BG60411B2 - Бис-диметоксиметил(триметоксибензил)изохинолинови соли, получаване и фармацевтични състави,които ги съдържат - Google Patents

Бис-диметоксиметил(триметоксибензил)изохинолинови соли, получаване и фармацевтични състави,които ги съдържат Download PDF

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Publication number
BG60411B2
BG60411B2 BG098109A BG9810993A BG60411B2 BG 60411 B2 BG60411 B2 BG 60411B2 BG 098109 A BG098109 A BG 098109A BG 9810993 A BG9810993 A BG 9810993A BG 60411 B2 BG60411 B2 BG 60411B2
Authority
BG
Bulgaria
Prior art keywords
compound
mixture
formula
trimethoxybenzyl
configuration
Prior art date
Application number
BG098109A
Other languages
Bulgarian (bg)
English (en)
Inventor
Roy Archibald Jun.
Hassan El-Sayad
David Yeowell
John Savarese
Original Assignee
The General Hospital Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The General Hospital Corporation filed Critical The General Hospital Corporation
Publication of BG60411B2 publication Critical patent/BG60411B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Jib Cranes (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Cephalosporin Compounds (AREA)
  • Cosmetics (AREA)
  • Fats And Perfumes (AREA)
  • Meat, Egg Or Seafood Products (AREA)
BG098109A 1984-07-18 1993-09-14 Бис-диметоксиметил(триметоксибензил)изохинолинови соли, получаване и фармацевтични състави,които ги съдържат BG60411B2 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848418303A GB8418303D0 (en) 1984-07-18 1984-07-18 Compounds

Publications (1)

Publication Number Publication Date
BG60411B2 true BG60411B2 (bg) 1995-02-28

Family

ID=10564058

Family Applications (1)

Application Number Title Priority Date Filing Date
BG098109A BG60411B2 (bg) 1984-07-18 1993-09-14 Бис-диметоксиметил(триметоксибензил)изохинолинови соли, получаване и фармацевтични състави,които ги съдържат

Country Status (30)

Country Link
US (1) US4761418A (lt)
EP (1) EP0181055B1 (lt)
JP (1) JPH0662568B2 (lt)
AT (1) ATE60759T1 (lt)
AU (1) AU574481B2 (lt)
BG (1) BG60411B2 (lt)
CA (1) CA1273341A (lt)
CY (1) CY1687A (lt)
DD (1) DD235638A5 (lt)
DE (2) DE3581699D1 (lt)
DK (1) DK168093B1 (lt)
ES (1) ES8609260A1 (lt)
FI (1) FI85019C (lt)
GB (1) GB8418303D0 (lt)
GE (1) GEP19960468B (lt)
HK (1) HK47593A (lt)
HU (1) HU193996B (lt)
IE (1) IE58138B1 (lt)
IL (1) IL75833A (lt)
LT (1) LT2078B (lt)
LU (1) LU88801I2 (lt)
LV (1) LV5483A3 (lt)
MC (1) MC1690A1 (lt)
MX (1) MX9203667A (lt)
NL (1) NL940023I2 (lt)
NZ (1) NZ212766A (lt)
PL (1) PL146066B1 (lt)
SG (1) SG3493G (lt)
SU (1) SU1468414A3 (lt)
ZA (1) ZA855407B (lt)

Families Citing this family (32)

