BE1002982A4 - Derives de 4'-phosphates de glucosides d'epipodophyllotoxine. - Google Patents

Derives de 4'-phosphates de glucosides d'epipodophyllotoxine. Download PDF

Info

Publication number
BE1002982A4
BE1002982A4 BE8800898A BE8800898A BE1002982A4 BE 1002982 A4 BE1002982 A4 BE 1002982A4 BE 8800898 A BE8800898 A BE 8800898A BE 8800898 A BE8800898 A BE 8800898A BE 1002982 A4 BE1002982 A4 BE 1002982A4
Authority
BE
Belgium
Prior art keywords
phosphate derivatives
glucosides
epipodophyllotoxin glucosides
epipodophyllotoxin
phosphate
Prior art date
Application number
BE8800898A
Other languages
English (en)
Inventor
Mark G Saulnier
Peter D Senter
John F Kadow
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of BE1002982A4 publication Critical patent/BE1002982A4/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)

Abstract

Les dérivés phosphates des glucosides de 4'-déméthylépipodophyllotoxine, qui sont des agents anti-tumeurs nouveaux, et leurs sels, offrent du point de vue pharmaceutique l'avantage d'une solubilité élevée dans l'eau.
BE8800898A 1987-08-04 1988-08-03 Derives de 4'-phosphates de glucosides d'epipodophyllotoxine. BE1002982A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (1)

Publication Number Publication Date
BE1002982A4 true BE1002982A4 (fr) 1991-10-15

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8800898A BE1002982A4 (fr) 1987-08-04 1988-08-03 Derives de 4'-phosphates de glucosides d'epipodophyllotoxine.

Country Status (34)

