DK0821682T3 - Benzimidazolforbindelser og deres anvendelse som modulatorer af gaba-a-receptorkomplekset - Google Patents

Benzimidazolforbindelser og deres anvendelse som modulatorer af gaba-a-receptorkomplekset

Info

Publication number: DK0821682T3
Authority: DK; Denmark
Prior art keywords: pct; phenyl; disorders; sec; alkyl
Prior art date: 1995-04-21

Application number

DK96914957T

Other languages

Danish (da)

English (en)

Inventor

Lene Teuber

Frank Waetjen

Yoshimasa Fukuda

Osamu Ushiroda

Toshiro Sasaki

Original Assignee

Neurosearch As

Meiji Seika Kaisha

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-21

Filing date

1996-04-19

Publication date

2000-12-04

1996-04-19 Application filed by Neurosearch As, Meiji Seika Kaisha filed Critical Neurosearch As

2000-12-04 Application granted granted Critical

2000-12-04 Publication of DK0821682T3 publication Critical patent/DK0821682T3/da

Links

125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010010904 Convulsion Diseases 0.000 abstract 1
208000026139 Memory disease Diseases 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
206010015037 epilepsy Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000019116 sleep disease Diseases 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK96914957T 1995-04-21 1996-04-19 Benzimidazolforbindelser og deres anvendelse som modulatorer af gaba-a-receptorkomplekset DK0821682T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK46095		1995-04-21
DK74195		1995-06-27
PCT/EP1996/001649 WO1996033191A1 (en)	1995-04-21	1996-04-19	Benzimidazole compounds and their use as modulators of the gabaa receptor complex

Publications (1)

Publication Number	Publication Date
DK0821682T3 true DK0821682T3 (da)	2000-12-04

Family

ID=26064049

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96914957T DK0821682T3 (da)	1995-04-21	1996-04-19	Benzimidazolforbindelser og deres anvendelse som modulatorer af gaba-a-receptorkomplekset

Country Status (27)

Country	Link
US (1)	US5922725A (de)
EP (1)	EP0821682B1 (de)
JP (1)	JP3171852B2 (de)
KR (1)	KR100283363B1 (de)
CN (1)	CN1089762C (de)
AT (1)	ATE194836T1 (de)
AU (1)	AU699623B2 (de)
BR (1)	BR9608056A (de)
CA (1)	CA2218552C (de)
CZ (1)	CZ287538B6 (de)
DE (1)	DE69609413T2 (de)
DK (1)	DK0821682T3 (de)
EE (1)	EE04308B1 (de)
ES (1)	ES2150671T3 (de)
GR (1)	GR3034558T3 (de)
HU (1)	HU224031B1 (de)
IS (1)	IS2020B (de)
MX (1)	MX9708147A (de)
NO (1)	NO314502B1 (de)
NZ (1)	NZ307532A (de)
PL (1)	PL184020B1 (de)
PT (1)	PT821682E (de)
RU (1)	RU2136676C1 (de)
SK (1)	SK282105B6 (de)
TR (1)	TR199701219T1 (de)
UA (1)	UA54394C2 (de)
WO (1)	WO1996033191A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998017651A1 (en) *	1996-10-21	1998-04-30	Neurosearch A/S	1-phenyl-benzimidazole compounds and their use as baga-a receptor modulators
JP3868502B2 (ja) *	1996-10-25	2007-01-17	ニューロサーチ・アクティーゼルスカブ	抗不安作用を有する化合物の同定方法
GB9702524D0 (en) *	1997-02-07	1997-03-26	Merck Sharp & Dohme	Therapeutic agents
NZ503435A (en) *	1997-10-10	2001-12-21	Neurosearch As	Oxime substituted 1-(3-(heteroaryl)phenyl)-benzimidazole compounds having GABA activity
AU1224499A (en) *	1997-12-09	1999-06-28	Neurosearch A/S	Chemical compounds for use as anxiolytic agents and a method for the identification of anxiolytic compounds
WO2000003971A1 (en) *	1998-07-15	2000-01-27	Meiji Seika Kaisha, Ltd.	Process for producing 4-substituted-2-nitro-fluorobenzenes
WO2000025780A1 (en) *	1998-10-29	2000-05-11	Bristol-Myers Squibb Company	Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
US6271241B1 (en)	1999-04-02	2001-08-07	Neurogen Corporation	Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors
US6627624B1 (en)	1999-04-02	2003-09-30	Neurogen Corporation	Aryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
US6281237B1 (en)	1999-04-02	2001-08-28	Neurogen Corporation	N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives
US6380210B1 (en)	1999-04-02	2002-04-30	Neurogen Corporation	Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
IL146403A0 (en)	1999-06-22	2002-07-25	Neurosearch As	Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds
EP1294723A1 (de)	2000-05-24	2003-03-26	MERCK SHARP & DOHME LTD.	3-phenyl-imidazo-pyrimidin derivate als liganden für gaba rezeptoren
TWI248936B (en) *	2001-03-21	2006-02-11	Merck Sharp & Dohme	Imidazo-pyrimidine derivatives as ligands for GABA receptors
ATE338758T1 (de) *	2001-03-23	2006-09-15	Merck Sharp & Dohme	Imidazopyrimidin-derivate als liganden für gaba- rezeptoren
WO2004069160A2 (en) *	2003-01-28	2004-08-19	Smithkline Beecham Corporation	Chemical compounds
DE602004011914T2 (de)	2003-04-03	2008-06-12	Neurosearch A/S	Benzimidazole derivate und ihre anwendung als gaba a rezeptor komplex modulatoren
EP1613618A2 (de)	2003-04-03	2006-01-11	Neurosearch A/S	Benzimidazol derivate und ihre verwendung als modulatoren des gaba-a rezeptoren komplexes
TWI391381B (zh) *	2006-03-24	2013-04-01	Neurosearch As	新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途
US8974526B2 (en)	2007-08-27	2015-03-10	Amo Groningen B.V.	Multizonal lens with extended depth of focus
WO2010055126A1 (en) *	2008-11-14	2010-05-20	Neurosearch A/S	Benzimidazole derivatives and their use for modulating the gabaa receptor complex
WO2011047315A1 (en)	2009-10-15	2011-04-21	Concert Pharmaceuticals, Inc.	Subsitituted benzimidazoles
JP6836693B2 (ja) *	2017-09-28	2021-03-03	シーストーン・ファーマスーティカルズ・（スージョウ）・カンパニー・リミテッドＣｓｔｏｎｅＰｈａｒｍａｃｅｕｔｉｃａｌｓ（Ｓｕｚｈｏｕ）Ｃｏ．，Ｌｔｄ．	Ａ２ａ受容体アンタゴニストとしての縮合環誘導体
US11886046B2 (en)	2019-12-30	2024-01-30	Amo Groningen B.V.	Multi-region refractive lenses for vision treatment

