|
ATE92501T1
(de)
|
1984-10-04 |
1993-08-15 |
Sandoz Ag |
Monoklonale antikoerper gegen zyklosporine.
|
|
EP0194972B1
(en)
|
1985-03-11 |
1992-07-29 |
Sandoz Ag |
Novel cyclosporins
|
|
US6534055B1
(en)
|
1988-11-23 |
2003-03-18 |
Genetics Institute, Inc. |
Methods for selectively stimulating proliferation of T cells
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
US6352694B1
(en)
|
1994-06-03 |
2002-03-05 |
Genetics Institute, Inc. |
Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
|
|
US6905680B2
(en)
|
1988-11-23 |
2005-06-14 |
Genetics Institute, Inc. |
Methods of treating HIV infected subjects
|
|
US5858358A
(en)
|
1992-04-07 |
1999-01-12 |
The United States Of America As Represented By The Secretary Of The Navy |
Methods for selectively stimulating proliferation of T cells
|
|
JP2762522B2
(ja)
|
1989-03-06 |
1998-06-04 |
藤沢薬品工業株式会社 |
血管新生阻害剤
|
|
DK0393934T3
(da)
|
1989-04-15 |
1994-11-21 |
Nippon Chemiphar Co |
Nye peptider samt antidemensmidler indeholdende disse peptider
|
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
|
PT98990A
(pt)
|
1990-09-19 |
1992-08-31 |
American Home Prod |
Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
|
|
US5892112A
(en)
|
1990-11-21 |
1999-04-06 |
Glycomed Incorporated |
Process for preparing synthetic matrix metalloprotease inhibitors
|
|
US5120842A
(en)
|
1991-04-01 |
1992-06-09 |
American Home Products Corporation |
Silyl ethers of rapamycin
|
|
US5100883A
(en)
|
1991-04-08 |
1992-03-31 |
American Home Products Corporation |
Fluorinated esters of rapamycin
|
|
US5118678A
(en)
|
1991-04-17 |
1992-06-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
US5409930A
(en)
|
1991-05-10 |
1995-04-25 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
|
|
US5118677A
(en)
|
1991-05-20 |
1992-06-02 |
American Home Products Corporation |
Amide esters of rapamycin
|
|
NZ243082A
(en)
|
1991-06-28 |
1995-02-24 |
Ici Plc |
4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
|
|
US5151413A
(en)
|
1991-11-06 |
1992-09-29 |
American Home Products Corporation |
Rapamycin acetals as immunosuppressant and antifungal agents
|
|
GB9125660D0
(en)
|
1991-12-03 |
1992-01-29 |
Smithkline Beecham Plc |
Novel compound
|
|
AU661533B2
(en)
|
1992-01-20 |
1995-07-27 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
DK0562853T3
(da)
|
1992-03-27 |
1996-07-01 |
American Home Prod |
29-Demethoxyrapamycin til fremkaldelse af immunsuppression
|
|
US5521184A
(en)
|
1992-04-03 |
1996-05-28 |
Ciba-Geigy Corporation |
Pyrimidine derivatives and processes for the preparation thereof
|
|
ZA935111B
(en)
|
1992-07-17 |
1994-02-04 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
|
ZA935112B
(en)
|
1992-07-17 |
1994-02-08 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
|
US5256790A
(en)
|
1992-08-13 |
1993-10-26 |
American Home Products Corporation |
27-hydroxyrapamycin and derivatives thereof
|
|
GB9221220D0
(en)
|
1992-10-09 |
1992-11-25 |
Sandoz Ag |
Organic componds
|
|
US5258389A
(en)
|
1992-11-09 |
1993-11-02 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
|
|
JP3560609B2
(ja)
|
1992-11-13 |
2004-09-02 |
イミュネックス・コーポレーション |
Ｅｌｋリガンドと呼ばれる新規なサイトカイン
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
US5629327A
(en)
|
1993-03-01 |
1997-05-13 |
Childrens Hospital Medical Center Corp. |
Methods and compositions for inhibition of angiogenesis
|
|
US5516658A
(en)
|
1993-08-20 |
1996-05-14 |
Immunex Corporation |
DNA encoding cytokines that bind the cell surface receptor hek
|
|
ES2164713T3
(es)
|
1993-09-20 |
2002-03-01 |
Univ Leland Stanford Junior |
Produccion recombinante de nuevos poliquetidos.
|
|
JPH08503971A
(ja)
|
1993-10-01 |
1996-04-30 |
チバ−ガイギー アクチェンゲゼルシャフト |
ピリミジンアミン誘導体及びその調製のための方法
|
|
US5656643A
(en)
|
1993-11-08 |
1997-08-12 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
|
|
WO1995014023A1
(en)
|
1993-11-19 |
1995-05-26 |
Abbott Laboratories |
Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
|
|
US5912253A
(en)
|
1993-12-17 |
1999-06-15 |
Novartis Ag |
Rapamycin derivatives
|
|
US5700823A
(en)
|
1994-01-07 |
1997-12-23 |
Sugen, Inc. |
Treatment of platelet derived growth factor related disorders such as cancers
|
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
|
IL112249A
(en)
|
1994-01-25 |
2001-11-25 |
Warner Lambert Co |
Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
|
|
WO1995024190A2
(en)
|
1994-03-07 |
1995-09-14 |
Sugen, Inc. |
Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
|
|
IL112873A
(en)
|
1994-03-08 |
2005-03-20 |
Wyeth Corp |
Rapamycin-fkbp12 binding proteins, their isolation and their use
|
|
EP0756627A1
(en)
|
1994-04-15 |
1997-02-05 |
Amgen Inc. |
Hek5, hek7, hek8, hek11, new eph-like receptor protein tyrosine kinases
|
|
EP0682027B1
(de)
|
1994-05-03 |
1997-10-15 |
Novartis AG |
Pyrrolopyrimidinderivate mit antiproliferativer Wirkung
|
|
GB9410142D0
(en)
|
1994-05-20 |
1994-07-06 |
Univ Warwick |
Carbapenems
|
|
US7175843B2
(en)
|
1994-06-03 |
2007-02-13 |
Genetics Institute, Llc |
Methods for selectively stimulating proliferation of T cells
|
|
US6303769B1
(en)
|
1994-07-08 |
2001-10-16 |
Immunex Corporation |
Lerk-5 dna
|
|
US5919905A
(en)
|
1994-10-05 |
1999-07-06 |
Immunex Corporation |
Cytokine designated LERK-6
|
|
GB9524630D0
(en)
|
1994-12-24 |
1996-01-31 |
Zeneca Ltd |
Chemical compounds
|
|
US6057124A
(en)
|
1995-01-27 |
2000-05-02 |
Amgen Inc. |
Nucleic acids encoding ligands for HEK4 receptors
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
MX9707453A
(es)
|
1995-03-30 |
1997-12-31 |
Pfizer |
Derivados de quinazolina.
|
|
ES2150113T3
(es)
|
1995-04-03 |
2000-11-16 |
Novartis Ag |
Derivados de pirazol y procedimientos para la preparacion de los mismos.
|
|
DK0821671T3
(da)
|
1995-04-20 |
2001-04-23 |
Pfizer |
Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer
|
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
US7067318B2
(en)
|
1995-06-07 |
2006-06-27 |
The Regents Of The University Of Michigan |
Methods for transfecting T cells
|
|
US6692964B1
(en)
|
1995-05-04 |
2004-02-17 |
The United States Of America As Represented By The Secretary Of The Navy |
Methods for transfecting T cells
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
US5650415A
(en)
|
1995-06-07 |
1997-07-22 |
Sugen, Inc. |
Quinoline compounds
|
|
EP0833828B1
(en)
|
1995-06-09 |
2002-11-20 |
Novartis AG |
Rapamycin derivatives
|
|
US5624677A
(en)
|
1995-06-13 |
1997-04-29 |
Pentech Pharmaceuticals, Inc. |
Controlled release of drugs delivered by sublingual or buccal administration
|
|
US6124453A
(en)
|
1995-07-04 |
2000-09-26 |
Novartis Ag |
Macrolides
|
|
MX9800215A
(es)
|
1995-07-06 |
1998-03-31 |
Novartis Ag |
Pirrolopirimidas y procesos para su preparacion.
|
|
DE19534177A1
(de)
|
1995-09-15 |
1997-03-20 |
Merck Patent Gmbh |
Cyclische Adhäsionsinhibitoren
|
|
AR004010A1
(es)
|
1995-10-11 |
1998-09-30 |
Glaxo Group Ltd |
Compuestos heterociclicos
|
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
DE69624081T2
(de)
|
1995-12-20 |
2003-06-12 |
Agouron Pharmaceuticals, Inc. |
Matrix-metalloprotease Inhibitoren
|
|
ATE217873T1
(de)
|
1996-01-23 |
2002-06-15 |
Novartis Erfind Verwalt Gmbh |
Pyrrolopyrimidinen und verfahren zu deren herstellung
|
|
JP3406763B2
(ja)
|
1996-01-30 |
2003-05-12 |
東レ・ダウコーニング・シリコーン株式会社 |
シリコーンゴム組成物
|
|
GB9603097D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline compounds
|
|
GB9603095D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline derivatives
|
|
DE19608588A1
(de)
|
1996-03-06 |
1997-09-11 |
Thomae Gmbh Dr K |
Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
|
DE19629652A1
(de)
|
1996-03-06 |
1998-01-29 |
Thomae Gmbh Dr K |
4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
|
ES2203793T3
(es)
|
1996-03-15 |
2004-04-16 |
Novartis Ag |
N-7-heterociclil-pirrolo(2,3-d)pirimidinas y su empleo.
|
|
HU228446B1
(en)
|
1996-04-12 |
2013-03-28 |
Warner Lambert Co |
Kinazoline derivatives as irreversible inhibitors of protein-kinase, pharmaceutical compositions containing these compounds and use thereof
|
|
GB9607729D0
(en)
|
1996-04-13 |
1996-06-19 |
Zeneca Ltd |
Quinazoline derivatives
|
|
EP0907642B1
(en)
|
1996-06-24 |
2005-11-02 |
Pfizer Inc. |
Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
|
|
AP1029A
(en)
|
1996-07-05 |
2001-12-11 |
Biotica Tech Limited |
Erythromycins and process for their preparation.
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
US6258823B1
(en)
|
1996-07-12 |
2001-07-10 |
Ariad Pharmaceuticals, Inc. |
Materials and method for treating or preventing pathogenic fungal infection
|
|
ID19609A
(id)
|
1996-07-13 |
1998-07-23 |
Glaxo Group Ltd |
Senyawa-senyawa heterosiklik
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
ES2191187T3
(es)
|
1996-07-13 |
2003-09-01 |
Glaxo Group Ltd |
Compuestos heteroaromaticos biciclicos como inhibidores de la proteina tirosin-quinasa.
|
|
EP0923585B1
(en)
|
1996-07-18 |
2002-05-08 |
Pfizer Inc. |
Phosphinate based inhibitors of matrix metalloproteases
|
|
US6111090A
(en)
|
1996-08-16 |
2000-08-29 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
|
ES2308787T3
(es)
|
1996-08-16 |
2008-12-01 |
Schering Corporation |
Antigenos de superficie de celular de mamiferos; reactivos relacionados.
|
|
WO1998007697A1
(en)
|
1996-08-23 |
1998-02-26 |
Pfizer Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
WO1998007726A1
(en)
|
1996-08-23 |
1998-02-26 |
Novartis Ag |
Substituted pyrrolopyrimidines and processes for their preparation
|
|
SE9603465D0
(sv)
|
1996-09-23 |
1996-09-23 |
Astra Ab |
New compounds
|
|
AU4779897A
(en)
|
1996-10-02 |
1998-04-24 |
Novartis Ag |
Fused pyrazole derivatives and processes for their preparation
|
|
US6251911B1
(en)
|
1996-10-02 |
2001-06-26 |
Novartis Ag |
Pyrimidine derivatives and processes for the preparation thereof
|
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
|
EP0837063A1
(en)
|
1996-10-17 |
1998-04-22 |
Pfizer Inc. |
4-Aminoquinazoline derivatives
|
|
GB9621757D0
(en)
|
1996-10-18 |
1996-12-11 |
Ciba Geigy Ag |
Phenyl-substituted bicyclic heterocyclyl derivatives and their use
|
|
WO1998030566A1
(en)
|
1997-01-06 |
1998-07-16 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
EP0977733B1
(en)
|
1997-02-03 |
2003-09-03 |
Pfizer Products Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
ES2301194T3
(es)
|
1997-02-05 |
2008-06-16 |
Warner-Lambert Company Llc |
Pirido 2,3-d pirimidinas y 4-aminopirimidinas como inhibidores de la proliferacion celular.
|
|
JP2000507975A
(ja)
|
1997-02-07 |
2000-06-27 |
ファイザー・インク |
Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
|
|
EA002546B1
(ru)
|
1997-02-11 |
2002-06-27 |
Пфайзер Инк. |
Производные арилсульфонилгидроксамовой кислоты
|
|
CO4950519A1
(es)
|
1997-02-13 |
2000-09-01 |
Novartis Ag |
Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
|
|
US6902913B2
(en)
|
1997-04-30 |
2005-06-07 |
Kosan Biosciences, Inc. |
Recombinant narbonolide polyketide synthase
|
|
US6150395A
(en)
|
1997-05-30 |
2000-11-21 |
The Regents Of The University Of California |
Indole-3-carbinol (I3C) derivatives and methods
|
|
US6329375B1
(en)
|
1997-08-05 |
2001-12-11 |
Sugen, Inc. |
Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors
|
|
AU730248B2
(en)
|
1997-08-08 |
2001-03-01 |
Pfizer Products Inc. |
Aryloxyarylsulfonylamino hydroxamic acid derivatives
|
|
WO2000012089A1
(en)
|
1998-08-31 |
2000-03-09 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
JP2001520039A
(ja)
|
1997-10-21 |
2001-10-30 |
ヒューマン ジノーム サイエンシーズ， インコーポレイテッド |
ヒト腫瘍壊死因子レセプター様タンパク質、ｔｒ１１，ｔｒ１１ｓｖ１およびｔｒ１１ｓｖ２
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
US6153383A
(en)
|
1997-12-09 |
2000-11-28 |
Verdine; Gregory L. |
Synthetic transcriptional modulators and uses thereof
|
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
RS49779B
(sr)
|
1998-01-12 |
2008-06-05 |
Glaxo Group Limited, |
Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
|
|
AU2591599A
(en)
|
1998-02-09 |
1999-08-23 |
Genentech Inc. |
Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same
|
|
ATE430149T1
(de)
|
1998-03-04 |
2009-05-15 |
Bristol Myers Squibb Co |
Heterocyclen substituierte imidazopyrazine als protein- tyrosin-kinase-inhibitoren
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
ES2347027T3
(es)
|
1998-05-22 |
2010-10-22 |
The Board Of Trustees Of The Leland Stanford Junior University |
Moleculas bifuncionales y terapias basadas en las mismas.
|
|
EA005032B1
(ru)
|
1998-05-29 |
2004-10-28 |
Сьюджен, Инк. |
Пирролзамещенные 2-индолиноны (варианты), фармацевтическая композиция (варианты), способ модулирования каталитической активности протеинкиназы, способ лечения или профилактики нарушения в организме, связанного с протеинкиназой
|
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
|
AU747427B2
(en)
|
1998-07-10 |
2002-05-16 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
NZ510819A
(en)
|
1998-10-02 |
2004-03-26 |
Kosan Biosciences Inc |
Polyketide synthase enzymes and recombinant DNA constructs therefor
|
|
US6686454B1
(en)
|
1998-10-09 |
2004-02-03 |
Isotechnika, Inc. |
Antibodies to specific regions of cyclosporine related compounds
|
|
DK1004578T3
(da)
|
1998-11-05 |
2004-06-28 |
Pfizer Prod Inc |
5-oxo-pyrrolidin-2-carboxylsyrehydroxamidderivater
|
|
CA2359801A1
(en)
|
1999-02-09 |
2000-08-17 |
Rajesh S. Gokhale |
Methods to mediate polyketide synthase module effectiveness
|
|
WO2000059509A1
(en)
|
1999-03-30 |
2000-10-12 |
Novartis Ag |
Phthalazine derivatives for treating inflammatory diseases
|
|
GB9912961D0
(en)
|
1999-06-03 |
1999-08-04 |
Pfizer Ltd |
Metalloprotease inhibitors
|
|
US6521424B2
(en)
|
1999-06-07 |
2003-02-18 |
Immunex Corporation |
Recombinant expression of Tek antagonists
|
|
ES2262518T5
(es)
|
1999-06-07 |
2009-05-08 |
Immunex Corporation |
Antagonistas de tek.
|
|
AU6085700A
(en)
|
1999-07-12 |
2001-01-30 |
Genentech Inc. |
Promotion or inhibition of angiogenesis and cardiovascularization by tumor necrosis factor ligand/receptor homologs
|
|
AU783158B2
(en)
|
1999-08-24 |
2005-09-29 |
Ariad Pharmaceuticals, Inc. |
28-epirapalogs
|
|
CZ301689B6
(cs)
|
1999-11-05 |
2010-05-26 |
Astrazeneca Ab |
Derivát chinazolinu a farmaceutický prostredek, který ho obsahuje
|
|
GB9927191D0
(en)
|
1999-11-17 |
2000-01-12 |
Angeletti P Ist Richerche Bio |
Methods and means for regulation of gene expression
|
|
AU1776501A
(en)
|
1999-11-19 |
2001-05-30 |
Board Of Trustees Of The Leland Stanford Junior University |
Bifunctional molecules and their use in the disruption of protein-protein interactions
|
|
US7220552B1
(en)
|
1999-11-19 |
2007-05-22 |
The Board Of Trustees Of The Leland Stanford Junior University |
Bifunctional molecules and their use in the disruption of protein-protein interactions
|
|
PT1233943E
(pt)
|
1999-11-24 |
2011-09-01 |
Sugen Inc |
Formulações para agentes farmacêuticos ionizáveis como ácidos livres ou bases livres
|
|
US6515004B1
(en)
|
1999-12-15 |
2003-02-04 |
Bristol-Myers Squibb Company |
N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
|
|
US6727225B2
(en)
|
1999-12-20 |
2004-04-27 |
Immunex Corporation |
TWEAK receptor
|
|
CA2399689A1
(en)
|
2000-02-08 |
2001-08-16 |
Trond Erling Ellingsen |
Gene cluster encoding a nystatin polyketide synthase and its manipulation and utility
|
|
US6797514B2
(en)
|
2000-02-24 |
2004-09-28 |
Xcyte Therapies, Inc. |
Simultaneous stimulation and concentration of cells
|
|
CA2406864A1
(en)
|
2000-02-24 |
2001-08-30 |
Life Technologies Corporation |
Simultaneous stimulation and concentration of cells
|
|
US7572631B2
(en)
|
2000-02-24 |
2009-08-11 |
Invitrogen Corporation |
Activation and expansion of T cells
|
|
US6867041B2
(en)
|
2000-02-24 |
2005-03-15 |
Xcyte Therapies, Inc. |
Simultaneous stimulation and concentration of cells
|
|
CA2400040A1
(en)
|
2000-02-25 |
2001-08-30 |
Immunex Corporation |
Integrin antagonists
|
|
TR200200767T1
(tr)
|
2000-05-23 |
2002-09-23 |
Vertex Pharmaceuticals Incorporated |
Kaspaz engelleyiciler ve kullanımları
|
|
US7176037B2
(en)
|
2000-07-13 |
2007-02-13 |
The Scripps Research Institute |
Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation
|
|
US6630500B2
(en)
|
2000-08-25 |
2003-10-07 |
Cephalon, Inc. |
Selected fused pyrrolocarbazoles
|
|
EP1343782B1
(en)
|
2000-12-21 |
2009-05-06 |
SmithKline Beecham Corporation |
Pyrimidineamines as angiogenesis modulators
|
|
US7105682B2
(en)
|
2001-01-12 |
2006-09-12 |
Amgen Inc. |
Substituted amine derivatives and methods of use
|
|
US20020147198A1
(en)
|
2001-01-12 |
2002-10-10 |
Guoqing Chen |
Substituted arylamine derivatives and methods of use
|
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
US7102009B2
(en)
|
2001-01-12 |
2006-09-05 |
Amgen Inc. |
Substituted amine derivatives and methods of use
|
|
US6878714B2
(en)
|
2001-01-12 |
2005-04-12 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
US20030153053A1
(en)
|
2001-08-06 |
2003-08-14 |
Ralph Reid |
Methods for altering polyketide synthase genes
|
|
US6809077B2
(en)
|
2001-10-12 |
2004-10-26 |
Enanta Pharmaceuticals, Inc. |
Cyclosporin analogs for the treatment of autoimmune diseases
|
|
US6987090B2
(en)
|
2002-05-09 |
2006-01-17 |
Lg Household & Health Care Ltd. |
Use of 3-position cyclosporin derivatives for hair growth
|
|
US7307088B2
(en)
|
2002-07-09 |
2007-12-11 |
Amgen Inc. |
Substituted anthranilic amide derivatives and methods of use
|
|
TWI329112B
(en)
|
2002-07-19 |
2010-08-21 |
Bristol Myers Squibb Co |
Novel inhibitors of kinases
|
|
US7012065B2
(en)
|
2003-02-07 |
2006-03-14 |
Enanta Pharmaceuticals, Inc. |
Cyclosporins for the treatment of immune disorders
|
|
EP1477563A3
(en)
|
2003-05-16 |
2004-11-24 |
Wyeth |
Cloning genes from streptomyces cyaneogriseus subsp.noncyanogenus for biosynthesis of antibiotics and methods of use
|
|
JP4638876B2
(ja)
|
2003-05-23 |
2011-02-23 |
ワイス |
Ｇｉｔｒリガンド及びｇｉｔｒリガンド関連分子及び抗体及びその使用
|
|
AU2004255340B2
(en)
|
2003-07-08 |
2008-05-01 |
Novartis Ag |
Use of rapamycin and rapamycin derivatives for the treatment of bone loss
|
|
EP1648900A4
(en)
|
2003-07-11 |
2010-02-10 |
Ariad Pharma Inc |
PHOSPHORUS MACROCYCLES
|
|
WO2005007190A1
(en)
|
2003-07-11 |
2005-01-27 |
Schering Corporation |
Agonists or antagonists of the clucocorticoid-induced tumour necrosis factor receptor (gitr) or its ligand for the treatment of immune disorders, infections and cancer
|
|
AR045134A1
(es)
|
2003-07-29 |
2005-10-19 |
Smithkline Beecham Plc |
Compuesto de 1h - imidazo [4,5-c] piridin-ilo, composicion farmaceutica que lo comprende, proceso para prepararla, su uso para preparar dicha composicion farmaceutica, combinacion farmaceutica, uso de la combinacion farmaceutica para la preparacion de un medicamento, procedimientos para preparar dic
|
|
NZ585188A
(en)
|
2003-08-15 |
2011-09-30 |
Novartis Ag |
2,4-Pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
|
|
EP1692318A4
(en)
|
2003-12-02 |
2008-04-02 |
Genzyme Corp |
COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF LUNG CANCER
|
|
GB0409799D0
(en)
|
2004-04-30 |
2004-06-09 |
Isis Innovation |
Method of generating improved immune response
|
|
EP1765402A2
(en)
|
2004-06-04 |
2007-03-28 |
Duke University |
Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity
|
|
BR122020017756B1
(pt)
|
2004-08-26 |
2022-02-15 |
Pfizer Inc |
Uso de compostos de aminoeteroarila enantiomericamente puros na preparação de um medicamento para o tratamento de crescimento celular anormal em um mamífero
|
|
PE20060608A1
(es)
|
2004-10-13 |
2006-08-22 |
Wyeth Corp |
Analogos de 17-hidroxiwortmanina como inhibidores de pi3k
|
|
AU2006230099B2
(en)
|
2005-03-25 |
2012-04-19 |
Gitr, Inc. |
GITR binding molecules and uses therefor
|
|
RU2494107C2
(ru)
|
2005-05-09 |
2013-09-27 |
Оно Фармасьютикал Ко., Лтд. |
Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
CN101267824A
(zh)
|
2005-09-20 |
2008-09-17 |
辉瑞产品公司 |
使用酪氨酸激酶抑制剂的治疗剂型和方法
|
|
WO2007133822A1
(en)
|
2006-01-19 |
2007-11-22 |
Genzyme Corporation |
Gitr antibodies for the treatment of cancer
|
|
US8653238B2
(en)
|
2006-02-27 |
2014-02-18 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods for transport of molecules with enhanced release properties across biological barriers
|
|
US20070203168A1
(en)
|
2006-02-28 |
2007-08-30 |
Zhao Jonathon Z |
Isomers of rapamycin and 42-Epi-rapamycin, methods of making and using the same
|
|
US7601852B2
(en)
|
2006-05-11 |
2009-10-13 |
Kosan Biosciences Incorporated |
Macrocyclic kinase inhibitors
|
|
WO2008070740A1
(en)
|
2006-12-07 |
2008-06-12 |
F.Hoffmann-La Roche Ag |
Phosphoinositide 3-kinase inhibitor compounds and methods of use
|
|
ES2776406T3
(es)
|
2007-07-12 |
2020-07-30 |
Gitr Inc |
Terapias de combinación que emplean moléculas de enlazamiento a GITR
|
|
AU2008298948B2
(en)
|
2007-09-12 |
2014-09-04 |
F. Hoffmann-La Roche Ag |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
|
US8354528B2
(en)
|
2007-10-25 |
2013-01-15 |
Genentech, Inc. |
Process for making thienopyrimidine compounds
|
|
KR100945483B1
(ko)
|
2007-10-25 |
2010-03-05 |
이화여자대학교 산학협력단 |
ｐｉｋＤ 조절유전자의 발현벡터를 이용한 스트렙토미세스베네주엘라에（Ｓｔｒｅｐｔｏｍｙｃｅｓｖｅｎｅｚｕｅｌａｅ）에서폴리케타이드（ｐｏｌｙｋｅｔｉｄｅ）의 생산성 증가방법
|
|
GB0805363D0
(en)
|
2008-03-20 |
2008-04-30 |
Sinvent As |
Novel NRPS-PKS gene cluster and its manipulation and utility
|
|
NZ590667A
(en)
|
2008-07-02 |
2013-01-25 |
Emergent Product Dev Seattle |
Tgf-b antagonist multi-target binding proteins
|
|
JPWO2010030002A1
(ja)
|
2008-09-12 |
2012-02-02 |
国立大学法人三重大学 |
外来性ｇｉｔｒリガンド発現細胞
|
|
WO2010031185A1
(en)
|
2008-09-19 |
2010-03-25 |
Protox Therapeutics Inc. |
Treating cancer stem cells using targeted cargo proteins
|
|
EP2342335B1
(en)
|
2008-09-24 |
2015-09-16 |
Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences |
Novel gene cluster
|
|
WO2010088573A1
(en)
|
2009-01-30 |
2010-08-05 |
Enanta Pharmaceuticals, Inc. |
Cyclosporin analogues for preventing or treating hepatitis c infection
|
|
SG174382A1
(en)
|
2009-04-06 |
2011-11-28 |
Wyeth Llc |
Treatment regimen utilizing neratinib for breast cancer
|
|
JP2012532929A
(ja)
|
2009-07-13 |
2012-12-20 |
プレジデント アンド フェロウズ オブ ハーバード カレッジ |
二機能性のステープリングされたポリペプチドおよびそれらの使用
|
|
EP2456777A2
(en)
|
2009-07-24 |
2012-05-30 |
Université Henri Poincaré - Nancy 1 |
Stambomycin and derivatives, their production and their use as drugs
|
|
EP2473531A4
(en)
|
2009-09-03 |
2013-05-01 |
Merck Sharp & Dohme |
Anti-gitr antibodies
|
|
US20130072439A1
(en)
|
2009-09-22 |
2013-03-21 |
Huw M. Nash |
Peptidomimetic macrocycles
|
|
US20120208720A1
(en)
|
2009-10-22 |
2012-08-16 |
Kenji Kashiwagi |
Rapid display method in translational synthesis of peptide
|
|
GB0919054D0
(en)
|
2009-10-30 |
2009-12-16 |
Isis Innovation |
Treatment of obesity
|
|
CN102958942A
(zh)
|
2009-12-29 |
2013-03-06 |
新兴产品开发西雅图有限公司 |
异二聚体结合蛋白及其应用
|
|
AU2011214135B2
(en)
|
2010-02-09 |
2014-07-31 |
Neurovive Pharmaceutical Ab |
Sanglifehrin based compounds
|
|
EP2646440A4
(en)
|
2010-11-30 |
2014-06-18 |
Univ Johns Hopkins |
CYCLIC HYBRID LIBRARIES AND SCREENS FOR THIS
|
|
UY33775A
(es)
|
2010-12-10 |
2012-07-31 |
Gilead Sciences Inc |
Inhibidores macrocíclicos de virus flaviviridae, composiciones farmacéuticas que los comprenden y sus usos
|
|
US9428845B1
(en)
|
2010-12-28 |
2016-08-30 |
Warp Drive Bio, Inc. |
Identifying new therapeutic agents
|
|
CN103703000B
(zh)
|
2011-03-23 |
2015-11-25 |
安姆根有限公司 |
Cdk4/6和flt3的稠合三环双重抑制剂
|
|
JO3063B1
(ar)
|
2011-03-29 |
2017-03-15 |
Neurovive Pharmaceutical Ab |
مركب مبتكر وطرق لانتاجه
|
|
AU2012257513B2
(en)
|
2011-05-19 |
2017-05-11 |
Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) |
Macrocyclic compounds as protein kinase inhibitors
|
|
WO2012174489A2
(en)
|
2011-06-15 |
2012-12-20 |
The Ohio State University |
Small molecule composite surfaces as inhibitors of protein-protein interactions
|
|
WO2013001310A1
(en)
|
2011-06-30 |
2013-01-03 |
Centro Nacional De Investigaciones Oncológicas (Cnio) |
Macrocyclic compounds and their use as cdk8 inhibitors
|
|
TW201311689A
(zh)
|
2011-08-05 |
2013-03-16 |
必治妥美雅史谷比公司 |
作為因子ｘｉａ抑制劑之新穎巨環化合物
|
|
DE102011111991A1
(de)
|
2011-08-30 |
2013-02-28 |
Lead Discovery Center Gmbh |
Neue Cyclosporin-Derivate
|
|
US20130108641A1
(en)
|
2011-09-14 |
2013-05-02 |
Sanofi |
Anti-gitr antibodies
|
|
EP2836482B1
(en)
|
2012-04-10 |
2019-12-25 |
The Regents of The University of California |
Compositions and methods for treating cancer
|
|
PT2859009T
(pt)
|
2012-06-08 |
2018-01-18 |
Gilead Sciences Inc |
Inibidores macrocíclicos dos vírus flaviviridae
|
|
EA026235B1
(ru)
|
2012-06-08 |
2017-03-31 |
Джилид Сайэнс, Инк. |
Макроциклические ингибиторы вирусов flaviviridae
|
|
AR091279A1
(es)
|
2012-06-08 |
2015-01-21 |
Gilead Sciences Inc |
Inhibidores macrociclicos de virus flaviviridae
|
|
PL2872157T3
(pl)
|
2012-07-12 |
2020-07-13 |
Hangzhou Dac Biotech Co., Ltd |
Koniugaty wiążących komórkę cząsteczek ze środkami cytotoksycznymi
|
|
US10131682B2
(en)
|
2012-11-24 |
2018-11-20 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
|
|
WO2014113584A1
(en)
|
2013-01-16 |
2014-07-24 |
Rhode Island Hospital |
Compositions and methods for the prevention and treatment of osteolysis and osteoporosis
|
|
LT2953952T
(lt)
|
2013-02-07 |
2017-08-25 |
Merck Patent Gmbh |
Makrocikliniai piridazinono dariniai
|
|
JP6473133B2
(ja)
|
2013-03-15 |
2019-02-20 |
アラクセス ファーマ エルエルシー |
Ｋｒａｓｇ１２ｃの共有結合性阻害剤
|
|
US9745319B2
(en)
|
2013-03-15 |
2017-08-29 |
Araxes Pharma Llc |
Irreversible covalent inhibitors of the GTPase K-Ras G12C
|
|
EP2984088B1
(en)
|
2013-04-12 |
2019-03-20 |
Asana BioSciences, LLC |
Quinazolines and azaquinazolines as dual inhibitors of ras/raf/mek/erk and pi3k/akt/pten/mtor pathways
|
|
AU2014256984B2
(en)
|
2013-04-26 |
2019-02-14 |
Indiana University Research & Technology Corporation |
Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)
|
|
WO2014180271A1
(zh)
|
2013-05-10 |
2014-11-13 |
苏州明锐医药科技有限公司 |
阿法替尼及其中间体的制备方法
|
|
EP2806274A1
(en)
|
2013-05-24 |
2014-11-26 |
AIT Austrian Institute of Technology GmbH |
Lung cancer diagnostic method and means
|
|
AU2014331794C1
(en)
|
2013-10-10 |
2019-09-12 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C
|
|
JP6523303B2
(ja)
|
2014-01-17 |
2019-05-29 |
ノバルティス アーゲー |
Ｓｈｐ２の活性を阻害するための１−ピリダジン／トリアジン−３−イル−ピペラジン／ピペリジン／ピロリジン誘導体およびその組成物
|
|
CN105899493B
(zh)
|
2014-01-17 |
2019-03-29 |
诺华股份有限公司 |
用于抑制shp2活性的1-(三嗪-3-基/哒嗪-3-基)-哌(-嗪)啶衍生物及其组合物
|
|
JO3517B1
(ar)
|
2014-01-17 |
2020-07-05 |
Novartis Ag |
ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
|
|
US10233431B2
(en)
|
2014-02-26 |
2019-03-19 |
The Regents Of The University Of California |
Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
|
|
US20170067894A1
(en)
|
2014-03-03 |
2017-03-09 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Method and device for detection of pseudomonas aeruginosa
|
|
CA2952557A1
(en)
|
2014-07-16 |
2016-01-21 |
Novogen ltd |
Functionalised and substituted indoles as anti-cancer agents
|
|
JO3474B1
(ar)
|
2014-08-29 |
2020-07-05 |
Amgen Inc |
مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1
|
|
ES2826443T3
(es)
|
2014-09-25 |
2021-05-18 |
Araxes Pharma Llc |
Inhibidores de proteínas mutantes KRAS G12C
|
|
US10011600B2
(en)
|
2014-09-25 |
2018-07-03 |
Araxes Pharma Llc |
Methods and compositions for inhibition of Ras
|
|
TW201629069A
(zh)
|
2015-01-09 |
2016-08-16 |
霍普驅動生物科技股份有限公司 |
參與協同結合之化合物及其用途
|
|
US10533016B2
(en)
|
2015-01-09 |
2020-01-14 |
Revolution Medicines, Inc. |
Compounds that participate in cooperative binding and uses thereof
|
|
US10077289B2
(en)
|
2015-03-31 |
2018-09-18 |
Allergan, Inc. |
Cyclosporins modified on the MeBmt sidechain by heterocyclic rings
|
|
JP2018513853A
(ja)
|
2015-04-10 |
2018-05-31 |
アラクセス ファーマ エルエルシー |
置換キナゾリン化合物およびその使用方法
|
|
JP6789239B2
(ja)
|
2015-04-15 |
2020-11-25 |
アラクセス ファーマ エルエルシー |
Ｋｒａｓの縮合三環系インヒビターおよびその使用の方法
|
|
US20180121597A1
(en)
|
2015-05-22 |
2018-05-03 |
Allosta Pharmaceuticals |
Methods to Prepare and Employ Binding Site Models for Modulation of Phosphatase Activity and Selectivity Determination
|
|
WO2016196569A1
(en)
|
2015-06-01 |
2016-12-08 |
Indiana University Research & Technology Corporation |
Small molecule inhibitors of protein tyrosine phosphatases and uses thereof
|
|
CN112625028B
(zh)
|
2015-06-19 |
2024-10-29 |
诺华股份有限公司 |
用于抑制shp2活性的化合物和组合物
|
|
ES2741746T3
(es)
|
2015-06-19 |
2020-02-12 |
Novartis Ag |
Compuestos y composiciones para inhibir la actividad de SHP2
|
|
ES2824576T3
(es)
|
2015-06-19 |
2021-05-12 |
Novartis Ag |
Compuestos y composiciones para inhibir la actividad de SHP2
|
|
MX388781B
(es)
|
2015-07-22 |
2025-03-20 |
Araxes Pharma Llc |
Compuestos de quinazolina sustituido y su uso como inhibidores de proteínas kras, hras y/o nras mutantes g12c.