Country Link
US (3) US4904768A (fr)
JP (1) JPH0699465B2 (fr)
KR (1) KR900006230B1 (fr)
CN (1) CN1027169C (fr)
AT (1) AT398974B (fr)
BE (1) BE1002982A4 (fr)
CA (1) CA1310637C (fr)
CH (1) CH676716A5 (fr)
CY (1) CY1625A (fr)
CZ (1) CZ286893B6 (fr)
DD (2) DD299067A5 (fr)
DE (1) DE3826562A1 (fr)
DK (2) DK169344B1 (fr)
ES (1) ES2010775A6 (fr)
FI (1) FI87790C (fr)
FR (1) FR2622193B1 (fr)
GB (1) GB2207674B (fr)
GR (1) GR1000490B (fr)
HK (1) HK6392A (fr)
HU (3) HU208147B (fr)
IE (1) IE61040B1 (fr)
IL (1) IL87290A (fr)
IT (1) IT1226825B (fr)
LU (2) LU87290A1 (fr)
MX (1) MX173843B (fr)
MY (1) MY104321A (fr)
NL (2) NL192683C (fr)
NO (4) NO170284C (fr)
NZ (1) NZ225615A (fr)
PT (1) PT88186B (fr)
SE (1) SE502214C2 (fr)
SG (1) SG101291G (fr)
SK (1) SK541288A3 (fr)
YU (3) YU143688A (fr)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (fr) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (fr) * 1991-12-23 1996-07-16 Uday Shankar Gogate Hexahydrate stable d'etoposide-4'-phosphate, sel disodique
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
US5942386A (en) * 1995-06-07 1999-08-24 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
AU726914B2 (en) 1996-04-01 2000-11-23 Epix Pharmaceuticals, Inc. Bioactivated diagnostic imaging contrast agents
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (fr) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology DERIVES D'ACETAL DE 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE
CA2385528C (fr) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions et methodes de traitement du cancer utilisant des immunoconjugues et des agents chimiotherapeutiques
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
BR0206206A (pt) * 2001-10-26 2005-01-11 Centre Nat Rech Scient Derivados de etoposide e análogos, e composições farmacêuticas contendo os mesmos
US7572442B2 (en) 2002-07-15 2009-08-11 Board Of Regents, The University Of Texas System Selected antibody compositions for binding to aminophospholipids
CN1747747B (zh) * 2003-01-06 2012-09-05 安吉奥开米公司 作为穿过血脑屏障的载体的抑酶肽及类似物
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
CN101160403B (zh) * 2005-02-18 2014-08-13 安吉奥开米公司 转运化合物穿过血脑屏障的分子
JP5436856B2 (ja) * 2005-07-15 2014-03-05 アンジオケム インコーポレーティッド 薬学的複合体における担体としてのアプロチニンポリペプチドの使用
CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
PE20070978A1 (es) * 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
TW200808739A (en) * 2006-04-06 2008-02-16 Novartis Vaccines & Diagnostic Quinazolines for PDK1 inhibition
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US8263644B2 (en) * 2007-09-13 2012-09-11 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
MX2010005104A (es) 2007-11-09 2010-08-04 Peregrine Pharmaceuticals Inc Composiciones de anticuerpo anti-factor de crecimiento endotelial vascular y metodos.
KR20100093129A (ko) 2007-12-20 2010-08-24 노파르티스 아게 Ｐｉ ３ 키나제 억제제로서 사용되는 티아졸 유도체
RU2518240C2 (ru) * 2008-04-18 2014-06-10 Ангиочем Инк. Композиция, на основе гидрофобных агентов и способ ее получения(варианты)
US8921314B2 (en) 2008-10-15 2014-12-30 Angiochem, Inc. Conjugates of GLP-1 agonists and uses thereof
RU2531591C2 (ru) 2008-10-15 2014-10-20 Ангиокем Инк. Конъюгаты этопозида и доксорубицина для доставки лекарственных средств
MX2011005963A (es) * 2008-12-05 2011-09-01 Angiochem Inc Conjugados de neurotensina o analogos de neurotensina y sus usos.
CN102300987A (zh) 2008-12-17 2011-12-28 安吉奥开米公司 膜型-1基质金属蛋白抑制剂及其用途
AU2010239069B2 (en) 2009-04-20 2015-05-14 Angiochem Inc Treatment of ovarian cancer using an anticancer agent conjugated to an Angiopep-2 analog
MX2012000016A (es) 2009-07-02 2012-03-26 Angiochem Inc Conjugados de peptidos multimericos y sus usos.
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
CN102762565A (zh) 2010-02-22 2012-10-31 弗·哈夫曼-拉罗切有限公司 吡啶并[3,2-d]嘧啶PI3δ抑制剂化合物及使用方法
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
CA2825605C (fr) 2011-01-31 2019-05-07 Novartis Ag Derives heterocycliques
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
PH12014500912A1 (en) 2011-10-28 2014-06-09 Novartis Ag Novel purine derivatives and their use in the treatment of disease
EP2788003A4 (fr) * 2011-12-09 2015-05-27 Demerx Inc Esters phosphoriques de noribogaïne
SG11201406550QA (en) 2012-05-16 2014-11-27 Novartis Ag Dosage regimen for a pi-3 kinase inhibitor
CA2896133A1 (fr) 2012-12-20 2014-06-26 Demerx, Inc. Noribogaine substituee
KR20160095035A (ko) 2013-12-06 2016-08-10 노파르티스 아게 알파-이소형 선택성 포스파티딜이노시톨 3-키나제 억제제를 위한 투여 요법
US10980892B2 (en) 2015-06-15 2021-04-20 Angiochem Inc. Methods for the treatment of leptomeningeal carcinomatosis
KR20180073674A (ko) 2015-11-02 2018-07-02 노파르티스 아게 포스파티딜이노시톨 3-키나제 억제제에 대한 투여 요법
WO2018060833A1 (fr) 2016-09-27 2018-04-05 Novartis Ag Schéma posologique pour l'alpelisib, un inhibiteur de la phosphatidylinositol 3-kinase spécifique de l'isoforme alpha
KR102378151B1 (ko) 2020-05-11 2022-03-24 주식회사 제이앤씨사이언스 베타-아포피크로포도필린의 신규한 유도체

