LU90138I2 - Etoposide phosphate et ses sels et dérivés pharmaceutiquement acceptables (etopophos) - Google Patents

Etoposide phosphate et ses sels et dérivés pharmaceutiquement acceptables (etopophos)

Info

Publication number: LU90138I2
Authority: LU; Luxembourg
Prior art keywords: etopophos; derivatives; pharmaceutically acceptable; acceptable salts; etoposide phosphate
Prior art date: 1987-08-04

Application number

LU90138C

Other languages

English (en)

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-04

Filing date

1997-09-24

Publication date

1997-11-26

1997-09-24 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1997-11-26 Publication of LU90138I2 publication Critical patent/LU90138I2/fr

Links

LIQODXNTTZAGID-OCBXBXKTSA-N etoposide phosphate Chemical compound COC1=C(OP(O)(O)=O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 LIQODXNTTZAGID-OCBXBXKTSA-N 0.000 title 2
229960000752 etoposide phosphate Drugs 0.000 title 2
150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Mechanical Coupling Of Light Guides (AREA)
Cable Accessories (AREA)

LU90138C 1987-08-04 1997-09-24 Etoposide phosphate et ses sels et dérivés pharmaceutiquement acceptables (etopophos) LU90138I2 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8149387A	1987-08-04	1987-08-04
US07/199,731 US4904768A (en)	1987-08-04	1988-05-27	Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (1)

Publication Number	Publication Date
LU90138I2 true LU90138I2 (fr)	1997-11-26

Family

ID=26765636

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LU87290A LU87290A1 (fr)	1987-08-04	1988-07-22	Derives de 4'-phosphates de glucosides d'epipodophyllotoxine
LU90138C LU90138I2 (fr)	1987-08-04	1997-09-24	Etoposide phosphate et ses sels et dérivés pharmaceutiquement acceptables (etopophos)

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
LU87290A LU87290A1 (fr)	1987-08-04	1988-07-22	Derives de 4'-phosphates de glucosides d'epipodophyllotoxine

Country Status (34)

