ATE401319T1 - Substituierte 2-(2,6-dioxopiperidin-3-yl)- phthalimide und verfahren zur verminderung des tnf-alpha spiegels - Google Patents

Substituierte 2-(2,6-dioxopiperidin-3-yl)- phthalimide und verfahren zur verminderung des tnf-alpha spiegels

Info

Publication number
ATE401319T1
ATE401319T1 AT04077432T AT04077432T ATE401319T1 AT E401319 T1 ATE401319 T1 AT E401319T1 AT 04077432 T AT04077432 T AT 04077432T AT 04077432 T AT04077432 T AT 04077432T AT E401319 T1 ATE401319 T1 AT E401319T1
Authority
AT
Austria
Prior art keywords
carbon atoms
hydrogen
alkyl
dioxopiperidine
phthalimides
Prior art date
Application number
AT04077432T
Other languages
English (en)
Inventor
George W Muller
David I Stirling
Roger Shen-Shu Chen
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Application granted granted Critical
Publication of ATE401319T1 publication Critical patent/ATE401319T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT04077432T 1997-05-30 1998-05-28 Substituierte 2-(2,6-dioxopiperidin-3-yl)- phthalimide und verfahren zur verminderung des tnf-alpha spiegels ATE401319T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4827897P 1997-05-30 1997-05-30

Publications (1)

Publication Number Publication Date
ATE401319T1 true ATE401319T1 (de) 2008-08-15

Family

ID=21953674

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04077432T ATE401319T1 (de) 1997-05-30 1998-05-28 Substituierte 2-(2,6-dioxopiperidin-3-yl)- phthalimide und verfahren zur verminderung des tnf-alpha spiegels
AT98924959T ATE275139T1 (de) 1997-05-30 1998-05-28 Substituierte 2-(2,6-dioxopiperidin-3-yl)- phthalimide und 1-oxoisoindoline und verfahren zur reduzierung des tnf-alpha-gehaltes

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT98924959T ATE275139T1 (de) 1997-05-30 1998-05-28 Substituierte 2-(2,6-dioxopiperidin-3-yl)- phthalimide und 1-oxoisoindoline und verfahren zur reduzierung des tnf-alpha-gehaltes

Country Status (24)

Country Link
US (3) US6395754B1 (de)
EP (3) EP0984955B1 (de)
JP (2) JP4307567B2 (de)
KR (1) KR100526212B1 (de)
CN (3) CN1258293A (de)
AT (2) ATE401319T1 (de)
AU (1) AU741982B2 (de)
CA (2) CA2291218C (de)
CY (1) CY1108348T1 (de)
CZ (1) CZ299812B6 (de)
DE (2) DE69825994T2 (de)
DK (2) DK0984955T3 (de)
ES (3) ES2229497T3 (de)
FI (1) FI19992490A7 (de)
HU (2) HU228769B1 (de)
MC (1) MC225A7 (de)
NO (6) NO322080B1 (de)
NZ (1) NZ501429A (de)
PL (1) PL193276B1 (de)
PT (2) PT1486496E (de)
RU (1) RU2209207C2 (de)
SK (1) SK163099A3 (de)
TR (4) TR200000107T2 (de)
WO (1) WO1998054170A1 (de)

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US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
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