SU470964A3 - Способ получени антибиотика - Google Patents

Способ получени антибиотика

Info

Publication number: SU470964A3
Authority: SU; USSR - Soviet Union
Prior art keywords: medium; antibiotic; chloroform; mycelium; agar
Prior art date: 1971-10-12

Application number

SU1739199A

Other languages

English (en)

Russian (ru)

Inventor

Л.Хамил Роберт

Мартин Хун Марвин

Original Assignee

Эли Лилли Энд Компани (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-10-12

Filing date

1972-01-21

Publication date

1975-05-15

1971-10-12 Priority claimed from US00188058A external-priority patent/US3843784A/en

1972-01-21 Application filed by Эли Лилли Энд Компани (Фирма) filed Critical Эли Лилли Энд Компани (Фирма)

1975-05-15 Application granted granted Critical

1975-05-15 Publication of SU470964A3 publication Critical patent/SU470964A3/ru

Links

230000003115 biocidal effect Effects 0.000 title description 11
238000000034 method Methods 0.000 title description 7
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 34
239000002609 medium Substances 0.000 description 20
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 16
239000000203 mixture Substances 0.000 description 15
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
229920001817 Agar Polymers 0.000 description 8
239000008272 agar Substances 0.000 description 8
235000010419 agar Nutrition 0.000 description 8
239000000049 pigment Substances 0.000 description 8
239000000243 solution Substances 0.000 description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
239000000758 substrate Substances 0.000 description 7
HELPZWNRUYNCJQ-QWJSOBSRSA-N (e)-3-[4-[(5z)-3,4-dihydroxy-5-[2-(3-hydroxy-4,5-dimethoxy-6-methyloxan-2-yl)oxy-1-methoxyethylidene]oxolan-2-yl]oxyphenyl]-n-[5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-2-methylprop-2-enamide Chemical compound OC1C(OC)C(OC)C(C)OC1OC\C(OC)=C\1C(O)C(O)C(OC=2C=CC(\C=C(/C)C(=O)NC3C(C(OC3CO)N3C4=NC=NC(=C4N=C3)N(C)C)O)=CC=2)O/1 HELPZWNRUYNCJQ-QWJSOBSRSA-N 0.000 description 6
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
239000000284 extract Substances 0.000 description 5
238000000855 fermentation Methods 0.000 description 5
230000004151 fermentation Effects 0.000 description 5
239000000706 filtrate Substances 0.000 description 5
239000000047 product Substances 0.000 description 5
239000000741 silica gel Substances 0.000 description 5
229910002027 silica gel Inorganic materials 0.000 description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical class N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 4
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
239000007788 liquid Substances 0.000 description 4
238000003756 stirring Methods 0.000 description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
238000010521 absorption reaction Methods 0.000 description 3
239000003463 adsorbent Substances 0.000 description 3
239000003242 anti bacterial agent Substances 0.000 description 3
229940041514 candida albicans extract Drugs 0.000 description 3
239000012153 distilled water Substances 0.000 description 3
239000008103 glucose Substances 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
235000015097 nutrients Nutrition 0.000 description 3
239000003208 petroleum Substances 0.000 description 3
239000002244 precipitate Substances 0.000 description 3
239000002994 raw material Substances 0.000 description 3
239000012138 yeast extract Substances 0.000 description 3
102100027211 Albumin Human genes 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
244000068988 Glycine max Species 0.000 description 2
235000010469 Glycine max Nutrition 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
241000936887 Saccharothrix mutabilis subsp. capreolus Species 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
241000187747 Streptomyces Species 0.000 description 2
238000005273 aeration Methods 0.000 description 2
230000008033 biological extinction Effects 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
235000013339 cereals Nutrition 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
238000002425 crystallisation Methods 0.000 description 2
230000008025 crystallization Effects 0.000 description 2
239000012531 culture fluid Substances 0.000 description 2
238000001727 in vivo Methods 0.000 description 2
238000011534 incubation Methods 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
229910052500 inorganic mineral Chemical class 0.000 description 2
239000011707 mineral Chemical class 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
230000001954 sterilising effect Effects 0.000 description 2
238000004659 sterilization and disinfection Methods 0.000 description 2
239000000725 suspension Substances 0.000 description 2
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
241001237963 Amanita flavoconia Species 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
241000282988 Capreolus Species 0.000 description 1
241000723418 Carya Species 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
241000700159 Rattus Species 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
240000003768 Solanum lycopersicum Species 0.000 description 1
241000209140 Triticum Species 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
230000003254 anti-foaming effect Effects 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000002518 antifoaming agent Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
239000002026 chloroform extract Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
235000013365 dairy product Nutrition 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000010828 elution Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000011010 flushing procedure Methods 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
238000002329 infrared spectrum Methods 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
238000002955 isolation Methods 0.000 description 1
235000009973 maize Nutrition 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
239000000401 methanolic extract Substances 0.000 description 1
238000004452 microanalysis Methods 0.000 description 1
244000005700 microbiome Species 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
150000002823 nitrates Chemical class 0.000 description 1
239000002245 particle Substances 0.000 description 1
208000028169 periodontal disease Diseases 0.000 description 1
239000013587 production medium Substances 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000010865 sewage Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000002689 soil Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000010183 spectrum analysis Methods 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000004448 titration Methods 0.000 description 1
239000012137 tryptone Substances 0.000 description 1

