ATE420117T1 - Kovalent an hyaluronsäure oder dessen derivate gebundene taxane - Google Patents

Kovalent an hyaluronsäure oder dessen derivate gebundene taxane

Info

Publication number: ATE420117T1
Authority: AT; Austria
Prior art keywords: hyaluronic acid; derivatives; covalently bonded; taxanes covalently; taxane
Prior art date: 2002-10-18

Application number

AT03748126T

Other languages

English (en)

Inventor

Luca Gilda De

Bettolo Rinaldo Marini

Luisa Migneco

Original Assignee

Fidia Farmaceutici

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-18

Filing date

2003-10-10

Publication date

2009-01-15

2003-10-10 Application filed by Fidia Farmaceutici filed Critical Fidia Farmaceutici

2009-01-15 Application granted granted Critical

2009-01-15 Publication of ATE420117T1 publication Critical patent/ATE420117T1/de

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 8
229940123237 Taxane Drugs 0.000 title abstract 5
229920002674 hyaluronan Polymers 0.000 title abstract 5
229960003160 hyaluronic acid Drugs 0.000 title abstract 5
230000015572 biosynthetic process Effects 0.000 abstract 2
238000003786 synthesis reaction Methods 0.000 abstract 2
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 2
208000023275 Autoimmune disease Diseases 0.000 abstract 1
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
229930012538 Paclitaxel Natural products 0.000 abstract 1
229960003668 docetaxel Drugs 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
208000037803 restenosis Diseases 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Polymers & Plastics (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Epoxy Compounds (AREA)

AT03748126T 2002-10-18 2003-10-10 Kovalent an hyaluronsäure oder dessen derivate gebundene taxane ATE420117T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT000271A ITPD20020271A1 (it)	2002-10-18	2002-10-18	Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.

Publications (1)

Publication Number	Publication Date
ATE420117T1 true ATE420117T1 (de)	2009-01-15

Family

ID=32104794

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03748126T ATE420117T1 (de)	2002-10-18	2003-10-10	Kovalent an hyaluronsäure oder dessen derivate gebundene taxane

Country Status (22)

