NO174351C - Fremgangsmåte for fremstilling av human insulinforlöper samt DNA-sekvens og vektor til anvendelse av fremgangsmåten - Google Patents

Fremgangsmåte for fremstilling av human insulinforlöper samt DNA-sekvens og vektor til anvendelse av fremgangsmåten

Info

Publication number: NO174351C
Authority: NO; Norway
Prior art keywords: chain; human insulin; vector; well; dna sequence
Prior art date: 1984-05-30

Application number

NO852132A

Other languages

English (en)

Other versions

NO174351B (no

NO852132L (no

Inventor

Jan Markussen

Niels Fiil

Mogens Trier Hansen

Lars Thim

Kjeld Norris

Hans Ole Voigt

Gustav Ammerer

Original Assignee

Novo Nordisk As

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-30

Filing date

1985-05-29

Publication date

1994-04-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26064247&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO174351(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1984-05-30 Priority claimed from DK266584A external-priority patent/DK266584D0/da

1985-05-29 Application filed by Novo Nordisk As, Novo Industri As filed Critical Novo Nordisk As

1985-12-02 Publication of NO852132L publication Critical patent/NO852132L/no

1994-01-10 Publication of NO174351B publication Critical patent/NO174351B/no

1994-04-20 Publication of NO174351C publication Critical patent/NO174351C/no

Links

101000976075 Homo sapiens Insulin Proteins 0.000 title abstract 4
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 4
239000002243 precursor Substances 0.000 title abstract 4
108091028043 Nucleic acid sequence Proteins 0.000 title abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
125000000539 amino acid group Chemical group 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/94—Saccharomyces
- Y10S435/942—Saccharomyces cerevisiae

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Mycology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

NO852132A 1984-05-30 1985-05-29 Fremgangsmåte for fremstilling av human insulinforlöper samt DNA-sekvens og vektor til anvendelse av fremgangsmåten NO174351C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK266584A DK266584D0 (da)	1984-05-30	1984-05-30	Dna-sekvens, der koder for en biosyntetisk insulinprecursor og fremgangsmaade til fremstilling af insulinprecursoren
DK58285A DK58285D0 (da)	1984-05-30	1985-02-08	Peptider samt fremstilling og anvendelse deraf

Publications (3)

Publication Number	Publication Date
NO852132L NO852132L (no)	1985-12-02
NO174351B NO174351B (no)	1994-01-10
NO174351C true NO174351C (no)	1994-04-20

Family

ID=26064247

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO852132A NO174351C (no)	1984-05-30	1985-05-29	Fremgangsmåte for fremstilling av human insulinforlöper samt DNA-sekvens og vektor til anvendelse av fremgangsmåten

Country Status (15)

Country	Link
US (1)	US4916212A (no)
EP (2)	EP0163529B1 (no)
JP (4)	JPH0630613B2 (no)
AT (1)	ATE143374T1 (no)
AU (1)	AU590197B2 (no)
CA (1)	CA1304022C (no)
DE (2)	DE3588125T2 (no)
DK (2)	DK58285D0 (no)
ES (2)	ES8609483A1 (no)
FI (1)	FI89183C (no)
GR (1)	GR851304B (no)
IE (1)	IE66387B1 (no)
NO (1)	NO174351C (no)
NZ (1)	NZ212243A (no)
PT (1)	PT80551B (no)