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Compounds Of Unknown Constitution (AREA)

SU1739199A 1971-10-12 1972-01-21 Способ получени антибиотика SU470964A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US00188058A US3843784A (en)	1970-12-24	1971-10-12	Antibiotics a201a and a201b and process for the production thereof

Publications (1)

Publication Number	Publication Date
SU470964A3 true SU470964A3 (ru)	1975-05-15

Family

ID=22691630

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SU1739199A SU470964A3 (ru)	1971-10-12	1972-01-21	Способ получени антибиотика

Country Status (3)

Country	Link
HU (1)	HU163865B (lt)
PL (1)	PL82898B1 (lt)
SU (1)	SU470964A3 (lt)

1971
- 1971-12-29 PL PL15255671A patent/PL82898B1/pl unknown
1972
- 1972-01-04 HU HUEI000399 patent/HU163865B/hu unknown
- 1972-01-21 SU SU1739199A patent/SU470964A3/ru active

Also Published As

Publication number	Publication date
PL82898B1 (lt)	1975-10-31
HU163865B (lt)	1973-11-28

Publication	Publication Date	Title
EP0170006A2 (en)	1986-02-05	Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents
NO161314B (no)	1989-04-24	Analogifremgansgmaate for fremstilling av terapeutisk aktive, organiske amidforbindelser.
IE893482L (en)	1990-04-28	The glycosidase inhibitor salbostatin, process for its¹preparation, and its use
SU1071226A3 (ru)	1984-01-30	Способ получени антибиотической смеси
JPH0341475B2 (lt)	1991-06-24
AU603271B2 (en)	1990-11-08	Derivatives of paraherquamide isolated from a fermentation broth active as antiparasitic agents
SU442605A1 (ru)	1974-09-05	Способ получени антибиотика
US5164389A (en)	1992-11-17	Anthelmintic bioconversion products
SU751332A3 (ru)	1980-07-23	Способ получени антибиотического комплекса а-35512
US2657170A (en)	1953-10-27	Antimycin and process for production
AU657011B2 (en)	1995-02-23	Antibiotic AB-041 and the process for its production
EP0074849A1 (en)	1983-03-23	A-32724 antibiotics and process for production thereof
JPH0740950B2 (ja)	1995-05-10	微生物によるニコチアナミンの製造法
SU632307A3 (ru)	1978-11-05	Способ получени полипептидного антибиотического комплекса, обладающего противогрибковой активностью
EP0259778B1 (de)	1990-03-28	Antibiotisch wirksames Gentisinsäurederivat
JPS6317834B2 (lt)	1988-04-15
CS207693B2 (en)	1981-08-31	Method of making the antibiotic a 40104
GB1583408A (en)	1981-01-28	Antibiotic x-14547
FR2476128A1 (fr)	1981-08-21	Procede microbiologique de production de narasine et cultures contenant le microorganisme producteur streptomyces lydicus deboer et al-
SU1760986A3 (ru)	1992-09-07	Способ получени 4 @ -дезокси-13(S)-дигидро-4 @ -йододоксорубицина
SU287650A1 (ru)		Патентно-техн^^нескаябиблиотека
JPH01320992A (ja)	1989-12-27	イソオキサゾール−４−カルボン酸の製造法及びそれを含有する除草剤
JPH0515385A (ja)	1993-01-26	新規な抗生物質アリサマイシンおよびその製法
JPS6015318B2 (ja)	1985-04-18	新抗生物質ｓｆ−１９４２物質，その製造法およびそれを含有する抗ガン剤
SU884575A3 (ru)	1981-11-23	Способ получени антибиотического комплекса