Country	Link
US (2)	US7897584B2 (de)
EP (2)	EP1560854B1 (de)
JP (1)	JP4704753B2 (de)
KR (1)	KR101076414B1 (de)
CN (1)	CN1705683B (de)
AT (1)	ATE420117T1 (de)
AU (1)	AU2003267441B2 (de)
BR (1)	BR0315431A (de)
CA (2)	CA2502531C (de)
DE (1)	DE60325760D1 (de)
DK (1)	DK1560854T3 (de)
ES (2)	ES2320439T3 (de)
HR (1)	HRP20050416B1 (de)
IL (1)	IL168086A (de)
IT (1)	ITPD20020271A1 (de)
NO (1)	NO333042B1 (de)
NZ (2)	NZ540034A (de)
PL (2)	PL216861B1 (de)
PT (1)	PT1560854E (de)
RU (1)	RU2384593C2 (de)
SI (1)	SI1560854T1 (de)
WO (1)	WO2004035629A2 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7923431B2 (en)	2001-12-21	2011-04-12	Ferrosan Medical Devices A/S	Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
JP4975964B2 (ja)	2002-06-26	2012-07-11	メディゲーネアクチエンゲゼルシャフト	脂肪親和性化合物から成る陽イオン性リポソームの製法
RU2369408C2 (ru)	2004-07-09	2009-10-10	Ферросан А/С	Гемостатическая композиция, включающая гиалуроновую кислоту
AU2006266741B2 (en) *	2005-07-06	2011-09-01	Seikagaku Corporation	Drug-introduced photo-crosslinked hyaluronic acid derived gel
ITPD20050242A1 (it) *	2005-08-03	2007-02-04	Fidia Farmaceutici	Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico
JP2009508852A (ja) *	2006-01-23	2009-03-05	クワンジュインスティチュートオブサイエンスアンドテクノロジー	薬理活性物質と粘膜粘着性高分子とが共有結合されたコンジュゲート及びこれを用いた薬理活性物質の経粘膜運搬方法
IE20060049A1 (en) *	2006-01-25	2007-08-08	Eurand Pharmaceuticals Ltd	A novel drug delivery system: use of hyaluronic acid as a carrier moleclue for different classes of therapeutic active agents
US8202986B2 (en)	2006-08-04	2012-06-19	Novozymes Biopolymer AIS	Branched hyaluronic acid and method of manufacture
WO2008089256A2 (en) *	2007-01-16	2008-07-24	Cappella, Inc.	Polymeric therapeutics
ITMI20071267A1 (it)	2007-06-22	2008-12-23	Fidia Farmaceutici	Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative
ITMI20071341A1 (it)	2007-07-05	2009-01-06	Fidia Farmaceutici	Derivati di acido ialuronico contenenti gruppi in grado di rilasciare no
IE20070900A1 (en) *	2007-12-12	2009-06-24	Eurand Pharmaceuticals Ltd	New anticancer conjugates
JP5302340B2 (ja) *	2008-01-30	2013-10-02	カンザス大学	リンパ管内化学療法薬物担体
WO2009109194A2 (en)	2008-02-29	2009-09-11	Ferrosan A/S	Device for promotion of hemostasis and/or wound healing
US9925209B2 (en)	2008-03-19	2018-03-27	The Board Of Regents Of The University Of Oklahoma	Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
US9687559B2 (en)	2008-03-19	2017-06-27	The Board Of Regents Of The University Of Oklahoma	Heparosan polymers and methods of making and using same for the enhancement of therapeutics
CA2722376C (en) *	2008-04-22	2017-05-30	Fidia Farmaceutici S.P.A.	Therapeutic use of new pharmaceutical preparations containing antitumoral drugs bound to hyaluronic acid in the treatment of neoplasias
IT1391006B1 (it) *	2008-10-08	2011-10-27	Fidia Farmaceutici	Uso terapeutico di nuove preparazioni farmaceutiche contenenti farmaci antitumorali legati all'acido ialuronico nel trattamento delle neoplasie
CA2773755C (en) *	2008-09-09	2017-04-25	The Board Of Regents Of The University Of Oklahoma	Heparosan polymers and methods of making and using same for the enhancement of therapeutics
EP2360188B1 (de)	2008-11-05	2014-09-17	National University Corporation Tokyo Medical and Dental University	Hyaluronsäurederivat und arzneimittel daraus
IT1397247B1 (it) *	2009-05-14	2013-01-04	Fidia Farmaceutici	Nuovi agenti regolatori dell'attivita' citochinica
IT1399351B1 (it) *	2009-06-16	2013-04-16	Fidia Farmaceutici	Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
KR20110032561A (ko) *	2009-09-23	2011-03-30	포항공과대학교 산학협력단	약물 전달체의 표적 특이성 조절 방법, 표적 특이적 약물 전달체, 및 표적-비특이적 약효 장기 지속성 약물 전달체
US8722644B2 (en)	2010-01-04	2014-05-13	Holy Stone Healthcare Co., Ltd.	Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer
WO2012086857A1 (ko) *	2010-12-21	2012-06-28	(주)파낙스이엠	광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법
JP6241624B2 (ja)	2012-03-06	2017-12-06	フェロサンメディカルデバイシーズエイ／エス	止血ペーストを収容する加圧容器
CN104168927B (zh) *	2012-03-27	2016-10-05	泰尔茂株式会社	涂布组合物及医疗器械
CN104349797B (zh)	2012-06-12	2017-10-27	弗罗桑医疗设备公司	干止血组合物
KR102130864B1 (ko)	2012-09-05	2020-07-08	추가이 세이야쿠 가부시키가이샤	아미노산 및 스테릴기가 도입된 히알루론산 유도체
US9635795B2 (en)	2012-10-23	2017-04-25	International Business Machines Corporation	Multiple expansion card insertion and extraction tool
CN103641925B (zh) *	2012-11-27	2016-08-17	王晖	水溶性多聚糖与紫杉烷类化合物的共价聚化合物，其制备方法及医药用途
EP3010419B1 (de)	2013-06-21	2020-05-20	Ferrosan Medical Devices A/S	Vakuumerweiterte trockenzusammensetzung und spritze zum zurückhalten davon
WO2015005458A1 (ja) *	2013-07-10	2015-01-15	生化学工業株式会社	グリコサミノグリカン誘導体及びその製造方法
US10675354B2 (en)	2013-07-10	2020-06-09	Seikagaku Corporation	Glycosaminoglycan derivative and method for producing same
EP3079731B1 (de)	2013-12-11	2018-08-08	Ferrosan Medical Devices A/S	Trockenzusammensetzung mit extrusionsverstärker
CN103861116A (zh) *	2014-03-06	2014-06-18	沈阳药大制剂新技术有限公司	一种抗肿瘤药物的前体药物及其制备和应用
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JP6726852B2 (ja)	2014-10-13	2020-07-22	フェッローサンメディカルディバイスエー／エス	止血および創傷治癒に使用するための乾燥組成物
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RU2705905C2 (ru)	2014-12-24	2019-11-12	Ферросан Медикал Дивайсиз А/С	Шприц для удерживания и смешивания первого и второго веществ
KR102512431B1 (ko) *	2015-01-09	2023-03-22	세이가가쿠 고교 가부시키가이샤	콘드로이틴 황산 유도체 및 방광 질환 처치제
KR20180014042A (ko) *	2015-05-29	2018-02-07	알바트로스 테크놀로지스 리미티드	약물을 전달하기 위한 가교된 히알루론산 및 이를 이용한 약학적 제제
AU2016290433B2 (en)	2015-07-03	2018-05-24	Ferrosan Medical Devices A/S	Syringe for mixing two components and for retaining a vacuum in a storage condition
CN108178803B (zh) *	2017-09-25	2020-03-10	温州医科大学	一种载药的肉桂醛-葡聚糖聚合物自组装纳米粒的制备及其抗肿瘤应用
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US12343323B2 (en) *	2018-06-20	2025-07-01	Santolecan Pharmaceuticals Llc	Taxane-lipid-polysaccharide dual conjugates, preparation methods thereof and uses thereof
IT201800009731A1 (it) *	2018-10-25	2020-04-25	Fidia Farm Spa	Coniugato paclitaxel - acido ialuronico nel trattamento del carcinoma vescicale non infiltrante
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IT202000008209A1 (it)	2020-04-17	2021-10-17	Fidia Farm Spa	Procedimento di sintesi di un coniugato acido ialuronico-paclitaxel
CN111892668B (zh) *	2020-07-03	2022-07-12	广东工业大学	一种化合物及其制备方法、荧光探针和抗肿瘤药物
CN115867319B (zh) *	2020-07-15	2024-01-02	上海椿安生物医药科技有限公司	用于局部递送治疗剂的药物递送系统以及其用途
CN114870031B (zh) *	2022-05-20	2023-07-07	四川大学	一种cd44靶向的紫杉烷类纳米晶体及其制备方法与应用
WO2024038087A1 (en) *	2022-08-16	2024-02-22	Synartro Ab	Method for preparing sterile compositions