Country	Link
US (3)	US4904768A (fr)
JP (1)	JPH0699465B2 (fr)
KR (1)	KR900006230B1 (fr)
CN (1)	CN1027169C (fr)
AT (1)	AT398974B (fr)
BE (1)	BE1002982A4 (fr)
CA (1)	CA1310637C (fr)
CH (1)	CH676716A5 (fr)
CY (1)	CY1625A (fr)
CZ (1)	CZ286893B6 (fr)
DD (2)	DD299067A5 (fr)
DE (1)	DE3826562A1 (fr)
DK (2)	DK169344B1 (fr)
ES (1)	ES2010775A6 (fr)
FI (1)	FI87790C (fr)
FR (1)	FR2622193B1 (fr)
GB (1)	GB2207674B (fr)
GR (1)	GR1000490B (fr)
HK (1)	HK6392A (fr)
HU (3)	HU208147B (fr)
IE (1)	IE61040B1 (fr)
IL (1)	IL87290A (fr)
IT (1)	IT1226825B (fr)
LU (2)	LU87290A1 (fr)
MX (1)	MX173843B (fr)
MY (1)	MY104321A (fr)
NL (2)	NL192683C (fr)
NO (4)	NO170284C (fr)
NZ (1)	NZ225615A (fr)
PT (1)	PT88186B (fr)
SE (1)	SE502214C2 (fr)
SG (1)	SG101291G (fr)
SK (1)	SK279325B6 (fr)
YU (3)	YU143688A (fr)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5191071A (en) *	1987-08-21	1993-03-02	Novo Nordisk A/S	Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) *	1989-05-19	1990-10-23	Bristol-Myers Company	Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) *	1989-06-07	1991-07-30	Bristol-Myers Company	Acylated derivatives of etoposide
US5066645A (en) *	1989-09-01	1991-11-19	Bristol-Myers Company	Epipodophyllotoxin altroside derivatives
US6610299B1 (en)	1989-10-19	2003-08-26	Aventis Pharma Deutschland Gmbh	Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en)	1989-10-20	2007-07-10	Sanofi-Aventis Pharma Deutschland Gmbh	Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en)	1990-10-18	2002-11-05	Aventis Pharma Deutschland Gmbh	Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) *	1989-11-06	1996-09-03	The Stehlin Foundation For Cancer Research	Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) *	1989-11-20	1991-07-23	Bristol-Myers Squibb Company	Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) *	1990-04-30	1992-01-14	Bristol-Myers Squibb Co.	4'-demethylepipodophyllotoxin glycosides
US4997931A (en) *	1990-06-11	1991-03-05	Bristol-Myers Squibb Company	Epipodophyllotoxin glycosides
TW260671B (fr) *	1991-04-29	1995-10-21	Bristol Myers Squibb Co
IT1250692B (it) *	1991-07-23	1995-04-21		Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) *	1991-10-08	1997-07-15	Bristol-Myers Squibb	Crystalline etoposide 4'-phosphate diethanolate
JPH07632B2 (ja) *	1991-12-23	1995-01-11	ブリストル−マイヤーズスクイブカンパニー	エトポシド４’−ホスフェート二ナトリウム塩の安定な六水和物
US6080751A (en) *	1992-01-14	2000-06-27	The Stehlin Foundation For Cancer Research	Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) *	1992-04-24	2000-07-10	日本化薬株式会社	エトポシド燐酸エステルの製造法
US5459248A (en) *	1993-11-04	1995-10-17	Bristol-Myers Squibb Company	Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) *	1994-10-21	1997-01-10	Pf Medicament	Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
EP0835303A4 (fr) *	1995-06-07	2000-09-13	Univ Jefferson	Agents antifongiques et leurs procedes d'identification et d'utlisation
AU726914B2 (en) *	1996-04-01	2000-11-23	Epix Pharmaceuticals, Inc.	Bioactivated diagnostic imaging contrast agents
US6207673B1 (en)	1997-03-12	2001-03-27	The University Of North Carolina At Chapel Hill	Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (fr) *	1997-12-23	1999-07-01	Korea Research Institute Of Chemical Technology	DERIVES D'ACETAL DE 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6624317B1 (en)	2000-09-25	2003-09-23	The University Of North Carolina At Chapel Hill	Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en)	2001-05-01	2003-01-14	Telik, Inc.	Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
EP1438319A1 (fr) *	2001-10-26	2004-07-21	Centre National De La Recherche Scientifique (Cnrs)	Derives d'etoposide, analogues et compositions pharmaceutiques contenant lesdits derives
KR20120068769A (ko)	2002-07-15	2012-06-27	더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템	음이온성 인지질 및 아미노인지질에 결합하는 선택된 항체 및 치료하는데 있어서 이의 용도
WO2004060403A2 (fr) *	2003-01-06	2004-07-22	Angiochem Inc.	Methode de transport d'un compose a travers une barriere sang/cerveau
CN100334090C (zh) *	2005-02-02	2007-08-29	南京医科大学	吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
RU2408605C2 (ru) *	2005-02-18	2011-01-10	Анджиокем Инк.	Полипептид, способный преодолевать гематоэнцефалический барьер, и его конъюгат
US20090016959A1 (en) *	2005-02-18	2009-01-15	Richard Beliveau	Delivery of antibodies to the central nervous system
ES2744225T3 (es)	2005-07-15	2020-02-24	Angiochem Inc	Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos
CN100410266C (zh) *	2006-01-11	2008-08-13	重庆华邦制药股份有限公司	鬼臼毒素磷酸酯衍生物的合成方法
JO2660B1 (en)	2006-01-20	2012-06-17	نوفارتيس ايه جي	Pi-3 inhibitors and methods of use
PE20070978A1 (es) *	2006-02-14	2007-11-15	Novartis Ag	COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
AR060358A1 (es) *	2006-04-06	2008-06-11	Novartis Vaccines & Diagnostic	Quinazolinas para la inhibicion de pdk 1
GB0625283D0 (en) *	2006-12-19	2007-01-24	Cyclacel Ltd	Combination
US9365634B2 (en) *	2007-05-29	2016-06-14	Angiochem Inc.	Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US8263644B2 (en) *	2007-09-13	2012-09-11	Bristol-Myers Squibb Company	Cytotoxic xanthone compounds
CA2705152C (fr)	2007-11-09	2016-10-11	Peregrine Pharmaceuticals, Inc.	Compositions d'anticorps anti-vegf et procedes correspondants
EP2240475B1 (fr)	2007-12-20	2013-09-25	Novartis AG	Dérivés de thiazole utilisés comme inhibiteur de la pi 3 kinase
MX355683B (es) *	2008-04-18	2018-04-26	Angiochem Inc	Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel, y métodos relacionados de preparación y uso.
WO2010043049A1 (fr)	2008-10-15	2010-04-22	Angiochem Inc.	Conjugués de l'étoposide et de la doxorubicine pour l'administration de médicaments
CA2740316A1 (fr)	2008-10-15	2010-04-22	Angiochem Inc.	Conjugues d'agonistes de glp-1 et leurs utilisations
CA2745524C (fr) *	2008-12-05	2020-06-09	Angiochem Inc.	Conjugues de neurotensine ou d'analogues de neurotensine et leurs applications
US8853353B2 (en)	2008-12-17	2014-10-07	Angiochem, Inc.	Membrane type-1 matrix metalloprotein inhibitors and uses thereof
MX2011011023A (es)	2009-04-20	2012-01-20	Angiochem Inc	Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2.
RU2012103240A (ru)	2009-07-02	2013-08-10	Ангиокем Инк.	Мультимерные пептидные конъюгаты и их применение
US8293753B2 (en)	2009-07-02	2012-10-23	Novartis Ag	Substituted 2-carboxamide cycloamino ureas
EP2539337A1 (fr)	2010-02-22	2013-01-02	F. Hoffmann-La Roche AG	Composés de pyrido[3,2-d]pyrimidine inhibiteurs de pi3k delta et procédés d'utilisation
US9586954B2 (en)	2010-06-22	2017-03-07	Demerx, Inc.	N-substituted noribogaine prodrugs
AR082418A1 (es)	2010-08-02	2012-12-05	Novartis Ag	Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
MX343706B (es)	2011-01-31	2016-11-18	Novartis Ag	Derivados heterocíclicos novedosos.
US9617274B1 (en)	2011-08-26	2017-04-11	Demerx, Inc.	Synthetic noribogaine
PT2771342T (pt)	2011-10-28	2016-08-17	Novartis Ag	Derivados de purina e o seu uso no tratamento de doença
CA2855994A1 (fr) *	2011-12-09	2013-06-13	Demerx, Inc.	Esters phosphoriques de noribogaine
WO2013173283A1 (fr)	2012-05-16	2013-11-21	Novartis Ag	Régime posologique pour un inhibiteur de pi-3 kinase
CA2896133A1 (fr)	2012-12-20	2014-06-26	Demerx, Inc.	Noribogaine substituee
CN105979947A (zh)	2013-12-06	2016-09-28	诺华股份有限公司	α-同工型选择性磷脂酰肌醇3-激酶抑制剂的剂量方案
EP3307326B9 (fr)	2015-06-15	2021-02-24	Angiochem Inc.	Procédés de traitement d'une carcinomatose leptoméningée
RU2018119085A (ru)	2015-11-02	2019-12-04	Новартис Аг	Схема введения ингибитора фосфатидилинозитол-3-киназы
WO2018060833A1 (fr)	2016-09-27	2018-04-05	Novartis Ag	Schéma posologique pour l'alpelisib, un inhibiteur de la phosphatidylinositol 3-kinase spécifique de l'isoforme alpha
KR102378151B1 (ko)	2020-05-11	2022-03-24	주식회사 제이앤씨사이언스	베타-아포피크로포도필린의 신규한 유도체

