IT1235356B - Forma cristallina della ciclosporina, la sua preparazione e composizioni farmaceutiche che la contengono - Google Patents

Forma cristallina della ciclosporina, la sua preparazione e composizioni farmaceutiche che la contengono

Info

Publication number: IT1235356B
Authority: IT; Italy
Prior art keywords: cyclosporine; contain; preparation; pharmaceutical compositions; crystalline form
Prior art date: 1987-12-21

Application number

IT8848690A

Other languages

English (en)

Other versions

IT8848690A0 (it

Inventor

Giron Danielle

List Martin

Richter Friederich

Weber Hans Peter

Yasuyuki Uike

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-21

Filing date

1988-12-20

Publication date

1992-06-30

1988-12-20 Application filed by Sandoz Ag filed Critical Sandoz Ag

1988-12-20 Publication of IT8848690A0 publication Critical patent/IT8848690A0/it

1992-06-30 Application granted granted Critical

1992-06-30 Publication of IT1235356B publication Critical patent/IT1235356B/it

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
108010036949 Cyclosporine Proteins 0.000 title 1
229960001265 ciclosporin Drugs 0.000 title 1
229930182912 cyclosporin Natural products 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

IT8848690A 1987-12-21 1988-12-20 Forma cristallina della ciclosporina, la sua preparazione e composizioni farmaceutiche che la contengono IT1235356B (it)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US13623087A	1987-12-21	1987-12-21
US17261388A	1988-03-24	1988-03-24
US21254888A	1988-06-28	1988-06-28

Publications (2)

Publication Number	Publication Date
IT8848690A0 IT8848690A0 (it)	1988-12-20
IT1235356B true IT1235356B (it)	1992-06-30

Family

ID=27384838

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8848690A IT1235356B (it)	1987-12-21	1988-12-20	Forma cristallina della ciclosporina, la sua preparazione e composizioni farmaceutiche che la contengono

Country Status (27)

Country	Link
JP (1)	JPH0791316B2 (it)
KR (1)	KR100188305B1 (it)
AT (1)	AT403163B (it)
AU (1)	AU626274B2 (it)
BE (1)	BE1002665A4 (it)
CA (1)	CA1341396C (it)
CH (1)	CH677926A5 (it)
CY (1)	CY1799A (it)
DE (1)	DE3843054C2 (it)
DK (1)	DK175220B1 (it)
ES (1)	ES2012580A6 (it)
FI (1)	FI89065C (it)
FR (1)	FR2624863B1 (it)
GB (1)	GB2211848B (it)
GR (1)	GR1002486B (it)
HK (1)	HK102894A (it)
HU (1)	HU203564B (it)
IE (1)	IE62006B1 (it)
IL (1)	IL88719A0 (it)
IT (1)	IT1235356B (it)
LU (1)	LU87409A1 (it)
MY (1)	MY103943A (it)
NL (1)	NL195096C (it)
NO (1)	NO177228C (it)
NZ (1)	NZ227384A (it)
SE (1)	SE503174C2 (it)
SG (1)	SG99494G (it)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5639724A (en)	1984-07-24	1997-06-17	Sandoz Ltd.	Cyclosporin galenic forms
US6007840A (en) *	1988-09-16	1999-12-28	Novartis Ag	Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (ko) *	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
US7081445B2 (en)	1989-02-20	2006-07-25	Novartis Ag	Cyclosporin galenic forms
US5294604A (en) *	1989-12-20	1994-03-15	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) *	1991-03-18	1991-05-01	Sandoz Ltd	Improvements in or relating to organic compounds
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
SG45449A1 (en) *	1992-05-13	1998-01-16	Sandoz Ltd	Ophthalmic compositions
DK0589843T3 (da)	1992-09-25	2002-04-02	Novartis Ag	Cyclosporinholdige farmaceutiske præparater
ES2177652T3 (es)	1994-11-03	2002-12-16	Novartis Ag	Nuevas formas de preparacion de ciclosporina para la aplicacion oral con composicion simple y alta biodisponibilidad, y procedimiento para su obtencion.
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US5766629A (en)	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
DE19544507B4 (de)	1995-11-29	2007-11-15	Novartis Ag	Cyclosporin enthaltende Präparate
US6262054B1 (en)	1996-02-01	2001-07-17	Sloan-Kettering Institute Of Cancer Research	Combination therapy method for treating breast cancer using edatrexate
KR20050084502A (ko)	1997-01-30	2005-08-26	노파르티스 아게	오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물
TW581681B (en)	1998-02-20	2004-04-01	Nektar Therapeutics	Liquid crystal forms of cyclosporin
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
CN100548271C (zh)	2004-01-20	2009-10-14	阿勒根公司	用于眼部的局部治疗、并优选包括有曲安奈德及透明质酸的组合物
CN1763084B (zh) *	2005-10-11	2010-04-21	山东新时代药业有限公司	高纯度环孢菌素a的制备方法
BR112013030554B1 (pt) *	2011-05-27	2020-12-15	Allergan, Inc.	Forma cristalina de ciclosporina a, métodos de preparação e métodos para uso da mesma
RU2641963C2 (ru) *	2011-11-15	2018-01-23	Аллерган, Инк.	Взвеси циклоспорина а формы 2
US20130123194A1 (en) *	2011-11-15	2013-05-16	Allergan, Inc.	Autoclavable suspensions of cyclosporin a form 2
CA2856034C (en) *	2011-11-15	2017-12-12	Allergan, Inc.	Cyclosporin a form 2 and method of making same
US8785394B2 (en) *	2011-11-15	2014-07-22	Allergan, Inc.	Sustained action formulation of cyclosporin form 2
TW202430537A (zh) *	2022-10-20	2024-08-01	日商中外製藥股份有限公司	環狀胜肽的結晶的製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH614931A5 (it) *	1975-11-04	1979-12-28	Sandoz Ag
CH640519A5 (en) *	1976-04-09	1984-01-13	Sandoz Ag	Process for preparing a modified form of the antibiotic S 7481/F-1
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds
DE2819094A1 (de) *	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
CH637124A5 (en) *	1978-10-18	1983-07-15	Sandoz Ag	Antibiotic, its preparation and use

