BG103251A - Оксадиазоли, методи за получаването им и приложението им като лекарствени средства - Google Patents

Оксадиазоли, методи за получаването им и приложението им като лекарствени средства

Info

Publication number
BG103251A
BG103251A BG103251A BG10325199A BG103251A BG 103251 A BG103251 A BG 103251A BG 103251 A BG103251 A BG 103251A BG 10325199 A BG10325199 A BG 10325199A BG 103251 A BG103251 A BG 103251A
Authority
BG
Bulgaria
Prior art keywords
methods
oxadidasols
medicines
receiving
preparation
Prior art date
Application number
BG103251A
Other languages
Bulgarian (bg)
English (en)
Inventor
Michael Brenner
Roland Maier
Marion Wienrich
Thomas Weiser
Rainer Palluk
Wolf-Dietrich Bechtel
Angelo Sagrada
Helmut Ensinger
Uwe Pschorn
Raffaele Cesana
Original Assignee
Boehringer Ingelheim Pharma Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of BG103251A publication Critical patent/BG103251A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG103251A 1996-10-18 1999-03-15 Оксадиазоли, методи за получаването им и приложението им като лекарствени средства BG103251A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19643037A DE19643037A1 (de) 1996-10-18 1996-10-18 Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
PCT/EP1997/005693 WO1998017652A1 (fr) 1996-10-18 1997-10-15 Oxadiazoles, procedes permettant de les preparer et leur utilisation comme medicaments

Publications (1)

Publication Number Publication Date
BG103251A true BG103251A (bg) 2000-02-29

Family

ID=7809114

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103251A BG103251A (bg) 1996-10-18 1999-03-15 Оксадиазоли, методи за получаването им и приложението им като лекарствени средства

Country Status (31)

Country Link
US (1) US6277872B1 (fr)
EP (1) EP0934288B1 (fr)
JP (1) JP3333523B2 (fr)
KR (1) KR20000049253A (fr)
CN (1) CN1086698C (fr)
AR (1) AR008496A1 (fr)
AT (1) ATE315034T1 (fr)
AU (1) AU737552B2 (fr)
BG (1) BG103251A (fr)
BR (1) BR9714354A (fr)
CA (1) CA2268954C (fr)
CO (1) CO4920253A1 (fr)
CZ (1) CZ138099A3 (fr)
DE (2) DE19643037A1 (fr)
EE (1) EE9900147A (fr)
ES (1) ES2256880T3 (fr)
HR (1) HRP970553A2 (fr)
HU (1) HUP0001652A3 (fr)
ID (1) ID18613A (fr)
IL (1) IL129315A0 (fr)
NO (1) NO312512B1 (fr)
NZ (1) NZ335598A (fr)
PE (1) PE11199A1 (fr)
PL (1) PL332432A1 (fr)
RU (1) RU2182905C2 (fr)
SK (1) SK49999A3 (fr)
TR (1) TR199900848T2 (fr)
TW (1) TW413678B (fr)
WO (1) WO1998017652A1 (fr)
YU (1) YU40997A (fr)
ZA (1) ZA979220B (fr)

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IT1300055B1 (it) 1998-04-17 2000-04-05 Boehringer Ingelheim Italia Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici
IT1300056B1 (it) * 1998-04-17 2000-04-05 Boehringer Ingelheim Italia Eterocicli con anello a 6 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmaci
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
WO2000047567A1 (fr) 1999-02-15 2000-08-17 Eisai Co., Ltd. Derives d'heterodiazinone
ATE257827T1 (de) 1999-07-21 2004-01-15 Hoffmann La Roche Triazolderivate
US6660753B2 (en) 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
ATE307129T1 (de) * 1999-08-19 2005-11-15 Nps Pharma Inc Heteropolycyclische verbindungen und ihre verwendung als antagonisten von metabotropen glutamatrezeptoren
EP1582519A3 (fr) * 1999-08-19 2005-12-21 Nps Pharmaceuticals, Inc. Composes heteropolycycliques et leur utilisation comme antagonistes des recepteurs glutamiques metabotropes
US6579880B2 (en) * 2000-06-06 2003-06-17 Ortho-Mcneil Pharmaceutical, Inc. Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8
WO2001096308A1 (fr) 2000-06-12 2001-12-20 Eisai Co., Ltd. Composes 1,2-dihydropyridine, leur procede de preparation et leur utilisation
JP4233868B2 (ja) * 2000-09-18 2009-03-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピリダジノンおよびトリアジノン化合物類ならびにそれらの医薬用途
PL369598A1 (en) * 2001-02-21 2005-05-02 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
CA2462289C (fr) * 2001-10-04 2010-02-23 Nicholas D. Cosford Composes de tetrazole substitues par heteroaryle, modulateurs du recepteur-5 metabotropique du glutamate
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
WO2004014881A2 (fr) * 2002-08-09 2004-02-19 Astra Zeneca Ab Nouveaux composes
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HRP20050168A2 (en) 2002-08-23 2005-10-31 Rigel Pharmaceuticals Pyridyl substituted heterocycles useful for treating or preventing hcv infection
GB0303503D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
RU2338746C2 (ru) * 2003-02-27 2008-11-20 НьюроСёрч А/С Новые диазабициклические арильные производные, содержащие их фармацевтические композиции и их применение
WO2004099164A1 (fr) * 2003-05-02 2004-11-18 Rigel Pharmaceuticals, Inc. Diphenyl isoxazoles, pyrazoles et oxadiazoles substitues, destines au traitement d'une infection par le vhc
US7326790B2 (en) 2003-05-02 2008-02-05 Rigel Pharmaceuticals, Inc. Diphenylisoxazole compounds and hydro isomers thereof
US7220745B2 (en) 2003-05-15 2007-05-22 Rigel Pharmaceuticals Heterocyclic compounds useful to treat HCV
US7410979B2 (en) 2003-11-19 2008-08-12 Rigel Pharmaceuticals, Inc. Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections
US8207147B2 (en) 2003-12-24 2012-06-26 Prosidion Limited Heterocyclic derivatives as GPCR receptor agonists
US7514434B2 (en) 2004-02-23 2009-04-07 Rigel Pharmaceuticals, Inc. Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
RU2007141401A (ru) * 2005-04-08 2009-05-20 ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) Терапевтический агент для лечения дискинезии
JP2008540425A (ja) 2005-05-02 2008-11-20 ライジェル ファーマシューティカルズ， インコーポレイテッド 代謝可能部分を含む複素環式抗ウイルス性化合物およびその使用
GB0510142D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds A1
HUP0500920A2 (en) * 2005-10-05 2007-07-30 Richter Gedeon Nyrt Oxadiazole derivatives, process for their preparation and their use
DE102005061427A1 (de) * 2005-12-22 2007-06-28 Grünenthal GmbH Substituierte Oxadiazol-Derivate
TWI404706B (zh) * 2006-01-11 2013-08-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
US20110207704A1 (en) * 2006-12-15 2011-08-25 Abbott Laboratories Novel Oxadiazole Compounds
RU2009127095A (ru) * 2006-12-15 2011-01-20 Эбботт Лэборетриз (Us) Новые оксадиазольные соединения
JO2701B1 (en) 2006-12-21 2013-03-03 جلاكسو جروب ليميتد Vehicles
US8404676B2 (en) * 2007-10-04 2013-03-26 Merck Serono Sa Oxadiazole diaryl compounds
US9045442B2 (en) * 2007-12-21 2015-06-02 University Of Notre Dame Du Lac Antibacterial compounds and methods of using same
ES2714453T3 (es) 2008-06-09 2019-05-28 Univ Muenchen Ludwig Maximilians Fármacos para inhibir la agregación de proteínas implicadas en enfermedades relacionadas con enfermedades neurodegenerativas y/o agregación de proteínas
RU2398770C1 (ru) * 2009-03-27 2010-09-10 Учреждение Российской академии наук Институт молекулярной генетики РАН (ИМГ РАН) Меченная тритием 3-[5-(2-фторфенил)-1,2,4-оксадиазол-3-ил]бензойная кислота
WO2011047129A1 (fr) 2009-10-15 2011-04-21 Southern Research Institute Traitement de maladies neurodégénératives, cause d'amélioration de la mémoire et analyse pour évaluer des composés associés
BR112015003824B1 (pt) * 2012-08-24 2022-10-04 Treventis Corporation Composto, composição farmacêutica e uso do composto
PL3110812T3 (pl) 2014-02-27 2019-10-31 Treventis Corp Związki antyamyloidowe zawierające benzofurazan
CN106231905B (zh) 2014-04-24 2019-04-09 住友化学株式会社 二芳基-唑化合物
WO2016049586A2 (fr) * 2014-09-25 2016-03-31 University Of Notre Dame Du Lac Antibiotiques autres que les bêta-lactamines
CN107286174B (zh) * 2016-04-11 2020-08-18 上海勋和医药科技有限公司 取代2,4-(1h,3h)嘧啶二酮作为parp抑制剂及其应用
WO2018049404A1 (fr) 2016-09-12 2018-03-15 University Of Notre Dame Du Lac Composés pour le traitement d'une infection par clostridium difficile
JP7283699B2 (ja) 2017-05-12 2023-05-30 マックス－プランク－ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ 黒色腫の治療または予防において使用するためのフェニル－ヘテロ環－フェニル誘導体
US10676467B2 (en) 2017-06-30 2020-06-09 Washington University Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof
WO2020124090A1 (fr) 2018-12-14 2020-06-18 Eisai R&D Management Co., Ltd. Formulations pharmaceutiques à base d'eau de composés de 1,2-dihydropyridine
JPWO2023042887A1 (fr) 2021-09-15 2023-03-23
JPWO2023042888A1 (fr) 2021-09-15 2023-03-23
EP4173485A1 (fr) 2021-10-27 2023-05-03 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Composés inhibant l'agrégation de protéine pour la lutte contre les maladies des plantes

