IT1235356B - Forma cristallina della ciclosporina, la sua preparazione e composizioni farmaceutiche che la contengono - Google Patents

Forma cristallina della ciclosporina, la sua preparazione e composizioni farmaceutiche che la contengono

Info

Publication number: IT1235356B
Authority: IT; Italy
Prior art keywords: cyclosporine; contain; preparation; pharmaceutical compositions; crystalline form
Prior art date: 1987-12-21

Application number

IT8848690A

Other languages

English (en)

Other versions

IT8848690A0 (it

Inventor

Giron Danielle

List Martin

Richter Friederich

Weber Hans Peter

Yasuyuki Uike

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-21

Filing date

1988-12-20

Publication date

1992-06-30

1988-12-20 Application filed by Sandoz Ag filed Critical Sandoz Ag

1988-12-20 Publication of IT8848690A0 publication Critical patent/IT8848690A0/it

1992-06-30 Application granted granted Critical

1992-06-30 Publication of IT1235356B publication Critical patent/IT1235356B/it

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
108010036949 Cyclosporine Proteins 0.000 title 1
229960001265 ciclosporin Drugs 0.000 title 1
229930182912 cyclosporin Natural products 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

IT8848690A 1987-12-21 1988-12-20 Forma cristallina della ciclosporina, la sua preparazione e composizioni farmaceutiche che la contengono IT1235356B (it)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US13623087A	1987-12-21	1987-12-21
US17261388A	1988-03-24	1988-03-24
US21254888A	1988-06-28	1988-06-28

Publications (2)

Publication Number	Publication Date
IT8848690A0 IT8848690A0 (it)	1988-12-20
IT1235356B true IT1235356B (it)	1992-06-30

Family

ID=27384838

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8848690A IT1235356B (it)	1987-12-21	1988-12-20	Forma cristallina della ciclosporina, la sua preparazione e composizioni farmaceutiche che la contengono

Country Status (27)

Country	Link
JP (1)	JPH0791316B2 (it)
KR (1)	KR100188305B1 (it)
AT (1)	AT403163B (it)
AU (1)	AU626274B2 (it)
BE (1)	BE1002665A4 (it)
CA (1)	CA1341396C (it)
CH (1)	CH677926A5 (it)
CY (1)	CY1799A (it)
DE (1)	DE3843054C2 (it)
DK (1)	DK175220B1 (it)
ES (1)	ES2012580A6 (it)
FI (1)	FI89065C (it)
FR (1)	FR2624863B1 (it)
GB (1)	GB2211848B (it)
GR (1)	GR1002486B (it)
HK (1)	HK102894A (it)
HU (1)	HU203564B (it)
IE (1)	IE62006B1 (it)
IL (1)	IL88719A0 (it)
IT (1)	IT1235356B (it)
LU (1)	LU87409A1 (it)
MY (1)	MY103943A (it)
NL (1)	NL195096C (it)
NO (1)	NO177228C (it)
NZ (1)	NZ227384A (it)
SE (1)	SE503174C2 (it)
SG (1)	SG99494G (it)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5639724A (en)	1984-07-24	1997-06-17	Sandoz Ltd.	Cyclosporin galenic forms
GB2222770B (en) *	1988-09-16	1992-07-29	Sandoz Ltd	Pharmaceutical compositions containing cyclosporins
US6007840A (en) *	1988-09-16	1999-12-28	Novartis Ag	Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en)	1989-02-20	2006-07-25	Novartis Ag	Cyclosporin galenic forms
US5294604A (en) *	1989-12-20	1994-03-15	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) *	1991-03-18	1991-05-01	Sandoz Ltd	Improvements in or relating to organic compounds
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
DE69307505T2 (de) *	1992-05-13	1997-07-24	Sandoz-Patent-Gmbh, 79539 Loerrach	Opthalmische zusammensetzungen enthaltend ein cyclosporin
EP1142568A1 (en)	1992-09-25	2001-10-10	Novartis AG	Pharmaceutical compositions containing cyclosporins
AU715165B2 (en)	1994-11-03	2000-01-20	Novartis Ag	Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them
US5766629A (en)	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
DE19544507B4 (de)	1995-11-29	2007-11-15	Novartis Ag	Cyclosporin enthaltende Präparate
US6262054B1 (en)	1996-02-01	2001-07-17	Sloan-Kettering Institute Of Cancer Research	Combination therapy method for treating breast cancer using edatrexate
EP1331002A3 (en)	1997-01-30	2004-01-14	Novartis AG	Oil-free pharmaceutical compositions containing cyclosporin A
TW581681B (en)	1998-02-20	2004-04-01	Nektar Therapeutics	Liquid crystal forms of cyclosporin
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
EP1706095B1 (en)	2004-01-20	2008-12-24	Allergan, Inc.	Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
CN1763084B (zh) *	2005-10-11	2010-04-21	山东新时代药业有限公司	高纯度环孢菌素a的制备方法
CA2836946C (en)	2011-05-27	2017-08-01	Allergan, Inc.	A crystalline form of cyclosporine a, methods of preparation, and methods for use thereof
RU2630970C2 (ru) *	2011-11-15	2017-09-15	Аллерган, Инк.	Автоклавируемые взвеси циклоспорина а формы 2
ES2666191T3 (es) *	2011-11-15	2018-05-03	Allergan, Inc.	Un proceso para la cristalización de la forma 2 de la ciclosporina A
RU2639393C2 (ru)	2011-11-15	2017-12-21	Аллерган, Инк.	Состав пролонгированного действия циклоспорина формы 2
JP6363506B2 (ja)	2011-11-15	2018-07-25	アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ	シクロスポリンａ２型の懸濁剤
EP4585605A1 (en) *	2022-10-20	2025-07-16	Chugai Seiyaku Kabushiki Kaisha	Method for producing cyclic peptide crystals