1988
- 1988-12-09 HU HU886374A patent/HU203564B/hu unknown
- 1988-12-19 NO NO885625A patent/NO177228C/no unknown
- 1988-12-19 AU AU27055/88A patent/AU626274B2/en not_active Expired
- 1988-12-19 FI FI885869A patent/FI89065C/fi not_active IP Right Cessation
- 1988-12-19 IE IE377988A patent/IE62006B1/en not_active IP Right Cessation
- 1988-12-19 CH CH4687/88A patent/CH677926A5/de not_active IP Right Cessation
- 1988-12-19 SE SE8804570A patent/SE503174C2/sv not_active IP Right Cessation
- 1988-12-19 NZ NZ227384A patent/NZ227384A/xx unknown
- 1988-12-19 DK DK198807054A patent/DK175220B1/da not_active IP Right Cessation
- 1988-12-19 IL IL88719A patent/IL88719A0/xx unknown
- 1988-12-19 FR FR888816886A patent/FR2624863B1/fr not_active Expired - Lifetime
- 1988-12-19 GB GB8829556A patent/GB2211848B/en not_active Expired - Lifetime
- 1988-12-20 LU LU87409A patent/LU87409A1/fr unknown
- 1988-12-20 KR KR1019880017194A patent/KR100188305B1/ko not_active Expired - Lifetime
- 1988-12-20 IT IT8848690A patent/IT1235356B/it active
- 1988-12-20 BE BE8801421A patent/BE1002665A4/fr not_active IP Right Cessation
- 1988-12-20 JP JP63321857A patent/JPH0791316B2/ja not_active Expired - Lifetime
- 1988-12-20 AT AT0309588A patent/AT403163B/de not_active IP Right Cessation
- 1988-12-20 GR GR880100850A patent/GR1002486B/el not_active IP Right Cessation
- 1988-12-21 CA CA000586611A patent/CA1341396C/en not_active Expired - Fee Related
- 1988-12-21 DE DE3843054A patent/DE3843054C2/de not_active Expired - Lifetime
- 1988-12-21 NL NL8803125A patent/NL195096C/nl active Search and Examination
- 1988-12-21 ES ES8803887A patent/ES2012580A6/es not_active Expired - Lifetime
- 1988-12-21 MY MYPI88001495A patent/MY103943A/en unknown
1994
- 1994-07-21 SG SG99494A patent/SG99494G/en unknown
- 1994-09-22 HK HK102894A patent/HK102894A/xx not_active IP Right Cessation
1995
- 1995-02-17 CY CY179995A patent/CY1799A/en unknown

