DK157933C - Insulinprecursorer - Google Patents

Insulinprecursorer

Info

Publication number
DK157933C
DK157933C DK323687A DK323687A DK157933C DK 157933 C DK157933 C DK 157933C DK 323687 A DK323687 A DK 323687A DK 323687 A DK323687 A DK 323687A DK 157933 C DK157933 C DK 157933C
Authority
DK
Denmark
Prior art keywords
chain
human insulin
insulin
bridging
lys
Prior art date
Application number
DK323687A
Other languages
English (en)
Other versions
DK323687D0 (da
DK157933B (da
DK323687A (da
Inventor
Jan Markussen
Niels Fiil
Mogens Trier Hansen
Lars Thim
Kjeld Norris
Hans Ole Voigt
Gustav Ammerer
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26064247&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK157933(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DK266584A external-priority patent/DK266584D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to DK323687A priority Critical patent/DK157933C/da
Publication of DK323687D0 publication Critical patent/DK323687D0/da
Publication of DK323687A publication Critical patent/DK323687A/da
Publication of DK157933B publication Critical patent/DK157933B/da
Application granted granted Critical
Publication of DK157933C publication Critical patent/DK157933C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/69—Increasing the copy number of the vector
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/94—Saccharomyces
    • Y10S435/942—Saccharomyces cerevisiae

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK323687A 1984-05-30 1987-06-25 Insulinprecursorer DK157933C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK323687A DK157933C (da) 1984-05-30 1987-06-25 Insulinprecursorer

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DK266584A DK266584D0 (da) 1984-05-30 1984-05-30 Dna-sekvens, der koder for en biosyntetisk insulinprecursor og fremgangsmaade til fremstilling af insulinprecursoren
DK266584 1984-05-30
DK58285 1985-02-08
DK58285A DK58285D0 (da) 1984-05-30 1985-02-08 Peptider samt fremstilling og anvendelse deraf
DK323687A DK157933C (da) 1984-05-30 1987-06-25 Insulinprecursorer
DK323687 1987-06-25

Publications (4)

Publication Number Publication Date
DK323687D0 DK323687D0 (da) 1987-06-25
DK323687A DK323687A (da) 1987-06-25
DK157933B DK157933B (da) 1990-03-05
DK157933C true DK157933C (da) 1990-08-27

Family

ID=26064247

Family Applications (2)

Application Number Title Priority Date Filing Date
DK58285A DK58285D0 (da) 1984-05-30 1985-02-08 Peptider samt fremstilling og anvendelse deraf
DK323687A DK157933C (da) 1984-05-30 1987-06-25 Insulinprecursorer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK58285A DK58285D0 (da) 1984-05-30 1985-02-08 Peptider samt fremstilling og anvendelse deraf

Country Status (15)

