IL75833A - Isoquinoline derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

Isoquinoline derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL75833A
Authority: IL; Israel
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; isoquinoline derivatives; image
Prior art date: 1984-07-18

Application number

IL75833A

Other languages

English (en)

Other versions

IL75833A0 (en

Original Assignee

Wellcome Found

Gen Hospital Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-18

Filing date

1985-07-17

Publication date

1988-11-30

1985-07-17 Application filed by Wellcome Found, Gen Hospital Corp filed Critical Wellcome Found

1985-11-29 Publication of IL75833A0 publication Critical patent/IL75833A0/xx

1988-11-30 Publication of IL75833A publication Critical patent/IL75833A/xx

Links

125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
150000001450 anions Chemical group 0.000 abstract 1
239000003158 myorelaxant agent Substances 0.000 abstract 1
239000000842 neuromuscular blocking agent Substances 0.000 abstract 1
229940125706 skeletal muscle relaxant agent Drugs 0.000 abstract 1
238000001356 surgical procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Jib Cranes (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Cephalosporin Compounds (AREA)
Cosmetics (AREA)
Fats And Perfumes (AREA)
Meat, Egg Or Seafood Products (AREA)

IL75833A 1984-07-18 1985-07-17 Isoquinoline derivatives,their preparation and pharmaceutical compositions containing them IL75833A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB848418303A GB8418303D0 (en)	1984-07-18	1984-07-18	Compounds

Publications (2)

Publication Number	Publication Date
IL75833A0 IL75833A0 (en)	1985-11-29
IL75833A true IL75833A (en)	1988-11-30

Family

ID=10564058

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL75833A IL75833A (en)	1984-07-18	1985-07-17	Isoquinoline derivatives,their preparation and pharmaceutical compositions containing them

Country Status (30)

Country	Link
US (1)	US4761418A (lt)
EP (1)	EP0181055B1 (lt)
JP (1)	JPH0662568B2 (lt)
AT (1)	ATE60759T1 (lt)
AU (1)	AU574481B2 (lt)
BG (1)	BG60411B2 (lt)
CA (1)	CA1273341A (lt)
CY (1)	CY1687A (lt)
DD (1)	DD235638A5 (lt)
DE (2)	DE3581699D1 (lt)
DK (1)	DK168093B1 (lt)
ES (1)	ES8609260A1 (lt)
FI (1)	FI85019C (lt)
GB (1)	GB8418303D0 (lt)
GE (1)	GEP19960468B (lt)
HK (1)	HK47593A (lt)
HU (1)	HU193996B (lt)
IE (1)	IE58138B1 (lt)
IL (1)	IL75833A (lt)
LT (1)	LT2078B (lt)
LU (1)	LU88801I2 (lt)
LV (1)	LV5483A3 (lt)
MC (1)	MC1690A1 (lt)
MX (1)	MX9203667A (lt)
NL (1)	NL940023I2 (lt)
NZ (1)	NZ212766A (lt)
PL (1)	PL146066B1 (lt)
SG (1)	SG3493G (lt)
SU (1)	SU1468414A3 (lt)
ZA (1)	ZA855407B (lt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5453510A (en) *	1990-07-13	1995-09-26	Burroughs Wellcome Co.	Neuromuscular blocking agents
US5240939A (en) *	1991-10-31	1993-08-31	Anaquest, Inc.	Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) *	1994-09-06	1996-04-23	Bencherif; Merouane	Depolarizing skeletal muscle relaxants
EP1526130A1 (en) *	1997-03-25	2005-04-27	Avera Pharmaceuticals, Inc.	Substituted isoquinolines as ultra short acting neuromuscular blockers
GB0204087D0 (en) *	2002-02-21	2002-04-10	Legislator 1563 Ltd	Di-ester derivatives as short acting neuromuscular blockers
EP1684753A2 (en) *	2003-10-28	2006-08-02	Cornell Research Foundation, Inc.	Neuromuscular blocking agents and antagonists thereof
US7872137B2 (en) *	2006-06-20	2011-01-18	Farmabios S.P.A.	Process for the preparation of mivacurium chloride
CN101588803B (zh) *	2006-12-06	2013-03-20	康乃尔研究基金会有限公司	中等持续时间神经肌肉阻断剂及其拮抗剂
AU2008222298A1 (en) *	2007-03-08	2008-09-12	Chemagis Ltd.	(1R,1'R)-atracurium salts separation process
EP2125743A1 (en) *	2007-03-26	2009-12-02	Chemagis Ltd.	(1r,1'r)-atracurium salts separation process
WO2008132748A1 (en) *	2007-05-01	2008-11-06	Chemagis Ltd.	Process for producing cisatracurium compounds and associated intermediates
US8357807B2 (en) *	2007-05-01	2013-01-22	Chemagis Ltd.	Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
AU2008264802A1 (en) *	2007-06-18	2008-12-24	Chemagis Ltd.	(1R,1'R)-atracurium salts separation process
CA2692636A1 (en) *	2007-07-09	2009-01-15	Chemagis Ltd.	Process for producing cisatracurium and associated intermediates
EP2197848A1 (en) *	2007-10-29	2010-06-23	Chemagis Ltd.	Novel r,r'-atracurium salts
ITMI20080319A1 (it)	2008-02-28	2009-08-29	Recordati Chem Pharm	Processo per la risoluzione di derivati isochinolinici
EP2283005A4 (en) *	2008-05-01	2011-08-31	Chemagis Ltd	CISATRACURIUM DERIVATIVES, PREPARATION AND USES THEREOF
US8592451B2 (en)	2009-03-17	2013-11-26	Cornell University	Reversible nondepolarizing neuromuscular blockade agents and methods for their use
WO2011022491A1 (en)	2009-08-19	2011-02-24	Cornell University	Cysteine for physiological injection
WO2013021398A2 (en) *	2011-08-05	2013-02-14	Sequent Scientific Limited	A process for preparation of mivacurium chloride
WO2014005122A2 (en) *	2012-06-29	2014-01-03	Savarese John J	Asymmetrical reversible neuromuscular blocking agents of ultra-short, short, or intermediate duration
CN103373959A (zh) *	2013-06-14	2013-10-30	安徽省先锋制药有限公司	顺式苄基异喹啉类化合物的制备方法及其用途
CN107782821B (zh) *	2016-08-26	2021-11-09	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂的分析方法
CN107778237A (zh) *	2016-08-26	2018-03-09	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN108938573B (zh) *	2017-05-26	2021-08-10	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) *	2017-09-30	2018-09-07	武汉嘉诺康医药技术有限公司	一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) *	2019-07-29	2022-04-29	武汉嘉诺康医药技术有限公司	一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) *	2019-11-11	2021-03-09	武汉大安制药有限公司	一种5’-甲氧基劳丹素的拆分方法
CN116410078B (zh) *	2021-12-29	2026-04-03	苏州特瑞药业股份有限公司	一种制备(e)-辛-4-烯-1,8-二酸的方法
CN117503696B (zh) *	2023-11-10	2026-06-26	福安药业集团庆余堂制药有限公司	一种可终端灭菌的米库氯铵注射液及其制剂工艺和用途
WO2025140288A1 (zh) *	2023-12-25	2025-07-03	上海森辉医药有限公司	一种四氢异喹啉及其药物用途
WO2025140279A1 (zh)	2023-12-25	2025-07-03	上海森辉医药有限公司	季铵化合物及其药物用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3004031A (en) *	1958-07-03	1961-10-10	Allen & Hauburys Ltd	Diquaternary salts of papaverino esters
GB863717A (en) *	1958-07-03	1961-03-22	Allen & Hanburys Ltd	Tetrahydropapaverine derivatives and their preparation
AU506657B2 (en) *	1975-12-10	1980-01-17	Wellcome Foundation Limited, The	Isoquinoline derivatives
NL7808067A (nl) *	1977-08-01	1979-02-05	Massachusetts Gen Hospital	Werkwijze voor het bereiden van een middel dat zenuw- spieren blokkeert.
US4192877A (en) *	1977-08-01	1980-03-11	Massachusetts General Hospital	Neuromuscular blocking agents
CA1125287A (en) *	1978-07-21	1982-06-08	John J. Savarese	Bis isoquinolinium compositions and methods of use
US4235906A (en) *	1978-07-21	1980-11-25	Massachusetts General Hospital	Bis-isoquinolinium compounds, compositions and methods of use
CA1153380A (en) *	1979-10-19	1983-09-06	Hassan A. El-Sayad	Neuromuscular blocking tetrahydroisoquinolinium salts
US4491665A (en) *	1979-10-19	1985-01-01	Burroughs Wellcome Co.	Method of preparing isomers of bis isoquinolinium compounds
DE3165714D1 (en) *	1980-12-17	1984-09-27	Wellcome Found	Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
JPS5899465A (ja) *	1981-11-23	1983-06-13	ザ・ウエルカム・フアウンデ−シヨン・リミテツド	イソキノリン誘導体

1984
- 1984-07-18 GB GB848418303A patent/GB8418303D0/en active Pending
1985
- 1985-07-11 PL PL1985254571A patent/PL146066B1/pl unknown
- 1985-07-17 JP JP60157963A patent/JPH0662568B2/ja not_active Expired - Lifetime
- 1985-07-17 DE DE8585305097T patent/DE3581699D1/de not_active Expired - Lifetime
- 1985-07-17 LU LU88801C patent/LU88801I2/fr unknown
- 1985-07-17 FI FI852807A patent/FI85019C/fi not_active IP Right Cessation
- 1985-07-17 IL IL75833A patent/IL75833A/xx not_active IP Right Cessation
- 1985-07-17 AT AT85305097T patent/ATE60759T1/de active
- 1985-07-17 US US06/756,025 patent/US4761418A/en not_active Expired - Lifetime
- 1985-07-17 IE IE179185A patent/IE58138B1/en not_active IP Right Cessation
- 1985-07-17 CA CA000486916A patent/CA1273341A/en not_active Expired - Lifetime
- 1985-07-17 ZA ZA855407A patent/ZA855407B/xx unknown
- 1985-07-17 AU AU45108/85A patent/AU574481B2/en not_active Expired
- 1985-07-17 DD DD85278691A patent/DD235638A5/de unknown
- 1985-07-17 DK DK324985A patent/DK168093B1/da not_active IP Right Cessation
- 1985-07-17 HU HU852745A patent/HU193996B/hu unknown
- 1985-07-17 MC MC851781A patent/MC1690A1/fr unknown
- 1985-07-17 EP EP85305097A patent/EP0181055B1/en not_active Expired - Lifetime
- 1985-07-17 NZ NZ212766A patent/NZ212766A/en unknown
- 1985-07-17 SU SU853926201A patent/SU1468414A3/ru active
- 1985-07-17 ES ES545319A patent/ES8609260A1/es not_active Expired
- 1985-07-17 DE DE1996175039 patent/DE19675039I2/de active Active
1992
- 1992-06-26 MX MX9203667A patent/MX9203667A/es unknown
1993
- 1993-01-08 SG SG34/93A patent/SG3493G/en unknown
- 1993-03-10 LV LV930178A patent/LV5483A3/xx unknown
- 1993-04-07 LT LTRP478A patent/LT2078B/lt not_active IP Right Cessation
- 1993-05-13 HK HK475/93A patent/HK47593A/en not_active IP Right Cessation
- 1993-09-14 BG BG098109A patent/BG60411B2/bg unknown
- 1993-10-10 CY CY1687A patent/CY1687A/xx unknown
- 1993-12-06 GE GEAP19931677A patent/GEP19960468B/en unknown
1994
- 1994-11-18 NL NL940023C patent/NL940023I2/nl unknown

