SG3493G - Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compositions containing them - Google Patents

Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compositions containing them

Info

Publication number: SG3493G
Authority: SG; Singapore
Prior art keywords: trimethoxybenzyl; dimethoxymethyl; bis; preparation; pharmaceutical compositions
Prior art date: 1984-07-18

Application number

SG34/93A

Other languages

English (en)

Original Assignee

Wellcome Found

Gen Hospital Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-18

Filing date

1993-01-08

Publication date

1993-03-12

1993-01-08 Application filed by Wellcome Found, Gen Hospital Corp filed Critical Wellcome Found

1993-03-12 Publication of SG3493G publication Critical patent/SG3493G/en

Links

BYTJTAASKAVKPX-UHFFFAOYSA-N 1-[dimethoxy-(2-methoxyphenyl)methyl]-2,3-bis(dimethoxymethyl)isoquinolin-2-ium Chemical class COC(OC)C=1[N+](=C(C2=CC=CC=C2C=1)C(C1=C(C=CC=C1)OC)(OC)OC)C(OC)OC BYTJTAASKAVKPX-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
150000001450 anions Chemical group 0.000 abstract 1
239000003158 myorelaxant agent Substances 0.000 abstract 1
239000000842 neuromuscular blocking agent Substances 0.000 abstract 1
229940125706 skeletal muscle relaxant agent Drugs 0.000 abstract 1
238000001356 surgical procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Jib Cranes (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)
Fats And Perfumes (AREA)
Meat, Egg Or Seafood Products (AREA)
Cephalosporin Compounds (AREA)

SG34/93A 1984-07-18 1993-01-08 Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compositions containing them SG3493G (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB848418303A GB8418303D0 (en)	1984-07-18	1984-07-18	Compounds

Publications (1)

Publication Number	Publication Date
SG3493G true SG3493G (en)	1993-03-12

Family

ID=10564058

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG34/93A SG3493G (en)	1984-07-18	1993-01-08	Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compositions containing them

Country Status (30)