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6613143A (fr) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH481094A (de) * 1966-12-13 1969-11-15 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (fr) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Procédé de préparation de 4'-déméthyl-épipodophyllotoxin-bêta-d-éthylidène-glucoside et dérivés acylés
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PROCEEDINGDS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 85, no. 13, July 1988, pages 4842-4846; P.D. SENTER et al.: "Anti-tumor effects of antibody-alkaline phosphatase conjugates in combination wth etoposide phosphate" *

Also Published As

Publication number Publication date
GB8818462D0 (en) 1988-09-07
CN1027169C (zh) 1994-12-28
NO920277D0 (no) 1992-01-22
ATA195588A (de) 1994-07-15
SG101291G (en) 1992-01-17
MX173843B (es) 1994-03-30
DE3826562C2 (fr) 1993-04-08
US4904768A (en) 1990-02-27
FI883596A0 (fi) 1988-08-01
DK11992D0 (da) 1992-01-31
NO172440C (no) 1993-07-21
HU211960A9 (en) 1996-01-29
IE61040B1 (en) 1994-09-07
NO170284C (no) 1992-09-30
GR880100512A (en) 1989-05-25
NO883299D0 (no) 1988-07-26
AU610619B2 (en) 1991-05-23
NL8801934A (nl) 1989-03-01
NO920665D0 (no) 1992-02-20
LU90138I2 (fr) 1997-11-26
USRE35524E (en) 1997-06-03
NO172440B (no) 1993-04-13
NL970042I2 (fr) 2005-06-01
DE3826562A1 (de) 1989-02-16
GR1000490B (el) 1992-07-30
HU905862D0 (en) 1991-03-28
IT1226825B (it) 1991-02-19
DK11992A (da) 1992-01-31
IT8821535A0 (it) 1988-07-28
IL87290A0 (en) 1989-01-31
AU2030688A (en) 1989-06-08
US5041424A (en) 1991-08-20
FI883596A7 (fi) 1989-02-05
NZ225615A (en) 1991-06-25
GB2207674A (en) 1989-02-08
AT398974B (de) 1995-02-27
KR900006230B1 (ko) 1990-08-27
SE502214C2 (sv) 1995-09-18
NO883299L (no) 1989-02-24
YU10490A (en) 1990-06-30
SK279325B6 (sk) 1998-10-07
LU87290A1 (fr) 1990-02-07
YU143688A (en) 1990-04-30
FR2622193A1 (fr) 1989-04-28
PT88186A (pt) 1989-06-30
SK541288A3 (en) 1998-10-07
CZ541288A3 (cs) 1999-12-15
HU202547B (en) 1991-03-28
CN1061225A (zh) 1992-05-20
CH676716A5 (fr) 1991-02-28
IL87290A (en) 1993-01-31
MY104321A (en) 1994-03-31
FI87790B (fi) 1992-11-13
YU10390A (en) 1990-06-30
FI87790C (fi) 1993-02-25
NO1998002I1 (no) 1998-01-14
GB2207674B (en) 1991-09-11
DK434088A (da) 1989-02-05
DD299067A5 (de) 1992-03-26
FR2622193B1 (fr) 1993-12-17
CZ286893B6 (cs) 2000-07-12
IE882378L (en) 1989-02-04
DD274423A5 (de) 1989-12-20
DK169344B1 (da) 1994-10-10
CY1625A (en) 1992-07-10
DK434088D0 (da) 1988-08-03
NO170284B (no) 1992-06-22
NL192683B (fr) 1997-08-01
ES2010775A6 (es) 1989-12-01
HUT47303A (en) 1989-02-28
HU208147B (en) 1993-08-30
JPH0699465B2 (ja) 1994-12-07
SE8802815L (sv) 1989-02-05
NO920665L (no) 1989-02-24
NO920277L (no) 1989-02-24
NL970042I1 (nl) 1998-03-02
JPH01100188A (ja) 1989-04-18
CA1310637C (fr) 1992-11-24
PT88186B (pt) 1995-07-03
KR890003790A (ko) 1989-04-18
MX9202851A (es) 1992-06-30
SE8802815D0 (sv) 1988-08-03
NL192683C (nl) 1997-12-02
HK6392A (en) 1992-01-17

