BE1002665A4 - Nouvelle forme cristalline de la ciclosporine, sa preparation et les compositions pharmaceutiques la contenant. - Google Patents
Nouvelle forme cristalline de la ciclosporine, sa preparation et les compositions pharmaceutiques la contenant. Download PDFInfo
- Publication number
- BE1002665A4 BE1002665A4 BE8801421A BE8801421A BE1002665A4 BE 1002665 A4 BE1002665 A4 BE 1002665A4 BE 8801421 A BE8801421 A BE 8801421A BE 8801421 A BE8801421 A BE 8801421A BE 1002665 A4 BE1002665 A4 BE 1002665A4
- Authority
- BE
- Belgium
- Prior art keywords
- ciclosporin
- crystalline form
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
- 108010036949 Cyclosporine Proteins 0.000 title abstract 3
- 229960001265 ciclosporin Drugs 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000000699 topical effect Effects 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention a pour objet de nouvelles compositions pharmaceutiques, en particulier sous forme topique, par exemple pour une utilisation dermique ou une application topique sur l'oeil, et des formes injectables, par exemple pour une injection dans la lésion ou intra-articulaire, comprenant la Ciclosporine comme substance active sous forme cristalline orthorhombique. La Ciclosporine sous forme cristalline orthorhombique non solvatée est préférée pour une utilisation dans les compositions de l'invention, est nouvelle et fait également partie de l'invention ainsi que son utilisation et ses procédés de préparation.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13623087A | 1987-12-21 | 1987-12-21 | |
| US17261388A | 1988-03-24 | 1988-03-24 | |
| US21254888A | 1988-06-28 | 1988-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE1002665A4 true BE1002665A4 (fr) | 1991-04-30 |
Family
ID=27384838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE8801421A BE1002665A4 (fr) | 1987-12-21 | 1988-12-20 | Nouvelle forme cristalline de la ciclosporine, sa preparation et les compositions pharmaceutiques la contenant. |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPH0791316B2 (fr) |
| KR (1) | KR100188305B1 (fr) |
| AT (1) | AT403163B (fr) |
| AU (1) | AU626274B2 (fr) |
| BE (1) | BE1002665A4 (fr) |
| CA (1) | CA1341396C (fr) |
| CH (1) | CH677926A5 (fr) |
| CY (1) | CY1799A (fr) |
| DE (1) | DE3843054C2 (fr) |
| DK (1) | DK175220B1 (fr) |
| ES (1) | ES2012580A6 (fr) |
| FI (1) | FI89065C (fr) |
| FR (1) | FR2624863B1 (fr) |
| GB (1) | GB2211848B (fr) |
| GR (1) | GR1002486B (fr) |
| HK (1) | HK102894A (fr) |
| HU (1) | HU203564B (fr) |
| IE (1) | IE62006B1 (fr) |
| IL (1) | IL88719A0 (fr) |
| IT (1) | IT1235356B (fr) |
| LU (1) | LU87409A1 (fr) |
| MY (1) | MY103943A (fr) |
| NL (1) | NL195096C (fr) |
| NO (1) | NO177228C (fr) |
| NZ (1) | NZ227384A (fr) |
| SE (1) | SE503174C2 (fr) |
| SG (1) | SG99494G (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639724A (en) | 1984-07-24 | 1997-06-17 | Sandoz Ltd. | Cyclosporin galenic forms |
| GB2222770B (en) * | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
| US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
| US7081445B2 (en) | 1989-02-20 | 2006-07-25 | Novartis Ag | Cyclosporin galenic forms |
| US5294604A (en) * | 1989-12-20 | 1994-03-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating ocular diseases by periocular administration of cyclosporine A or G |
| GB9105705D0 (en) * | 1991-03-18 | 1991-05-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
| SG45449A1 (en) * | 1992-05-13 | 1998-01-16 | Sandoz Ltd | Ophthalmic compositions |
| DK0589843T3 (da) | 1992-09-25 | 2002-04-02 | Novartis Ag | Cyclosporinholdige farmaceutiske præparater |
| ATE218359T1 (de) | 1994-11-03 | 2002-06-15 | Novartis Erfind Verwalt Gmbh | Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung |
| US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US5766629A (en) | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| DE19544507B4 (de) | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin enthaltende Präparate |