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1979000936A1 (en) *	1978-04-17	1979-11-15	Basab Materialhantering Ab	A device for raising and transport of goods
DE2853765A1 (de) *	1978-12-13	1980-06-26	Bayer Ag	Verfahren zur herstellung von benzimidazolylbenzofuranen
US4329348A (en) *	1979-02-26	1982-05-11	Ciba-Geigy Corporation	N-Oxacyclic-alkylpiperidines as psychostimulants
PH30434A (en) *	1989-04-07	1997-05-09	Janssen Pharmaceutica Nv	Hydroxyalkylfuranyl derivatives
ATE163290T1 (de) *	1991-06-24	1998-03-15	Neurosearch As	Imidazol-verbindungen, verfahren zu ihrer herstellung und ihre anwendung
US5158969A (en) *	1991-08-21	1992-10-27	Neurosearch A/S	Indole derivatives as potassium channel blockers
DK40192D0 (da) *	1992-03-26	1992-03-26	Neurosearch As	Imidazolforbindelser, deres fremstilling og anvendelse
AU675484B2 (en) *	1993-03-24	1997-02-06	Neurosearch A/S	Benzimidazole compounds, their use and preparation
IT1261432B (it) *	1993-03-26	1996-05-23	Sigma Tau Ind Farmaceuti	Uso di acil l- carnitina gammaidrossibutirrato per il trattamento dell'alcolismo.