Similar Documents

Publication Publication Date Title
MY104321A (en) Epipodophyllotoxin glucoside 4-phospate deravatives
BG102163A (en) Inhibitors of adenosinekinase modified in c-4'position
ES2180757T3 (es) Sintesis enzimatica mejorada de oligosacaridos.
MY103388A (en) Azithromycin and derivatives as antiprotozoal agents
BG46601A3 (bg) Метод за получаване на авермектинови производни
HUT52341A (en) Method for producing preparations
ES8602553A1 (es) Un sistema de purificacion de aguas residuales y un procedi-miento para su ejecucion
FR2714907B1 (fr) Nouveaux dérivés de l'Adénosine, leurs procédés de préparation, compositions pharmaceutiques les contenant.
SE9502474L (sv) Farmaceutiska kompositioner för förhindrande och behandling av cancerösa sjukdomar samt process för beredning av dessa
BE892943A (fr) Nouveaux derives 4'-iodo de glycosides d'anthracyclines
FR2412565A1 (fr) Nouveaux derives de type n-acyl-2', n-alkyl-2', di-n-acyl-4,2', di-n-alkyl-4,2', n-acyl-4 n-alkyl-2' et n-alkyl-4 n-acyl-2', desoxy-2 fortimicine b
DK583785A (da) Soedemiddel, fremgangsmaade til fremstilling deraf og anvendelse deraf
FR2412567A1 (fr) N-acyl-2' et n-alkyl-2' o-demethyl-3 fortimicines a et b, utiles notamment comme antibiotiques
FR2687678B1 (fr) Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
IT7826293A0 (it) Procedimento per la n-protezione selettiva di amminoglicosidi e prodotti intermedi amminoglicosidi selettivamente protetti cosi'ottenuti.
FR2722194B1 (fr) Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent
FR2574412B1 (fr) Procede de fabrication de derives de nucleosides utiles notamment comme agents anticancereux
OA09439A (fr) "Nouveaux dérivés benzoxazolinoniques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent".
WO1989012380A3 (fr) Utilisations therapeutiques de derives de 2,5'-oligoadenylate
FR2668150B1 (fr) Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.
EP0305972A3 (fr) Dérivés du 3'-déméthoxyépipodophyllotoxine glucoside
DK0443471T3 (da) 2-Deoxy-2-methylidencytidin-dihydrat, fremgangsmåder til fremstilling heraf, samt præparater
NZ219440A (en) Nucleoside of c 5 sugar
PT84130A (fr) Procede de preparation de nouveaux derives de 3-alkoxyflavones et de leurs compositions therapeutiques
BE892032A (fr) Nouveaux derives de 1-benzyl-4-(4-(2-pyrimidinylamino)benzyl-2,3-dioxopiperazines, leurs sels, un procede de preparation de ces derives et sels et un agent carcinostatique les contenant

Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *BRISTOL-MYERS SQUIBB CY

Effective date: 20080803

CCRE Expiry of a supplementary protection certificate

Free format text: PRODUCT NAME: ETOPOSIDE PHOSPHATE; NAT. REGISTRATION NO/DATE: 203 IS 254 F 12 19970123; FIRST REGISTRATION: SE 12 512 19960412

Spc suppl protection certif: 97C0017

Filing date: 19970320

Expiry date: 20080803

Extension date: 20110412

Effective date: 20090731