ES551941A0 - Un procedimiento para preparar un precursor de insulina - Google Patents

Un procedimiento para preparar un precursor de insulina

Info

Publication number: ES551941A0
Authority: ES; Spain
Prior art keywords: chain; human insulin; insulin; bridging; lys
Prior art date: 1984-05-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES551941A

Other languages

English (en)

Other versions

ES8702488A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novo Nordisk AS

Original Assignee

Novo Industri AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-30

Filing date

1986-02-13

Publication date

1986-12-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26064247&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES551941(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1984-05-30 Priority claimed from DK266584A external-priority patent/DK266584D0/da

1986-02-13 Application filed by Novo Industri AS filed Critical Novo Industri AS

1986-12-16 Publication of ES551941A0 publication Critical patent/ES551941A0/es

1986-12-16 Publication of ES8702488A1 publication Critical patent/ES8702488A1/es

Status Expired legal-status Critical Current

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
239000002243 precursor Substances 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 3
108090001061 Insulin Proteins 0.000 title abstract 3
229940125396 insulin Drugs 0.000 title abstract 3
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 3
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 3
125000000539 amino acid group Chemical group 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/94—Saccharomyces
- Y10S435/942—Saccharomyces cerevisiae

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Mycology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

ES551941A 1984-05-30 1986-02-13 Un procedimiento para preparar un precursor de insulina Expired ES8702488A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK266584A DK266584D0 (da)	1984-05-30	1984-05-30	Dna-sekvens, der koder for en biosyntetisk insulinprecursor og fremgangsmaade til fremstilling af insulinprecursoren
DK58285A DK58285D0 (da)	1984-05-30	1985-02-08	Peptider samt fremstilling og anvendelse deraf

Publications (2)

Publication Number	Publication Date
ES551941A0 true ES551941A0 (es)	1986-12-16
ES8702488A1 ES8702488A1 (es)	1986-12-16

Family

ID=26064247

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES543594A Expired ES8609483A1 (es)	1984-05-30	1985-05-29	Un procedimiento para producir un precursor de insulina
ES551941A Expired ES8702488A1 (es)	1984-05-30	1986-02-13	Un procedimiento para preparar un precursor de insulina

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ES543594A Expired ES8609483A1 (es)	1984-05-30	1985-05-29	Un procedimiento para producir un precursor de insulina

Country Status (15)

