) 2010-07-19 2016-12-30 Гайлид Сайэнсиз, Инк. Способы получения диастереомерно чистых фосфорамидатных пролекарств
PT2595980E (pt) 2010-07-22 2014-11-27 Gilead Sciences Inc Métodos e compostos para tratar infeções pelo vírus da família paramyxoviridae
CN102351931B (zh) 2010-09-07 2014-01-22 河南省科学院高新技术研究中心 嘧啶核苷衍生物、合成方法及其在制备抗肿瘤、抗病毒药物中的应用
TW201305185A (zh) 2010-09-13 2013-02-01 吉李德科學股份有限公司 用於抗病毒治療之２’－氟取代之碳－核苷類似物
DE102010045369A1 (de) 2010-09-14 2012-03-15 Merck Patent Gmbh Materialien für organische Elektrolumineszenzvorrichtungen
WO2012040127A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Substituted nucleotide analogs
US20120070411A1 (en) 2010-09-22 2012-03-22 Alios Biopharma, Inc. Substituted nucleotide analogs
AU2011305652B2 (en) 2010-09-22 2016-10-20 Janssen Biopharma, Inc. Azido nucleosides and nucleotide analogs
WO2012068340A2 (en) 2010-11-18 2012-05-24 Opko Curna Llc Antagonat compositions and methods of use
ES2716158T3 (es) 2010-11-30 2019-06-10 Gilead Pharmasset Llc 2'-spiro-nucleótidos para el tratamiento de hepatitis C
WO2012083048A2 (en) 2010-12-15 2012-06-21 Abbott Laboratories Anti-viral compounds
TW201306841A (zh) 2010-12-20 2013-02-16 Gilead Sciences Inc 治療ｃ型肝炎病毒（ｈｃｖ）之方法
EP2655334B1 (en) 2010-12-22 2018-10-03 Eutropics Pharmaceuticals, Inc. Compositions and methods useful for treating diseases
US8772474B2 (en) 2010-12-22 2014-07-08 Alios Biopharma, Inc. Cyclic nucleotide analogs
TWI450891B (zh) 2010-12-29 2014-09-01 Dev Center Biotechnology 新穎微管蛋白抑制劑
CN103717222A (zh) 2011-02-24 2014-04-09 浙江大学 桥二硫二氧代哌嗪及其在治疗癌症方面的用途
KR102198749B1 (ko) 2011-03-02 2021-01-06 제롬 쉔타그 단독으로 또는 c형 간염 바이러스 감염과 결합되는 간 지방증의 치료를 위한 조성물, 방법 및 진단
CN103502218B (zh) 2011-03-04 2016-08-17 生命科技公司 用于缀合生物分子的化合物和方法
AR085908A1 (es) 2011-03-16 2013-11-06 Hoffmann La Roche DERIVADOS DE 3-BUTIN-2-OL Y DE CARBONITRILO CON ACTIVIDAD INHIBIDORA DE LA QUINASA INDUCTORA DE NF-kB (NIK)
JP2012216832A (ja) 2011-03-30 2012-11-08 Mitsubishi Chemicals Corp 光電変換素子、太陽電池、太陽電池モジュール及びインク
WO2012139028A2 (en) 2011-04-06 2012-10-11 The Trustees Of Princeton University Anti-viral combination therapy
EP2697241B1 (en) 2011-04-13 2019-06-12 Gilead Sciences, Inc. 1'-substituted pyrimidine n-nucleoside analogs for antiviral treatment
EP2697242B1 (en) 2011-04-13 2018-10-03 Merck Sharp & Dohme Corp. 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2012142085A1 (en) 2011-04-13 2012-10-18 Merck Sharp & Dohme Corp. 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
GB201108825D0 (en) 2011-05-25 2011-07-06 Univ Dundee Morpholino compounds, uses and methods
US20130018011A1 (en) 2011-06-10 2013-01-17 Hassan Javanbakht Method of treating dengue fever
EP2726610A1 (en) 2011-06-30 2014-05-07 Stella ApS Hcv combination therapy
FR2977586B1 (fr) 2011-07-08 2013-07-12 Rhodia Operations Procede de fabrication de composes comprenant des fonctions nitriles
WO2013033268A2 (en) 2011-08-29 2013-03-07 Coferon, Inc. Bivalent bromodomain ligands, and methods of using same
BR112014005110A2 (pt) 2011-09-02 2017-04-18 Bayer Ip Gmbh pirimidinas aneladas substituídas e utilização das mesmas
CN102286047A (zh) 2011-09-14 2011-12-21 郑州大学 2’-脱氧-2’-氟-4’-三氮唑取代-β-D胞苷类似物、其制备方法及其应用
HRP20180237T4 (hr) 2011-09-16 2020-12-11 Gilead Pharmasset Llc Metode za liječenje hcv-a
JP2014530195A (ja) 2011-09-16 2014-11-17 アッヴィ・インコーポレイテッド Ｈｃｖを治療するための方法
US8575119B2 (en) 2011-09-23 2013-11-05 Enanta Pharmaceuticals, Inc. 2′-chloroacetylenyl substituted nucleoside derivatives
US20150272885A1 (en) 2011-10-14 2015-10-01 Stc.Unm Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereof
FR2982858B1 (fr) 2011-11-18 2013-11-29 Rhodia Operations Procede de fabrication de composes comprenant des fonctions nitriles
US20130244966A1 (en) 2011-12-12 2013-09-19 Catabasis Pharmaceuticals, Inc. Fatty acid antiviral conjugates and their uses
FR2984322B1 (fr) 2011-12-16 2013-12-20 Rhodia Operations Procede de fabrication de composes comprenant des fonctions nitriles
EP2794630A4 (en) 2011-12-22 2015-04-01 Alios Biopharma Inc SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE
KR102072041B1 (ko) 2011-12-22 2020-01-31 앨리오스 바이오파마 인크. 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체
WO2013101552A1 (en) 2011-12-28 2013-07-04 Abbvie Inc. Methods for treating hcv
CN102603836A (zh) 2012-02-10 2012-07-25 郑州大学 五味子丙素简化物、类似物及其制备方法和应用
NZ629996A (en) 2012-03-13 2016-10-28 Gilead Sciences Inc 2’- substituted carba-nucleoside analogs for antiviral treatment
TWI635111B (zh) 2012-03-16 2018-09-11 Merck Patent Gmbh 共軛聚合物
WO2013142159A1 (en) 2012-03-21 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
SI2827875T1 (sl) 2012-03-21 2019-04-30 Alios Biopharma, Inc. Substituirani nukleozidi, nukleotidi in njihovi analogi
NZ631601A (en) 2012-03-21 2016-06-24 Alios Biopharma Inc Solid forms of a thiophosphoramidate nucleotide prodrug
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
NZ630805A (en) 2012-03-22 2016-01-29 Alios Biopharma Inc Pharmaceutical combinations comprising a thionucleotide analog
CN104204009B (zh) 2012-03-29 2016-08-17 英派尔科技开发有限公司 二氧杂硼烷共聚物及其应用
US20150057243A1 (en) 2012-04-02 2015-02-26 Northern University Compositions and Methods for the Inhibition of Methyltransferases
JP2013237721A (ja) 2012-05-11 2013-11-28 Nitto Denko Corp 再剥離用水分散型アクリル系粘着剤組成物、及び粘着シート
CN104380493A (zh) 2012-06-04 2015-02-25 默克专利有限公司 有机半导体
US9682970B2 (en) 2012-06-29 2017-06-20 Biotium, Inc. Fluorescent compounds and uses thereof
EP2870169A1 (en) 2012-07-03 2015-05-13 Bristol-Myers Squibb Company Process for preparing diastereomerically enriched phosphoramidate derivatives of nucleoside compounds for treatment of viral infections
JP2015525775A (ja) 2012-07-23 2015-09-07 メルク パテント ゲーエムベーハー リガンドおよびその製造方法
US20140038991A1 (en) 2012-08-06 2014-02-06 Astar Biotech Llc Protein Kinase Inhibitors
WO2014026198A1 (en) 2012-08-10 2014-02-13 Epizyme, Inc. Inhibitors of protein methyltransferase dot1l and methods of use thereof
WO2014031872A2 (en) 2012-08-23 2014-02-27 The Broad Institute, Inc. Small molecule inhibitors for treating parasitic infections
WO2014035140A2 (en) 2012-08-30 2014-03-06 Kainos Medicine, Inc. Compounds and compositions for modulating histone methyltransferase activity
EP2712868A1 (en) 2012-09-28 2014-04-02 B. Braun Melsungen AG 5-Fluoruoracil Derivatives
ES2674980T3 (es) 2012-10-08 2018-07-05 Idenix Pharmaceuticals Llc Análogos de 2'-cloro nucleósidos para infección por VHC
DE102012109685A1 (de) 2012-10-11 2014-04-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Umwandlung reaktiver Gruppen an Si-C-gebundenen Resten von Silanen unter gleichzeitiger Vergrößerung von deren räumlichem Abstand zueinander
EP2909210A4 (en) 2012-10-17 2016-04-06 Merck Sharp & Dohme 2'-DISUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHOD FOR THE USE THEREOF FOR THE TREATMENT OF VIRUS DISEASES
EP2909209B1 (en) 2012-10-17 2022-08-03 Merck Sharp & Dohme LLC 2'-cyano substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases
KR20120135501A (ko) 2012-10-29 2012-12-14 에스에프씨 주식회사 축합환 화합물 및 이를 포함한 유기 발광 소자
WO2014090369A1 (en) 2012-12-14 2014-06-19 Merck Patent Gmbh Birefringent rm lens