|
|
EP3356353A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058915A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058902A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
US10882847B2
(en)
|
2015-09-28 |
2021-01-05 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
WO2017058807A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
US10647703B2
(en)
|
2015-09-28 |
2020-05-12 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
EP3356354A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017059207A1
(en)
|
2015-10-01 |
2017-04-06 |
Warp Drive Bio, Inc. |
Methods and reagents for analyzing protein-protein interfaces
|
|
WO2017078499A2
(ko)
|
2015-11-06 |
2017-05-11 |
경북대학교 산학협력단 |
단백질 타이로신 탈인산화효소 억제제를 포함하는 신경염증성 질환의 예방 또는 치료용 조성물
|
|
US11008372B2
(en)
|
2015-11-07 |
2021-05-18 |
Board Of Regents, The University Of Texas System |
Targeting proteins for degradation
|
|
KR20180081596A
(ko)
|
2015-11-16 |
2018-07-16 |
아락세스 파마 엘엘씨 |
치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법
|
|
CR20180323A
(es)
|
2015-11-20 |
2018-08-06 |
Idorsia Pharmaceuticals Ltd |
Derivados de indol n-sustituídos como moduladores de los receptores de pge2
|
|
WO2017100546A1
(en)
|
2015-12-09 |
2017-06-15 |
Araxes Pharma Llc |
Methods for preparation of quinazoline derivatives
|
|
US9932288B2
(en)
|
2015-12-09 |
2018-04-03 |
West Virginia University |
Chemical compound for inhibition of SHP2 function and for use as an anti-cancer agent
|
|
WO2017156397A1
(en)
|
2016-03-11 |
2017-09-14 |
Board Of Regents, The University Of Texas Sysytem |
Heterocyclic inhibitors of ptpn11
|
|
WO2017172979A1
(en)
|
2016-03-30 |
2017-10-05 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use
|
|
JP7039489B2
(ja)
|
2016-05-18 |
2022-03-22 |
ミラティ セラピューティクス， インコーポレイテッド |
Ｋｒａｓ ｇ１２ｃ阻害剤
|
|
AU2017274199B2
(en)
|
2016-05-31 |
2021-09-23 |
Board Of Regents, The University Of Texas System |
Heterocyclic inhibitors of PTPN11
|
|
EA202092441A1
(ru)
|
2016-06-07 |
2021-05-21 |
Джакобио Фармасьютикалс Ко., Лтд. |
Новые гетероциклические производные, применимые в качестве ингибиторов shp2
|
|
MX383856B
(es)
|
2016-06-14 |
2025-03-14 |
Novartis Ag |
Compuestos y composiciones para inhibir la actividad de shp2.
|
|
KR102598895B1
(ko)
|
2016-07-12 |
2023-11-07 |
레볼루션 메디슨즈, 인크. |
다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진
|
|
US11529347B2
(en)
|
2016-09-22 |
2022-12-20 |
Relay Therapeutics, Inc. |
SHP2 phosphatase inhibitors and methods of use thereof
|
|
US10280172B2
(en)
|
2016-09-29 |
2019-05-07 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
EP3523289A1
(en)
|
2016-10-07 |
2019-08-14 |
Araxes Pharma LLC |
Heterocyclic compounds as inhibitors of ras and methods of use thereof
|
|
TW202500565A
(zh)
|
2016-10-24 |
2025-01-01 |
美商傳達治療有限公司 |
Shp2磷酸酶抑制劑及其使用方法
|
|
JP2020501519A
(ja)
|
2016-10-28 |
2020-01-23 |
ギンゴー バイオワークス， インコーポレイテッド |
化合物の生産のための組成物および方法
|
|
WO2018091634A1
(en)
|
2016-11-18 |
2018-05-24 |
Neurovive Pharmaceutical Ab |
Use of sanglifehrin macrocyclic analogues as anticancer compounds
|
|
BR112019012263A2
(pt)
|
2016-12-15 |
2020-01-28 |
The Regents Of The University Of California |
composições e métodos para tratar câncer
|
|
JP7219218B2
(ja)
|
2016-12-22 |
2023-02-07 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
新規のベンジルアミノ置換キナゾリンおよびｓｏｓ１阻害剤としての誘導体
|
|
WO2018119183A2
(en)
|
2016-12-22 |
2018-06-28 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
WO2018129402A1
(en)
|
2017-01-06 |
2018-07-12 |
Oregon Health & Science University |
Compositions and methods used in diagnosing and treating colorectal cancer
|
|
US20190343836A1
(en)
|
2017-01-10 |
2019-11-14 |
Novartis Ag |
Pharmaceutical combination comprising an alk inhibitor and a shp2 inhibitor
|
|
MX2019008695A
(es)
|
2017-01-23 |
2019-09-11 |
Revolution Medicines Inc |
Compuestos biciclicos como inhibidores alostericos de shp2.
|
|
MX2019008696A
(es)
|
2017-01-23 |
2019-09-13 |
Revolution Medicines Inc |
Compuestos de piridina como inhibidores de shp2 alostericos.
|
|
US20200385364A1
(en)
|
2017-01-26 |
2020-12-10 |
Araxes Pharma Llc |
Fused n-heterocyclic compounds and methods of use thereof
|
|
WO2018140599A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
Benzothiophene and benzothiazole compounds and methods of use thereof
|
|
WO2018140513A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
|
|
EP3573954A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
|
|
WO2018140514A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
|
|
CN110382482A
(zh)
|
2017-01-26 |
2019-10-25 |
亚瑞克西斯制药公司 |
稠合的杂-杂二环化合物及其使用方法
|
|
JOP20190186A1
(ar)
|
2017-02-02 |
2019-08-01 |
Astellas Pharma Inc |
مركب كينازولين
|
|
EP3589647A1
(en)
|
2017-02-28 |
2020-01-08 |
Novartis AG |
Shp inhibitor compositions and uses for chimeric antigen receptor therapy
|
|
CA3056970A1
(en)
|
2017-03-21 |
2018-09-27 |
Bayer Pharma Aktiengesellschaft |
2-methyl-quinazolines
|
|
KR20240026521A
(ko)
|
2017-03-23 |
2024-02-28 |
자코바이오 파마슈티칼스 컴퍼니 리미티드 |
Shp2 억제제로서 유용한 신규한 헤테로환형 유도체
|
|
KR20240093922A
(ko)
|
2017-04-05 |
2024-06-24 |
레볼루션 메디슨즈, 인크. |
단백질-단백질 계면을 분석하기 위한 방법 및 시약
|
|
AU2018248417A1
(en)
|
2017-04-05 |
2019-11-14 |
Revolution Medicines, Inc. |
Compounds that participate in cooperative binding and uses thereof
|
|
US10800787B2
(en)
|
2017-04-20 |
2020-10-13 |
Apotex Inc. |
Process for the preparation of acalabrutinib
|
|
CA3061907A1
(en)
|
2017-05-02 |
2018-11-08 |
Revolution Medicines, Inc. |
Rapamycin analogs as mtor inhibitors
|
|
WO2018206539A1
(en)
|
2017-05-11 |
2018-11-15 |
Astrazeneca Ab |
Heteroaryl compounds that inhibit g12c mutant ras proteins
|
|
EA201992781A1
(ru)
|
2017-05-22 |
2020-04-01 |
Эмджен Инк. |
Ингибиторы g12c kras и способы их применения
|
|
JP2020521741A
(ja)
|
2017-05-25 |
2020-07-27 |
アラクセス ファーマ エルエルシー |
がんの処置のための化合物およびその使用の方法
|
|
US11639346B2
(en)
|
2017-05-25 |
2023-05-02 |
Araxes Pharma Llc |
Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS
|
|
AU2018271990A1
(en)
|
2017-05-25 |
2019-12-12 |
Araxes Pharma Llc |
Covalent inhibitors of KRAS
|
|
WO2018218133A1
(en)
|
2017-05-26 |
2018-11-29 |
Relay Therapeutics, Inc. |
Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors
|
|
CA3074690A1
(en)
|
2017-09-07 |
2019-03-14 |
Revolution Medicines, Inc. |
Shp2 inhibitor compositions and methods for treating cancer
|
|
MA50077A
(fr)
|
2017-09-08 |
2020-07-15 |
Amgen Inc |
Inhibiteurs de kras g12c et leurs procédés d'utilisation
|
|
WO2019051469A1
(en)
|
2017-09-11 |
2019-03-14 |
Krouzon Pharmaceuticals, Inc. |
Octahydrocyclopenta[c]pyrrole allosteric inhibitors of shp2
|
|
HRP20230377T1
(hr)
|
2017-11-15 |
2023-06-23 |
Mirati Therapeutics, Inc. |
Inhibitori mutacije kras g12c
|
|
WO2019110751A1
(en)
|
2017-12-08 |
2019-06-13 |
Astrazeneca Ab |
Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents
|
|
RS64167B1
(sr)
|
2017-12-21 |
2023-05-31 |
Boehringer Ingelheim Int |
Benzilamino supstituisani piridopirimidinoni i derivati kao sos1 inhibitori
|
|
US11426422B2
(en)
|
2018-01-30 |
2022-08-30 |
Research Development Foundation |
SHP2 inhibitors and methods of use thereof
|
|
TW201942115A
(zh)
|
2018-02-01 |
2019-11-01 |
美商輝瑞股份有限公司 |
作為抗癌藥之經取代的喹唑啉和吡啶並嘧啶衍生物
|
|
TW201942116A
(zh)
|
2018-02-09 |
2019-11-01 |
美商輝瑞股份有限公司 |
作為抗癌劑之四氫喹唑啉衍生物
|
|
US11044675B2
(en)
|
2018-02-13 |
2021-06-22 |
Idac Holdings, Inc. |
Methods, apparatuses and systems for adaptive uplink power control in a wireless network
|
|
KR102614939B1
(ko)
|
2018-02-13 |
2023-12-19 |
블루레이 테라퓨틱스 (상하이) 컴퍼니 리미티드 |
피리미딘-융합고리 화합물 및 그의 제조방법과 용도
|
|
WO2019165073A1
(en)
|
2018-02-21 |
2019-08-29 |
Relay Therapeutics, Inc. |
Shp2 phosphatase inhibitors and methods of use thereof
|
|
NZ766835A
(en)
|
2018-03-02 |
2023-09-29 |
Otsuka Pharma Co Ltd |
Pharmaceutical compounds
|
|
SG11202009245TA
(en)
|
2018-03-21 |
2020-10-29 |
Relay Therapeutics Inc |
Shp2 phosphatase inhibitors and methods of use thereof
|
|
RU2020133727A
(ru)
|
2018-03-21 |
2022-04-21 |
Сучжоу Пухе Биофарма Ко., Лтд. |
Ингибиторы shp2 и их применение
|
|
WO2019183364A1
(en)
|
2018-03-21 |
2019-09-26 |
Relay Therapeutics, Inc. |
Pyrazolo[3,4-b]pyrazine shp2 phosphatase inhibitors and methods of use thereof
|
|
CA3097231A1
(en)
|
2018-04-18 |
2019-10-24 |
Bayer Pharma Aktiengesellschaft |
2-methyl-aza-quinazolines
|
|
CN112368289B
(zh)
|
2018-05-01 |
2024-02-20 |
锐新医药公司 |
作为mtor抑制剂的c26-连接的雷帕霉素类似物
|
|
IL300091A
(en)
|
2018-05-01 |
2023-03-01 |
Revolution Medicines Inc |
C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors
|
|
KR102611661B1
(ko)
|
2018-05-02 |
2023-12-08 |
나비레 파르마, 인코퍼레이티드 |
Ptpn11의 치환된 헤테로사이클릭 억제제
|
|
ES2995514T3
(en)
|
2018-05-04 |
2025-02-10 |
Amgen Inc |
Kras g12c inhibitors and methods of using the same
|
|
WO2019213516A1
(en)
|
2018-05-04 |
2019-11-07 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
US11932633B2
(en)
|
2018-05-07 |
2024-03-19 |
Mirati Therapeutics, Inc. |
KRas G12C inhibitors
|
|
TW202012415A
(zh)
|
2018-05-08 |
2020-04-01 |
瑞典商阿斯特捷利康公司 |
化學化合物
|
|
EP3790886B1
(en)
|
2018-05-10 |
2024-06-26 |
Amgen Inc. |
Kras g12c inhibitors for the treatment of cancer
|
|
ES2938987T3
(es)
|
2018-06-01 |
2023-04-18 |
Amgen Inc |
Inhibidores de KRAS G12c y métodos de uso de los mismos
|
|
US20210230300A1
(en)
|
2018-06-04 |
2021-07-29 |
Bayer Aktiengesellschaft |
Inhibitors of shp2
|
|
US20190375749A1
(en)
|
2018-06-11 |
2019-12-12 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
ES3060664T3
(en)
|
2018-06-12 |
2026-03-27 |
Amgen Inc |
Kras g12c inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer
|
|
JP7174143B2
(ja)
|
2018-07-24 |
2022-11-17 |
大鵬薬品工業株式会社 |
Ｓｈｐ２活性を阻害するヘテロ二環性化合物
|
|
MX2021000887A
(es)
|
2018-08-01 |
2021-03-31 |
Araxes Pharma Llc |
Compuestos espiroheterociclicos y metodos de uso de los mismos para el tratamiento de cancer.
|
|
US11518770B2
(en)
|
2018-08-06 |
2022-12-06 |
Purdue Research Foundation |
Sesquiterpenoid analogs
|
|
LT3833670T
(lt)
|
2018-08-10 |
2024-06-25 |
Navire Pharma, Inc. |
6-(4-amino-3-metil-2-oksa-8-azaspiro[4.5]dekan-8-il)-3-(2,3-dichlorfenil)-2-metilpirimidin-4(3h)-ono dariniai ir susiję junginiai kaip ptpn11 (shp2) inhibitoriai, skirti vėžiui gydyti
|
|
WO2020035031A1
(en)
|
2018-08-16 |
2020-02-20 |
Genentech, Inc. |
Fused ring compounds
|
|
US20210230170A1
(en)
|
2018-08-31 |
2021-07-29 |
Mirati Therapeutics, Inc. |
Kras g12c inhibitors
|
|
JP7542538B2
(ja)
|
2018-09-18 |
2024-08-30 |
ニカング セラピューティクス， インコーポレイテッド |
Ｓｒｃホモロジー－２ホスファターゼ阻害剤としての縮合三環式環誘導体
|
|
CN112839935A
(zh)
|
2018-09-26 |
2021-05-25 |
北京加科思新药研发有限公司 |
可用作shp2抑制剂的新型杂环衍生物
|
|
CA3112322A1
(en)
|
2018-09-29 |
2020-04-02 |
Novartis Ag |
Manufacture of compounds and compositions for inhibiting the activity of shp2
|
|
JP2022502385A
(ja)
|
2018-09-29 |
2022-01-11 |
ノバルティス アーゲー |
Ｓｈｐ２の活性を阻害するための化合物の製造方法
|
|
WO2020072656A1
(en)
|
2018-10-03 |
2020-04-09 |
Gilead Sciences, Inc. |
Imidozopyrimidine derivatives
|
|
TW202028183A
(zh)
|
2018-10-10 |
2020-08-01 |
大陸商江蘇豪森藥業集團有限公司 |
含氮雜芳類衍生物調節劑、其製備方法和應用
|
|
WO2020073945A1
(zh)
|
2018-10-10 |
2020-04-16 |
江苏豪森药业集团有限公司 |
双环类衍生物抑制剂、其制备方法和应用
|
|
US12187721B2
(en)
|
2018-10-17 |
2025-01-07 |
Array Biopharma Inc. |
Protein tyrosine phosphatase inhibitors
|
|
US10684219B2
(en)
|
2018-10-30 |
2020-06-16 |
Chevron U.S.A. Inc. |
Method for determining hydrocarbon concentration in drilled solids using near infrared spectroscopy
|
|
CN111138412B
(zh)
|
2018-11-06 |
2023-09-15 |
上海奕拓医药科技有限责任公司 |
一种螺芳环化合物及其应用
|
|
JP2022506887A
(ja)
|
2018-11-07 |
2022-01-17 |
シャンハイ リンジーン バイオファーマ カンパニー リミテッド |
窒素含有縮合複素環系ｓｈｐ２阻害剤化合物、製造方法及び使用
|
|
US11053226B2
(en)
|
2018-11-19 |
2021-07-06 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
WO2020104635A1
(en)
|
2018-11-23 |
2020-05-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of shp2 inhibitors for the treatment of insulin resistance
|
|
CN113272303B
(zh)
|
2018-11-30 |
2024-09-17 |
上海拓界生物医药科技有限公司 |
嘧啶并五元氮杂环类衍生物、其制备方法及其在医药上的应用
|
|
KR20210116479A
(ko)
|
2018-12-21 |
2021-09-27 |
레볼루션 메디슨즈, 인크. |
공동 결합에 참여하는 화합물 및 그의 용도
|
|
US20200268897A1
(en)
|
2019-01-08 |
2020-08-27 |
Yale University |
Phosphatase Binding Compounds and Methods of Using Same
|
|
WO2020146613A1
(en)
|
2019-01-10 |
2020-07-16 |
Mirati Therapeutics, Inc. |
Kras g12c inhibitors
|
|
CN113316574B
(zh)
|
2019-01-31 |
2024-01-30 |
贝达药业股份有限公司 |
Shp2抑制剂及其应用
|
|
CN113365988B
(zh)
|
2019-01-31 |
2023-10-03 |
贝达药业股份有限公司 |
Shp2抑制剂及其应用
|
|
MX2021009562A
(es)
|
2019-02-12 |
2021-09-08 |
Novartis Ag |
Combinacion farmaceutica que comprende tno155 y un inhibidor de pd-1.
