YU143688A - Process for obtaining 4-phosphatic derivatives of epidofilotoxine glucozide - Google Patents

Process for obtaining 4-phosphatic derivatives of epidofilotoxine glucozide

Info

Publication number
YU143688A
YU143688A YU01436/88A YU143688A YU143688A YU 143688 A YU143688 A YU 143688A YU 01436/88 A YU01436/88 A YU 01436/88A YU 143688 A YU143688 A YU 143688A YU 143688 A YU143688 A YU 143688A
Authority
YU
Yugoslavia
Prior art keywords
glucozide
epidofilotoxine
phosphatic
derivatives
obtaining
Prior art date
Application number
YU01436/88A
Other languages
English (en)
Inventor
M G Saulnier
P D Senter
J F Kadow
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of YU143688A publication Critical patent/YU143688A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
YU01436/88A 1987-08-04 1988-07-25 Process for obtaining 4-phosphatic derivatives of epidofilotoxine glucozide YU143688A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (1)

Publication Number Publication Date
YU143688A true YU143688A (en) 1990-04-30

Family

ID=26765636

Family Applications (3)

Application Number Title Priority Date Filing Date
YU01436/88A YU143688A (en) 1987-08-04 1988-07-25 Process for obtaining 4-phosphatic derivatives of epidofilotoxine glucozide
YU00103/90A YU10390A (en) 1987-08-04 1990-01-19 Process for obtaining 4'phosphate derivatives of epipodofilotoxine glucoside
YU00104/90A YU10490A (en) 1987-08-04 1990-01-19 Process for obtaining 4'phosphate derivatives of epipodofilotoxine glucoside

Family Applications After (2)

Application Number Title Priority Date Filing Date
YU00103/90A YU10390A (en) 1987-08-04 1990-01-19 Process for obtaining 4'phosphate derivatives of epipodofilotoxine glucoside
YU00104/90A YU10490A (en) 1987-08-04 1990-01-19 Process for obtaining 4'phosphate derivatives of epipodofilotoxine glucoside

Country Status (34)

Country Link
US (3) US4904768A (da)
JP (1) JPH0699465B2 (da)
KR (1) KR900006230B1 (da)
CN (1) CN1027169C (da)
AT (1) AT398974B (da)
BE (1) BE1002982A4 (da)
CA (1) CA1310637C (da)
CH (1) CH676716A5 (da)
CY (1) CY1625A (da)
CZ (1) CZ286893B6 (da)
DD (2) DD299067A5 (da)
DE (1) DE3826562A1 (da)
DK (2) DK169344B1 (da)
ES (1) ES2010775A6 (da)
FI (1) FI87790C (da)
FR (1) FR2622193B1 (da)
GB (1) GB2207674B (da)
GR (1) GR1000490B (da)
HK (1) HK6392A (da)
HU (3) HU208147B (da)
IE (1) IE61040B1 (da)
IL (1) IL87290A (da)
IT (1) IT1226825B (da)
LU (2) LU87290A1 (da)
MX (1) MX173843B (da)
MY (1) MY104321A (da)
NL (2) NL192683C (da)
NO (4) NO170284C (da)
NZ (1) NZ225615A (da)
PT (1) PT88186B (da)
SE (1) SE502214C2 (da)
SG (1) SG101291G (da)
SK (1) SK541288A3 (da)
YU (3) YU143688A (da)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
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US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (da) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
US5942386A (en) * 1995-06-07 1999-08-24 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
AU726914B2 (en) 1996-04-01 2000-11-23 Epix Pharmaceuticals, Inc. Bioactivated diagnostic imaging contrast agents
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
BR0206206A (pt) * 2001-10-26 2005-01-11 Centre Nat Rech Scient Derivados de etoposide e análogos, e composições farmacêuticas contendo os mesmos
US7572442B2 (en) 2002-07-15 2009-08-11 Board Of Regents, The University Of Texas System Selected antibody compositions for binding to aminophospholipids
CN1747747B (zh) * 2003-01-06 2012-09-05 安吉奥开米公司 作为穿过血脑屏障的载体的抑酶肽及类似物
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
CN101160403B (zh) * 2005-02-18 2014-08-13 安吉奥开米公司 转运化合物穿过血脑屏障的分子
JP5436856B2 (ja) * 2005-07-15 2014-03-05 アンジオケム インコーポレーティッド 薬学的複合体における担体としてのアプロチニンポリペプチドの使用
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US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US8263644B2 (en) * 2007-09-13 2012-09-11 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
MX2010005104A (es) 2007-11-09 2010-08-04 Peregrine Pharmaceuticals Inc Composiciones de anticuerpo anti-factor de crecimiento endotelial vascular y metodos.
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FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (da) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH481094A (de) * 1966-12-13 1969-11-15 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Also Published As

