ATE306547T1 - Menschliche hybrid-wirtszelle zur expression von säugetier-genen - Google Patents

Menschliche hybrid-wirtszelle zur expression von säugetier-genen

Info

Publication number: ATE306547T1
Authority: AT; Austria
Prior art keywords: cells; human; recombinant; genes; host cell
Prior art date: 1998-12-10

Application number

AT99963067T

Other languages

German (de)

English (en)

Inventor

Myung-Sam Cho

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-10

Filing date

1999-12-08

Publication date

2005-10-15

1999-12-08 Application filed by Bayer Ag filed Critical Bayer Ag

2005-10-15 Application granted granted Critical

2005-10-15 Publication of ATE306547T1 publication Critical patent/ATE306547T1/de

Links

108090000623 proteins and genes Proteins 0.000 title abstract 2
241000124008 Mammalia Species 0.000 title 1
210000004027 cell Anatomy 0.000 abstract 7
230000004927 fusion Effects 0.000 abstract 2
230000014509 gene expression Effects 0.000 abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
210000003292 kidney cell Anatomy 0.000 abstract 2
208000011691 Burkitt lymphomas Diseases 0.000 abstract 1
108060003951 Immunoglobulin Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 abstract 1
102100037877 Intercellular adhesion molecule 1 Human genes 0.000 abstract 1
102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
210000003719 b-lymphocyte Anatomy 0.000 abstract 1
210000004754 hybrid cell Anatomy 0.000 abstract 1
102000018358 immunoglobulin Human genes 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
238000003259 recombinant expression Methods 0.000 abstract 1
238000004114 suspension culture Methods 0.000 abstract 1
238000001890 transfection Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/02—Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

AT99963067T 1998-12-10 1999-12-08 Menschliche hybrid-wirtszelle zur expression von säugetier-genen ATE306547T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/209,920 US6136599A (en)	1998-12-10	1998-12-10	Human hybrid host cell for mammalian gene expression
PCT/US1999/029332 WO2000034462A1 (en)	1998-12-10	1999-12-08	Human hybrid host cell for mammalian gene expression

Publications (1)

Publication Number	Publication Date
ATE306547T1 true ATE306547T1 (de)	2005-10-15

Family

ID=22780882

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99963067T ATE306547T1 (de)	1998-12-10	1999-12-08	Menschliche hybrid-wirtszelle zur expression von säugetier-genen

Country Status (27)