AU2013361193B2 (en) 2012-12-21 2018-05-24 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9243022B2 (en) 2012-12-21 2016-01-26 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
FR2999917B1 (fr) 2012-12-26 2017-06-23 Oreal Polymere a empreinte moleculaire pour pieger selectivement les molecules odorantes
US20140200215A1 (en) 2013-01-15 2014-07-17 Intermune, Inc. Lysophosphatidic acid receptor antagonists
JP6024479B2 (ja) 2013-01-28 2016-11-16 コニカミノルタ株式会社 光学フィルム、円偏光板および画像表示装置
AU2014214561C1 (en) 2013-02-11 2019-01-17 Mitokinin, Inc. Compositions and methods for treating neurodegenerative diseases
US9580400B2 (en) 2013-02-26 2017-02-28 Northeastern University Cannabinergic nitrate esters and related analogs
US20150065439A1 (en) 2013-02-28 2015-03-05 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions
US20140309413A1 (en) 2013-03-11 2014-10-16 Vertex Pharmaceuticals Incorporated Methods of stereoselective synthesis of substituted nucleoside analogs
US9790291B2 (en) 2013-03-14 2017-10-17 Formosa Plastics Corporation, Usa Non-phthalate compounds as electron donors for polyolefin catalysts
US10138256B2 (en) 2013-03-15 2018-11-27 Celgene Car Llc MK2 inhibitors and uses thereof
JP6329764B2 (ja) 2013-03-15 2018-05-23 信越化学工業株式会社 対称ハイパーブランチ型シリコーン変性重合性化合物、及びそのモジュール化した製造方法
ES2952714T3 (es) 2013-06-26 2023-11-03 Janssen Pharmaceuticals Inc Nucleósidos sustituidos, nucleótidos y análogos de los mismos
WO2015003146A1 (en) 2013-07-03 2015-01-08 Georgetown University Boronic acid derivatives of resveratrol for activating deacetylase enzymes
AU2014287471C1 (en) 2013-07-10 2019-11-28 Vertex Pharmaceuticals Incorporated Fused piperidine amides as modulators of ion channels
CN104086612A (zh) 2013-07-17 2014-10-08 郑州大学 4-取代胺基-2′-脱氧-2′-氟-4′-叠氮-β-D-胞苷类核苷化合物、制备方法及其应用
WO2015016187A1 (ja) 2013-07-29 2015-02-05 富士フイルム株式会社 非水二次電池用電解液および非水二次電池
WO2015024120A1 (en) 2013-08-19 2015-02-26 Queen's University At Kingston Carbene functionalized composite materials
WO2015031710A1 (en) 2013-08-29 2015-03-05 Baylor College Of Medicine Compositions and methods for the treatment of metabolic and body weight related disorders
TW201542581A (zh) 2013-09-11 2015-11-16 艾默理大學 核苷酸與核苷治療組成物及其相關用途
US20160257657A1 (en) 2013-09-20 2016-09-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
KR101628288B1 (ko) 2013-09-30 2016-06-08 주식회사 엘지화학 음성 광학 분산도를 갖는 광학 소자 제조용 조성물 및 이로부터 제조된 광학 이방체
EP3052511A4 (en) 2013-10-02 2017-05-31 Moderna Therapeutics, Inc. Polynucleotide molecules and uses thereof
CN105829333A (zh) * 2013-10-11 2016-08-03 艾丽奥斯生物制药有限公司 取代的核苷、核苷酸及其类似物
CN105658219A (zh) 2013-10-25 2016-06-08 艾伯维公司 用于治疗hcv的方法
UA119050C2 (uk) 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
US20150167017A1 (en) 2013-12-13 2015-06-18 Moderna Therapeutics, Inc. Alternative nucleic acid molecules and uses thereof
CN103709220B (zh) 2014-01-13 2016-02-17 河南省科学院高新技术研究中心 3-甲基尿苷及4-甲基胞苷核苷类化合物、合成方法及其药物用途
EP2896678B1 (en) 2014-01-21 2018-10-17 Merck Patent GmbH Liquid crystal display
CR20160400A (es) 2014-02-06 2016-11-07 Riboscience Llc Derivados de nucleosido sustituidos con 4´-difluorometilo como inhibidores de la replicación de arn de la influenza
JP6144215B2 (ja) 2014-02-07 2017-06-07 富士フイルム株式会社 光電変換素子およびその使用方法、光センサ、並びに、撮像素子
WO2015129672A1 (ja) 2014-02-27 2015-09-03 Dic株式会社 液晶表示装置
EP2918658B1 (de) 2014-03-10 2020-05-13 Merck Patent GmbH Flüssigkristalline Medien mit homöotroper Ausrichtung
US9399637B2 (en) 2014-03-28 2016-07-26 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
WO2015143712A1 (en) 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
