DK2474545T3 - Heteroaryl-substituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-b]pyrimidiner som Janus-kinaseinhibitorer - Google Patents

Heteroaryl-substituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-b]pyrimidiner som Janus-kinaseinhibitorer Download PDF

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DK2474545T3
DK2474545T3 DK11152714.9T DK11152714T DK2474545T3 DK 2474545 T3 DK2474545 T3 DK 2474545T3 DK 11152714 T DK11152714 T DK 11152714T DK 2474545 T3 DK2474545 T3 DK 2474545T3
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pyrrolo
mol
methyl
compound
pyrazol
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DK11152714.9T
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James D Rodgers
Stacey Shepard
Thomas P Maduskuie
Haisheng Wang
Nikoo Falahatpisheh
Maria Rafalski
Argyrios G Arvanitis
Louis Storace
Ravi Kumar Jalluri
Jordan S Fridman
Krishna Vaddi
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Incyte Holdings Corp
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (20)

1. Forbindelse, som er 3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-lH-pyrazol-l-yl]propannitril, eller et farmaceutisk acceptabelt salt deraf, til anvendelse i behandling afen cancer valgt fra akut lymfoblastisk leukæmi, cancer af hovedet og hals, gastrisk cancer, glioblastom, melanom, Sezary syndrom, og mycosis fungoides hos en patient.
2. Forbindelsen eller salt til anvendelse ifølge krav 1, hvor canceren er akut lymfoblastisk leukæmi.
3. Forbindelsen eller salt til anvendelse ifølge krav 1, hvor canceren er cancer af hovedet og hals.
4. Forbindelsen eller salt til anvendelse ifølge krav 1, hvor canceren er gastrisk cancer.
5. Forbindelsen eller salt til anvendelse ifølge krav 1, hvor canceren er glioblastom.
6. Forbindelsen eller salt til anvendelse ifølge krav 1, hvor canceren er melanom.
7. Forbindelsen eller salt til anvendelse ifølge krav 1, hvor canceren er Sezary syndrom.
8. Forbindelsen eller salt til anvendelse ifølge krav 1, hvor canceren er mycosis fungoides.
9. Forbindelsen ellersalt til anvendelse ifølge krav 1, hvor forbindelsen ellersaltet administreres i kombination med et yderligere farmaceutisk middel.
10. Forbindelsen eller salt til anvendelse ifølge krav 9, hvor det ene yderligere farmaceutiske middel er et kemoterapeutisk middel.
11. Forbindelsen eller salt til anvendelse ifølge krav 10, hvor det kemoterapeutiske middel er revlimid.
12. Forbindelsen eller salt til anvendelse ifølge krav 10, hvor det kemoterapeutiske middel er et DNA-skadende middel.
13. Forbindelsen eller salt til anvendelse ifølge krav 12, hvor det DNA-skadende middel er valgt fra melphalan, doxorubicin, cyclophosphamid, vineristin, etoposid, og carmustin.
14. Forbindelsen eller salt til anvendelse ifølge krav 9, hvor det yderligere farmaceutiske middel er valgt fra melphalan plus prednison, doxorubicin, dexamethason, og bortezomib.
15. Forbindelsen eller salt til anvendelse ifølge krav 9, hvor det yderligere farmaceutiske middel er et corticosteroid.
16. Forbindelsen eller salt til anvendelse ifølge krav 15, hvor corticosteroidet er dexamethason.
17. Forbindelsen eller salt til anvendelse ifølge krav 15, hvor corticosteroidet er prednison.
18. Forbindelsen eller salt til anvendelse ifølge krav 1, hvor ca. 5 til ca. 1000 mg af forbindelsen eller saltet administreres til patienten.
19. Forbindelsen eller salt til anvendelse ifølge krav 9, hvor forbindelsen eller saltet og det yderligere farmaceutiske middel administreres simultant til patienten.
20. Forbindelsen eller salt til anvendelse ifølge krav 9, hvor forbindelsen eller saltet og det yderligere farmaceutiske middel indgives sekventielt til patienten.
DK11152714.9T 2005-12-13 2006-12-12 Heteroaryl-substituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-b]pyrimidiner som Janus-kinaseinhibitorer DK2474545T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US74990505P 2005-12-13 2005-12-13
US81023106P 2006-06-02 2006-06-02
US85062506P 2006-10-10 2006-10-10
US85687206P 2006-11-03 2006-11-03
US85940406P 2006-11-16 2006-11-16
EP06839328A EP1966202B1 (en) 2005-12-13 2006-12-12 Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors

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DK2474545T3 true DK2474545T3 (da) 2017-01-23

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DK16197502.4T DK3184526T3 (da) 2005-12-13 2006-12-12 Pyrrolo[2,3-d]pyrimidinderivativer som janus-kinase-inhibitor
DK11152708.1T DK2348023T5 (da) 2005-12-13 2006-12-12 Heteroaryl-substituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-b]pyrimidiner som Janus-kinase-inhibitorer
DK11152714.9T DK2474545T3 (da) 2005-12-13 2006-12-12 Heteroaryl-substituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-b]pyrimidiner som Janus-kinaseinhibitorer
DK11152723.0T DK2426129T3 (da) 2005-12-13 2006-12-12 Heteroaryl-substituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-b]pyrimidiner som Janus kinase-inhibitorer
DK11152730.5T DK2455382T3 (da) 2005-12-13 2006-12-12 Heteroaryl substituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-b]pyrimidiner som Janus kinase-inhibitorer
DK11152677.8T DK2343299T3 (da) 2005-12-13 2006-12-12 Heteroaryl-substituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-b]pyrimidiner som Janus kinase-inhibitorer
DK06839328.9T DK1966202T3 (da) 2005-12-13 2006-12-12 Heteroarylsubstituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-d]pyrimidiner som Januskinaseinhibitorer

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DK16197502.4T DK3184526T3 (da) 2005-12-13 2006-12-12 Pyrrolo[2,3-d]pyrimidinderivativer som janus-kinase-inhibitor
DK11152708.1T DK2348023T5 (da) 2005-12-13 2006-12-12 Heteroaryl-substituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-b]pyrimidiner som Janus-kinase-inhibitorer

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DK11152723.0T DK2426129T3 (da) 2005-12-13 2006-12-12 Heteroaryl-substituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-b]pyrimidiner som Janus kinase-inhibitorer
DK11152730.5T DK2455382T3 (da) 2005-12-13 2006-12-12 Heteroaryl substituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-b]pyrimidiner som Janus kinase-inhibitorer
DK11152677.8T DK2343299T3 (da) 2005-12-13 2006-12-12 Heteroaryl-substituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-b]pyrimidiner som Janus kinase-inhibitorer
DK06839328.9T DK1966202T3 (da) 2005-12-13 2006-12-12 Heteroarylsubstituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-d]pyrimidiner som Januskinaseinhibitorer

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US (16) US7598257B2 (da)
EP (10) EP2455382B1 (da)
JP (4) JP5017278B2 (da)
KR (4) KR101324737B1 (da)
CN (4) CN101448826A (da)
AR (1) AR057995A1 (da)
AT (1) ATE525374T1 (da)
AU (1) AU2006326548B2 (da)
BE (1) BE2013C014I2 (da)
BR (1) BRPI0619817B8 (da)
CA (1) CA2632466C (da)
CR (2) CR10065A (da)
CY (8) CY1112762T1 (da)
DK (7) DK3184526T3 (da)
EA (3) EA019504B1 (da)
EC (2) ECSP088540A (da)
ES (10) ES2612489T3 (da)
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HR (7) HRP20110903T1 (da)
HU (7) HUE028588T2 (da)
IL (3) IL192019A (da)
LT (6) LT3184526T (da)
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NZ (2) NZ569015A (da)
PL (7) PL2343299T3 (da)
PT (7) PT2474545T (da)
RS (7) RS54683B1 (da)
SG (3) SG10202003901UA (da)
SI (7) SI2455382T1 (da)
TW (6) TWI553008B (da)
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