Country	Link
US (1)	US6136599A (es)
EP (1)	EP1137768B1 (es)
JP (3)	JP4332300B2 (es)
KR (1)	KR100627753B1 (es)
CN (1)	CN1230532C (es)
AT (1)	ATE306547T1 (es)
AU (1)	AU757188B2 (es)
BG (1)	BG65263B1 (es)
BR (1)	BRPI9916095B8 (es)
CA (1)	CA2353698C (es)
CU (2)	CU23382A3 (es)
CZ (1)	CZ302677B6 (es)
DE (1)	DE69927707T2 (es)
DK (1)	DK1137768T3 (es)
ES (1)	ES2249929T3 (es)
HU (1)	HU229775B1 (es)
ID (1)	ID30448A (es)
IL (2)	IL143351A0 (es)
NO (1)	NO330548B1 (es)
PL (1)	PL205549B1 (es)
RO (1)	RO121563B1 (es)
RU (1)	RU2228355C2 (es)
SI (1)	SI20693B (es)
SK (1)	SK287888B6 (es)
TR (1)	TR200101642T2 (es)
UA (1)	UA77642C2 (es)
WO (1)	WO2000034462A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6358703B1 (en)	1998-12-10	2002-03-19	Bayer Corporation	Expression system for factor VIII
US6136599A (en) *	1998-12-10	2000-10-24	Bayer Corporation	Human hybrid host cell for mammalian gene expression
US6348192B1 (en) *	1999-05-11	2002-02-19	Bayer Corporation	Interleukin-2 mutein expressed from mammalian cells
US20040235715A1 (en) *	1999-11-12	2004-11-25	Bayer Corporation	Method of producing glycosylated bikunin
US6569657B1 (en) *	2000-06-27	2003-05-27	Millennium Pharmaceuticals, Inc.	32140, a novel human aldehyde dehydrogenase and uses therefor
US7094587B2 (en) *	2000-06-27	2006-08-22	Millennium Pharmaceuticals, Inc.	16002 Molecules and uses therefor
MY139948A (en) *	2000-09-28	2009-11-30	Bayer Corp	Enhanced transfection system
US7723102B2 (en) *	2000-09-28	2010-05-25	Bayer Corporation	Enhanced transfection system
US20060073141A1 (en) *	2001-06-28	2006-04-06	Domantis Limited	Compositions and methods for treating inflammatory disorders
KR100496861B1 (ko)	2002-09-26	2005-06-22	삼성전자주식회사	하나의 핸들러에 2개 이상의 테스트 보드를 갖는 테스트장비 및 그 테스트 방법
US7285269B2 (en)	2002-12-02	2007-10-23	Amgen Fremont, Inc.	Antibodies directed to tumor necrosis factor
US7244616B2 (en)	2003-06-27	2007-07-17	Bayer Pharmaceuticals Corporation	Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
PT2363414T (pt)	2004-11-12	2022-08-04	Bayer Healthcare Llc	Modificação de fviii direcionada a sítio
JP2010528647A (ja)	2007-06-06	2010-08-26	ドマンティスリミテッド	ポリペプチド、抗体可変ドメインおよびアンタゴニスト
JP5628790B2 (ja)	2008-04-07	2014-11-19	バイエル・ヘルスケア・エルエルシー	糖タンパク質の組換え生産の方法
KR101005967B1 (ko) *	2008-04-12	2011-01-05	(주)셀트리온	우수한 재조합 단백질을 생산하기 위한 인간 숙주 세포
US9090948B2 (en)	2008-09-30	2015-07-28	Abbott Molecular Inc.	Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
CN102612556A (zh) *	2009-06-10	2012-07-25	Bts研究国际股份有限公司	制备杂交细胞/嵌合细胞的方法及其应用
US11649449B2 (en)	2015-09-03	2023-05-16	CHO Plus, Inc.	Hybrid cell lines for high level production of a target protein
WO2018017144A1 (en)	2016-07-19	2018-01-25	Brandeis University	Compositions and methods for identifying rna binding polypeptide targets
AU2019270342A1 (en)	2018-05-16	2020-10-29	Morphosys Ag	Antibodies targeting glycoprotein VI
CA3125527A1 (en)	2018-12-20	2020-06-25	Orionis Biosciences, Inc.	Particle based small molecule-protein complex trap
JP7617012B2 (ja)	2019-03-14	2025-01-17	モルフォシス・アーゲー	Ｃ５ａＲを標的とする抗体
EP3980524A4 (en) *	2019-06-10	2023-01-11	Cho Plus Inc.	Cell lines for high level production of protein-based pharmaceuticals
US20230357398A1 (en)	2020-09-24	2023-11-09	Morphosys Ag	Novel human antibodies binding to human cd3 epsilon
CN113604425B (zh) *	2021-06-22	2022-10-18	中山康天晟合生物技术有限公司	一种适应无血清培养基环境的wayne293 lvpro细胞及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6045849B2 (ja) *	1980-08-25	1985-10-12	林原健	ヒトエリトロポエチンの製造方法
JPS6030654B2 (ja) *	1980-12-31	1985-07-17	株式会社林原生物化学研究所	ヒトコロニ−刺激因子の製造方法
US6136599A (en) *	1998-12-10	2000-10-24	Bayer Corporation	Human hybrid host cell for mammalian gene expression