Also Published As

Publication number	Publication date
NZ227384A (en)	1991-09-25
DK705488A (da)	1989-06-22
CH677926A5 (it)	1991-07-15
LU87409A1 (fr)	1989-07-07
NL195096C (nl)	2004-02-09
DK175220B1 (da)	2004-07-12
JPH01211598A (ja)	1989-08-24
FR2624863A1 (fr)	1989-06-23
IT8848690A0 (it)	1988-12-20
SE8804570D0 (sv)	1988-12-19
KR100188305B1 (ko)	1999-06-01
BE1002665A4 (fr)	1991-04-30
GR1002486B (el)	1996-12-09
GR880100850A (el)	1994-03-31
MY103943A (en)	1993-10-30
HK102894A (en)	1994-09-30
CY1799A (en)	1995-02-17
CA1341396C (en)	2002-11-05
NL8803125A (nl)	1989-07-17
AT403163B (de)	1997-11-25
ES2012580A6 (es)	1990-04-01
JPH0791316B2 (ja)	1995-10-04
FR2624863B1 (fr)	1991-04-26
NO885625D0 (no)	1988-12-19
GB2211848B (en)	1991-11-06
ATA309588A (de)	1997-04-15
FI885869A0 (fi)	1988-12-19
FI89065C (fi)	1993-09-30
SE8804570L (sv)	1989-06-22
DE3843054A1 (de)	1989-07-27
AU626274B2 (en)	1992-07-30
DK705488D0 (da)	1988-12-19
NO885625L (no)	1989-06-22
SE503174C2 (sv)	1996-04-15
IL88719A0 (en)	1989-07-31
IE62006B1 (en)	1994-12-14
AU2705588A (en)	1989-06-22
FI885869L (fi)	1989-06-22
FI89065B (fi)	1993-04-30
IE883779L (en)	1989-06-21
KR890009975A (ko)	1989-08-05
SG99494G (en)	1994-10-28
HUT49893A (en)	1989-11-28
NO177228B (no)	1995-05-02
DE3843054C2 (de)	2003-08-21
NO177228C (no)	1995-08-09
HU203564B (en)	1991-08-28
GB8829556D0 (en)	1989-02-08
GB2211848A (en)	1989-07-12

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19971205

Publication	Publication Date	Title
IT8848690A0 (it)	1988-12-20	Forma cristallina della ciclosporina, la sua preparazione e composizioni farmaceutiche che la comprendono
DK89090D0 (da)	1990-04-09	Farmaceutisk praeparat
SE8801813L (sv)	1988-11-15	Pharmaceutical composition
IT8748729A0 (it)	1987-12-18	Idrosoli di sostanze farmacologicamente attive e composizioni farmaceutiche che li contengono
DK159688A (da)	1988-09-24	Antimikrobielt praeparat med forsinket frigivelse
IT1240605B (it)	1993-12-17	Composizione farmaceutica solida e procedimento per la sua preparazione
IT8748544A0 (it)	1987-10-28	Alfa-amminoacidi sostituiti,loro preparazione e composizioni farmaceutiche che li contengono
TR24553A (tr)	1991-11-21	Granueler halinde fosfor icermiyen agartma-maddesi ni aktiflestirici bilesimleri
IT8222768A0 (it)	1982-08-06	Alcaloidi peptidici della segale cornuta, loro preparazione e composizioni farmaceutiche che licontengono.
IT8922164A0 (it)	1989-10-27	Composizione farmaceutica e procedimento per la sua preparazione
IT8719165A0 (it)	1987-01-26	Derivato di acido tiazolidin-4-carbossilico, sua preparazione e composizioni farmaceutiche che lo contengono.
IT1226586B (it)	1991-01-24	Composizioni farmaceutiche che favoriscono la cicatrizzazione di ferite e procedimento per prepararle
FI884750A7 (fi)	1989-04-17	Shampookoostumuksia
IT1216139B (it)	1990-02-22	Composizione dietetica eprocedimento per la sua preparazione.
IT1204306B (it)	1989-03-01	(-)-1beta-etil-1alfa-idrossimentil-1,2,3,4,6,7,12,12balfa-ottaidroindolo (2,3-a)chinolizina,procedimento per la sua preparazione e composizioni farmaceutiche che la contengono
ITMI912002A0 (it)	1991-07-19	Composizione farmaceutica solida e procedimento per la sua preparazione
DK276288D0 (da)	1988-05-20	Farmaceutisk praeparat
IT8548964A0 (it)	1985-12-20	8alfa-acilamminoergoline,loro preparazione e composizioni farmaceutiche che le contengono
IT8721958A0 (it)	1987-09-18	Derivato di taurina, sua preparazione e composizioni farmaceutiche relative
IT1216814B (it)	1990-03-14	Composizioni farmaceutiche
FI881648L (fi)	1988-10-11	Shampookoostumuksia
BR8807102A (pt)	1989-10-17	Preparacao de novos adocantes de proteina
IT8747852A0 (it)	1987-04-15	Benzammidi sostituite, procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
IT1237343B (it)	1993-05-31	Dicloridrato di acetildicarnitina, procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono
IT1217192B (it)	1990-03-14	Tioeteri chinolinici,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono