ATE479425T1 - Sialsäure-derivate enthaltende feste dispersion - Google Patents

Sialsäure-derivate enthaltende feste dispersion

Info

Publication number: ATE479425T1
Authority: AT; Austria
Prior art keywords: solid dispersion; acid derivatives; dispersion containing; alpha; alkyl group
Prior art date: 1998-04-10

Application number

AT99916044T

Other languages

English (en)

Inventor

Takeshi Inamori

Chikako Takahashi

Yoshiyuki Fujimura

Original Assignee

Mitsubishi Chem Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-10

Filing date

1999-04-09

Publication date

2010-09-15

1999-04-09 Application filed by Mitsubishi Chem Corp filed Critical Mitsubishi Chem Corp

2010-09-15 Application granted granted Critical

2010-09-15 Publication of ATE479425T1 publication Critical patent/ATE479425T1/de

Links

239000007962 solid dispersion Substances 0.000 title abstract 2
239000002253 acid Substances 0.000 title 1
229920002521 macromolecule Polymers 0.000 abstract 2
SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical class CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 abstract 2
125000006732 (C1-C15) alkyl group Chemical group 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
-1 steroid compound Chemical group 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Colloid Chemistry (AREA)
Medicinal Preparation (AREA)

AT99916044T 1998-04-10 1999-04-09 Sialsäure-derivate enthaltende feste dispersion ATE479425T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP9889998		1998-04-10
PCT/JP1999/001907 WO1999052931A1 (fr)	1998-04-10	1999-04-09	Dispersion solide contenant un derive d'acide sialique

Publications (1)

Publication Number	Publication Date
ATE479425T1 true ATE479425T1 (de)	2010-09-15

Family

ID=14231987

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99916044T ATE479425T1 (de)	1998-04-10	1999-04-09	Sialsäure-derivate enthaltende feste dispersion

Country Status (9)

Country	Link
US (1)	US6444649B1 (de)
EP (1)	EP1070725B9 (de)
JP (1)	JP4427900B2 (de)
KR (1)	KR100525275B1 (de)
CN (1)	CN1183154C (de)
AT (1)	ATE479425T1 (de)
CA (1)	CA2328085C (de)
DE (1)	DE69942721D1 (de)
WO (1)	WO1999052931A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1027886B1 (de)	1999-02-10	2008-07-09	Pfizer Products Inc.	Pharmazeutische feste Dispersionen
US20100048524A1 (en)	2008-03-14	2010-02-25	Angela Brodie	Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
WO2009123877A1 (en) *	2008-03-21	2009-10-08	Braincells, Inc.	A method of treating a nervous system disorder by modulation of neurogenesis with mcc-257
US9119866B2 (en) *	2008-04-08	2015-09-01	Huiru Wang	Glycan-based drugs, therapies and biomarkers
EP2116139A1 (de) *	2008-05-08	2009-11-11	Nestec S.A.	Sialisäure zur Stärkung der Gehirngesundheit bei älteren Menschen
US9241896B2 (en) *	2008-12-19	2016-01-26	Ultragenyx Pharmaceutical Inc.	Methods and formulations for treating sialic acid deficiencies
WO2010091306A1 (en)	2009-02-05	2010-08-12	Tokai Pharmaceuticals	Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
BR112013000776A2 (pt)	2010-07-13	2016-05-24	Ultragenyx Pharmaceutical Inc	método e formulação para tratamento de deficiência de ácido siálico
CN103813794A (zh) *	2011-07-18	2014-05-21	拓凯制药公司	用于治疗前列腺癌的新型组合物及方法
WO2013063149A1 (en)	2011-10-24	2013-05-02	Ultragenyx Pharmaceutical, Inc.	Sialic acid analogs
EP2968370A4 (de)	2013-03-14	2016-09-21	Univ Maryland	Mittel zur androgenrezeptor-abwärtsregelung und verwendungen davon
EP3033088A4 (de)	2013-08-12	2017-03-08	Tokai Pharmaceuticals, Inc.	Biomarker zur behandlung neoplastischer störungen mit androgen-anzielenden therapien
WO2017048817A1 (en)	2015-09-14	2017-03-23	Ultragenyx Pharmaceutical Inc.	Crystal forms of sialic acid or salt or solvate thereof
CN110577557B (zh) *	2018-06-08	2022-03-11	沈阳药科大学	唾液酸脂质衍生物及其制备方法和应用
CN110478324B (zh) *	2019-08-27	2022-02-08	嘉必优生物技术（武汉）股份有限公司	一种唾液酸微粒及其制备方法