1998
- 1998-12-10 US US09/209,920 patent/US6136599A/en not_active Expired - Lifetime
1999
- 1999-08-12 UA UA2001074776A patent/UA77642C2/uk unknown
- 1999-12-08 SK SK791-2001A patent/SK287888B6/sk not_active IP Right Cessation
- 1999-12-08 TR TR2001/01642T patent/TR200101642T2/xx unknown
- 1999-12-08 HU HU0104681A patent/HU229775B1/hu unknown
- 1999-12-08 EP EP99963067A patent/EP1137768B1/en not_active Expired - Lifetime
- 1999-12-08 IL IL14335199A patent/IL143351A0/xx unknown
- 1999-12-08 AT AT99963067T patent/ATE306547T1/de active
- 1999-12-08 DK DK99963067T patent/DK1137768T3/da active
- 1999-12-08 AU AU19383/00A patent/AU757188B2/en not_active Expired
- 1999-12-08 CZ CZ20012023A patent/CZ302677B6/cs not_active IP Right Cessation
- 1999-12-08 WO PCT/US1999/029332 patent/WO2000034462A1/en not_active Ceased
- 1999-12-08 RU RU2001119161/13A patent/RU2228355C2/ru active
- 1999-12-08 ID IDW00200101235A patent/ID30448A/id unknown
- 1999-12-08 CA CA2353698A patent/CA2353698C/en not_active Expired - Lifetime
- 1999-12-08 BR BRPI9916095A patent/BRPI9916095B8/pt not_active IP Right Cessation
- 1999-12-08 CN CNB998142999A patent/CN1230532C/zh not_active Expired - Lifetime
- 1999-12-08 RO ROA200100648A patent/RO121563B1/ro unknown
- 1999-12-08 KR KR1020017007224A patent/KR100627753B1/ko not_active Expired - Lifetime
- 1999-12-08 SI SI9920096A patent/SI20693B/sl active Search and Examination
- 1999-12-08 DE DE69927707T patent/DE69927707T2/de not_active Expired - Lifetime
- 1999-12-08 PL PL349625A patent/PL205549B1/pl unknown
- 1999-12-08 ES ES99963067T patent/ES2249929T3/es not_active Expired - Lifetime
- 1999-12-08 JP JP2000586896A patent/JP4332300B2/ja not_active Expired - Lifetime
2001
- 2001-05-24 IL IL143351A patent/IL143351A/en not_active IP Right Cessation
- 2001-06-06 BG BG105566A patent/BG65263B1/bg unknown
- 2001-06-07 CU CU20010130A patent/CU23382A3/es not_active IP Right Cessation
- 2001-06-07 NO NO20012806A patent/NO330548B1/no not_active IP Right Cessation
2002
- 2002-08-26 CU CU20020182A patent/CU23238A1/es unknown
2009
- 2009-03-06 JP JP2009053279A patent/JP5508740B2/ja not_active Expired - Lifetime
2014
- 2014-02-24 JP JP2014032748A patent/JP5826311B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
SK7912001A3 (en)	2002-03-05
DE69927707D1 (de)	2006-02-23
NO330548B1 (no)	2011-05-16
IL143351A (en)	2009-12-24
EP1137768A1 (en)	2001-10-04
PL205549B1 (pl)	2010-04-30
AU1938300A (en)	2000-06-26
EP1137768A4 (en)	2002-09-18
JP2014131513A (ja)	2014-07-17
HUP0104681A2 (hu)	2002-04-29
KR20020002360A (ko)	2002-01-09
TR200101642T2 (tr)	2001-11-21
UA77642C2 (en)	2007-01-15
IL143351A0 (en)	2002-04-21
CA2353698C (en)	2012-02-21
CN1230532C (zh)	2005-12-07
BG65263B1 (bg)	2007-10-31
SI20693B (sl)	2008-12-31
JP2002531125A (ja)	2002-09-24
ES2249929T3 (es)	2006-04-01
CZ20012023A3 (cs)	2001-10-17
KR100627753B1 (ko)	2006-09-26
SI20693A (sl)	2002-04-30
HUP0104681A3 (en)	2005-10-28
CN1339063A (zh)	2002-03-06
JP5826311B2 (ja)	2015-12-02
JP2009148295A (ja)	2009-07-09
NO20012806D0 (no)	2001-06-07
DE69927707T2 (de)	2006-07-13
CU23238A1 (es)	2007-09-26
ID30448A (id)	2001-12-06
BRPI9916095B8 (pt)	2021-05-25
BR9916095A (pt)	2001-09-04
SK287888B6 (sk)	2012-03-02
CZ302677B6 (cs)	2011-08-31
RO121563B1 (ro)	2007-11-30
JP5508740B2 (ja)	2014-06-04
BG105566A (en)	2002-03-29
BRPI9916095B1 (pt)	2015-10-13
HU229775B1 (en)	2014-07-28
NO20012806L (no)	2001-06-07
CA2353698A1 (en)	2000-06-15
RU2228355C2 (ru)	2004-05-10
CU23382A3 (es)	2009-06-25
US6136599A (en)	2000-10-24
EP1137768B1 (en)	2005-10-12
WO2000034462A1 (en)	2000-06-15
AU757188B2 (en)	2003-02-06
DK1137768T3 (da)	2005-12-19
JP4332300B2 (ja)	2009-09-16

Legal Events

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2006-05-15

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Publication	Publication Date	Title
ATE306547T1 (de)	2005-10-15	Menschliche hybrid-wirtszelle zur expression von säugetier-genen
Tjian et al.	1978	Biological activity of purified simian virus 40 T antigen proteins.
AP1678A (en)	2006-11-27	Novel modified nucleic acid sequences and methods for increasing mRNA levels and protein expression in cell systems.
ATE369384T1 (de)	2007-08-15	Expression und export von interferon-alpha proteinen als fc fusionsproteine
SE0201328D0 (sv)	2002-05-03	Hematopoietic differentiation of human embryonic stem cells
DE69532532D1 (de)	2004-03-11	Chimerische papillomavirus-ahnliche partikel
ES2213925T3 (es)	2004-09-01	Seleccion entre positivos y negativos en el caso de la recombinacion homologa.
JPH04228066A (ja)	1992-08-18	外来遺伝子発現用培養細胞
Chang et al.	1986	Transformation of human cultured fibroblasts with plasmids carrying dominant selection markers and immortalizing potential
KR890005264A (ko)	1989-05-13	인터류킨-2를 생산하는 재조합 진핵 세포, 그의 제조 방법 및 그의 제조용 벡터 및 인터류킨-2의 제조방법
NZ329360A (en)	1999-05-28	Immortalised retinal derived cell lines capable of being implanted in the retina and carrying a therapeutic substance to the eye and the central nervous system and other applications of the cell thereof
NZ512235A (en)	2004-03-26	Human hybrid host cell for mammalian gene expression
DK0870044T3 (da)	2004-08-02	Reguleret proteinekspression i stabilt transfekterede pattedyrsceller
Graessmann et al.	1979	Fused cells are suited for microinjection
JP2507882B2 (ja)	1996-06-19	外部増殖因子非依存性増殖良好細胞株の製造法
JP2500384B2 (ja)	1996-05-29	生理活性物質の製造法
Odörfer et al.	2007	Marker tolerant, immunocompetent animals as a new tool for regenerative medicine and long-term cell tracking
Waldman et al.	1984	Transfer of herpes simplex virus thymidine kinase synthesized in bacteria by a high-expression plasmid to tissue culture cells by protoplast fusion
Hohenwarter et al.	1997	Human endothelial cell lines established by mutated forms of the simian virus 40 large T oncogene
Bayley et al.	1988	Immortalization of rat keratinocytes by transfection with polyomavirus large T gene
Lanfranchl et al.	1984	Globin synthesis in heterokaryons formed between chick erythrocytes and human K562 cells or rat L6 myoblasts
JPH0732705B2 (ja)	1995-04-12	動物細胞増殖用組成物およびそれを用いる動物細胞の増殖方法
AU666800B2 (en)	1996-02-22	Process for producing exogenous protein
Colman	1987	Microinjection and organelle transplantation techniques: Methods and applications: edited by JE Celis, A. Graessmann and A. Loyter, Academic Press, 1986.£ 47/$75.50 (hbk)£ 23/$36.95 (pbk)(xi+ 379 pages) ISBN 0 12 164722 6
Graessmann et al.	1983	Gene Transfer into Culture Cells and its Application to Study Cell Transformation