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Also Published As

Publication number Publication date
PL332432A1 (en) 1999-09-13
ATE315034T1 (de) 2006-02-15
NZ335598A (en) 2001-06-29
JP2000505089A (ja) 2000-04-25
BR9714354A (pt) 2000-04-11
NO312512B1 (no) 2002-05-21
AR008496A1 (es) 2000-01-19
PE11199A1 (es) 1999-03-03
CN1086698C (zh) 2002-06-26
HUP0001652A2 (hu) 2001-01-29
DE19643037A1 (de) 1998-04-23
CA2268954C (fr) 2006-06-13
EP0934288A1 (fr) 1999-08-11
TR199900848T2 (xx) 1999-06-21
JP3333523B2 (ja) 2002-10-15
DE59712543D1 (de) 2006-03-30
EP0934288B1 (fr) 2006-01-04
ES2256880T3 (es) 2006-07-16
ID18613A (id) 1998-04-23
CA2268954A1 (fr) 1998-04-30
RU2182905C2 (ru) 2002-05-27
HUP0001652A3 (en) 2002-12-28
SK49999A3 (en) 1999-11-08
CZ138099A3 (cs) 1999-11-17
AU737552B2 (en) 2001-08-23
NO991815D0 (no) 1999-04-16
HK1020956A1 (en) 2000-05-26
ZA979220B (en) 1998-04-20
CO4920253A1 (es) 2000-05-29
US6277872B1 (en) 2001-08-21
CN1233245A (zh) 1999-10-27
WO1998017652A1 (fr) 1998-04-30
AU4867697A (en) 1998-05-15
HRP970553A2 (en) 1998-08-31
NO991815L (no) 1999-04-16
YU40997A (sh) 2000-10-30
KR20000049253A (ko) 2000-07-25
IL129315A0 (en) 2000-02-17
EE9900147A (et) 1999-12-15
TW413678B (en) 2000-12-01

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