|
|
WO2020165732A1
(en)
|
2019-02-12 |
2020-08-20 |
Novartis Ag |
Pharmaceutical combination comprising tno155 and a krasg12c inhibitor
|
|
KR20210126653A
(ko)
|
2019-02-12 |
2021-10-20 |
노파르티스 아게 |
Tno155 및 리보시클립을 포함하는 약제학적 조합물
|
|
WO2020173935A1
(en)
|
2019-02-26 |
2020-09-03 |
Boehringer Ingelheim International Gmbh |
New isoindolinone substituted indoles and derivatives as ras inhibitors
|
|
WO2020180768A1
(en)
|
2019-03-01 |
2020-09-10 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
|
CN113727758A
(zh)
|
2019-03-01 |
2021-11-30 |
锐新医药公司 |
双环杂环基化合物及其用途
|
|
CN111647000B
(zh)
|
2019-03-04 |
2021-10-12 |
勤浩医药（苏州）有限公司 |
吡嗪类衍生物及其在抑制shp2中的应用
|
|
CA3127361A1
(en)
|
2019-03-07 |
2020-09-10 |
Merck Patent Gmbh |
Carboxamide-pyrimidine derivatives as shp2 antagonists
|
|
WO2020201991A1
(en)
|
2019-04-02 |
2020-10-08 |
Array Biopharma Inc. |
Protein tyrosine phosphatase inhibitors
|
|
CA3127475A1
(en)
|
2019-04-08 |
2020-10-15 |
Merck Patent Gmbh |
Pyrimidinone derivatives as shp2 antagonists
|
|
CN117209471A
(zh)
|
2019-06-14 |
2023-12-12 |
北京盛诺基医药科技股份有限公司 |
一种shp2磷酸酶变构抑制剂
|
|
AU2020306124A1
(en)
|
2019-06-28 |
2022-02-03 |
Tuojie Biotech (Shanghai) Co., Ltd. |
Pyrimidine five-membered nitrogen heterocyclic derivative, preparation method thereof and pharmaceutical use thereof
|
|
CN112300160A
(zh)
|
2019-08-01 |
2021-02-02 |
上海奕拓医药科技有限责任公司 |
一种螺芳环化合物、其制备及应用
|
|
EP3772513A1
(en)
|
2019-08-09 |
2021-02-10 |
C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening |
Shp2 inhibitors
|
|
GB201911928D0
(en)
|
2019-08-20 |
2019-10-02 |
Otsuka Pharma Co Ltd |
Pharmaceutical compounds
|
|
CN114127053B
(zh)
|
2019-09-06 |
2023-06-13 |
四川科伦博泰生物医药股份有限公司 |
一种取代吡嗪化合物、其制备方法和用途
|
|
CA3155066A1
(en)
|
2019-09-20 |
2021-03-25 |
Shanghai Jemincare Pharmaceuticals Co., Ltd |
Fused pyridone compound, and preparation method therefor and use thereof
|
|
US20230010886A1
(en)
|
2019-09-23 |
2023-01-12 |
Suzhou Puhe BioPharma Co., Ltd. |
Shp2 inhibitors and uses thereof
|
|
AU2020354475A1
(en)
|
2019-09-24 |
2022-05-05 |
Relay Therapeutics, Inc. |
SHP2 phosphatase inhibitors and methods of making and using the same
|
|
CN112724145A
(zh)
|
2019-10-14 |
2021-04-30 |
杭州雷索药业有限公司 |
用于抑制shp2活性的吡嗪衍生物
|
|
CA3157789A1
(en)
|
2019-10-15 |
2021-04-22 |
Bayer Aktiengesellschaft |
2-methyl-aza-quinazolines
|
|
CN214807781U
(zh)
|
2019-10-22 |
2021-11-23 |
巴德阿克塞斯系统股份有限公司 |
可快速插入的中心导管
|
|
CN114867726B
(zh)
|
2019-10-28 |
2023-11-28 |
默沙东有限责任公司 |
Kras g12c突变体的小分子抑制剂
|
|
MX2022005359A
(es)
*
|
2019-11-04 |
2022-06-02 |
Revolution Medicines Inc |
Inhibidores de ras.
|
|
WO2021091956A1
(en)
|
2019-11-04 |
2021-05-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
CN120699039A
(zh)
|
2019-11-04 |
2025-09-26 |
锐新医药公司 |
Ras抑制剂
|
|
TW202128688A
(zh)
|
2019-11-08 |
2021-08-01 |
美商銳新醫藥公司 |
雙環雜芳基化合物及其用途
|
|
WO2021088945A1
(zh)
|
2019-11-08 |
2021-05-14 |
南京圣和药业股份有限公司 |
作为shp2抑制剂的化合物及其应用
|
|
EP4065231A1
(en)
|
2019-11-27 |
2022-10-05 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
|
CA3154914A1
(en)
|
2019-11-29 |
2021-06-03 |
Lupin Limited |
Substituted tricyclic compounds
|
|
WO2021110796A1
(en)
|
2019-12-04 |
2021-06-10 |
Bayer Aktiengesellschaft |
Inhibitors of shp2
|
|
CN114829362A
(zh)
|
2019-12-10 |
2022-07-29 |
成都倍特药业股份有限公司 |
一种可用作shp2抑制剂的含氮杂原子的六元并五元芳环衍生物
|
|
WO2021119525A1
(en)
|
2019-12-11 |
2021-06-17 |
Tiaki Therapeutics Inc. |
Shp1 and shp2 inhibitors and their methods of use
|
|
WO2021126816A1
(en)
|
2019-12-16 |
2021-06-24 |
Amgen Inc. |
Dosing regimen of a kras g12c inhibitor
|
|
WO2021126799A1
(en)
|
2019-12-18 |
2021-06-24 |
Merck Sharp & Dohme Corp. |
Macrocyclic peptides as potent inhibitors of k-ras g12d mutant
|
|
WO2021120045A1
(en)
|
2019-12-18 |
2021-06-24 |
InventisBio Co., Ltd. |
Heterocyclic compounds, preparation methods and uses thereof
|
|
WO2021121397A1
(zh)
|
2019-12-19 |
2021-06-24 |
首药控股(北京)股份有限公司 |
取代的炔基杂环化合物
|
|
WO2021121371A1
(zh)
|
2019-12-19 |
2021-06-24 |
贝达药业股份有限公司 |
Kras g12c抑制剂及其在医药上的应用
|
|
CA3165238A1
(en)
|
2019-12-19 |
2021-06-24 |
Jacobio Pharmaceuticals Co., Ltd. |
Kras mutant protein inhibitors
|
|
PH12022551513A1
(en)
|
2019-12-20 |
2023-04-24 |
Mirati Therapeutics Inc |
Sos1 inhibitors
|
|
EP4076667A1
(en)
|
2019-12-20 |
2022-10-26 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
WO2021120890A1
(en)
|
2019-12-20 |
2021-06-24 |
Novartis Ag |
Pyrazolyl derivatives useful as anti-cancer agents
|
|
CN114929704B
(zh)
|
2019-12-27 |
2024-07-23 |
微境生物医药科技(上海)有限公司 |
含螺环的喹唑啉化合物
|
|
KR20220132543A
(ko)
|
2019-12-27 |
2022-09-30 |
루핀 리미티드 |
치환된 삼환 화합물
|
|
CN113045565A
(zh)
|
2019-12-27 |
2021-06-29 |
微境生物医药科技(上海)有限公司 |
新型K-Ras G12C抑制剂
|
|
WO2021139678A1
(zh)
|
2020-01-07 |
2021-07-15 |
广州百霆医药科技有限公司 |
吡啶并嘧啶类kras g12c突变蛋白抑制剂
|
|
TWI770760B
(zh)
|
2020-01-08 |
2022-07-11 |
大陸商蘇州亞盛藥業有限公司 |
螺環四氫喹唑啉
|
|
US20210269434A1
(en)
|
2020-01-10 |
2021-09-02 |
Incyte Corporation |
Tricyclic compounds as inhibitors of kras
|
|
CN115175908B
(zh)
|
2020-01-13 |
2024-07-23 |
苏州泽璟生物制药股份有限公司 |
芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用
|
|
WO2021143823A1
(zh)
|
2020-01-16 |
2021-07-22 |
浙江海正药业股份有限公司 |
吡啶或嘧啶类衍生物及其制备方法和用途
|
|
CN114867720B
(zh)
|
2020-01-16 |
2024-10-22 |
浙江海正药业股份有限公司 |
杂芳基类衍生物及其制备方法和用途
|
|
CN113135910A
(zh)
|
2020-01-19 |
2021-07-20 |
北京诺诚健华医药科技有限公司 |
嘧啶-4(3h)-酮类杂环化合物、其制备方法及其在医药学上的应用
|
|
WO2021150613A1
(en)
|
2020-01-20 |