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH614931A5 (it) *	1975-11-04	1979-12-28	Sandoz Ag
CH640519A5 (en) *	1976-04-09	1984-01-13	Sandoz Ag	Process for preparing a modified form of the antibiotic S 7481/F-1
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds
DE2819094A1 (de) *	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
CH637124A5 (en) *	1978-10-18	1983-07-15	Sandoz Ag	Antibiotic, its preparation and use

1988
- 1988-12-09 HU HU886374A patent/HU203564B/hu unknown
- 1988-12-19 GB GB8829556A patent/GB2211848B/en not_active Expired - Lifetime
- 1988-12-19 CH CH4687/88A patent/CH677926A5/de not_active IP Right Cessation
- 1988-12-19 AU AU27055/88A patent/AU626274B2/en not_active Expired
- 1988-12-19 IL IL88719A patent/IL88719A0/xx unknown
- 1988-12-19 DK DK198807054A patent/DK175220B1/da not_active IP Right Cessation
- 1988-12-19 NZ NZ227384A patent/NZ227384A/xx unknown
- 1988-12-19 FI FI885869A patent/FI89065C/fi not_active IP Right Cessation
- 1988-12-19 NO NO885625A patent/NO177228C/no unknown
- 1988-12-19 FR FR888816886A patent/FR2624863B1/fr not_active Expired - Lifetime
- 1988-12-19 SE SE8804570A patent/SE503174C2/sv not_active IP Right Cessation
- 1988-12-19 IE IE377988A patent/IE62006B1/en not_active IP Right Cessation
- 1988-12-20 GR GR880100850A patent/GR1002486B/el not_active IP Right Cessation
- 1988-12-20 BE BE8801421A patent/BE1002665A4/fr not_active IP Right Cessation
- 1988-12-20 AT AT0309588A patent/AT403163B/de not_active IP Right Cessation
- 1988-12-20 JP JP63321857A patent/JPH0791316B2/ja not_active Expired - Lifetime
- 1988-12-20 IT IT8848690A patent/IT1235356B/it active
- 1988-12-20 KR KR1019880017194A patent/KR100188305B1/ko not_active Expired - Lifetime
- 1988-12-20 LU LU87409A patent/LU87409A1/fr unknown
- 1988-12-21 MY MYPI88001495A patent/MY103943A/en unknown
- 1988-12-21 CA CA000586611A patent/CA1341396C/en not_active Expired - Fee Related
- 1988-12-21 NL NL8803125A patent/NL195096C/nl active Search and Examination
- 1988-12-21 DE DE3843054A patent/DE3843054C2/de not_active Expired - Lifetime
- 1988-12-21 ES ES8803887A patent/ES2012580A6/es not_active Expired - Lifetime
1994
- 1994-07-21 SG SG99494A patent/SG99494G/en unknown
- 1994-09-22 HK HK102894A patent/HK102894A/xx not_active IP Right Cessation
1995
- 1995-02-17 CY CY179995A patent/CY1799A/en unknown