Country Link
US (1) US4916212A (da)
EP (2) EP0163529B1 (da)
JP (4) JPH0630613B2 (da)
AT (1) ATE143374T1 (da)
AU (1) AU590197B2 (da)
CA (1) CA1304022C (da)
DE (2) DE3583824D1 (da)
DK (2) DK58285D0 (da)
ES (2) ES8609483A1 (da)
FI (1) FI89183C (da)
GR (1) GR851304B (da)
IE (1) IE66387B1 (da)
NO (1) NO174351C (da)
NZ (1) NZ212243A (da)
PT (1) PT80551B (da)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
US4963665A (en) * 1986-01-07 1990-10-16 Washington University Human preproinsulin-like growth factor I
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
DK450187D0 (da) * 1987-08-28 1987-08-28 Novo Industri As Fremgangsmaade til fremstilling af proteiner
DK463887D0 (da) * 1987-09-07 1987-09-07 Novo Industri As Gaerleader
US4904584A (en) * 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
DK336188D0 (da) * 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
EP0347781B1 (de) * 1988-06-23 1994-02-16 Hoechst Aktiengesellschaft Mini-Proinsulin, seine Herstellung und Verwendung
US6875589B1 (en) 1988-06-23 2005-04-05 Hoechst Aktiengesellschaft Mini-proinsulin, its preparation and use
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK105489D0 (da) * 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
WO1992010284A2 (en) 1990-12-07 1992-06-25 Cnc Development, Inc. Catalytic chemical reactor
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
CA2089541A1 (en) 1992-02-18 1993-08-19 Bruce H. Frank Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
US5891680A (en) * 1995-02-08 1999-04-06 Whitehead Institute For Biomedical Research Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
KR0150565B1 (ko) * 1995-02-15 1998-08-17 김정재 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
EP2431462A3 (en) 1995-03-17 2012-05-23 Novozymes A/S Novel endoglucanases
IL118127A0 (en) * 1995-05-05 1996-09-12 Lilly Co Eli Single chain insulin with high bioactivity
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
US5840542A (en) * 1995-07-28 1998-11-24 Mogam Biotechnology Research Institute Method for manufacture of proinsulin with high export yield
EP1975177B1 (en) 1996-03-01 2011-04-13 Novo Nordisk A/S An appetite-suppressing peptide, its compositions and use
ATE408631T1 (de) * 1998-03-31 2008-10-15 Tonghua Gantech Biotechnology Chimäres protein welches eine intramolekulare chaperon-ähnliche sequenz enthält und dessen anwendung zur insulinproduktion
CN1125081C (zh) 1999-09-08 2003-10-22 中国科学院上海生物化学研究所 重组天然和新型人胰岛素及其制备方法
JP2003530316A (ja) 1999-12-22 2003-10-14 ノボ ノルディスク アクティーゼルスカブ スクランブルした一本鎖ポリペプチドの抽出的再生法
US6777207B2 (en) 1999-12-29 2004-08-17 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
RU2283846C2 (ru) * 1999-12-29 2006-09-20 Ново Нордиск А/С Предшественник инсулина, способ его получения и применение
US6521738B2 (en) 1999-12-29 2003-02-18 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogs
JP4795599B2 (ja) 1999-12-29 2011-10-19 ノボ ノルディスク アクティーゼルスカブ 酵母において改良された発酵収率を有するインスリン前駆体及びインスリン前駆体類似体の製造方法
US7378390B2 (en) * 1999-12-29 2008-05-27 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
AU4935701A (en) 2000-03-24 2001-10-08 Genentech Inc Use of insulin for the treatment of cartilagenous disorders
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
US6926898B2 (en) * 2000-04-12 2005-08-09 Human Genome Sciences, Inc. Albumin fusion proteins
AR025646A1 (es) * 2000-09-13 2002-12-04 Beta Lab Sa Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa.
KR100449454B1 (ko) * 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
US20020164712A1 (en) * 2000-12-11 2002-11-07 Tonghua Gantech Biotechnology Ltd. Chimeric protein containing an intramolecular chaperone-like sequence
ES2432967T3 (es) 2001-03-22 2013-12-05 Novo Nordisk Health Care Ag Derivados del Factor VII de coagulación
EP1377608B1 (en) * 2001-04-02 2009-09-16 Novo Nordisk A/S Insulin precursors and a process for their preparation
US7105314B2 (en) 2001-04-02 2006-09-12 Novo Nordisk A/S Method for making human insulin precursors
WO2002097038A2 (en) * 2001-05-25 2002-12-05 Human Genome Sciences, Inc. Chemokine beta-1 fusion proteins
HUP0500060A3 (en) 2001-09-27 2010-01-28 Novo Nordisk Healthcare Ag Human coagulation factor vii polypeptides
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
WO2003059934A2 (en) * 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
CA2841097A1 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin and g-csf fusion proteins
CA2925807C (en) 2002-09-13 2020-09-15 Cornell Research Foundation, Inc. Using mutations to improve aspergillus phytases
WO2004024862A2 (en) * 2002-09-13 2004-03-25 Wockhardt Limited Yeast protein expression secretion system
WO2004085472A1 (en) * 2003-03-27 2004-10-07 Novo Nordisk A/S Method for making human insulin precursors and human insulin
TWI345587B (en) 2003-06-17 2011-07-21 Sembiosys Genetics Inc Methods for the production of insulin in plants
CN101870729A (zh) 2003-09-09 2010-10-27 诺和诺德医疗保健公司 凝固因子ⅶ多肽
EP1687428A1 (en) 2003-11-14 2006-08-09 Novo Nordisk A/S Processes for making acylated insulin
ES2369895T3 (es) * 2003-12-03 2011-12-07 Novo Nordisk A/S Insulina monocatenaria.
WO2006082204A1 (en) 2005-02-02 2006-08-10 Novo Nordisk A/S Insulin derivatives
ES2435522T3 (es) 2005-02-02 2013-12-20 Novo Nordisk A/S Derivados de insulina
AU2006237329B2 (en) 2005-04-18 2012-04-12 Novo Nordisk A/S IL-21 variants
ATE513921T1 (de) 2005-08-16 2011-07-15 Novo Nordisk As Verfahren zur herstellung reifer insulinpolypeptide
JP5690047B2 (ja) 2005-09-14 2015-03-25 ノボ ノルディスク ヘルス ケア アーゲー ヒト凝固第ｖｉｉ因子ポリペプチド
EP1996709A2 (en) * 2006-03-13 2008-12-03 Novo Nordisk A/S Acylated single chain insulin
CN101541830A (zh) 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 蛋白酶抗性的胰岛素类似物
WO2008037735A1 (en) 2006-09-27 2008-04-03 Novo Nordisk A/S Method for making maturated insulin polypeptides
WO2008062010A2 (en) 2006-11-22 2008-05-29 Novo Nordisk A/S Method for making activated carboxypeptidases
US7790677B2 (en) * 2006-12-13 2010-09-07 Elona Biotechnologies Insulin production methods and pro-insulin constructs
US10100098B2 (en) 2006-12-13 2018-10-16 Stelis Biopharma Private Limited Insulin production methods and proinsulin constructs
US8575096B2 (en) 2007-08-13 2013-11-05 Novo Nordisk A/S Rapid acting insulin analogues
WO2009022006A1 (en) 2007-08-15 2009-02-19 Novo Nordisk A/S Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids
AU2008288413B2 (en) 2007-08-15 2013-09-26 Novo Nordisk A/S Insulin analogues with an acyl and aklylene glycol moiety
CN101605889A (zh) * 2008-02-12 2009-12-16 伊藤火腿株式会社 含有高表达分泌胰岛素前体的融合蛋白、编码该融合蛋白的dna和胰岛素的制备方法
EP2262539B1 (en) 2008-04-01 2015-07-15 Novo Nordisk A/S Insulin albumin conjugates
US20120107267A1 (en) 2009-03-11 2012-05-03 Novo Nordisk A/S Interleukin-21 variants having antagonistic binding to the il-21 receptor
ES2543705T3 (es) 2009-06-26 2015-08-21 Novo Nordisk A/S Preparación que contiene insulina, nicotinamida y arginina
CA2767755C (en) 2009-07-17 2021-10-12 Rigshospitalet Inhibitors of complement activation
ES2583259T3 (es) 2009-12-01 2016-09-20 Novo Nordisk A/S Nuevas liasas alfa-amidantes de peptidil alfa-hidroxiglicina
AU2011222883B2 (en) 2010-03-05 2016-05-26 Omeros Corporation Chimeric inhibitor molecules of complement activation
EP2585483A1 (en) * 2010-06-23 2013-05-01 Novo Nordisk A/S Human insulin containing additional disulfide bonds
CA2802510A1 (en) 2010-06-23 2011-12-29 Novo Nordisk A/S Insulin derivatives containing additional disulfide bonds
EP2585484A1 (en) 2010-06-23 2013-05-01 Novo Nordisk A/S Insulin analogues containing additional disulfide bonds
WO2012080320A1 (en) 2010-12-14 2012-06-21 Novo Nordisk A/S Fast-acting insulin in combination with long-acting insulin
KR20140030125A (ko) 2010-12-14 2014-03-11 노보 노르디스크 에이/에스 인슐린, 니코틴아미드 및 아미노산을 포함하는 제제
CN103533952B (zh) 2011-03-15 2017-02-15 诺沃—诺迪斯克有限公司 包含半胱氨酸置换的人胰岛素类似物和衍生物
CN102675452B (zh) 2011-03-17 2015-09-16 重庆富进生物医药有限公司 具持续降血糖和受体高结合的人胰岛素及类似物的偶联物
EP2720711A1 (en) 2011-06-15 2014-04-23 Novo Nordisk A/S Multi substituted insulins
PL2812024T3 (pl) 2012-02-09 2018-09-28 Var2 Pharmaceuticals Aps Celowanie glikanów siarczanu chondroityny
WO2013186138A1 (en) 2012-06-14 2013-12-19 Novo Nordisk A/S Preparation comprising insulin, nicotinamide and arginine
CN104704118A (zh) 2012-10-15 2015-06-10 诺和诺德保健Ag（股份有限公司） 凝血因子vii多肽
EP2925345B1 (en) 2012-12-03 2018-09-05 Merck Sharp & Dohme Corp. Method for making o-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
US9867869B2 (en) 2012-12-12 2018-01-16 Massachusetts Institute Of Technology Insulin derivatives for diabetes treatment
US20160115216A1 (en) 2013-06-07 2016-04-28 Novo Nordisk A/S Method for Making Mature Insulin Polypeptides
GB201321489D0 (en) 2013-12-05 2014-01-22 Chemical & Biopharmaceutical Lab Of Patras S A Biologically active insulin derivatives
PL233560B1 (pl) 2014-12-05 2019-10-31 Mabion Spolka Akcyjna Sposób otrzymywania insuliny lub analogu insuliny z prekursora rekombinowanego białka
EA037848B1 (ru) 2016-07-14 2021-05-27 Общество С Ограниченной Ответственностью "Биохимический Агент" Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты)
BR112019004314A2 (pt) 2016-09-06 2019-05-28 Chemical & Biopharmaceutical Laboratories Of Patras S A derivados pró-insulina
CA3071686A1 (en) 2017-08-17 2019-02-21 Novo Nordisk A/S Novel acylated insulin analogues and uses thereof
CN112789504A (zh) 2018-07-13 2021-05-11 瓦克特诊断有限责任公司 使用重组疟疾蛋白var2csa分离胎儿来源的循环细胞
EP3845240B1 (en) 2018-09-12 2024-11-06 Amphastar Nanjing Pharmaceuticals, Inc. Pro-insulin aspart structure and method for preparing insulin aspart
BR112022013009A2 (pt) 2019-12-30 2022-09-06 Gan & Lee Pharmaceuticals Co Ltd Derivados de insulina, composição farmacêutica, uso do derivado da insulina e métodos para tratar ou prevenir diabetes, para aumentar a capacidade de um derivado de insulina e para aumentar a potência de um derivado de insulina
AU2020418207A1 (en) 2019-12-30 2022-08-25 Gan & Lee Pharmaceuticals Co., Ltd. Long-acting GLP-1 compound
WO2022049409A1 (en) 2020-09-02 2022-03-10 Sia Terragen Express diagnosticum for sars-cov-2
WO2023144240A1 (en) 2022-01-26 2023-08-03 Novo Nordisk Research Centre Oxford Limited Glucose sensitive insulin derivatives and uses thereof
WO2023143458A1 (zh) 2022-01-28 2023-08-03 甘李药业股份有限公司 酰化胰岛素