Country	Link
US (1)	US4916212A (es)
EP (2)	EP0163529B1 (es)
JP (4)	JPH0630613B2 (es)
AT (1)	ATE143374T1 (es)
AU (1)	AU590197B2 (es)
CA (1)	CA1304022C (es)
DE (2)	DE3583824D1 (es)
DK (2)	DK58285D0 (es)
ES (2)	ES8609483A1 (es)
FI (1)	FI89183C (es)
GR (1)	GR851304B (es)
IE (1)	IE66387B1 (es)
NO (1)	NO174351C (es)
NZ (1)	NZ212243A (es)
PT (1)	PT80551B (es)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
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DK105489D0 (da) *	1989-03-03	1989-03-03	Novo Nordisk As	Polypeptid
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US5840542A (en) *	1995-07-28	1998-11-24	Mogam Biotechnology Research Institute	Method for manufacture of proinsulin with high export yield
DE69717092T2 (de)	1996-03-01	2003-07-24	Novo Nordisk A/S, Bagsvaerd	Gebrauch einer pharmazeutischen Zusammensetzung, enthaltend ein appetitzügelndes Peptid
DE69840035D1 (de) *	1998-03-31	2008-10-30	Tonghua Gantech Biotechnology	Chimäres protein welches eine intramolekulare chap zur insulinproduktion
CN1125081C (zh)	1999-09-08	2003-10-22	中国科学院上海生物化学研究所	重组天然和新型人胰岛素及其制备方法
WO2001046453A1 (en)	1999-12-22	2001-06-28	Novo Nordisk A/S	Method for extractive refolding of scrambled single-chain polypeptides
EP1246933B1 (en)	1999-12-29	2010-07-21	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
US6777207B2 (en)	1999-12-29	2004-08-17	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
KR20030004317A (ko) *	1999-12-29	2003-01-14	노보 노르디스크 에이/에스	인슐린 선구물질 및 인슐린 선구물질 유사체의 제조 방법
US6521738B2 (en)	1999-12-29	2003-02-18	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogs
US7378390B2 (en)	1999-12-29	2008-05-27	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
CA2402191C (en)	2000-03-24	2012-03-13	Genentech, Inc.	Use of insulin for the treatment of cartilagenous disorders
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KR100449454B1 (ko) *	2000-10-02	2004-09-21	이현철	단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
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DK2074141T3 (en)	2006-09-22	2016-11-28	Novo Nordisk As	The protease resistant insulin analogues.
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1985
- 1985-02-08 DK DK58285A patent/DK58285D0/da unknown
- 1985-05-28 GR GR851304A patent/GR851304B/el unknown
- 1985-05-29 EP EP85303775A patent/EP0163529B1/en not_active Expired - Lifetime
- 1985-05-29 DE DE8585303775T patent/DE3583824D1/de not_active Expired - Lifetime
- 1985-05-29 JP JP60116297A patent/JPH0630613B2/ja not_active Expired - Lifetime
- 1985-05-29 EP EP90121887A patent/EP0427296B1/en not_active Expired - Lifetime
- 1985-05-29 NO NO852132A patent/NO174351C/no not_active IP Right Cessation
- 1985-05-29 DE DE3588125T patent/DE3588125T2/de not_active Expired - Fee Related
- 1985-05-29 ES ES543594A patent/ES8609483A1/es not_active Expired
- 1985-05-29 AU AU43092/85A patent/AU590197B2/en not_active Ceased
- 1985-05-29 PT PT80551A patent/PT80551B/pt not_active IP Right Cessation
- 1985-05-29 FI FI852135A patent/FI89183C/fi not_active IP Right Cessation
- 1985-05-29 US US06/739,123 patent/US4916212A/en not_active Expired - Lifetime
- 1985-05-29 NZ NZ212243A patent/NZ212243A/en unknown
- 1985-05-29 IE IE133185A patent/IE66387B1/en not_active IP Right Cessation
- 1985-05-29 AT AT90121887T patent/ATE143374T1/de active
- 1985-05-29 CA CA000482722A patent/CA1304022C/en not_active Expired - Lifetime
1986
- 1986-02-13 ES ES551941A patent/ES8702488A1/es not_active Expired
1987
- 1987-06-25 DK DK323687A patent/DK157933C/da not_active IP Right Cessation
1993
- 1993-05-24 JP JP5121649A patent/JPH07121226B2/ja not_active Expired - Fee Related
- 1993-05-24 JP JP5121694A patent/JPH0746998B2/ja not_active Expired - Fee Related
1995
- 1995-06-08 JP JP7142085A patent/JP2519023B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK157933B (da)	1990-03-05
DK323687A (da)	1987-06-25
FI852135A0 (fi)	1985-05-29
EP0163529B1 (en)	1991-08-21
JPS611389A (ja)	1986-01-07
PT80551A (en)	1985-06-01
FI89183C (fi)	1993-08-25
JPH0630613B2 (ja)	1994-04-27
PT80551B (en)	1987-04-09
NO174351B (no)	1994-01-10
JPH06141865A (ja)	1994-05-24
IE851331L (en)	1985-11-30
DE3588125D1 (de)	1996-10-31
NZ212243A (en)	1988-05-30
EP0427296A1 (en)	1991-05-15
FI89183B (fi)	1993-05-14
FI852135L (fi)	1985-12-01
DK323687D0 (da)	1987-06-25
ES8609483A1 (es)	1986-09-01
JPH07121226B2 (ja)	1995-12-25
NO852132L (no)	1985-12-02
ES8702488A1 (es)	1986-12-16
JPH0746998B2 (ja)	1995-05-24
US4916212A (en)	1990-04-10
NO174351C (no)	1994-04-20
DE3583824D1 (de)	1991-09-26
JPH07309896A (ja)	1995-11-28
GR851304B (es)	1985-11-25
DK157933C (da)	1990-08-27
ATE143374T1 (de)	1996-10-15
AU4309285A (en)	1985-12-05
JP2519023B2 (ja)	1996-07-31
ES543594A0 (es)	1986-09-01
IE66387B1 (en)	1995-12-27
JPH06141866A (ja)	1994-05-24
CA1304022C (en)	1992-06-23
AU590197B2 (en)	1989-11-02
DK58285D0 (da)	1985-02-08
DE3588125T2 (de)	1997-02-13
EP0163529A1 (en)	1985-12-04
EP0427296B1 (en)	1996-09-25

Publication	Publication Date	Title
ES551941A0 (es)	1986-12-16	Un procedimiento para preparar un precursor de insulina
HUT54213A (en)	1991-01-28	Process for the enzymatic removal of n-terminal sequence of proteins
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ES8801674A1 (es)	1988-02-16	Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante.
EP0150126A3 (en)	1987-06-03	The synthesis of protein with an identification peptide
ES8802235A1 (es)	1988-04-16	Procedimiento para preparar un polipeptido
IL74426A (en)	1989-09-10	Atrial peptides and pharmaceutical compositions comprising them
PL356005A1 (en)	2004-05-31	Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
EP0195680A3 (en)	1987-06-10	The synthesis of protein with an identification peptide
DE3380819D1 (en)	1989-12-14	A precursor of a c-terminal amidated peptide and production thereof
ES8506092A1 (es)	1985-06-16	Un metodo de producir un precursor del factor de liberacion de la hormona del crecimiento humana
ES2044928T3 (es)	1994-01-16	Enzima alfa-amidante en terminal c y procedimiento para la produccion y el uso del mismo.
JPS6420086A (en)	1989-01-24	Polypeptide and production thereof
DK238585A (da)	1985-12-01	Peptider og fremstilling deraf
WO1990000179A3 (fr)	1990-03-08	Nouvelles proteins, adn les codant et leur usage
EP0327360A3 (en)	1990-05-02	Novel polypeptides and dna encoding said polypeptides
EP0266006A3 (en)	1990-04-11	Novel hypotensive diuretic peptides
CA1267086C (en)	1990-03-27	METHOD OF ADMINISTRATION OF EAR DIURETIC PEPTIDES
DE3686036D1 (en)	1992-08-20	New fusion protein contg. small interleukin 2 ballast fragments
AU2900989A (en)	1989-07-19	Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2)
DK301090A (da)	1990-12-19	Insulinprecursorer
GB1210557A (en)	1970-10-28	Synthesis of polypeptides containing cysteine