EP3131538B1 (en) 2014-04-15 2019-12-18 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO New anti-clostridium compounds
US20170136132A1 (en) 2014-06-19 2017-05-18 Moderna Therapeutics, Inc. Alternative nucleic acid molecules and uses thereof
WO2015196130A2 (en) 2014-06-19 2015-12-23 Moderna Therapeutics, Inc. Alternative nucleic acid molecules and uses thereof
US10286086B2 (en) 2014-06-19 2019-05-14 Modernatx, Inc. Alternative nucleic acid molecules and uses thereof
WO2015198915A1 (ja) 2014-06-23 2015-12-30 Dic株式会社 重合性液晶組成物及び該組成物を用いて作製した光学異方体、位相差膜、位相差パターニング膜
US9603864B2 (en) 2014-06-24 2017-03-28 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
SG11201610597QA (en) 2014-06-24 2017-01-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
WO2016010026A1 (ja) 2014-07-15 2016-01-21 Dic株式会社 液晶表示装置
TWI678369B (zh) 2014-07-28 2019-12-01 美商基利科學股份有限公司 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類
KR102289820B1 (ko) 2014-08-01 2021-08-17 삼성전자주식회사 축합환 화합물 및 이를 포함한 유기 발광 소자
WO2016029186A1 (en) 2014-08-22 2016-02-25 Arizona Board Of Regents On Behalf Of Arizona State University Metal-assisted delayed fluorescent materials as co-host materials for fluorescent oleds
EP3372655B1 (en) 2014-08-25 2019-12-18 Merck Patent GmbH Liquid-crystal medium
JP6326140B2 (ja) 2014-08-27 2018-05-16 富士フイルム株式会社 化合物、組成物、膜、光学機器
CN107108676A (zh) 2014-09-15 2017-08-29 美迪维尔公司 用于制备非对映异构纯的磷酰胺酯前药的方法
WO2016066582A1 (en) 2014-10-28 2016-05-06 Bci Pharma Nucleoside kinase inhibitors
TWI698444B (zh) 2014-10-29 2020-07-11 美商基利科學股份有限公司 製備核糖苷的方法
CA2966033A1 (en) 2014-10-31 2016-05-06 Cocrystal Pharma, Inc. 2',2'-dihalo nucleoside analogs for treatment of the flaviviridae family of viruses and cancer
WO2016070952A1 (en) 2014-11-06 2016-05-12 Merck Patent Gmbh Light modulation element
WO2016074762A1 (en) 2014-11-11 2016-05-19 Merck Patent Gmbh Bimesogenic compounds and mesogenic media
CN105646629A (zh) 2014-11-25 2016-06-08 广州市恒诺康医药科技有限公司 L-核苷类化合物及其应用
CN105777580B (zh) 2014-12-18 2018-05-18 湖南化工研究院有限公司 酰基乙腈类化合物及其制备方法与应用
KR20170097154A (ko) 2014-12-19 2017-08-25 메르크 파텐트 게엠베하 광 변조 소자
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
MA41441A (fr) 2014-12-19 2017-12-12 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
JP2018502113A (ja) 2014-12-30 2018-01-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ビメソゲン化合物およびメソゲン性媒体
WO2016115222A1 (en) 2015-01-14 2016-07-21 Riboscience Llc 4'-azido substituted nucleoside derivatives as inhibitors of ebola virus rna replication
JP6729395B2 (ja) 2015-01-20 2020-07-22 Jnc株式会社 液晶組成物および液晶表示素子
WO2016116508A1 (de) 2015-01-20 2016-07-28 Cynora Gmbh Organische moleküle, insbesondere zur verwendung in optoelektronischen bauelementen
EP3048159B1 (en) 2015-01-22 2019-08-07 Merck Patent GmbH Liquid crystal medium
EP3248060B1 (en) 2015-01-23 2020-09-02 Merck Patent GmbH Light modulation element
KR20170104618A (ko) 2015-01-23 2017-09-15 메르크 파텐트 게엠베하 광 변조 소자
KR102539268B1 (ko) 2015-02-10 2023-06-07 메르크 파텐트 게엠베하 액정 매질
JP6485106B2 (ja) 2015-02-24 2019-03-20 Jnc株式会社 液晶組成物および液晶表示素子
WO2016145142A1 (en) 2015-03-10 2016-09-15 Emory University Nucleotide and nucleoside therapeutics compositions and uses related thereto
KR102587314B1 (ko) 2015-03-13 2023-10-12 메르크 파텐트 게엠베하 액정 매질
KR20160110900A (ko) 2015-03-13 2016-09-22 메르크 파텐트 게엠베하 액정 매질
WO2016148170A1 (ja) 2015-03-17 2016-09-22 富士フイルム株式会社 有機半導体組成物、及び、有機半導体素子の製造方法
US10647921B2 (en) 2015-03-24 2020-05-12 Jnc Corporation Liquid crystal composition and liquid crystal display device