Also Published As

Publication number	Publication date
GB8418303D0 (en)	1984-08-22
NL940023I1 (nl)	1995-01-02
IE851791L (en)	1986-01-18
EP0181055A1 (en)	1986-05-14
FI85019B (fi)	1991-11-15
CA1273341A (en)	1990-08-28
ES545319A0 (es)	1986-09-01
HUT40626A (en)	1987-01-28
ATE60759T1 (de)	1991-02-15
PL254571A1 (en)	1986-07-15
DK324985D0 (da)	1985-07-17
PL146066B1 (en)	1988-12-31
FI85019C (fi)	1992-02-25
ES8609260A1 (es)	1986-09-01
JPH0662568B2 (ja)	1994-08-17
US4761418A (en)	1988-08-02
NZ212766A (en)	1988-03-30
AU574481B2 (en)	1988-07-07
ZA855407B (en)	1986-04-30
AU4510885A (en)	1986-01-23
CY1687A (en)	1993-10-10
SU1468414A3 (ru)	1989-03-23
EP0181055B1 (en)	1991-02-06
JPS6187666A (ja)	1986-05-06
FI852807A0 (fi)	1985-07-17
SG3493G (en)	1993-03-12
DE19675039I2 (de)	2003-01-09
NL940023I2 (nl)	1998-06-02
HK47593A (en)	1993-05-21
MC1690A1 (fr)	1986-07-18
IE58138B1 (en)	1993-07-14
DD235638A5 (de)	1986-05-14
BG60411B2 (bg)	1995-02-28
DK324985A (da)	1986-01-19
DE3581699D1 (de)	1991-03-14
FI852807L (fi)	1986-01-19
MX9203667A (es)	1992-07-31
IL75833A0 (en)	1985-11-29
HU193996B (en)	1987-12-28
DK168093B1 (da)	1994-02-07
LV5483A3 (lv)	1994-03-10
GEP19960468B (en)	1996-08-29
LU88801I2 (fr)	1996-11-05
LT2078B (lt)	1993-06-15

Legal Events

Date	Code	Title
1999-12-31	KB	Patent renewed
2003-09-17	KB	Patent renewed
2005-11-20	EXP	Patent expired

Publication	Publication Date	Title
IL75833A0 (en)	1985-11-29	Isoquinoline derivatives,their preparation and pharmaceutical compositions containing them
HU900583D0 (en)	1990-04-28	Lasting dissolving of pharmaceutical compositions
DE3562238D1 (en)	1988-05-26	Substituted sulfonamidobenzamides, antiarrythmic agents and compositions thereof
NZ208831A (en)	1988-09-29	Imidazolium derivatives and pharmaceutical compositions
ES8305684A1 (es)	1983-05-01	Procedimiento para la obtencion de derivados aminopropanolicos de 2-hidroxi b-fenil-propiofenonas.
IL78691A0 (en)	1986-08-31	Quinolylglycinamide derivatives,their preparation and pharmaceutical compositions containing them
ZA879280B (en)	1989-08-30	Basically substituted phenylacetonitriles,their preparation and drugs containing these compounds
DE3369983D1 (en)	1987-04-09	Isoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and their use
HU900746D0 (en)	1990-04-28	Process for preparation of 2,3,23-trihydroxy-urz-12-en and it's derivatives and for pharmaceutical compositions containing that compounds
AU632578B2 (en)	1993-01-07	Dibenzo (1,5) dioxocin-5-one derivatives, their use in medicaments and processes for their preparation
HU895241D0 (en)	1990-01-28	Process for the preparation of substituted 1,3,5-triazin-trione derivatives and pharmaceutical compositions containing said compounds as active ingredient
IL69848A0 (en)	1983-12-30	15-cycloaliphatic derivatives of 11,14-didehydrocarboprostacyclins,their preparation and pharmaceutical compositions containing them
GR3015706T3 (en)	1995-07-31	Benzylselenobenzamides of aminopyridines and picolylamines.
ES2027507A6 (es)	1992-06-01	Procedimiento de preparacion de derivados selenofenicos.
IL69274A (en)	1986-08-31	(substituted amino)derivatives of 3-benzylidene-pyrrolo(2,1-b)quinazolin-9-ones and 6-benzylidene-pyrido(2,1-b)quinazolin-11-ones,their preparation and pharmaceutical compositions containing them
IL95384A0 (en)	1991-06-30	1,3-oxazines,their preparation and pharmaceutical compositions containing them
IT1262567B (it)	1996-07-04	Pirrolidin-2-oni,loro preparazione,composizioni farmaceutiche che li contengono e loro uso in terapia.
ZA8683B (en)	1986-08-27	Antihypertensive agents,pharmaceutical compositions containing them and process for the preparation of the agents and compositions
GB8812620D0 (en)	1988-06-29	Pharmaceutical composition for treatment of migraine &c