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1985
- 1985-02-08 DK DK58285A patent/DK58285D0/da unknown
- 1985-05-28 GR GR851304A patent/GR851304B/el unknown
- 1985-05-29 AT AT90121887T patent/ATE143374T1/de active
- 1985-05-29 PT PT80551A patent/PT80551B/pt not_active IP Right Cessation
- 1985-05-29 DE DE3588125T patent/DE3588125T2/de not_active Expired - Fee Related
- 1985-05-29 ES ES543594A patent/ES8609483A1/es not_active Expired
- 1985-05-29 NO NO852132A patent/NO174351C/no not_active IP Right Cessation
- 1985-05-29 FI FI852135A patent/FI89183C/fi not_active IP Right Cessation
- 1985-05-29 EP EP85303775A patent/EP0163529B1/en not_active Expired - Lifetime
- 1985-05-29 IE IE133185A patent/IE66387B1/en not_active IP Right Cessation
- 1985-05-29 DE DE8585303775T patent/DE3583824D1/de not_active Expired - Lifetime
- 1985-05-29 JP JP60116297A patent/JPH0630613B2/ja not_active Expired - Lifetime
- 1985-05-29 NZ NZ212243A patent/NZ212243A/en unknown
- 1985-05-29 CA CA000482722A patent/CA1304022C/en not_active Expired - Lifetime
- 1985-05-29 US US06/739,123 patent/US4916212A/en not_active Expired - Lifetime
- 1985-05-29 EP EP90121887A patent/EP0427296B1/en not_active Expired - Lifetime
- 1985-05-29 AU AU43092/85A patent/AU590197B2/en not_active Ceased
1986
- 1986-02-13 ES ES551941A patent/ES8702488A1/es not_active Expired
1987
- 1987-06-25 DK DK323687A patent/DK157933C/da not_active IP Right Cessation
1993
- 1993-05-24 JP JP5121694A patent/JPH0746998B2/ja not_active Expired - Fee Related
- 1993-05-24 JP JP5121649A patent/JPH07121226B2/ja not_active Expired - Fee Related
1995
- 1995-06-08 JP JP7142085A patent/JP2519023B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK157933C (da)	1990-08-27
ES8609483A1 (es)	1986-09-01
DE3588125D1 (de)	1996-10-31
IE851331L (en)	1985-11-30
PT80551B (en)	1987-04-09
JPH06141866A (ja)	1994-05-24
ES551941A0 (es)	1986-12-16
EP0427296A1 (en)	1991-05-15
ES543594A0 (es)	1986-09-01
JPH07121226B2 (ja)	1995-12-25
PT80551A (en)	1985-06-01
ES8702488A1 (es)	1986-12-16
JP2519023B2 (ja)	1996-07-31
NO174351B (no)	1994-01-10
FI852135A0 (fi)	1985-05-29
FI852135L (fi)	1985-12-01
DE3583824D1 (de)	1991-09-26
DE3588125T2 (de)	1997-02-13
DK58285D0 (da)	1985-02-08
ATE143374T1 (de)	1996-10-15
DK323687D0 (da)	1987-06-25
EP0163529A1 (en)	1985-12-04
JPH07309896A (ja)	1995-11-28
US4916212A (en)	1990-04-10
NO852132L (no)	1985-12-02
JPS611389A (ja)	1986-01-07
DK157933B (da)	1990-03-05
JPH0746998B2 (ja)	1995-05-24
GR851304B (no)	1985-11-25
CA1304022C (en)	1992-06-23
IE66387B1 (en)	1995-12-27
FI89183B (fi)	1993-05-14
NZ212243A (en)	1988-05-30
DK323687A (da)	1987-06-25
FI89183C (fi)	1993-08-25
JPH0630613B2 (ja)	1994-04-27
EP0163529B1 (en)	1991-08-21
AU4309285A (en)	1985-12-05
JPH06141865A (ja)	1994-05-24
AU590197B2 (en)	1989-11-02
EP0427296B1 (en)	1996-09-25

Legal Events

Date	Code	Title	Description
2003-12-29	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN NOVEMBER 2003

Publication	Publication Date	Title
AU590197B2 (en)	1989-11-02	Insulin precursors, process for their preparation and process for preparing human insulin from such insulin precursors
HUT54213A (en)	1991-01-28	Process for the enzymatic removal of n-terminal sequence of proteins
EP0150126A3 (en)	1987-06-03	The synthesis of protein with an identification peptide
IE891976L (en)	1989-12-20	Propeptides
AU595221B2 (en)	1990-03-29	Fusion proteins, a process for their preparation and their use
AU7565991A (en)	1991-11-27	Variant cd44 surface proteins, dna sequences coding them, antibodies against these proteins and their use in diagnosis and therapy
EP1396542A3 (en)	2004-05-06	P-Selectin Ligand Protein
DK164940C (da)	1993-02-01	Polypeptid med human-gamma-interferonaktivitet, genteknologisk fremgangsmaade til fremstilling deraf, hybrid-plasmider indeholdende en dna-sekvens, der koder for peptidet, vaertsorganismer indeholdende hybridplasmiderne, samt laegemidler, som indeholder polypeptidet
EP0111389A3 (en)	1985-08-14	Substantially pure porcine growth hormone, dna sequences therefor, and expression vehicles and transfected microorganisms for the production of porcine growth hormone
DE293530T1 (de)	1989-11-16	Hormone.
EP0494702A3 (en)	1992-11-19	Production of factor xiiia by gene technology
ATE79409T1 (de)	1992-08-15	Herstellungsverfahren fuer humanes atriales natriuretisches polypeptid.
EP0195680A3 (en)	1987-06-10	The synthesis of protein with an identification peptide
DE3779711D1 (en)	1992-07-16	Simultaneous solid-phase synthesis of different peptide(s)
EP0232107A3 (en)	1988-04-27	Human lymphotoxin polypeptide derivative
ES8506092A1 (es)	1985-06-16	Un metodo de producir un precursor del factor de liberacion de la hormona del crecimiento humana
EP0249412A3 (en)	1989-02-22	C-terminal alpha-amidating enzyme and process for production and use thereof
JPS6420086A (en)	1989-01-24	Polypeptide and production thereof
DK238585A (da)	1985-12-01	Peptider og fremstilling deraf
GB1210557A (en)	1970-10-28	Synthesis of polypeptides containing cysteine
TH4142A (th)	1987-05-01	สารคล้ายคลึงอินซูลินและกรรมวิธีสำหรับการเตรียม?สารดังกล่าว
TH4171B (th)	1994-11-22	สารคล้ายคลึงอินซูลินและกรรมวิธีสำหรับการเตรียม?สารดังกล่าว
DK301090A (da)	1990-12-19	Insulinprecursorer