Country	Link
US (1)	US4761418A (fr)
EP (1)	EP0181055B1 (fr)
JP (1)	JPH0662568B2 (fr)
AT (1)	ATE60759T1 (fr)
AU (1)	AU574481B2 (fr)
BG (1)	BG60411B2 (fr)
CA (1)	CA1273341A (fr)
CY (1)	CY1687A (fr)
DD (1)	DD235638A5 (fr)
DE (2)	DE3581699D1 (fr)
DK (1)	DK168093B1 (fr)
ES (1)	ES8609260A1 (fr)
FI (1)	FI85019C (fr)
GB (1)	GB8418303D0 (fr)
GE (1)	GEP19960468B (fr)
HK (1)	HK47593A (fr)
HU (1)	HU193996B (fr)
IE (1)	IE58138B1 (fr)
IL (1)	IL75833A (fr)
LT (1)	LT2078B (fr)
LU (1)	LU88801I2 (fr)
LV (1)	LV5483A3 (fr)
MC (1)	MC1690A1 (fr)
MX (1)	MX9203667A (fr)
NL (1)	NL940023I2 (fr)
NZ (1)	NZ212766A (fr)
PL (1)	PL146066B1 (fr)
SG (1)	SG3493G (fr)
SU (1)	SU1468414A3 (fr)
ZA (1)	ZA855407B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5453510A (en) *	1990-07-13	1995-09-26	Burroughs Wellcome Co.	Neuromuscular blocking agents
US5240939A (en) *	1991-10-31	1993-08-31	Anaquest, Inc.	Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) *	1994-09-06	1996-04-23	Bencherif; Merouane	Depolarizing skeletal muscle relaxants
ATE295351T1 (de) *	1997-03-25	2005-05-15	Avera Pharmaceuticals Inc	Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker
GB0204087D0 (en) *	2002-02-21	2002-04-10	Legislator 1563 Ltd	Di-ester derivatives as short acting neuromuscular blockers
US20050192243A1 (en) *	2003-10-28	2005-09-01	Savarese John J.	Neuromuscular blocking agents and antagonists thereof
US7872137B2 (en) *	2006-06-20	2011-01-18	Farmabios S.P.A.	Process for the preparation of mivacurium chloride
AU2007328210B2 (en) *	2006-12-06	2012-11-22	Cornell Research Foundation, Inc.	Intermediate duration neuromuscular blocking agents and antagonists thereof
AU2008222298A1 (en) *	2007-03-08	2008-09-12	Chemagis Ltd.	(1R,1'R)-atracurium salts separation process
BRPI0808581A2 (pt) *	2007-03-26	2014-09-16	Chemagis Ltd	"método para separar cisatracúrio com alta pureza de uma mistura de isômeros de (1r, 1'r) - atracúrio"
WO2008132746A1 (fr) *	2007-05-01	2008-11-06	Chemagis Ltd.	Nouveaux composés d'isoquinolinium utiles dans la préparation de cisatracurium et intermédiaires associés
WO2009007946A1 (fr) *	2007-07-09	2009-01-15	Chemagis Ltd.	Procédé de fabrication de cisatracurium et d'intermédiaires associés
EP2155684B1 (fr) *	2007-05-01	2014-04-09	Chemagis Ltd.	Procédé de fabrication de composés de cisatracurium et intermédiaires associés
CA2687157A1 (fr) *	2007-06-18	2008-12-24	Chemagis Ltd.	Procede de separation de sels de (1r,1'r)-atracurium
AU2008320380A1 (en) *	2007-10-29	2009-05-07	Chemagis Ltd.	Novel R,R'-atracurium salts
ITMI20080319A1 (it)	2008-02-28	2009-08-29	Recordati Chem Pharm	Processo per la risoluzione di derivati isochinolinici
AU2009241211A1 (en) *	2008-05-01	2009-11-05	Chemagis Ltd.	Cisatracurium derivatives, preparation and uses thereof
WO2010107488A1 (fr)	2009-03-17	2010-09-23	Cornell University	Agents de blocage neuromusculaires non dépolarisants réversibles et leur méthode
WO2011022491A1 (fr)	2009-08-19	2011-02-24	Cornell University	Cystéine pour injection physiologique
WO2013021398A2 (fr) *	2011-08-05	2013-02-14	Sequent Scientific Limited	Procédé de préparation du chlorure de mivacurium
ES2625329T3 (es)	2012-06-29	2017-07-19	Cornell University	Agentes bloqueantes neuromusculares asimétricos reversibles de duración ultra-corta, corta o intermedia
CN103373959A (zh) *	2013-06-14	2013-10-30	安徽省先锋制药有限公司	顺式苄基异喹啉类化合物的制备方法及其用途
CN107778237A (zh) *	2016-08-26	2018-03-09	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN107782821B (zh) *	2016-08-26	2021-11-09	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂的分析方法
CN108938573B (zh) *	2017-05-26	2021-08-10	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) *	2017-09-30	2018-09-07	武汉嘉诺康医药技术有限公司	一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) *	2019-07-29	2022-04-29	武汉嘉诺康医药技术有限公司	一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) *	2019-11-11	2021-03-09	武汉大安制药有限公司	一种5’-甲氧基劳丹素的拆分方法
CN116410078A (zh) *	2021-12-29	2023-07-11	苏州特瑞药业股份有限公司	一种制备(e)-辛-4-烯-1,8-二酸的方法
WO2025140288A1 (fr) *	2023-12-25	2025-07-03	上海森辉医药有限公司	Tétrahydroisoquinoléine et son utilisation pharmaceutique

