GR1002486B - Νεα κρυσταλλικη μορφη κυκλοσπορινης, μεθοδος παραγωγης της,φαρμακευτικες συνθεσεις περιεχουσες αυτη και η χρησις της. - Google Patents

Νεα κρυσταλλικη μορφη κυκλοσπορινης, μεθοδος παραγωγης της,φαρμακευτικες συνθεσεις περιεχουσες αυτη και η χρησις της.

Info

Publication number: GR1002486B
Authority: GR; Greece
Prior art keywords: ciclosporin; crystal form; new; production; compositions containing
Prior art date: 1987-12-21

Application number

GR880100850A

Other languages

English (en)

Other versions

GR880100850A (el

Inventor

Danielle Dr. Giron

Hans Peter Dr. Weber

Yasuyuki Uike

Martin Dr. List

Friedrich Dr. Richter

Original Assignee

Novartis Ag (Novartis Sa) (Novartis Inc.)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-21

Filing date

1988-12-20

Publication date

1996-12-09

1988-12-20 Application filed by Novartis Ag (Novartis Sa) (Novartis Inc.) filed Critical Novartis Ag (Novartis Sa) (Novartis Inc.)

1994-03-31 Publication of GR880100850A publication Critical patent/GR880100850A/el

1996-12-09 Publication of GR1002486B publication Critical patent/GR1002486B/el

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
108010036949 Cyclosporine Proteins 0.000 title abstract 3
229960001265 ciclosporin Drugs 0.000 title abstract 3
239000013078 crystal Substances 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
239000004480 active ingredient Substances 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

GR880100850A 1987-12-21 1988-12-20 Νεα κρυσταλλικη μορφη κυκλοσπορινης, μεθοδος παραγωγης της,φαρμακευτικες συνθεσεις περιεχουσες αυτη και η χρησις της. GR1002486B (el)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US13623087A	1987-12-21	1987-12-21
US17261388A	1988-03-24	1988-03-24
US21254888A	1988-06-28	1988-06-28

Publications (2)

Publication Number	Publication Date
GR880100850A GR880100850A (el)	1994-03-31
GR1002486B true GR1002486B (el)	1996-12-09

Family

ID=27384838

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR880100850A GR1002486B (el)	1987-12-21	1988-12-20	Νεα κρυσταλλικη μορφη κυκλοσπορινης, μεθοδος παραγωγης της,φαρμακευτικες συνθεσεις περιεχουσες αυτη και η χρησις της.

Country Status (27)

Country	Link
JP (1)	JPH0791316B2 (el)
KR (1)	KR100188305B1 (el)
AT (1)	AT403163B (el)
AU (1)	AU626274B2 (el)
BE (1)	BE1002665A4 (el)
CA (1)	CA1341396C (el)
CH (1)	CH677926A5 (el)
CY (1)	CY1799A (el)
DE (1)	DE3843054C2 (el)
DK (1)	DK175220B1 (el)
ES (1)	ES2012580A6 (el)
FI (1)	FI89065C (el)
FR (1)	FR2624863B1 (el)
GB (1)	GB2211848B (el)
GR (1)	GR1002486B (el)
HK (1)	HK102894A (el)
HU (1)	HU203564B (el)
IE (1)	IE62006B1 (el)
IL (1)	IL88719A0 (el)
IT (1)	IT1235356B (el)
LU (1)	LU87409A1 (el)
MY (1)	MY103943A (el)
NL (1)	NL195096C (el)
NO (1)	NO177228C (el)
NZ (1)	NZ227384A (el)
SE (1)	SE503174C2 (el)
SG (1)	SG99494G (el)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5639724A (en)	1984-07-24	1997-06-17	Sandoz Ltd.	Cyclosporin galenic forms
US6007840A (en) *	1988-09-16	1999-12-28	Novartis Ag	Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (ko) *	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
US7081445B2 (en)	1989-02-20	2006-07-25	Novartis Ag	Cyclosporin galenic forms
US5294604A (en) *	1989-12-20	1994-03-15	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) *	1991-03-18	1991-05-01	Sandoz Ltd	Improvements in or relating to organic compounds
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
SG45449A1 (en) *	1992-05-13	1998-01-16	Sandoz Ltd	Ophthalmic compositions
DK0589843T3 (da)	1992-09-25	2002-04-02	Novartis Ag	Cyclosporinholdige farmaceutiske præparater
ES2177652T3 (es)	1994-11-03	2002-12-16	Novartis Ag	Nuevas formas de preparacion de ciclosporina para la aplicacion oral con composicion simple y alta biodisponibilidad, y procedimiento para su obtencion.
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US5766629A (en)	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
DE19544507B4 (de)	1995-11-29	2007-11-15	Novartis Ag	Cyclosporin enthaltende Präparate
US6262054B1 (en)	1996-02-01	2001-07-17	Sloan-Kettering Institute Of Cancer Research	Combination therapy method for treating breast cancer using edatrexate
KR20050084502A (ko)	1997-01-30	2005-08-26	노파르티스 아게	오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물
TW581681B (en)	1998-02-20	2004-04-01	Nektar Therapeutics	Liquid crystal forms of cyclosporin
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
CN100548271C (zh)	2004-01-20	2009-10-14	阿勒根公司	用于眼部的局部治疗、并优选包括有曲安奈德及透明质酸的组合物
CN1763084B (zh) *	2005-10-11	2010-04-21	山东新时代药业有限公司	高纯度环孢菌素a的制备方法
BR112013030554B1 (pt) *	2011-05-27	2020-12-15	Allergan, Inc.	Forma cristalina de ciclosporina a, métodos de preparação e métodos para uso da mesma
RU2641963C2 (ru) *	2011-11-15	2018-01-23	Аллерган, Инк.	Взвеси циклоспорина а формы 2
US20130123194A1 (en) *	2011-11-15	2013-05-16	Allergan, Inc.	Autoclavable suspensions of cyclosporin a form 2
CA2856034C (en) *	2011-11-15	2017-12-12	Allergan, Inc.	Cyclosporin a form 2 and method of making same
US8785394B2 (en) *	2011-11-15	2014-07-22	Allergan, Inc.	Sustained action formulation of cyclosporin form 2
TW202430537A (zh) *	2022-10-20	2024-08-01	日商中外製藥股份有限公司	環狀胜肽的結晶的製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH614931A5 (el) *	1975-11-04	1979-12-28	Sandoz Ag
CH640519A5 (en) *	1976-04-09	1984-01-13	Sandoz Ag	Process for preparing a modified form of the antibiotic S 7481/F-1
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds
DE2819094A1 (de) *	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
CH637124A5 (en) *	1978-10-18	1983-07-15	Sandoz Ag	Antibiotic, its preparation and use