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1171314A (fr) *	1955-05-13	1959-01-23	Sandoz Ag	Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (fr) *	1965-09-21	1967-03-22
CH464957A (de) *	1965-12-14	1968-11-15	Sandoz Ag	Verfahren zur Herstellung eines neuen Glucosids
CH544752A (de) *	1966-12-13	1974-01-15	Sandoz Ag	Verfahren zur Herstellung neuer Glucoside
CH514578A (de) *	1968-02-27	1971-10-31	Sandoz Ag	Verfahren zur Herstellung von Glucosiden
CH543502A (de) *	1970-11-20	1973-10-31	Sandoz Ag	Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) *	1971-06-05	1975-05-29	Villax I	Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) *	1973-06-07	1977-07-15	Sandoz Ag	Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) *	1977-07-11	1979-02-09	Rhone Poulenc Ind	Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (fr) *	1982-11-26	1987-11-04	Nippon Kayaku Kabushiki Kaisha	Procédé de préparation de 4'-déméthyl-épipodophyllotoxin-bêta-d-éthylidène-glucoside et dérivés acylés
US4567253A (en) *	1984-02-03	1986-01-28	Tony Durst	2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) *	1984-03-31	1985-10-21	Green Cross Corp:The	水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) *	1984-05-22	1985-12-06	Nippon Kayaku Co Ltd	エトポシドの新規製造法
US4739046A (en) *	1985-08-19	1988-04-19	Luzio Nicholas R Di	Soluble phosphorylated glucan
IL77334A (en) *	1985-12-16	1991-04-15	Univ Bar Ilan	Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) *	1987-01-08	1990-04-10	Bristol-Myers Company	Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) *	1987-02-06	1988-08-10	Nippon Kayaku Co Ltd	４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) *	1987-07-01	1989-10-17	Bristol-Meyers Company	3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