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB863717A (en) *	1958-07-03	1961-03-22	Allen & Hanburys Ltd	Tetrahydropapaverine derivatives and their preparation
US3004031A (en) *	1958-07-03	1961-10-10	Allen & Hauburys Ltd	Diquaternary salts of papaverino esters
AU506657B2 (en) *	1975-12-10	1980-01-17	Wellcome Foundation Limited, The	Isoquinoline derivatives
US4192877A (en) *	1977-08-01	1980-03-11	Massachusetts General Hospital	Neuromuscular blocking agents
AU523706B2 (en) *	1977-08-01	1982-08-12	The Massachusetts General Hospital	Neuromuscular blocking agents
CA1125287A (fr) *	1978-07-21	1982-06-08	John J. Savarese	Modes d'emploi de substances a base de bis-isoquinolinium
US4235906A (en) *	1978-07-21	1980-11-25	Massachusetts General Hospital	Bis-isoquinolinium compounds, compositions and methods of use
US4491665A (en) *	1979-10-19	1985-01-01	Burroughs Wellcome Co.	Method of preparing isomers of bis isoquinolinium compounds
CA1153380A (fr) *	1979-10-19	1983-09-06	Hassan A. El-Sayad	Sels de tetrahydroisoquinolinium, agents de blocage neuromusculaire
EP0054309B1 (fr) *	1980-12-17	1984-08-22	The Wellcome Foundation Limited	Bloqueurs neuromusculaires à action prolongée, compositions pharmaceutiques les contenant et leurs procédés de préparation
JPS5899465A (ja) *	1981-11-23	1983-06-13	ザ・ウエルカム・フアウンデ−シヨン・リミテツド	イソキノリン誘導体

1984
- 1984-07-18 GB GB848418303A patent/GB8418303D0/en active Pending
1985
- 1985-07-11 PL PL1985254571A patent/PL146066B1/pl unknown
- 1985-07-17 US US06/756,025 patent/US4761418A/en not_active Expired - Lifetime
- 1985-07-17 AU AU45108/85A patent/AU574481B2/en not_active Expired
- 1985-07-17 HU HU852745A patent/HU193996B/hu unknown
- 1985-07-17 JP JP60157963A patent/JPH0662568B2/ja not_active Expired - Lifetime
- 1985-07-17 EP EP85305097A patent/EP0181055B1/fr not_active Expired - Lifetime
- 1985-07-17 NZ NZ212766A patent/NZ212766A/en unknown
- 1985-07-17 MC MC851781A patent/MC1690A1/fr unknown
- 1985-07-17 ZA ZA855407A patent/ZA855407B/xx unknown
- 1985-07-17 IE IE179185A patent/IE58138B1/en not_active IP Right Cessation
- 1985-07-17 ES ES545319A patent/ES8609260A1/es not_active Expired
- 1985-07-17 SU SU853926201A patent/SU1468414A3/ru active
- 1985-07-17 DE DE8585305097T patent/DE3581699D1/de not_active Expired - Lifetime
- 1985-07-17 DD DD85278691A patent/DD235638A5/de unknown
- 1985-07-17 CA CA000486916A patent/CA1273341A/fr not_active Expired - Lifetime
- 1985-07-17 AT AT85305097T patent/ATE60759T1/de active
- 1985-07-17 DE DE1996175039 patent/DE19675039I2/de active Active
- 1985-07-17 IL IL75833A patent/IL75833A/xx not_active IP Right Cessation
- 1985-07-17 DK DK324985A patent/DK168093B1/da not_active IP Right Cessation
- 1985-07-17 FI FI852807A patent/FI85019C/fi not_active IP Right Cessation
- 1985-07-17 LU LU88801C patent/LU88801I2/fr unknown
1992
- 1992-06-26 MX MX9203667A patent/MX9203667A/es unknown
1993
- 1993-01-08 SG SG34/93A patent/SG3493G/en unknown
- 1993-03-10 LV LV930178A patent/LV5483A3/xx unknown
- 1993-04-07 LT LTRP478A patent/LT2078B/xx not_active IP Right Cessation
- 1993-05-13 HK HK475/93A patent/HK47593A/en not_active IP Right Cessation
- 1993-09-14 BG BG098109A patent/BG60411B2/bg unknown
- 1993-10-10 CY CY1687A patent/CY1687A/xx unknown
- 1993-12-06 GE GEAP19931677A patent/GEP19960468B/en unknown
1994
- 1994-11-18 NL NL940023C patent/NL940023I2/nl unknown