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4440859A (en) * 1977-05-27 1984-04-03 The Regents Of The University Of California Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
US4431740A (en) * 1979-09-12 1984-02-14 The Regents Of The University Of California DNA Transfer vector and transformed microorganism containing human proinsulin and pre-proinsulin genes
IE50892B1 (en) * 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
CA1202581A (en) * 1980-03-27 1986-04-01 Saran A. Narang Adaptor molecules for dna and their application to synthesis of gene-derived products
PL127843B1 (en) * 1980-03-27 1983-11-30 Lilly Co Eli Process for preparing insulin precursor
ZA811895B (en) * 1980-04-07 1982-04-28 Univ California Expression of hormone genomic clones
JPS5750948A (en) * 1980-09-12 1982-03-25 Shionogi & Co Ltd Insulin analog and preparation
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
IE52768B1 (en) * 1981-04-06 1988-02-17 Boots Co Ltd 1-arylcyclobutylalkylamine compounds useful as therapeutic agents
CA1204682A (en) * 1981-06-19 1986-05-20 Saran A. Narang Adaptors, and synthesis and cloning of proinsulin genes
ZA824218B (en) * 1981-06-29 1983-04-27 Cetus Corp Plasmid for producing human insulin
DK368882A (da) * 1981-08-25 1983-02-26 Alan John Kingsman Expessions vektorer
EP0090433A1 (en) * 1982-03-31 1983-10-05 Genetics Institute, Inc. Creation of DNA sequences encoding modified proinsulin precursors
AU1559483A (en) * 1982-03-31 1983-10-24 Genetics Institute Inc. Creation of dna sequences encoding modified proinsulin precursors
DK172738B1 (da) * 1983-04-07 1999-06-21 Chiron Corp Fremgangsmåde til at udtrykke modent insulin og DNA-struktur til anvendelse ved fremgangsmåden
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
JP2523562B2 (ja) * 1985-10-25 1996-08-14 ザイモジェネティックス インコーポレーテッド 外来タンパク質を分泌することを目的としたｂａｒ１の使用法