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4851521A (en) *	1985-07-08	1989-07-25	Fidia, S.P.A.	Esters of hyaluronic acid
GB8713662D0 (en) *	1987-06-11	1987-07-15	Skandigen Ab	Hyaluronic acid derivatives
IT1219587B (it)	1988-05-13	1990-05-18	Fidia Farmaceutici	Polisaccaridi carbossiilici autoreticolati
US5356883A (en) *	1989-08-01	1994-10-18	Research Foundation Of State University Of N.Y.	Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
CA2070672C (en) *	1990-10-18	2002-10-08	Kazuo Akima	Compound of medicinal ingredient and hyaluronic acid and process for producing the same
JP2604930B2 (ja) *	1990-12-14	1997-04-30	株式会社ディ・ディ・エス研究所	ヒアルロン酸およびコンドロイチン誘導体
AU4406793A (en) *	1992-06-04	1993-12-30	Clover Consolidated, Limited	Water-soluble polymeric carriers for drug delivery
US5817321A (en) *	1992-10-08	1998-10-06	Supratek Pharma, Inc.	Biological agent compositions
WO1994019376A1 (fr) *	1993-02-26	1994-09-01	Drug Delivery System Institute, Ltd.	Derive de polysaccharide et vehicule de medicament
US5616568A (en)	1993-11-30	1997-04-01	The Research Foundation Of State University Of New York	Functionalized derivatives of hyaluronic acid
ITPD940054A1 (it)	1994-03-23	1995-09-23	Fidia Advanced Biopolymers Srl	Polisaccaridi solfatati
US5977163A (en) *	1996-03-12	1999-11-02	Pg-Txl Company, L. P.	Water soluble paclitaxel prodrugs
CA2175282A1 (en)	1996-04-29	1997-10-30	Rudolf Edgar Falk	Use of forms of hyaluronic acid (ha) for the treatment of cancer
CA2208924A1 (en)	1997-07-09	1999-01-09	Hyal Pharmaceutical Corporation	Sparing paclitaxel by the use of hyaluronan
AU752280C (en) *	1998-05-20	2005-03-03	Chugai Seiyaku Kabushiki Kaisha	Conjugate of therapeutic agent for joint disease and hyaluronic acid.
ITPD980169A1 (it) *	1998-07-06	2000-01-06	Fidia Advanced Biopolymers Srl	Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
AU8889998A (en)	1998-08-21	2000-03-14	Pharmachemie B.V.	Water soluble analogs and prodrugs of paclitaxel
DE60036915T2 (de)	1999-01-13	2008-08-07	Alchemia Oncology Pty Ltd., Hawthorn	Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln
JP2001081103A (ja) *	1999-09-13	2001-03-27	Denki Kagaku Kogyo Kk	ヒアルロン酸結合薬剤
US6593308B2 (en)	1999-12-03	2003-07-15	The Regents Of The University Of California	Targeted drug delivery with a hyaluronan ligand
EP1250152B1 (de)	1999-12-28	2013-05-15	Bioniche Urology IP Inc.	Hyaluronsäure enthaltende synergistische Zusammensetzung zur Krebsbehandlung
IT1317358B1 (it)	2000-08-31	2003-06-16	Fidia Advanced Biopolymers Srl	Derivati cross-linkati dell'acido ialuronico.
IT1317359B1 (it)	2000-08-31	2003-06-16	Fidia Advanced Biopolymers Srl	Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e

