DK0660717T3 - Aminosteroider til ophthalmisk anvendelse - Google Patents

Aminosteroider til ophthalmisk anvendelse

Info

Publication number: DK0660717T3
Authority: DK; Denmark
Prior art keywords: therapeutic agents; stabilizing; amounts; stabilized; cyclodextrin
Prior art date: 1990-06-12

Application number

DK91910700T

Other languages

Danish (da)

English (en)

Inventor

Santosh Kumar Chandrasekaran

John C Babcock

Lyle M Bowman

Jon R Polansky

Sheng-Wang Tsao

Erwin Chun-Chit Si

Original Assignee

Insite Vision Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-12

Filing date

1991-05-17

Publication date

1998-12-21

1991-05-17 Application filed by Insite Vision Inc filed Critical Insite Vision Inc

1998-12-21 Application granted granted Critical

1998-12-21 Publication of DK0660717T3 publication Critical patent/DK0660717T3/da

Links

230000000087 stabilizing effect Effects 0.000 abstract 4
-1 amino-substituted steroid Chemical class 0.000 abstract 3
239000003814 drug Substances 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 3
229940124597 therapeutic agent Drugs 0.000 abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
229920000642 polymer Polymers 0.000 abstract 2
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 2
GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 abstract 1
229920000858 Cyclodextrin Polymers 0.000 abstract 1
WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 abstract 1
229940080345 gamma-cyclodextrin Drugs 0.000 abstract 1
125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 1
230000003381 solubilizing effect Effects 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nanotechnology (AREA)
Ophthalmology & Optometry (AREA)
General Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Immunology (AREA)
Medical Informatics (AREA)
Molecular Biology (AREA)
Crystallography & Structural Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK91910700T 1990-06-12 1991-05-17 Aminosteroider til ophthalmisk anvendelse DK0660717T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/537,062 US5124154A (en)	1990-06-12	1990-06-12	Aminosteroids for ophthalmic use
PCT/US1991/003321 WO1991019482A1 (en)	1990-06-12	1991-05-17	Aminosteroids for ophthalmic use

Publications (1)

Publication Number	Publication Date
DK0660717T3 true DK0660717T3 (da)	1998-12-21

Family

ID=24141030

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91910700T DK0660717T3 (da)	1990-06-12	1991-05-17	Aminosteroider til ophthalmisk anvendelse

Country Status (12)

Country	Link
US (3)	US5124154A (de)
EP (1)	EP0660717B1 (de)
JP (1)	JPH05507916A (de)
AT (1)	ATE163853T1 (de)
AU (1)	AU8090791A (de)
CA (1)	CA2085245A1 (de)
DE (1)	DE69129078T2 (de)
DK (1)	DK0660717T3 (de)
ES (1)	ES2116292T3 (de)
NZ (1)	NZ238240A (de)
WO (1)	WO1991019482A1 (de)
ZA (1)	ZA913908B (de)

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1990
- 1990-06-12 US US07/537,062 patent/US5124154A/en not_active Expired - Fee Related
1991
- 1991-05-17 ES ES91910700T patent/ES2116292T3/es not_active Expired - Lifetime
- 1991-05-17 AU AU80907/91A patent/AU8090791A/en not_active Abandoned
- 1991-05-17 DE DE69129078T patent/DE69129078T2/de not_active Expired - Fee Related
- 1991-05-17 CA CA002085245A patent/CA2085245A1/en not_active Abandoned
- 1991-05-17 JP JP91510422A patent/JPH05507916A/ja active Pending
- 1991-05-17 WO PCT/US1991/003321 patent/WO1991019482A1/en not_active Ceased
- 1991-05-17 EP EP91910700A patent/EP0660717B1/de not_active Expired - Lifetime
- 1991-05-17 AT AT91910700T patent/ATE163853T1/de not_active IP Right Cessation
- 1991-05-17 DK DK91910700T patent/DK0660717T3/da active
- 1991-05-23 ZA ZA913908A patent/ZA913908B/xx unknown
- 1991-05-23 NZ NZ238240A patent/NZ238240A/xx unknown
1992
- 1992-12-02 US US07/984,445 patent/US5332582A/en not_active Expired - Lifetime
1994
- 1994-02-28 US US08/202,469 patent/US5538721A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE163853T1 (de)	1998-03-15
EP0660717B1 (de)	1998-03-11
EP0660717A4 (de)	1994-03-18
ES2116292T3 (es)	1998-07-16
US5332582A (en)	1994-07-26
JPH05507916A (ja)	1993-11-11
US5124154A (en)	1992-06-23
US5538721A (en)	1996-07-23
CA2085245A1 (en)	1991-12-13
WO1991019482A1 (en)	1991-12-26
AU8090791A (en)	1992-01-07
EP0660717A1 (de)	1995-07-05
ZA913908B (en)	1992-02-26
NZ238240A (en)	1993-08-26
DE69129078D1 (de)	1998-04-16
DE69129078T2 (de)	1998-11-12

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