1988
- 1988-05-27 US US07/199,731 patent/US4904768A/en not_active Ceased
- 1988-07-21 MY MYPI88000819A patent/MY104321A/en unknown
- 1988-07-22 LU LU87290A patent/LU87290A1/fr active Protection Beyond IP Right Term
- 1988-07-25 YU YU01436/88A patent/YU143688A/xx unknown
- 1988-07-26 NO NO883299A patent/NO170284C/no not_active IP Right Cessation
- 1988-07-28 IT IT8821535A patent/IT1226825B/it active
- 1988-07-29 FR FR8810258A patent/FR2622193B1/fr not_active Expired - Lifetime
- 1988-07-29 NZ NZ225615A patent/NZ225615A/en unknown
- 1988-08-01 FI FI883596A patent/FI87790C/fi not_active IP Right Cessation
- 1988-08-01 IL IL87290A patent/IL87290A/xx not_active IP Right Cessation
- 1988-08-02 SK SK5412-88A patent/SK279325B6/sk unknown
- 1988-08-02 CZ CS19885412A patent/CZ286893B6/cs not_active IP Right Cessation
- 1988-08-03 JP JP63194307A patent/JPH0699465B2/ja not_active Expired - Lifetime
- 1988-08-03 GB GB8818462A patent/GB2207674B/en not_active Expired - Lifetime
- 1988-08-03 PT PT88186A patent/PT88186B/pt not_active IP Right Cessation
- 1988-08-03 BE BE8800898A patent/BE1002982A4/fr not_active IP Right Cessation
- 1988-08-03 ES ES8802434A patent/ES2010775A6/es not_active Expired
- 1988-08-03 IE IE237888A patent/IE61040B1/en not_active IP Right Cessation
- 1988-08-03 DD DD88326917A patent/DD299067A5/de unknown
- 1988-08-03 DK DK434088A patent/DK169344B1/da not_active IP Right Cessation
- 1988-08-03 AT AT0195588A patent/AT398974B/de active
- 1988-08-03 HU HU905862A patent/HU208147B/hu unknown
- 1988-08-03 SE SE8802815A patent/SE502214C2/sv not_active IP Right Cessation
- 1988-08-03 HU HU884081A patent/HU202547B/hu unknown
- 1988-08-03 NL NL8801934A patent/NL192683C/nl not_active IP Right Cessation
- 1988-08-03 DD DD88318652A patent/DD274423A5/de unknown
- 1988-08-03 KR KR1019880009910A patent/KR900006230B1/ko not_active Expired
- 1988-08-04 GR GR880100512A patent/GR1000490B/el not_active IP Right Cessation
- 1988-08-04 CH CH2962/88A patent/CH676716A5/de not_active IP Right Cessation
- 1988-08-04 DE DE3826562A patent/DE3826562A1/de active Granted
- 1988-08-04 CA CA000573861A patent/CA1310637C/fr not_active Expired - Lifetime
1989
- 1989-12-14 US US07/450,718 patent/US5041424A/en not_active Expired - Lifetime
1990
- 1990-01-19 YU YU00103/90A patent/YU10390A/xx unknown
- 1990-01-19 YU YU00104/90A patent/YU10490A/xx unknown
1991
- 1991-10-30 CN CN91108384A patent/CN1027169C/zh not_active Expired - Lifetime
- 1991-11-29 SG SG1012/91A patent/SG101291G/en unknown
1992
- 1992-01-16 HK HK63/92A patent/HK6392A/xx not_active IP Right Cessation
- 1992-01-22 NO NO920277A patent/NO920277D0/no unknown
- 1992-01-31 DK DK011992A patent/DK11992A/da not_active Application Discontinuation
- 1992-02-20 NO NO920665A patent/NO172440C/no not_active IP Right Cessation
- 1992-06-12 MX MX9202851A patent/MX173843B/es unknown
- 1992-07-10 CY CY1625A patent/CY1625A/en unknown
1994
- 1994-04-19 US US08/229,659 patent/USRE35524E/en not_active Expired - Lifetime
1995
- 1995-06-22 HU HU95P/P00387P patent/HU211960A9/hu unknown
1997
- 1997-09-24 LU LU90138C patent/LU90138I2/fr unknown
- 1997-12-05 NL NL970042C patent/NL970042I1/nl unknown
1998
- 1998-01-14 NO NO1998002C patent/NO1998002I1/no unknown