2002
- 2002-10-18 IT IT000271A patent/ITPD20020271A1/it unknown
2003
- 2003-10-10 ES ES03748126T patent/ES2320439T3/es not_active Expired - Lifetime
- 2003-10-10 CA CA2502531A patent/CA2502531C/en not_active Expired - Lifetime
- 2003-10-10 PL PL392566A patent/PL216861B1/pl unknown
- 2003-10-10 CN CN200380101570XA patent/CN1705683B/zh not_active Expired - Lifetime
- 2003-10-10 JP JP2004544138A patent/JP4704753B2/ja not_active Expired - Lifetime
- 2003-10-10 BR BR0315431-9A patent/BR0315431A/pt not_active IP Right Cessation
- 2003-10-10 EP EP03748126A patent/EP1560854B1/de not_active Expired - Lifetime
- 2003-10-10 AU AU2003267441A patent/AU2003267441B2/en not_active Expired
- 2003-10-10 SI SI200331554T patent/SI1560854T1/sl unknown
- 2003-10-10 PT PT03748126T patent/PT1560854E/pt unknown
- 2003-10-10 RU RU2005115116/04A patent/RU2384593C2/ru active
- 2003-10-10 US US10/531,853 patent/US7897584B2/en not_active Expired - Lifetime
- 2003-10-10 PL PL03376349A patent/PL376349A1/xx unknown
- 2003-10-10 NZ NZ540034A patent/NZ540034A/en not_active IP Right Cessation
- 2003-10-10 CA CA2783175A patent/CA2783175C/en not_active Expired - Lifetime
- 2003-10-10 DE DE60325760T patent/DE60325760D1/de not_active Expired - Lifetime
- 2003-10-10 DK DK03748126T patent/DK1560854T3/da active
- 2003-10-10 NZ NZ547668A patent/NZ547668A/en not_active IP Right Cessation
- 2003-10-10 KR KR1020057006412A patent/KR101076414B1/ko not_active Expired - Lifetime
- 2003-10-10 ES ES08169661.9T patent/ES2544481T3/es not_active Expired - Lifetime
- 2003-10-10 EP EP20080169661 patent/EP2045270B1/de not_active Expired - Lifetime
- 2003-10-10 WO PCT/EP2003/011239 patent/WO2004035629A2/en not_active Ceased
- 2003-10-10 AT AT03748126T patent/ATE420117T1/de active
- 2003-10-10 HR HRP20050416AA patent/HRP20050416B1/hr not_active IP Right Cessation
2005
- 2005-04-17 IL IL168086A patent/IL168086A/en unknown
- 2005-05-18 NO NO20052399A patent/NO333042B1/no not_active IP Right Cessation
2011
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Also Published As