WO2016161176A1 (en) 2015-04-01 2016-10-06 The California Institute For Biomedical Research Methods for treating viral infections
FR3034767A1 (fr) 2015-04-07 2016-10-14 Centre Nat Rech Scient Reduction des fonctions carbonyles de glucides et derives de glucides en milieu aqueux par le dithionite de sodium
JPWO2016170948A1 (ja) 2015-04-23 2018-02-15 Jnc株式会社 液晶組成物および液晶表示素子
WO2016172631A2 (en) 2015-04-24 2016-10-27 President And Fellows Of Harvard College Substrate selective inhibitors of insulin-degrading enzyme (ide) and uses thereof
CN107709344B (zh) 2015-05-01 2022-07-15 共晶制药股份有限公司 用于治疗黄病毒科病毒和癌症的核苷类似物
CN106279322B (zh) 2015-05-15 2019-07-30 上海唐润医药科技有限公司 抗丙肝病毒的核苷类化合物及其应用
DE102015210388A1 (de) 2015-06-05 2016-12-08 Siemens Aktiengesellschaft Organische Heterozyklische Alkalimetallsalze als n-Dotierstoffe in der Organischen Elektronik
CN107848975A (zh) 2015-07-06 2018-03-27 拜耳作物科学股份公司 作为杀虫剂的含氮杂环
WO2017019830A1 (en) 2015-07-29 2017-02-02 Medivation Technologies, Inc. Methods and compositions for targeted therapeutics
WO2017019822A1 (en) 2015-07-29 2017-02-02 Medivation Technologies, Inc. Pellet composition containing repair cells
WO2017019817A1 (en) 2015-07-29 2017-02-02 Medivation Technologies, Inc. Methods and compositions for targeted therapeutics
EP3331530A4 (en) 2015-08-03 2018-12-19 Raze Therapeutics Inc. Mthfd2 inhibitors and uses thereof
AU2016301188A1 (en) 2015-08-06 2018-02-15 Chimerix, Inc. Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents
CN108137641B (zh) 2015-08-13 2022-04-01 默沙东公司 作为sting激动剂的环状双核苷酸化合物
TWI730980B (zh) 2015-08-26 2021-06-21 比利時商健生藥品公司 使用作為ｐｒｍｔ５抑制劑之新穎經６-６雙環芳香環取代之核苷類似物
CN107949620B (zh) 2015-09-09 2022-02-11 默克专利股份有限公司 液晶介质
CN106518767A (zh) 2015-09-11 2017-03-22 中国人民解放军军事医学科学院毒物药物研究所 取代苯并吡唑二芳基脲类化合物,其制备方法及其医药用途
CN106518766A (zh) 2015-09-11 2017-03-22 中国人民解放军军事医学科学院毒物药物研究所 新型二芳基脲类化合物,其制备方法及其医药用途
JP2018532869A (ja) 2015-09-15 2018-11-08 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ホメオトロピック配向を有する液晶媒体
DK3349758T3 (da) 2015-09-16 2022-06-13 Gilead Sciences Inc Fremgangsmåder til behandling af arenaviridae-virusinfektioner
CN105218523B (zh) 2015-09-18 2019-08-23 上海吉铠医药科技有限公司 吡啶衍生物pim激酶抑制剂及其制备方法与在制药中的应用
CN105254624B (zh) 2015-09-18 2019-08-09 上海吉铠医药科技有限公司 异噻唑衍生物pim激酶抑制剂及其制备方法与在制药中的应用
CN105130959B (zh) 2015-09-18 2018-08-03 上海吉铠医药科技有限公司 嘧啶衍生物pim激酶抑制剂及其制备方法与在制药中的应用
EP3356347A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
US11464774B2 (en) 2015-09-30 2022-10-11 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
JP2018530587A (ja) 2015-10-16 2018-10-18 モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． ｍＲＮＡキャップ類似体およびｍＲＮＡキャッピングの方法
WO2017066782A1 (en) 2015-10-16 2017-04-20 Modernatx, Inc. Hydrophobic mrna cap analogs
DK3362461T3 (da) 2015-10-16 2022-05-09 Modernatx Inc Mrna-cap-analoger med modificeret phosphatbinding
US11866754B2 (en) 2015-10-16 2024-01-09 Modernatx, Inc. Trinucleotide mRNA cap analogs
WO2017066791A1 (en) 2015-10-16 2017-04-20 Modernatx, Inc. Sugar substituted mrna cap analogs
KR20180074672A (ko) 2015-10-23 2018-07-03 제이엔씨 주식회사 액정 조성물 및 액정 표시 소자
WO2017073933A1 (ko) 2015-10-26 2017-05-04 주식회사 엘지화학 스피로형 화합물 및 이를 포함하는 유기 발광 소자
CN107108498B (zh) 2015-10-26 2020-08-21 株式会社Lg化学 胺化合物和包含其的有机发光元件
WO2017073931A1 (ko) 2015-10-28 2017-05-04 주식회사 엘지화학 스피로형 화합물 및 이를 포함하는 유기 발광 소자
CN108601735A (zh) 2015-11-25 2018-09-28 加利福尼亚大学董事会 用于癌症治疗的药物制剂
MX2018006749A (es) 2015-12-03 2018-08-15 Bayer Cropscience Ag Derivados de 3-(acetil)-1-[(1,3-tiazol-5-il)metil]-1h-imidazo[1,2- a]piridin-4-io-2-olato halogenados mesoionicos y compuestos relacionados como insecticidas.