Also Published As

Publication number	Publication date
MC1690A1 (fr)	1986-07-18
PL254571A1 (en)	1986-07-15
ATE60759T1 (de)	1991-02-15
FI852807L (fi)	1986-01-19
CA1273341A (fr)	1990-08-28
NZ212766A (en)	1988-03-30
SU1468414A3 (ru)	1989-03-23
IE851791L (en)	1986-01-18
JPS6187666A (ja)	1986-05-06
LV5483A3 (lv)	1994-03-10
ES545319A0 (es)	1986-09-01
IL75833A (en)	1988-11-30
FI852807A0 (fi)	1985-07-17
LU88801I2 (fr)	1996-11-05
GB8418303D0 (en)	1984-08-22
NL940023I2 (nl)	1998-06-02
US4761418A (en)	1988-08-02
DK324985A (da)	1986-01-19
IE58138B1 (en)	1993-07-14
AU4510885A (en)	1986-01-23
FI85019C (fi)	1992-02-25
ZA855407B (en)	1986-04-30
DK324985D0 (da)	1985-07-17
MX9203667A (es)	1992-07-31
PL146066B1 (en)	1988-12-31
DD235638A5 (de)	1986-05-14
EP0181055A1 (fr)	1986-05-14
AU574481B2 (en)	1988-07-07
HK47593A (en)	1993-05-21
LT2078B (lt)	1993-06-15
DK168093B1 (da)	1994-02-07
EP0181055B1 (fr)	1991-02-06
NL940023I1 (nl)	1995-01-02
DE3581699D1 (de)	1991-03-14
ES8609260A1 (es)	1986-09-01
IL75833A0 (en)	1985-11-29
GEP19960468B (en)	1996-08-29
BG60411B2 (bg)	1995-02-28
HU193996B (en)	1987-12-28
JPH0662568B2 (ja)	1994-08-17
HUT40626A (en)	1987-01-28
DE19675039I2 (de)	2003-01-09
FI85019B (fi)	1991-11-15
CY1687A (en)	1993-10-10

Publication	Publication Date	Title
CY1687A (en)	1993-10-10	Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compositions containing them
NZ208831A (en)	1988-09-29	Imidazolium derivatives and pharmaceutical compositions
DE3562238D1 (en)	1988-05-26	Substituted sulfonamidobenzamides, antiarrythmic agents and compositions thereof
IL66009A0 (en)	1982-09-30	2-aryl-3,4-diazabicyclo(4.n.0)alk-2-en-5-ones,their preparation and pharmaceutical compositions containing them
IL78691A0 (en)	1986-08-31	Quinolylglycinamide derivatives,their preparation and pharmaceutical compositions containing them
ES8305684A1 (es)	1983-05-01	Procedimiento para la obtencion de derivados aminopropanolicos de 2-hidroxi b-fenil-propiofenonas.
DE3369983D1 (en)	1987-04-09	Isoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and their use
IL94693A0 (en)	1991-04-15	Dibenzo(1,5)dioxocin-5-one derivatives,their preparation and pharmaceutical compositions containing them
DE3468875D1 (en)	1988-02-25	Substituted isoquinoline derivatives, method for their preparation, and pharmaceutical compositions containing these compounds
IL69848A0 (en)	1983-12-30	15-cycloaliphatic derivatives of 11,14-didehydrocarboprostacyclins,their preparation and pharmaceutical compositions containing them
IL69274A (en)	1986-08-31	(substituted amino)derivatives of 3-benzylidene-pyrrolo(2,1-b)quinazolin-9-ones and 6-benzylidene-pyrido(2,1-b)quinazolin-11-ones,their preparation and pharmaceutical compositions containing them
ES2027507A6 (es)	1992-06-01	Procedimiento de preparacion de derivados selenofenicos.
ZA8683B (en)	1986-08-27	Antihypertensive agents,pharmaceutical compositions containing them and process for the preparation of the agents and compositions
GR850484B (fr)	1985-06-26