1988
- 1988-12-09 HU HU886374A patent/HU203564B/hu unknown
- 1988-12-19 NO NO885625A patent/NO177228C/no unknown
- 1988-12-19 AU AU27055/88A patent/AU626274B2/en not_active Expired
- 1988-12-19 FI FI885869A patent/FI89065C/fi not_active IP Right Cessation
- 1988-12-19 IE IE377988A patent/IE62006B1/en not_active IP Right Cessation
- 1988-12-19 CH CH4687/88A patent/CH677926A5/de not_active IP Right Cessation
- 1988-12-19 SE SE8804570A patent/SE503174C2/sv not_active IP Right Cessation
- 1988-12-19 NZ NZ227384A patent/NZ227384A/xx unknown
- 1988-12-19 DK DK198807054A patent/DK175220B1/da not_active IP Right Cessation
- 1988-12-19 IL IL88719A patent/IL88719A0/xx unknown
- 1988-12-19 FR FR888816886A patent/FR2624863B1/fr not_active Expired - Lifetime
- 1988-12-19 GB GB8829556A patent/GB2211848B/en not_active Expired - Lifetime
- 1988-12-20 LU LU87409A patent/LU87409A1/fr unknown
- 1988-12-20 KR KR1019880017194A patent/KR100188305B1/ko not_active Expired - Lifetime
- 1988-12-20 IT IT8848690A patent/IT1235356B/it active
- 1988-12-20 BE BE8801421A patent/BE1002665A4/fr not_active IP Right Cessation
- 1988-12-20 JP JP63321857A patent/JPH0791316B2/ja not_active Expired - Lifetime
- 1988-12-20 AT AT0309588A patent/AT403163B/de not_active IP Right Cessation
- 1988-12-20 GR GR880100850A patent/GR1002486B/el not_active IP Right Cessation
- 1988-12-21 CA CA000586611A patent/CA1341396C/en not_active Expired - Fee Related
- 1988-12-21 DE DE3843054A patent/DE3843054C2/de not_active Expired - Lifetime
- 1988-12-21 NL NL8803125A patent/NL195096C/nl active Search and Examination
- 1988-12-21 ES ES8803887A patent/ES2012580A6/es not_active Expired - Lifetime
- 1988-12-21 MY MYPI88001495A patent/MY103943A/en unknown
1994
- 1994-07-21 SG SG99494A patent/SG99494G/en unknown
- 1994-09-22 HK HK102894A patent/HK102894A/xx not_active IP Right Cessation
1995
- 1995-02-17 CY CY179995A patent/CY1799A/en unknown