2021-07-29 |
Incyte Corporation |
Spiro compounds as inhibitors of kras
|
|
WO2021147965A1
(zh)
|
2020-01-21 |
2021-07-29 |
南京明德新药研发有限公司 |
作为kras抑制剂的大环类化合物
|
|
WO2021147879A1
(zh)
|
2020-01-21 |
2021-07-29 |
贝达药业股份有限公司 |
Shp2抑制剂及其应用
|
|
WO2021148010A1
(zh)
|
2020-01-22 |
2021-07-29 |
南京明德新药研发有限公司 |
吡唑并杂芳环类化合物及其应用
|
|
EP4093406A4
(en)
|
2020-01-24 |
2024-02-28 |
Taiho Pharmaceutical Co., Ltd. |
IMPROVEMENT OF THE ANTI-TUMORAL ACTIVITY OF SHP2 INHIBITOR PYRIMIDINONE IN COMBINATION WITH NEW ANTI-CANCER DRUGS AGAINST CANCER
|
|
GB202001344D0
(en)
|
2020-01-31 |
2020-03-18 |
Redx Pharma Plc |
Ras Inhibitors
|
|
CN112159405B
(zh)
|
2020-02-04 |
2021-09-14 |
广州必贝特医药技术有限公司 |
吡啶并嘧啶酮类化合物及其应用
|
|
US20230346790A1
(en)
|
2020-02-06 |
2023-11-02 |
Wellmarker Bio Co., Ltd. |
Pharmaceutical composition for prevention or treatment of cancers associated with kras mutation
|
|
EP4077328A4
(en)
|
2020-02-20 |
2023-11-29 |
Beta Pharma, Inc. |
PYRIDOPYRIMIDE DERIVATIVES AS KRAS INHIBITORS
|
|
TW202140450A
(zh)
|
2020-02-24 |
2021-11-01 |
大陸商泰勵生物科技（上海）有限公司 |
用於癌症治療的ｋｒａｓ抑制劑
|
|
CN114845997B
(zh)
|
2020-02-24 |
2024-03-29 |
上海喆邺生物科技有限公司 |
芳香类化合物及其在制备抗肿瘤药物中的应用
|
|
EP4110333A4
(en)
|
2020-02-24 |
2023-12-06 |
Mirati Therapeutics, Inc. |
Sos1 inhibitors
|
|
US20210292330A1
(en)
|
2020-02-28 |
2021-09-23 |
Erasca, Inc. |
Pyrrolidine-fused heterocycles
|
|
EP4143189A1
(en)
|
2020-04-30 |
2023-03-08 |
Gilead Sciences, Inc. |
Macrocyclic inhibitors of peptidylarginine deiminases
|
|
GB2595975B
(en)
|
2020-06-09 |
2022-12-07 |
Pardes Biosciences Inc |
Inhibitors of cysteine proteases and methods of use thereof
|
|
IL299131A
(en)
|
2020-06-18 |
2023-02-01 |
Revolution Medicines Inc |
Methods for delaying, preventing and treating acquired resistance to RAS inhibitors
|
|
MX2023002248A
(es)
|
2020-09-03 |
2023-05-16 |
Revolution Medicines Inc |
Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2.
|
|
MX2023003060A
(es)
|
2020-09-15 |
2023-04-05 |
Revolution Medicines Inc |
Derivados indolicos como inhibidores de ras en el tratamiento del cancer.
|
|
EP4225383A4
(en)
|
2020-10-08 |
2024-12-11 |
Kumquat Biosciences Inc. |
MODULATORS OF CELLULAR PROLIFERATION AND THEIR USES
|
|
US12404261B2
(en)
|
2020-12-22 |
2025-09-02 |
Novartis Ag |
Compounds and compositions for treating conditions associated with cGAS
|
|
JP2023554521A
(ja)
|
2020-12-22 |
2023-12-27 |
ファイザー・インク |
Ｅｉｆ４ｅ阻害剤の固体形態
|
|
WO2022139304A1
(ko)
|
2020-12-22 |
2022-06-30 |
한미약품 주식회사 |
Sos1 억제제로서의 신규한 퀴나졸린 유도체 화합물 및 이의 용도
|
|
IL307396A
(en)
|
2021-04-02 |
2023-12-01 |
Massachusetts Gen Hospital |
Methods for inhibiting RAS
|
|
TW202304452A
(zh)
|
2021-04-09 |
2023-02-01 |
美商銳新醫藥公司 |
Ｓｏｓ１抑制劑與ｒａｓ抑制劑於治療癌症之用途
|
|
KR20240017814A
(ko)
|
2021-05-05 |
2024-02-08 |
바이오젠 엠에이 인코포레이티드 |
브루톤 티로신 키나제의 분해를 표적으로 하는 화합물
|
|
AU2022269596A1
(en)
|
2021-05-05 |
2023-11-16 |
Constellation Pharmaceuticals, Inc. |
Modulators of trex1
|
|
AU2022268962A1
(en)
|
2021-05-05 |
2023-12-14 |
Revolution Medicines, Inc. |
Ras inhibitors for the treatment of cancer
|
|
CA3217393A1
(en)
|
2021-05-05 |
2022-11-10 |
Elena S. Koltun |
Ras inhibitors
|
|
WO2022235866A1
(en)
|
2021-05-05 |
2022-11-10 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
|
MX2023013912A
(es)
|
2021-05-25 |
2024-02-12 |
Revolution Medicines Inc |
Metodos para inhibir ras.
|
|
WO2022271658A1
(en)
|
2021-06-23 |
2022-12-29 |
Erasca, Inc. |
Tricyclic kras inhibitors
|
|
WO2023015559A1
(en)
|
2021-08-13 |
2023-02-16 |
Nutshell Biotech (Shanghai) Co., Ltd. |
Macrocycle compounds as inhibitors of ras
|
|
AR126854A1
(es)
|
2021-08-27 |
2023-11-22 |
Hoffmann La Roche |
Compuestos macrocíclicos para el tratamiento de cáncer
|
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
|
CN118922423A
(zh)
|
2022-01-10 |
2024-11-08 |
锐新医药公司 |
Ras抑制剂
|
|
CN119136806A
(zh)
|
2022-03-08 |
2024-12-13 |
锐新医药公司 |
用于治疗免疫难治性肺癌的方法
|
|
WO2023240263A1
(en)
|
2022-06-10 |
2023-12-14 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
|
CN120693161A
(zh)
|
2022-10-12 |
2025-09-23 |
锐新医药公司 |
用于治疗癌症的包含第一ras抑制剂、第二ras抑制剂以及shp2抑制剂的组合物
|
|
JP2026504244A
(ja)
|
2022-11-09 |
2026-02-04 |
レヴォリューション・メディスンズ，インコーポレイテッド |
化合物、複合体、ならびにそれらの調製方法及びそれらの使用方法
|
|
EP4687905A1
(en)
|
2023-03-30 |
2026-02-11 |
Revolution Medicines, Inc. |
Compositions for inducing ras gtp hydrolysis and uses thereof
|
|
KR20260005904A
(ko)
|
2023-04-07 |
2026-01-12 |
레볼루션 메디슨즈, 인크. |
매크로사이클릭 ras 억제제
|
|
CN121263418A
(zh)
|
2023-04-07 |
2026-01-02 |
锐新医药公司 |
大环ras抑制剂
|
|
KR20250172857A
(ko)
|
2023-04-14 |
2025-12-09 |
레볼루션 메디슨즈, 인크. |
Ras 억제제의 결정형
|
|
AU2024252105A1
(en)
|
2023-04-14 |
2025-10-16 |
Revolution Medicines, Inc. |
Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof
|
|
US20240368190A1
(en)
|
2023-04-14 |
2024-11-07 |
Revolution Medicines, Inc. |
Synthesis of ras inhibitors
|
|
CN121464125A
(zh)
|
2023-04-14 |
2026-02-03 |
锐新医药公司 |
Ras抑制剂的合成
|
|
AU2024265078A1
(en)
|
2023-05-04 |
2025-12-11 |
Revolution Medicines, Inc. |
Combination therapy for a ras related disease or disorder
|
|
WO2025019318A2
(en)
*
|
2023-07-14 |
2025-01-23 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
IL326136A
(en)
|
2023-08-07 |
2026-03-01 |
Revolution Medicines Inc |
RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein
|
|
US20250115551A1
(en)
|
2023-10-03 |
2025-04-10 |
Revolution Medicines, Inc. |
Synthesis of ras inhibitors
|