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US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
EP1526130A1 (en) * 1997-03-25 2005-04-27 Avera Pharmaceuticals, Inc. Substituted isoquinolines as ultra short acting neuromuscular blockers
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
EP1684753A2 (en) * 2003-10-28 2006-08-02 Cornell Research Foundation, Inc. Neuromuscular blocking agents and antagonists thereof
US7872137B2 (en) * 2006-06-20 2011-01-18 Farmabios S.P.A. Process for the preparation of mivacurium chloride
CN101588803B (zh) * 2006-12-06 2013-03-20 康乃尔研究基金会有限公司 中等持续时间神经肌肉阻断剂及其拮抗剂
AU2008222298A1 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
EP2125743A1 (en) * 2007-03-26 2009-12-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
WO2008132748A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
US8357807B2 (en) * 2007-05-01 2013-01-22 Chemagis Ltd. Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
AU2008264802A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
CA2692636A1 (en) * 2007-07-09 2009-01-15 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
EP2197848A1 (en) * 2007-10-29 2010-06-23 Chemagis Ltd. Novel r,r'-atracurium salts
ITMI20080319A1 (it) 2008-02-28 2009-08-29 Recordati Chem Pharm Processo per la risoluzione di derivati isochinolinici
EP2283005A4 (en) * 2008-05-01 2011-08-31 Chemagis Ltd CISATRACURIUM DERIVATIVES, PREPARATION AND USES THEREOF
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
WO2011022491A1 (en) 2009-08-19 2011-02-24 Cornell University Cysteine for physiological injection
WO2013021398A2 (en) * 2011-08-05 2013-02-14 Sequent Scientific Limited A process for preparation of mivacurium chloride
WO2014005122A2 (en) * 2012-06-29 2014-01-03 Savarese John J Asymmetrical reversible neuromuscular blocking agents of ultra-short, short, or intermediate duration
CN103373959A (zh) * 2013-06-14 2013-10-30 安徽省先锋制药有限公司 顺式苄基异喹啉类化合物的制备方法及其用途
CN107782821B (zh) * 2016-08-26 2021-11-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂的分析方法
CN107778237A (zh) * 2016-08-26 2018-03-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN108938573B (zh) * 2017-05-26 2021-08-10 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) * 2017-09-30 2018-09-07 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) * 2019-07-29 2022-04-29 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) * 2019-11-11 2021-03-09 武汉大安制药有限公司 一种5’-甲氧基劳丹素的拆分方法
CN116410078B (zh) * 2021-12-29 2026-04-03 苏州特瑞药业股份有限公司 一种制备(e)-辛-4-烯-1,8-二酸的方法
CN117503696B (zh) * 2023-11-10 2026-06-26 福安药业集团庆余堂制药有限公司 一种可终端灭菌的米库氯铵注射液及其制剂工艺和用途
WO2025140288A1 (zh) * 2023-12-25 2025-07-03 上海森辉医药有限公司 一种四氢异喹啉及其药物用途
WO2025140279A1 (zh) 2023-12-25 2025-07-03 上海森辉医药有限公司 季铵化合物及其药物用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
GB863717A (en) * 1958-07-03 1961-03-22 Allen & Hanburys Ltd Tetrahydropapaverine derivatives and their preparation
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
NL7808067A (nl) * 1977-08-01 1979-02-05 Massachusetts Gen Hospital Werkwijze voor het bereiden van een middel dat zenuw- spieren blokkeert.
US4192877A (en) * 1977-08-01 1980-03-11 Massachusetts General Hospital Neuromuscular blocking agents
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
US4235906A (en) * 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
CA1153380A (en) * 1979-10-19 1983-09-06 Hassan A. El-Sayad Neuromuscular blocking tetrahydroisoquinolinium salts
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
DE3165714D1 (en) * 1980-12-17 1984-09-27 Wellcome Found Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
JPS5899465A (ja) * 1981-11-23 1983-06-13 ザ・ウエルカム・フアウンデ−シヨン・リミテツド イソキノリン誘導体

Also Published As

Publication number Publication date
GB8418303D0 (en) 1984-08-22
NL940023I1 (nl) 1995-01-02
IE851791L (en) 1986-01-18
EP0181055A1 (en) 1986-05-14
FI85019B (fi) 1991-11-15
CA1273341A (en) 1990-08-28
ES545319A0 (es) 1986-09-01
IL75833A (en) 1988-11-30
HUT40626A (en) 1987-01-28
ATE60759T1 (de) 1991-02-15
PL254571A1 (en) 1986-07-15
DK324985D0 (da) 1985-07-17
PL146066B1 (en) 1988-12-31
FI85019C (fi) 1992-02-25
ES8609260A1 (es) 1986-09-01
JPH0662568B2 (ja) 1994-08-17
US4761418A (en) 1988-08-02
NZ212766A (en) 1988-03-30
AU574481B2 (en) 1988-07-07
ZA855407B (en) 1986-04-30
AU4510885A (en) 1986-01-23
CY1687A (en) 1993-10-10
SU1468414A3 (ru) 1989-03-23
EP0181055B1 (en) 1991-02-06
JPS6187666A (ja) 1986-05-06
FI852807A0 (fi) 1985-07-17
SG3493G (en) 1993-03-12
DE19675039I2 (de) 2003-01-09
NL940023I2 (nl) 1998-06-02
HK47593A (en) 1993-05-21
MC1690A1 (fr) 1986-07-18
IE58138B1 (en) 1993-07-14
DD235638A5 (de) 1986-05-14
DK324985A (da) 1986-01-19
DE3581699D1 (de) 1991-03-14
FI852807L (fi) 1986-01-19
MX9203667A (es) 1992-07-31
IL75833A0 (en) 1985-11-29
HU193996B (en) 1987-12-28
DK168093B1 (da) 1994-02-07
LV5483A3 (lv) 1994-03-10
GEP19960468B (en) 1996-08-29
LU88801I2 (fr) 1996-11-05
LT2078B (lt) 1993-06-15

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