| US6262054B1 (en) * | 1996-02-01 | 2001-07-17 | Sloan-Kettering Institute Of Cancer Research | Combination therapy method for treating breast cancer using edatrexate |
| PT988046E (pt) | 1997-01-30 | 2004-12-31 | Novartis Ag | Composicoes farmaceuticas sem oleo contendo ciclosporina a |
| TW581681B (en) | 1998-02-20 | 2004-04-01 | Nektar Therapeutics | Liquid crystal forms of cyclosporin |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| EP1706095B1 (fr) | 2004-01-20 | 2008-12-24 | Allergan, Inc. | Compositions pour therapie localisee de l'oeil, de preference a base de triamcinolone acetonide et d'acide hyaluronique |
| CN1763084B (zh) * | 2005-10-11 | 2010-04-21 | 山东新时代药业有限公司 | 高纯度环孢菌素a的制备方法 |
| UA113627C2 (xx) | 2011-05-27 | 2017-02-27 | Кристалічна форма циклоспорину a, фармацевтична композиція та спосіб лікування | |
| JP6363506B2 (ja) | 2011-11-15 | 2018-07-25 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | シクロスポリンａ２型の懸濁剤 |
| CN108714137B (zh) * | 2011-11-15 | 2022-02-01 | 阿勒根公司 | 环孢菌素a形式2的可热压性悬浮液 |
| CN104039813B (zh) | 2011-11-15 | 2017-08-29 | 阿勒根公司 | 环孢菌素a形式2及其制备方法 |
| KR102029513B1 (ko) * | 2011-11-15 | 2019-10-07 | 알러간, 인코포레이티드 | 사이클로스포린 제2형의 지속 작용 제형 |
| US20260132169A1 (en) * | 2022-10-20 | 2026-05-14 | Chugai Seiyaku Kabushiki Kaisha | Method for producing cyclic peptide crystals |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH614931A5 (fr) * | 1975-11-04 | 1979-12-28 | Sandoz Ag | |
| CH640519A5 (en) * | 1976-04-09 | 1984-01-13 | Sandoz Ag | Process for preparing a modified form of the antibiotic S 7481/F-1 |
| DE2819094A1 (de) * | 1977-05-10 | 1978-11-23 | Sandoz Ag | Cyclosporin-derivate, ihre verwendung und herstellung |
| CH637124A5 (en) * | 1978-10-18 | 1983-07-15 | Sandoz Ag | Antibiotic, its preparation and use |
-
1988
- 1988-12-09 HU HU886374A patent/HU203564B/hu unknown
- 1988-12-19 FR FR888816886A patent/FR2624863B1/fr not_active Expired - Lifetime
- 1988-12-19 GB GB8829556A patent/GB2211848B/en not_active Expired - Lifetime
- 1988-12-19 SE SE8804570A patent/SE503174C2/sv not_active IP Right Cessation
- 1988-12-19 FI FI885869A patent/FI89065C/fi not_active IP Right Cessation
- 1988-12-19 DK DK198807054A patent/DK175220B1/da not_active IP Right Cessation
- 1988-12-19 AU AU27055/88A patent/AU626274B2/en not_active Expired
- 1988-12-19 NZ NZ227384A patent/NZ227384A/xx unknown
- 1988-12-19 IL IL88719A patent/IL88719A0/xx unknown
- 1988-12-19 IE IE377988A patent/IE62006B1/en not_active IP Right Cessation
- 1988-12-19 NO NO885625A patent/NO177228C/no unknown
- 1988-12-19 CH CH4687/88A patent/CH677926A5/de not_active IP Right Cessation
- 1988-12-20 AT AT0309588A patent/AT403163B/de not_active IP Right Cessation
- 1988-12-20 JP JP63321857A patent/JPH0791316B2/ja not_active Expired - Lifetime
- 1988-12-20 KR KR1019880017194A patent/KR100188305B1/ko not_active Expired - Lifetime
- 1988-12-20 LU LU87409A patent/LU87409A1/fr unknown
- 1988-12-20 IT IT8848690A patent/IT1235356B/it active
- 1988-12-20 BE BE8801421A patent/BE1002665A4/fr not_active IP Right Cessation
- 1988-12-20 GR GR880100850A patent/GR1002486B/el not_active IP Right Cessation
- 1988-12-21 CA CA000586611A patent/CA1341396C/fr not_active Expired - Fee Related
- 1988-12-21 DE DE3843054A patent/DE3843054C2/de not_active Expired - Lifetime
- 1988-12-21 MY MYPI88001495A patent/MY103943A/en unknown
- 1988-12-21 NL NL8803125A patent/NL195096C/nl active Search and Examination
- 1988-12-21 ES ES8803887A patent/ES2012580A6/es not_active Expired - Lifetime
-
1994
- 1994-07-21 SG SG99494A patent/SG99494G/en unknown
- 1994-09-22 HK HK102894A patent/HK102894A/xx not_active IP Right Cessation
-
1995
- 1995-02-17 CY CY179995A patent/CY1799A/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
Non-Patent Citations (1)
| Title |
|---|
| THE MERCK INDEX, édition 10, 1983, page 396, résumé no.2748, Merck & Co., Inc., Rahway, N.J., US; "Cyclosporins" * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE20 | Patent expired |
Owner name: *NOVARTIS A.G. Effective date: 20081220 |