KR20180093956A (ko) 2015-12-11 2018-08-22 메르크 파텐트 게엠베하 중합가능 화합물 및 이의 액정 디스플레이에서의 용도
CN106892920B (zh) 2015-12-18 2019-12-13 中国医学科学院医药生物技术研究所 苦豆碱衍生物、其制备方法及用途
KR102419178B1 (ko) 2015-12-29 2022-07-11 삼성디스플레이 주식회사 유기 발광 소자
US10745427B2 (en) 2016-03-09 2020-08-18 Janssen Biopharma, Inc. Acyclic antivirals
CN108884108B (zh) 2016-03-10 2021-08-31 詹森药业有限公司 用于用作prmt5抑制剂的取代核苷类似物
WO2017161028A1 (en) 2016-03-16 2017-09-21 Kura Oncology, Inc. Substituted inhibitors of menin-mll and methods of use
WO2017165489A1 (en) 2016-03-23 2017-09-28 Emory University Antiviral agents for treating zika and dengue virus infections
CN107286190A (zh) 2016-04-13 2017-10-24 刘沛 核苷之烃氧基苄基氨基磷酸/膦酸酯衍生物的制备及其医药用途
WO2017184668A1 (en) 2016-04-20 2017-10-26 Gilead Sciences, Inc. Methods for treating flaviviridae virus infections
WO2017205980A1 (en) 2016-06-01 2017-12-07 Greencentre Canada Etching metal using n-heterocyclic carbenes
GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
WO2018009623A1 (en) 2016-07-08 2018-01-11 Atea Pharmaceuticals, Inc. β-D-2'-DEOXY-2'-SUBSTITUTED-4'-SUBSTITUTED-2-SUBSTITUTED-N6-SUBSTITUTED-6-AMINOPURINE NUCLEOTIDES FOR THE TREATMENT OF PARAMYXOVIRUS AND ORTHOMYXOVIRUS INFECTIONS
JP2019527381A (ja) 2016-07-20 2019-09-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 光学スイッチ素子において使用するためのスイッチ層
JP2019524795A (ja) 2016-08-12 2019-09-05 ヤンセン バイオファーマ インク． 置換ヌクレオシド、ヌクレオチド、及びそのアナログ
JP2018044028A (ja) 2016-09-12 2018-03-22 オルガノサイエンス株式会社 液晶組成物
KR20230156818A (ko) 2016-10-03 2023-11-14 시질론 테라퓨틱스, 인크. 화합물, 장치, 및 이의 용도
WO2018065356A1 (en) 2016-10-05 2018-04-12 Merck Patent Gmbh Organic semiconducting compounds
US10858344B2 (en) 2016-11-23 2020-12-08 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
WO2018106820A1 (en) 2016-12-07 2018-06-14 Kura Oncology, Inc. Methods of promoting beta cell proliferation
WO2018106818A1 (en) 2016-12-07 2018-06-14 Kura Oncology, Inc. Methods of promoting beta cell proliferation
WO2018110529A1 (ja) 2016-12-16 2018-06-21 Dic株式会社 表示素子用封止材料組成物、及び、それを用いた表示素子
JP6547912B2 (ja) 2016-12-19 2019-07-24 Dic株式会社 重合性組成物、及び、それを用いた光学異方体
WO2018119263A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds derivatives as pd-l1 internalization inducers
ES2924186T3 (es) 2017-01-27 2022-10-05 Janssen Biotech Inc Dinucleótidos cíclicos como agonistas de STING
US12089486B2 (en) 2017-02-08 2024-09-10 Universal Display Corporation Organic electroluminescent materials and devices
CN110869028B (zh) 2017-03-14 2023-01-20 吉利德科学公司 治疗猫冠状病毒感染的方法
CN110691779B (zh) 2017-03-24 2023-10-10 库拉肿瘤学公司 治疗血液系统恶性肿瘤和尤因肉瘤的方法
WO2018183635A1 (en) 2017-03-31 2018-10-04 Peloton Therapeutics, Inc. Cd73 inhibitors and uses thereof
EP3611174B1 (en) 2017-04-07 2022-06-08 Medshine Discovery Inc. [1,2,4]triazolo[1,5-c]pyrimidine derivative as a2a receptor inhibitor
EP3609977B1 (de) 2017-04-13 2024-05-29 Merck Patent GmbH Zusammensetzung für organische elektronische vorrichtungen
EP4219513A1 (en) 2017-05-01 2023-08-02 Gilead Sciences, Inc. Crystalline form of (s)-2-ethylbutyl 2-(((s)-(((2r,3s,4r,5r)-5-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate
US11466047B2 (en) 2017-05-12 2022-10-11 Merck Sharp & Dohme Llc Cyclic di-nucleotide compounds as sting agonists
US11666555B2 (en) 2017-05-17 2023-06-06 Drexel University RelA inhibitors for biofilm disruption
CN110869338A (zh) 2017-05-25 2020-03-06 斯克利普斯研究所 烷烃到烯烃的氧化
CN110958880B (zh) 2017-05-30 2023-08-08 东莞东阳光太景医药研发有限责任公司 固体分散制剂
US10004719B1 (en) 2017-05-30 2018-06-26 Taigen Biotechnology Co., Ltd. Solid dispersion formulation
GB2577652A (en) 2017-05-31 2020-04-01 Commw Scient Ind Res Org Inhibiting hydrocarbon hydrate agglomeration
US11542248B2 (en) 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
JP2018203945A (ja) 2017-06-08 2018-12-27 Dic株式会社 重合性液晶組成物、及び、それを用いた光学異方体
WO2018237194A1 (en) 2017-06-21 2018-12-27 Wave Life Sciences Ltd. Compounds, compositions and methods for synthesis
CN111093627B (zh) 2017-07-11 2024-03-08 吉利德科学公司 用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物
US11548893B2 (en) 2017-07-15 2023-01-10 Arisan Therapeutics Inc. Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection
EA202090595A1 (ru) 2017-09-08 2020-06-29 Дзе Борд Оф Трастиз Оф Дзе Лелэнд Стэнфорд Джуниор Юниверсити Ингибиторы enpp1 и способы модуляции иммунного ответа
US20200361955A1 (en) 2017-09-13 2020-11-19 Raynergy Tek Incorporation Organic semiconducting compounds
WO2019053696A1 (en) * 2017-09-18 2019-03-21 Alios Biopharma, Inc. SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
KR20190041918A (ko) 2017-10-13 2019-04-23 메르크 파텐트 게엠베하 액정 매질
EP3700527A4 (en) 2017-10-25 2021-03-10 Children's Medical Center Corporation PAPD5 INHIBITORS AND METHOD OF USING THEM
WO2019086400A1 (en) 2017-11-02 2019-05-09 Merck Patent Gmbh Organic semiconducting compounds
CN109748944B (zh) 2017-11-03 2021-12-10 中国科学院上海药物研究所 5’-脱氧-5’-异丙基取代氨基核苷类化合物、其制备方法和用途
CN109748921B (zh) 2017-11-03 2022-03-22 中国科学院上海药物研究所 N-叔丁氧羰基保护的杂环类化合物、其制备方法及其用于制备c-核苷类似物的方法
CN109748943A (zh) 2017-11-03 2019-05-14 中国科学院上海药物研究所 2’-c-甲基取代核苷类化合物及其制备与用途
WO2019092171A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
JP7207321B2 (ja) 2017-11-16 2023-01-18 Jsr株式会社 レジスト下層膜形成用組成物、レジスト下層膜及びその形成方法、パターニングされた基板の製造方法並びに化合物
EP3502210B1 (en) 2017-12-20 2020-09-09 Merck Patent GmbH Liquid-crystal medium
WO2019125974A1 (en) 2017-12-20 2019-06-27 Merck Sharp & Dohme Corp. Cyclic di-nucleotide compounds as sting agonists
EP3502209B1 (en) 2017-12-20 2020-10-14 Merck Patent GmbH Liquid-crystalline media having homeotropic alignment
KR20190076339A (ko) 2017-12-22 2019-07-02 한미약품 주식회사 신규한 2,6-나프티리딘 2-옥시드 유도체 화합물 및 이의 용도
WO2019133712A1 (en) 2017-12-27 2019-07-04 Schinazi Raymond F Combined modalities for nucleosides and/or nadph oxidase (nox) inhibitors as myeloid-specific antiviral agents
CN111094317B (zh) 2017-12-29 2023-03-31 上海和誉生物医药科技有限公司 一种具有cd73抑制活性的膦酸衍生物、其制备方法和应用
JP2019137753A (ja) 2018-02-08 2019-08-22 シャープ株式会社 液晶組成物および液晶ディスプレイ
EA202091897A1 (ru) 2018-02-08 2020-10-27 Энио Фарма Неконденсированные производные тиофена и их применение
WO2019173682A1 (en) 2018-03-09 2019-09-12 Arcus Biosciences, Inc. Parenterally administered immune enhancing drugs