1996
- 1996-04-19 BR BR9608056-6A patent/BR9608056A/pt not_active IP Right Cessation
- 1996-04-19 MX MX9708147A patent/MX9708147A/es not_active IP Right Cessation
- 1996-04-19 DE DE69609413T patent/DE69609413T2/de not_active Expired - Lifetime
- 1996-04-19 EE EE9700282A patent/EE04308B1/xx not_active IP Right Cessation
- 1996-04-19 WO PCT/EP1996/001649 patent/WO1996033191A1/en not_active Ceased
- 1996-04-19 UA UA97115592A patent/UA54394C2/uk unknown
- 1996-04-19 JP JP53148496A patent/JP3171852B2/ja not_active Expired - Fee Related
- 1996-04-19 EP EP96914957A patent/EP0821682B1/de not_active Expired - Lifetime
- 1996-04-19 CN CN96193421A patent/CN1089762C/zh not_active Expired - Fee Related
- 1996-04-19 CA CA002218552A patent/CA2218552C/en not_active Expired - Fee Related
- 1996-04-19 AT AT96914957T patent/ATE194836T1/de not_active IP Right Cessation
- 1996-04-19 US US08/945,123 patent/US5922725A/en not_active Expired - Lifetime
- 1996-04-19 RU RU97119174A patent/RU2136676C1/ru not_active IP Right Cessation
- 1996-04-19 SK SK1406-97A patent/SK282105B6/sk unknown
- 1996-04-19 CZ CZ19973291A patent/CZ287538B6/cs not_active IP Right Cessation
- 1996-04-19 AU AU56906/96A patent/AU699623B2/en not_active Ceased
- 1996-04-19 PT PT96914957T patent/PT821682E/pt unknown
- 1996-04-19 ES ES96914957T patent/ES2150671T3/es not_active Expired - Lifetime
- 1996-04-19 NZ NZ307532A patent/NZ307532A/xx unknown
- 1996-04-19 KR KR1019970707463A patent/KR100283363B1/ko not_active Expired - Fee Related
- 1996-04-19 TR TR97/01219T patent/TR199701219T1/xx unknown
- 1996-04-19 HU HU9802272A patent/HU224031B1/hu not_active IP Right Cessation
- 1996-04-19 DK DK96914957T patent/DK0821682T3/da active
- 1996-04-19 PL PL96322944A patent/PL184020B1/pl not_active IP Right Cessation
1997
- 1997-10-17 IS IS4593A patent/IS2020B/is unknown
- 1997-10-20 NO NO19974843A patent/NO314502B1/no unknown
2000
- 2000-10-04 GR GR20000402248T patent/GR3034558T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
IS2020B (is)	2005-06-15
CZ287538B6 (en)	2000-12-13
TR199701219T1 (xx)	1998-03-21
NO974843D0 (no)	1997-10-20
AU699623B2 (en)	1998-12-10
AU5690696A (en)	1996-11-07
MX9708147A (es)	1997-12-31
CZ329197A3 (cs)	1998-03-18
SK140697A3 (en)	1998-05-06
WO1996033191A1 (en)	1996-10-24
EP0821682A1 (de)	1998-02-04
PL322944A1 (en)	1998-03-02
JP3171852B2 (ja)	2001-06-04
GR3034558T3 (en)	2001-01-31
CA2218552A1 (en)	1996-10-24
ES2150671T3 (es)	2000-12-01
SK282105B6 (sk)	2001-11-06
DE69609413T2 (de)	2000-11-23
ATE194836T1 (de)	2000-08-15
EE04308B1 (et)	2004-06-15
IS4593A (is)	1997-10-17
PT821682E (pt)	2000-11-30
NO974843L (no)	1997-12-15
HU224031B1 (hu)	2005-05-30
CN1089762C (zh)	2002-08-28
UA54394C2 (uk)	2003-03-17
RU2136676C1 (ru)	1999-09-10
HUP9802272A3 (en)	2002-02-28
CA2218552C (en)	2002-04-16
KR100283363B1 (ko)	2001-03-02
PL184020B1 (pl)	2002-08-30
HK1018048A1 (en)	1999-12-10
JPH11511734A (ja)	1999-10-12
KR19990007940A (ko)	1999-01-25
EP0821682B1 (de)	2000-07-19
HUP9802272A2 (hu)	1999-09-28
EE9700282A (et)	1998-06-15
NO314502B1 (no)	2003-03-31
NZ307532A (en)	1999-03-29
US5922725A (en)	1999-07-13
BR9608056A (pt)	1999-11-30
CN1182425A (zh)	1998-05-20
DE69609413D1 (de)	2000-08-24

Publication	Publication Date	Title
DK0821682T3 (da)	2000-12-04	Benzimidazolforbindelser og deres anvendelse som modulatorer af gaba-a-receptorkomplekset
CA2218493A1 (en)	1996-10-24	Benzimidazole compounds and their use as modulators of the gabaa receptor complex
ATE454375T1 (de)	2010-01-15	1-phenyl-benzimidazolverbindungen und ihre verwendung als modulatoren des gaba-a-rezeptors
ES2161382T3 (es)	2001-12-01	Derivados de pirazol, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
NO980919D0 (no)	1998-03-03	8-azabicyklo(3.2.1)okt-2-ene derivater, deres fremstilling og anvendelse
ATE383338T1 (de)	2008-01-15	N-(phenyl(piperidin-2-yl)methyl)benzamid-deriva e,verfahren zu deren herstellung und ihre therapeutische verwendung
DE60107435D1 (de)	2004-12-30	2-adamantylethylamine und deren verwendung bei der behandlung von abnormalitäten in der glutamat transmission
PT729455E (pt)	2005-01-31	Arilpiperazinas derivadas de indol como ligados para os receptores 5ht1-like, 5ht1b e 5ht1d
ATE15890T1 (de)	1985-10-15	Ein fungizides indanylbenzamid.
DE69402935D1 (de)	1997-06-05	Substituierte arylalkylaminobenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel
NO961404L (no)	1996-10-11	4-indolylpiperazinyl-derivater
TR200200969T2 (tr)	2002-07-22	Karbonilamino türevlerinin CNS bozukluklarına karşı kullanılması
DK0847384T3 (da)	2000-07-17	Carbamoylcarboxylsyreamider
MX9708096A (es)	1998-01-31	Compuestos de bencimidazol y su uso para preparar composiciones utiles como moduladores del complejo receptor de gabaa.
TW429147B (en)	2001-04-11	Pharmaceutical composition for the treatment of CNS disorders
DK0651747T3 (da)	1996-05-20	Carbostyrilderivater