Also Published As

Publication number	Publication date
IE61040B1 (en)	1994-09-07
JPH0699465B2 (ja)	1994-12-07
FI883596A7 (fi)	1989-02-05
CZ541288A3 (cs)	1999-12-15
SK541288A3 (en)	1998-10-07
MY104321A (en)	1994-03-31
NL192683B (fr)	1997-08-01
US4904768A (en)	1990-02-27
NL192683C (nl)	1997-12-02
IL87290A (en)	1993-01-31
NO170284C (no)	1992-09-30
NO170284B (no)	1992-06-22
DK169344B1 (da)	1994-10-10
DK434088A (da)	1989-02-05
NL8801934A (nl)	1989-03-01
CZ286893B6 (cs)	2000-07-12
DE3826562C2 (fr)	1993-04-08
KR900006230B1 (ko)	1990-08-27
MX173843B (es)	1994-03-30
DE3826562A1 (de)	1989-02-16
US5041424A (en)	1991-08-20
GR1000490B (el)	1992-07-30
IT8821535A0 (it)	1988-07-28
KR890003790A (ko)	1989-04-18
AT398974B (de)	1995-02-27
HK6392A (en)	1992-01-17
SE502214C2 (sv)	1995-09-18
NO883299D0 (no)	1988-07-26
IT1226825B (it)	1991-02-19
FI883596A0 (fi)	1988-08-01
IE882378L (en)	1989-02-04
CN1027169C (zh)	1994-12-28
NL970042I2 (fr)	2005-06-01
ATA195588A (de)	1994-07-15
PT88186A (pt)	1989-06-30
CY1625A (en)	1992-07-10
SK279325B6 (sk)	1998-10-07
NO920665L (no)	1989-02-24
NO172440B (no)	1993-04-13
HU208147B (en)	1993-08-30
YU10490A (en)	1990-06-30
FR2622193A1 (fr)	1989-04-28
NO920277L (no)	1989-02-24
FI87790C (fi)	1993-02-25
DK434088D0 (da)	1988-08-03
JPH01100188A (ja)	1989-04-18
GB8818462D0 (en)	1988-09-07
HU211960A9 (en)	1996-01-29
NO172440C (no)	1993-07-21
SG101291G (en)	1992-01-17
USRE35524E (en)	1997-06-03
GB2207674A (en)	1989-02-08
HU202547B (en)	1991-03-28
AU610619B2 (en)	1991-05-23
ES2010775A6 (es)	1989-12-01
NL970042I1 (nl)	1998-03-02
FI87790B (fi)	1992-11-13
AU2030688A (en)	1989-06-08
IL87290A0 (en)	1989-01-31
SE8802815L (sv)	1989-02-05
YU143688A (en)	1990-04-30
HU905862D0 (en)	1991-03-28
SE8802815D0 (sv)	1988-08-03
MX9202851A (es)	1992-06-30
BE1002982A4 (fr)	1991-10-15
PT88186B (pt)	1995-07-03
NO920277D0 (no)	1992-01-22
HUT47303A (en)	1989-02-28
DK11992D0 (da)	1992-01-31
NO920665D0 (no)	1992-02-20
GR880100512A (en)	1989-05-25
CA1310637C (fr)	1992-11-24
GB2207674B (en)	1991-09-11
LU87290A1 (fr)	1990-02-07
DD274423A5 (de)	1989-12-20
NO883299L (no)	1989-02-24
DD299067A5 (de)	1992-03-26
FR2622193B1 (fr)	1993-12-17
CH676716A5 (fr)	1991-02-28
NZ225615A (en)	1991-06-25
YU10390A (en)	1990-06-30
NO1998002I1 (no)	1998-01-14
CN1061225A (zh)	1992-05-20
DK11992A (da)	1992-01-31

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DK295288A (da)	1988-12-02	(1h-azol-1-ylmethyl)substituerede benzotriazolderivater
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DK54488D0 (da)	1988-02-03	Adenosin-5'-carboxamid-derivater
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LU88843I2 (fr)	1997-03-14	Ropivacaine et ses dérivés pharmaceutiquement acceptables (Naropine R)
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FI890028A0 (fi)	1989-01-04	Menetelmä 2-substituoitujen adenosiinijohdannaisten valmistamiseksi
FI884553A7 (fi)	1989-04-06	Analogiamenetelmä terapeuttisesti käyttökelpoisten 9-aminotetrahydroakridiinijohdannaisten valmistamiseksi