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US4229441A (en)	1978-12-01	1980-10-21	Merck & Co., Inc.	Immunologic adjuvant
JPS5877811A (ja)	1981-11-04	1983-05-11	Kanebo Ltd	安定な易吸収性ニフエジピン製剤の製法
JPH064671B2 (ja)	1985-04-02	1994-01-19	メクト株式会社	シアル酸誘導体及びその製造方法
JPH0631291B2 (ja)	1985-06-07	1994-04-27	第一製薬株式会社	Ｓ−ノイラミン酸誘導体
JPS62209094A (ja) *	1986-03-10	1987-09-14	Nippon Zoki Pharmaceut Co Ltd	新規シアル酸誘導体及びその製造方法
JPH0696535B2 (ja)	1986-05-12	1994-11-30	メクト株式会社	シアロシルコレステロ−ルの神経障害疾患治療剤
JPH07116216B2 (ja) *	1986-09-04	1995-12-13	メクト株式会社	シアロシルコレステロ−ルの製造方法
AU594468B2 (en) *	1986-05-12	1990-03-08	Mect Corporation	Sialosylcholesterol, process for its preparation, and drug for treating diseases of nervous system
JPH07116206B2 (ja)	1986-08-08	1995-12-13	和光純薬工業株式会社	新規なシアル酸誘導体
JPH0714952B2 (ja)	1986-08-08	1995-02-22	和光純薬工業株式会社	シアル酸誘導体
JPS6368526A (ja)	1986-09-11	1988-03-28	Mect Corp	シアリルグリセライドからなる神経障害疾患治療剤
JPS6452794A (en)	1987-05-29	1989-02-28	Kanto Ishi Pharma Co Ltd	Sialic acid-containing thioglycerolipid derivative and production thereof
JPH0193529A (ja)	1987-10-05	1989-04-12	Mect Corp	シアロシルコレステロールの脱髄性疾患治療剤
JP2729201B2 (ja)	1988-01-21	1998-03-18	メクト株式会社	アミド結合を持ったシアル酸誘導体
JPH0377898A (ja)	1989-08-17	1991-04-03	Mect Corp	シアロシルコレステロールからなる筋ジストロフィー症治療剤
JP2793279B2 (ja)	1989-08-22	1998-09-03	メクト株式会社	シアロシルコレステロールを含有する抗痴呆薬
JPH03151398A (ja)	1989-11-06	1991-06-27	Mect Corp	シアル酸結合生理活性ペプチド及びその製造方法
EP0642523B1 (de)	1991-11-11	1997-07-16	Symbicom Ab	Gangliosideanaloge
IT1260156B (it)	1992-08-03	1996-03-28	Fidia Spa	Derivati dell'acido neuraminico
JP3778372B2 (ja)	1993-12-24	2006-05-24	三菱化学株式会社	シアル酸誘導体
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JPH092957A (ja) *	1995-06-22	1997-01-07	Mitsubishi Chem Corp	末梢性神経障害の治療、予防薬