Also Published As

Publication number Publication date
AU4309285A (en) 1985-12-05
IE66387B1 (en) 1995-12-27
JPH07309896A (ja) 1995-11-28
GR851304B (da) 1985-11-25
NZ212243A (en) 1988-05-30
DE3583824D1 (de) 1991-09-26
ES8609483A1 (es) 1986-09-01
EP0427296A1 (en) 1991-05-15
NO174351C (no) 1994-04-20
DE3588125T2 (de) 1997-02-13
DK323687D0 (da) 1987-06-25
JPH0630613B2 (ja) 1994-04-27
DK157933B (da) 1990-03-05
JPS611389A (ja) 1986-01-07
JPH06141866A (ja) 1994-05-24
IE851331L (en) 1985-11-30
FI852135L (fi) 1985-12-01
NO852132L (no) 1985-12-02
DK58285D0 (da) 1985-02-08
FI89183C (fi) 1993-08-25
DK323687A (da) 1987-06-25
EP0163529A1 (en) 1985-12-04
ATE143374T1 (de) 1996-10-15
EP0427296B1 (en) 1996-09-25
US4916212A (en) 1990-04-10
AU590197B2 (en) 1989-11-02
FI852135A0 (fi) 1985-05-29
PT80551B (en) 1987-04-09
FI89183B (fi) 1993-05-14
JP2519023B2 (ja) 1996-07-31
JPH07121226B2 (ja) 1995-12-25
ES543594A0 (es) 1986-09-01
JPH0746998B2 (ja) 1995-05-24
ES8702488A1 (es) 1986-12-16
DE3588125D1 (de) 1996-10-31
PT80551A (en) 1985-06-01
EP0163529B1 (en) 1991-08-21
NO174351B (no) 1994-01-10
JPH06141865A (ja) 1994-05-24
ES551941A0 (es) 1986-12-16
CA1304022C (en) 1992-06-23

Similar Documents

Publication Publication Date Title
ATE143374T1 (de) Insulin-vorläufer
KR850004273A (ko) 안정성이 증대된 재조합 감마 인터페론 및 그의 제조방법
ES8801674A1 (es) Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante.
NZ513422A (en) G-CSF analogues that do not possess any hematopoietic activity and are useful as antagonists against G-CSF effect, such as overproduction of G-CSF
ES8802235A1 (es) Procedimiento para preparar un polipeptido
HU902697D0 (en) Process for the enzymatic removal of the n-terminal sequence of proteins
EP0150126A3 (en) The synthesis of protein with an identification peptide
DK336188D0 (da) Propeptider
IL74426A (en) Atrial peptides and pharmaceutical compositions comprising them
CA2207078A1 (en) Insulin derivatives with increased zinc binding
EP0195680A3 (en) The synthesis of protein with an identification peptide
EP0095351A3 (en) A precursor of a c-terminal amidated peptide and production thereof
EP0232107A3 (en) Human lymphotoxin polypeptide derivative
ES8506092A1 (es) Un metodo de producir un precursor del factor de liberacion de la hormona del crecimiento humana
ES2044928T3 (es) Enzima alfa-amidante en terminal c y procedimiento para la produccion y el uso del mismo.
ATE78872T1 (de) Herstellung von polypeptiden.
ES8801316A1 (es) Un procedimiento para preparar un material peptidico que tiene actividad humoral timica
DK238585A (da) Peptider og fremstilling deraf
WO1990000179A3 (fr) Nouvelles proteins, adn les codant et leur usage
EP0327360A3 (en) Novel polypeptides and dna encoding said polypeptides
FR2423481A2 (fr) Nouveaux polypeptides a activite thymique ou a activite antagoniste et leurs procedes de synthese
EP0266006A3 (en) Novel hypotensive diuretic peptides
DE3686036D1 (en) New fusion protein contg. small interleukin 2 ballast fragments
CA1267086C (en) METHOD OF ADMINISTRATION OF EAR DIURETIC PEPTIDES
DK301090A (da) Insulinprecursorer

Legal Events

Date Code Title Description
PBP Patent lapsed

Country of ref document: DK