CN108276352B (zh) 2018-03-13 2022-09-20 华东理工大学 一种具有杀线虫活性的含氮杂环化合物及其制法和用途
WO2019195056A1 (en) 2018-04-04 2019-10-10 Sigilon Therapeutics, Inc. Methods, compositions, and implantable elements comprising stem cells
WO2019215076A1 (de) 2018-05-08 2019-11-14 Bayer Aktiengesellschaft Verfahren zur herstellung stickstoffhaltiger heterocyclen
CN108727344A (zh) 2018-05-14 2018-11-02 嘉兴特科罗生物科技有限公司 一种化合物及其合成方法和应用
US11945803B2 (en) 2018-08-07 2024-04-02 Tosk, Inc. Modulators of RAS GTPase
WO2020032152A1 (ja) 2018-08-09 2020-02-13 ヤマサ醤油株式会社 ４'－置換ヌクレオシド誘導体の立体選択的合成法
CN110215456A (zh) 2019-06-25 2019-09-10 华中农业大学 一种由gc376与gs-441524组成的猫冠状病毒抑制剂组合物
CN110330540A (zh) 2019-08-08 2019-10-15 木天(济南)生物科技有限公司 核苷盐及其制备方法
CN110724174B (zh) 2019-09-10 2021-02-05 广州六顺生物科技股份有限公司 吡咯并三嗪类化合物、组合物及其应用
CN110776512A (zh) 2019-11-28 2020-02-11 成都傲飞生物化学品有限责任公司 一种核苷类似物的制备方法
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
TWI791193B (zh) 2020-02-18 2023-02-01 美商基利科學股份有限公司 抗病毒化合物
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
CN111620909B (zh) 2020-06-05 2022-12-02 广东中科药物研究有限公司 一种瑞德西韦的前体药物及其制备方法与应用

Also Published As

Publication number Publication date
EP4644394A2 (en) 2025-11-05
KR20250133471A (ko) 2025-09-05
JP2023514182A (ja) 2023-04-05
JP7429799B2 (ja) 2024-02-08
ES3052691T3 (en) 2026-01-13
KR20220143064A (ko) 2022-10-24
US20210292348A1 (en) 2021-09-23
US20250002513A1 (en) 2025-01-02
PT4106876T (pt) 2025-11-13
EP4106876B1 (en) 2025-09-17
CN118598916A (zh) 2024-09-06
AU2024227286A1 (en) 2024-10-31
EP4106876A1 (en) 2022-12-28
JP2024045349A (ja) 2024-04-02
AU2021224588B2 (en) 2024-07-18
CN115135383A (zh) 2022-09-30
WO2021168004A1 (en) 2021-08-26
AR121356A1 (es) 2022-05-11
AU2021224588A1 (en) 2022-08-25
TW202140038A (zh) 2021-11-01
TWI777411B (zh) 2022-09-11
SI4106876T1 (sl) 2025-11-28
US12030903B2 (en) 2024-07-09
EP4644394A3 (en) 2026-03-04
CN115135383B (zh) 2024-06-11
CA3171648A1 (en) 2021-08-26

Similar Documents

Publication Publication Date Title
IL307478A (en) Thionucleosides as antiviral agents
DK4165024T3 (da) Cyclobutyldihydroquinolinsulfonamid-forbindelser
EP4129997A4 (en) Octahydropyrazinodiazanaphthyridine dione compounds
EP4199925B1 (en) ORETIN RECEPTOR AGONISTS CYCLOPENTAPYRROLE
EP4366831A4 (en) ANTI-VIRAL COMPOUNDS
EP4186256C0 (en) INTER-AGENCY COMMUNICATION VIA AN AD-HOC NETWORK SLICE
IL310528A (en) Pyrazolopyridinone compounds
EP4137404A4 (en) Multicopter
EP4293025C0 (en) COMPOSED WITH 4-AMINOQUINAZOLINE
EP4149556C0 (en) PEG LIPIDOIDS COMPOUNDS
DK4320112T3 (da) Pyridinylsubstituerede oxoisoindolinforbindelser
EP4107782A4 (en) MICROARRAYS
EP4208295C0 (de) Fleischwolf
EP4232456A4 (en) COMPOUNDS OF ANTIVIRAL MEDICINES
EP4504707A4 (en) ANTIVIRAL HETEROCYCLIC COMPOUNDS
EP4143199C0 (en) NUCLEOTIDE PROMEDICINAL COMPOUNDS
EP3957265A4 (en) MICROSCOPE COVER
EP4063561C0 (en) REFINER SEGMENT
EP4159839A4 (en) ANTIVIRAL AGENT
EP4204218C0 (en) TAPE LAYING HEAD
EP4163277C0 (en) NEW PYRAZOLE DERIVATIVES
EP4192823C0 (en) TRIAZOLES DIFLUOROMETHYL-PYRIDIN-2-YL
EP4137402A4 (en) MULTICOPTER
PT4038149T (pt) Compostos anti-incrustação
EP4151230A4 (en) ANTIVIRAL AGENT