Also Published As

Publication number	Publication date
IE883779L (en)	1989-06-21
GB2211848A (en)	1989-07-12
NZ227384A (en)	1991-09-25
IL88719A0 (en)	1989-07-31
NL8803125A (nl)	1989-07-17
CH677926A5 (it)	1991-07-15
SE8804570D0 (sv)	1988-12-19
MY103943A (en)	1993-10-30
NO177228B (no)	1995-05-02
ES2012580A6 (es)	1990-04-01
FR2624863A1 (fr)	1989-06-23
KR100188305B1 (ko)	1999-06-01
DE3843054A1 (de)	1989-07-27
CA1341396C (en)	2002-11-05
HK102894A (en)	1994-09-30
JPH01211598A (ja)	1989-08-24
DK705488D0 (da)	1988-12-19
NL195096C (nl)	2004-02-09
HUT49893A (en)	1989-11-28
GB8829556D0 (en)	1989-02-08
KR890009975A (ko)	1989-08-05
DE3843054C2 (de)	2003-08-21
AU2705588A (en)	1989-06-22
GR1002486B (el)	1996-12-09
HU203564B (en)	1991-08-28
GB2211848B (en)	1991-11-06
JPH0791316B2 (ja)	1995-10-04
DK175220B1 (da)	2004-07-12
FI89065C (fi)	1993-09-30
FR2624863B1 (fr)	1991-04-26
AU626274B2 (en)	1992-07-30
NO885625L (no)	1989-06-22
BE1002665A4 (fr)	1991-04-30
IE62006B1 (en)	1994-12-14
SE8804570L (sv)	1989-06-22
FI885869L (fi)	1989-06-22
FI89065B (fi)	1993-04-30
GR880100850A (el)	1994-03-31
SE503174C2 (sv)	1996-04-15
SG99494G (en)	1994-10-28
CY1799A (en)	1995-02-17
NO177228C (no)	1995-08-09
ATA309588A (de)	1997-04-15
AT403163B (de)	1997-11-25
FI885869A0 (fi)	1988-12-19
LU87409A1 (fr)	1989-07-07
DK705488A (da)	1989-06-22
NO885625D0 (no)	1988-12-19
IT8848690A0 (it)	1988-12-20

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19971205

Publication	Publication Date	Title
IT1235356B (it)	1992-06-30	Forma cristallina della ciclosporina, la sua preparazione e composizioni farmaceutiche che la contengono
DK89090A (da)	1990-04-09	Farmaceutisk praeparat
SE8801813L (sv)	1988-11-15	Pharmaceutical composition
KR890701101A (ko)	1989-12-19	제약학적 조성물
IT8748729A0 (it)	1987-12-18	Idrosoli di sostanze farmacologicamente attive e composizioni farmaceutiche che li contengono
DK159688D0 (da)	1988-03-23	Antimikrobielt praeparat med forsinket frigivelse
DK130287D0 (da)	1987-03-13	Oralt praeparat
IT1240605B (it)	1993-12-17	Composizione farmaceutica solida e procedimento per la sua preparazione
IT8748544A0 (it)	1987-10-28	Alfa-amminoacidi sostituiti,loro preparazione e composizioni farmaceutiche che li contengono
TR24553A (tr)	1991-11-21	Granueler halinde fosfor icermiyen agartma-maddesi ni aktiflestirici bilesimleri
IT8222768A0 (it)	1982-08-06	Alcaloidi peptidici della segale cornuta, loro preparazione e composizioni farmaceutiche che licontengono.
IT8922164A0 (it)	1989-10-27	Composizione farmaceutica e procedimento per la sua preparazione
IT1226586B (it)	1991-01-24	Composizioni farmaceutiche che favoriscono la cicatrizzazione di ferite e procedimento per prepararle
IT1216139B (it)	1990-02-22	Composizione dietetica eprocedimento per la sua preparazione.
DK139388A (da)	1988-12-08	Farmaceutisk praeparat
ITMI912002A0 (it)	1991-07-19	Composizione farmaceutica solida e procedimento per la sua preparazione
IT8620136A0 (it)	1986-04-18	(-)-1beta-etil-1alfa-idrossimentil1,2,3,4,6,7,12,12balfa-ottaidroindo lo [2,3-a] chinolizina, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono
DK276288D0 (da)	1988-05-20	Farmaceutisk praeparat
IT8548964A0 (it)	1985-12-20	8alfa-acilamminoergoline,loro preparazione e composizioni farmaceutiche che le contengono
IT8721958A0 (it)	1987-09-18	Derivato di taurina, sua preparazione e composizioni farmaceutiche relative
IT1216814B (it)	1990-03-14	Composizioni farmaceutiche
FI881648L (fi)	1988-10-11	Shampookoostumuksia
BR8807102A (pt)	1989-10-17	Preparacao de novos adocantes de proteina
IT8522364A0 (it)	1985-10-04	Derivato diidropiridinico, procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono.
DK138888A (da)	1988-09-19	Farmaceutisk praeparat