Publication number Publication date
GB8818462D0 (en) 1988-09-07
CN1027169C (zh) 1994-12-28
NO920277D0 (no) 1992-01-22
ATA195588A (de) 1994-07-15
SG101291G (en) 1992-01-17
MX173843B (es) 1994-03-30
DE3826562C2 (da) 1993-04-08
US4904768A (en) 1990-02-27
FI883596A0 (fi) 1988-08-01
DK11992D0 (da) 1992-01-31
NO172440C (no) 1993-07-21
HU211960A9 (en) 1996-01-29
IE61040B1 (en) 1994-09-07
NO170284C (no) 1992-09-30
GR880100512A (en) 1989-05-25
NO883299D0 (no) 1988-07-26
AU610619B2 (en) 1991-05-23
NL8801934A (nl) 1989-03-01
NO920665D0 (no) 1992-02-20
LU90138I2 (fr) 1997-11-26
USRE35524E (en) 1997-06-03
NO172440B (no) 1993-04-13
NL970042I2 (da) 2005-06-01
DE3826562A1 (de) 1989-02-16
GR1000490B (el) 1992-07-30
HU905862D0 (en) 1991-03-28
IT1226825B (it) 1991-02-19
DK11992A (da) 1992-01-31
IT8821535A0 (it) 1988-07-28
IL87290A0 (en) 1989-01-31
AU2030688A (en) 1989-06-08
US5041424A (en) 1991-08-20
FI883596A7 (fi) 1989-02-05
NZ225615A (en) 1991-06-25
GB2207674A (en) 1989-02-08
AT398974B (de) 1995-02-27
KR900006230B1 (ko) 1990-08-27
SE502214C2 (sv) 1995-09-18
NO883299L (no) 1989-02-24
YU10490A (en) 1990-06-30
SK279325B6 (sk) 1998-10-07
LU87290A1 (fr) 1990-02-07
FR2622193A1 (fr) 1989-04-28
PT88186A (pt) 1989-06-30
SK541288A3 (en) 1998-10-07
CZ541288A3 (cs) 1999-12-15
HU202547B (en) 1991-03-28
CN1061225A (zh) 1992-05-20
CH676716A5 (da) 1991-02-28
IL87290A (en) 1993-01-31
MY104321A (en) 1994-03-31
FI87790B (fi) 1992-11-13
YU10390A (en) 1990-06-30
FI87790C (fi) 1993-02-25
NO1998002I1 (no) 1998-01-14
GB2207674B (en) 1991-09-11
DK434088A (da) 1989-02-05
DD299067A5 (de) 1992-03-26
BE1002982A4 (fr) 1991-10-15
FR2622193B1 (fr) 1993-12-17
CZ286893B6 (cs) 2000-07-12
IE882378L (en) 1989-02-04
DD274423A5 (de) 1989-12-20
DK169344B1 (da) 1994-10-10
CY1625A (en) 1992-07-10
DK434088D0 (da) 1988-08-03
NO170284B (no) 1992-06-22
NL192683B (da) 1997-08-01
ES2010775A6 (es) 1989-12-01
HUT47303A (en) 1989-02-28
HU208147B (en) 1993-08-30
JPH0699465B2 (ja) 1994-12-07
SE8802815L (sv) 1989-02-05
NO920665L (no) 1989-02-24
NO920277L (no) 1989-02-24
NL970042I1 (nl) 1998-03-02
JPH01100188A (ja) 1989-04-18
CA1310637C (en) 1992-11-24
PT88186B (pt) 1995-07-03
KR890003790A (ko) 1989-04-18
MX9202851A (es) 1992-06-30
SE8802815D0 (sv) 1988-08-03
NL192683C (nl) 1997-12-02
HK6392A (en) 1992-01-17

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