1999
- 1999-04-09 WO PCT/JP1999/001907 patent/WO1999052931A1/ja not_active Ceased
- 1999-04-09 CA CA002328085A patent/CA2328085C/en not_active Expired - Fee Related
- 1999-04-09 US US09/646,873 patent/US6444649B1/en not_active Expired - Fee Related
- 1999-04-09 EP EP99916044A patent/EP1070725B9/de not_active Expired - Lifetime
- 1999-04-09 DE DE69942721T patent/DE69942721D1/de not_active Expired - Lifetime
- 1999-04-09 JP JP2000543487A patent/JP4427900B2/ja not_active Expired - Fee Related
- 1999-04-09 AT AT99916044T patent/ATE479425T1/de not_active IP Right Cessation
- 1999-04-09 CN CNB998071471A patent/CN1183154C/zh not_active Expired - Fee Related
- 1999-04-09 KR KR10-2000-7011279A patent/KR100525275B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2328085C (en)	2006-08-22
EP1070725B9 (de)	2011-02-23
CN1305489A (zh)	2001-07-25
CA2328085A1 (en)	1999-10-21
WO1999052931A1 (fr)	1999-10-21
EP1070725A4 (de)	2008-12-31
DE69942721D1 (de)	2010-10-14
JP4427900B2 (ja)	2010-03-10
EP1070725B1 (de)	2010-09-01
HK1038023A1 (en)	2002-03-01
EP1070725A1 (de)	2001-01-24
KR100525275B1 (ko)	2005-11-02
KR20010042603A (ko)	2001-05-25
US6444649B1 (en)	2002-09-03
CN1183154C (zh)	2005-01-05

Legal Events

Date	Code	Title	Description
2011-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69942721D1 (de)	2010-10-14	Sialsäure-derivate enthaltende feste dispersion
ATE260255T1 (de)	2004-03-15	5-oxo-pyrrolidine-2-carbonsäure- hydroxamidderivate
EA200200374A1 (ru)	2002-10-31	Производные хинолилпропилпиперидина, их получение и содержащие их композиции
DE69434136D1 (de)	2004-12-23	Dolastatin-derivate
EP0945452A4 (de)	2002-06-05	Zuckerderivate, geliermittel, geliermittelzubereitungen, verfahren zu ihrer herstellung und gelzubereitungen
BG106622A (en)	2002-12-29	Process for preparing 4-trifluoromethylsulphinylpyrazole derivative
AU3775685A (en)	1985-07-25	Xanthine derivatives
ATE240734T1 (de)	2003-06-15	Zubereitung von xanthinderivaten als feste dispersion
CA2325045A1 (en)	1999-11-25	Gamma-aminobutyric acid derivatives containing, solid compositions and process for preparing the same
TR200100609T1 (tr)	2001-07-23	Sıvı çekici formunda dengelenmiş eczacılıkla ilgili bileşik
ATE255579T1 (de)	2003-12-15	Pyrrolidin-derivate die eine phospholipase-a2- hemmende wirkung haben
ATE278661T1 (de)	2004-10-15	Anthranilsäurederivate
FI906204A0 (fi)	1990-12-17	Menetelmä farmaseuttisesti vaikuttavien peptidiyhdisteiden valmistamiseksi
WO2002024623A3 (en)	2003-02-20	Novel alkanoic acid derivatives
NO20025035D0 (no)	2002-10-18	Oksadiazolderivater som har anticancer-effekter
AU2044697A (en)	1997-10-29	Phenylalkylcarboxylic acid derivatives
EP1847534A3 (de)	2008-09-24	Thiadiazolin-Derivate zu Behandlung von Krebs
NZ334299A (en)	1999-05-28	Fat emulsion containing xanthine derivative
AU6582394A (en)	1994-11-21	Novel bisoxadiazolidine derivative
ES2186191T3 (es)	2003-05-01	Productos de reaccion del acido fosfonico y su uso en composiciones de recubrimiento.
AU711128C (en)	2002-11-07	Anti-helicobacter pylori compositions containing 1-methylcarbapenem derivatives as the active ingredient
AU2408602A (en)	2002-06-03	Indole derivatives and use thereof in medicines
FI913658A0 (fi)	1991-07-31	4-amino-d4,6-steroider och deras anvaendning som 5a-reduktas-inhibitorer.
AU5715894A (en)	1994-07-19	Methotrexate derivative
EP1004290A3 (de)	2001-10-24	Kosmetische oder pharmazeutische Zubereitungen, enthaltend 1,3,5-Triazinderivate und Zinkoxid