Publication number	Publication date
CA2783175C (en)	2013-12-24
AU2003267441A1 (en)	2004-05-04
KR20050065595A (ko)	2005-06-29
PT1560854E (pt)	2009-04-15
CA2783175A1 (en)	2004-04-29
EP2045270B1 (de)	2015-05-06
HRP20050416B1 (hr)	2013-09-30
US20110159052A1 (en)	2011-06-30
DK1560854T3 (da)	2009-04-20
NO20052399D0 (no)	2005-05-18
EP1560854B1 (de)	2009-01-07
EP1560854A2 (de)	2005-08-10
NZ547668A (en)	2008-04-30
IL168086A (en)	2010-11-30
RU2005115116A (ru)	2006-01-20
CN1705683A (zh)	2005-12-07
NO333042B1 (no)	2013-02-18
PL216861B1 (pl)	2014-05-30
KR101076414B1 (ko)	2011-10-25
DE60325760D1 (de)	2009-02-26
HK1082753A1 (en)	2006-06-16
BR0315431A (pt)	2005-08-16
PL392566A1 (pl)	2010-11-22
NO20052399L (no)	2005-05-18
NZ540034A (en)	2007-11-30
JP4704753B2 (ja)	2011-06-22
WO2004035629A2 (en)	2004-04-29
US8034795B2 (en)	2011-10-11
CA2502531A1 (en)	2004-04-29
AU2003267441B2 (en)	2010-01-14
CA2502531C (en)	2012-10-02
PL376349A1 (en)	2005-12-27
JP2006504747A (ja)	2006-02-09
WO2004035629A8 (en)	2005-06-09
RU2384593C2 (ru)	2010-03-20
HRP20050416A2 (en)	2006-02-28
ITPD20020271A1 (it)	2004-04-19
CN1705683B (zh)	2010-04-28
SI1560854T1 (sl)	2009-06-30
ES2320439T3 (es)	2009-05-22
WO2004035629A9 (en)	2005-07-07
US7897584B2 (en)	2011-03-01
EP2045270A3 (de)	2009-06-03
WO2004035629A3 (en)	2004-06-24
US20060116346A1 (en)	2006-06-01
ES2544481T3 (es)	2015-08-31
EP2045270A2 (de)	2009-04-08

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