Also Published As

Publication number	Publication date
NZ227384A (en)	1991-09-25
DK705488A (da)	1989-06-22
CH677926A5 (el)	1991-07-15
LU87409A1 (fr)	1989-07-07
NL195096C (nl)	2004-02-09
DK175220B1 (da)	2004-07-12
JPH01211598A (ja)	1989-08-24
FR2624863A1 (fr)	1989-06-23
IT8848690A0 (it)	1988-12-20
SE8804570D0 (sv)	1988-12-19
KR100188305B1 (ko)	1999-06-01
BE1002665A4 (fr)	1991-04-30
GR880100850A (el)	1994-03-31
MY103943A (en)	1993-10-30
HK102894A (en)	1994-09-30
IT1235356B (it)	1992-06-30
CY1799A (en)	1995-02-17
CA1341396C (en)	2002-11-05
NL8803125A (nl)	1989-07-17
AT403163B (de)	1997-11-25
ES2012580A6 (es)	1990-04-01
JPH0791316B2 (ja)	1995-10-04
FR2624863B1 (fr)	1991-04-26
NO885625D0 (no)	1988-12-19
GB2211848B (en)	1991-11-06
ATA309588A (de)	1997-04-15
FI885869A0 (fi)	1988-12-19
FI89065C (fi)	1993-09-30
SE8804570L (sv)	1989-06-22
DE3843054A1 (de)	1989-07-27
AU626274B2 (en)	1992-07-30
DK705488D0 (da)	1988-12-19
NO885625L (no)	1989-06-22
SE503174C2 (sv)	1996-04-15
IL88719A0 (en)	1989-07-31
IE62006B1 (en)	1994-12-14
AU2705588A (en)	1989-06-22
FI885869L (fi)	1989-06-22
FI89065B (fi)	1993-04-30
IE883779L (en)	1989-06-21
KR890009975A (ko)	1989-08-05
SG99494G (en)	1994-10-28
HUT49893A (en)	1989-11-28
NO177228B (no)	1995-05-02
DE3843054C2 (de)	2003-08-21
NO177228C (no)	1995-08-09
HU203564B (en)	1991-08-28
GB8829556D0 (en)	1989-02-08
GB2211848A (en)	1989-07-12

Legal Events

Date	Code	Title	Description
2008-12-21	MA	Right expired

Publication	Publication Date	Title
MY103943A (en)	1993-10-30	Orthorhombic ciclosporin crystal form, process for its production and pharmaceutical compositions containing it
EG18379A (en)	1992-11-30	Novel pharmacological compounds
CA2000786A1 (en)	1990-05-07	3-piperidinyl-1,2-benzisoxazoles
EP0335901A4 (en)	1990-11-28	Methods and compositions for the treatment of non-ige-mediated diseases
IE891798L (en)	1989-12-02	Novel ó-glucosidase inhibitors
PH31617A (en)	1999-01-12	Novel thienylcarboxylates of amino alcohols, theirquaternary products and use of these compounds.
GEP20022636B (en)	2002-02-25	4-[5-Methyl-3-Phenylisoxazol-4-Yl] Benzenesulfonamide, Its Crystal Structure B, Pharmaceutical Composition Containing The Same, Methods For Treatment Or Prophylaxis Of Disorders Caused By Cyclooxygen-2
UA35574C2 (uk)	2001-04-16	Похідні заміщеної гетероциклом фенілциклогексанкарбонової кислоти, суміші їх ізомерів або окремі ізомери та їх солі
ATE330943T1 (de)	2006-07-15	Herstellungsverfahren von huperzine a und deren analogen und verbindungen nützlich dazu
EP0288959A3 (en)	1990-05-23	Novel glycoprotein, production process thereof and immunosuppressive agent containing same as effective ingredient
HUT50347A (en)	1990-01-29	Process for production of cefalosporin-salts and injectable compositions containing them as active sobstance
MY107449A (en)	1995-12-31	Bcrf1 proteins as inhibitors of interferon- gamma.
HUT58765A (en)	1992-03-30	Process for producing peptide compounds and pharmaceutical compositions containing them as active components
HUT55034A (en)	1991-04-29	Process for producing peptides with hemoregulating effect and pharmaceutical compositions comprising such compounds as active ingredient
AU6415994A (en)	1994-10-24	Substituted caprolactams and derivatives thereof useful for treatment of hiv disease
CA2047802A1 (en)	1992-01-26	Pharmaceutical compositions
EP0273310A3 (en)	1991-01-09	5-aryl-3h-1,2,4-triazol-3-ones and their use as anticonvulsants
WO1990007260A3 (en)	1990-11-01	2,3-methanoproline
GR3015132T3 (en)	1995-05-31	Novel ureas and thioureas, preparation thereof and application in therapy.
ZA889540B (en)	1990-08-29	New cyclosporin crystal form,processes for its production,pharmaceutical compositions containing it and its use
ES8300475A1 (es)	1982-11-01	Un procedimiento para la preparacion de un alergeno
ES8204713A1 (es)	1982-05-16	Un procedimiento para aislar un polipeptido purificado
AU578125B2 (en)	1988-10-13	Pyrazine diazohydroxide compounds
MY103584A (en)	1993-08-28	8(alpha)-acylaminoergoline, its preparation and pharmaceutical compositions containing it
GEP20002095B (en)	2000-05-10	Antracycline Disaccharides, Process for Their Preparation and Pharmaceutical Compositions